ZA919965B - Cloning and expression of borrelia lipoproteins - Google Patents

Cloning and expression of borrelia lipoproteins

Info

Publication number: ZA919965B
Authority: ZA; South Africa
Prior art keywords: ospa; pet9; borrelia; cloning; protein
Prior art date: 1990-12-21

Application number

ZA919965A

Other languages

English (en)

Inventor

John J Dunn

J Dunn John

Alan G Barbour

G Barbour Alan

Original Assignee

Ass Universities Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-21

Filing date

1991-12-18

Publication date

1992-11-25

1991-12-18 Application filed by Ass Universities Inc filed Critical Ass Universities Inc

1992-11-25 Publication of ZA919965B publication Critical patent/ZA919965B/xx

Links

241000589968 Borrelia Species 0.000 title abstract 2
102000004895 Lipoproteins Human genes 0.000 title abstract 2
108090001030 Lipoproteins Proteins 0.000 title abstract 2
208000016604 Lyme disease Diseases 0.000 title abstract 2
238000010367 cloning Methods 0.000 title abstract 2
101710105714 Outer surface protein A Proteins 0.000 abstract 3
101900341263 Borrelia burgdorferi Outer surface protein A Proteins 0.000 abstract 2
230000003321 amplification Effects 0.000 abstract 2
239000013604 expression vector Substances 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
238000003199 nucleic acid amplification method Methods 0.000 abstract 2
241000588724 Escherichia coli Species 0.000 abstract 1
108091034117 Oligonucleotide Proteins 0.000 abstract 1
108090000233 Signal peptidase II Proteins 0.000 abstract 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
239000013612 plasmid Substances 0.000 abstract 1
238000003752 polymerase chain reaction Methods 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
102000004169 proteins and genes Human genes 0.000 abstract 1
230000002194 synthesizing effect Effects 0.000 abstract 1
230000001131 transforming effect Effects 0.000 abstract 1
230000014616 translation Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/20—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Spirochaetales (O), e.g. Treponema, Leptospira
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
Biotechnology (AREA)
Medicinal Chemistry (AREA)
Plant Pathology (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Compounds Of Unknown Constitution (AREA)
Saccharide Compounds (AREA)
Steroid Compounds (AREA)
External Artificial Organs (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

ZA919965A 1990-12-21 1991-12-18 Cloning and expression of borrelia lipoproteins ZA919965B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US63207290A	1990-12-21	1990-12-21

Publications (1)

Publication Number	Publication Date
ZA919965B true ZA919965B (en)	1992-11-25

Family

ID=24533958

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA919965A ZA919965B (en)	1990-12-21	1991-12-18	Cloning and expression of borrelia lipoproteins

Country Status (14)

Country	Link
US (1)	US5571718A (fr)
EP (1)	EP0492964B1 (fr)
JP (1)	JP2706397B2 (fr)
AT (1)	ATE204020T1 (fr)
AU (1)	AU656159B2 (fr)
CA (1)	CA2057536C (fr)
DE (1)	DE69132681T2 (fr)
DK (1)	DK0492964T3 (fr)
FI (1)	FI105924B (fr)
IE (1)	IE66473B1 (fr)
IL (1)	IL100422A0 (fr)
NO (1)	NO303453B1 (fr)
PT (1)	PT99918B (fr)
ZA (1)	ZA919965B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4015911A1 (de)	1989-09-19	1991-03-28	Max Planck Gesellschaft	Impfstoff gegen die lyme-krankheit
SG122738A1 (en)	1990-06-15	2006-06-29	Univ Yale	Compositions and methods for the prevention and diagnosis of lyme disease
US6113914A (en) *	1991-08-15	2000-09-05	Smithkline Beecham Biologicals (S.A.)	Osp A proteins of Borrelia burgdorferi subgroups, encoding genes and vaccines
US6676942B1 (en) *	1991-08-15	2004-01-13	Smithkline Beecham Biologicals (S.A.)	Osp a proteins of Borrelia burgdorferi subgroups, encoding genes and vaccines
CA2121121C (fr) *	1991-10-18	2003-06-10	Lorne F. Erdile	Preparation de proteines recombinantes de type borrelia
BE1006728A3 (fr) *	1993-02-19	1994-11-29	Wallone Region	Sondes d'acides nucleiques specifiques au spirochete borrelia burgdorferi.
US5439808A (en)	1993-07-23	1995-08-08	North American Vaccine, Inc.	Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis
US6004534A (en) *	1993-07-23	1999-12-21	Massachusetts Institute Of Technology	Targeted polymerized liposomes for improved drug delivery
US7008625B2 (en)	1993-11-01	2006-03-07	Research Foundation Of The State University Of New York	Recombinant constructs of Borrelia burgdorferi
US6248562B1 (en)	1993-11-01	2001-06-19	Research Foundation State University Of New York	Chimeric proteins comprising borrelia polypeptides and uses therefor
US5747287A (en) *	1995-04-28	1998-05-05	North American Vaccine, Inc.	Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis
DE69733944T3 (de) *	1996-02-21	2012-07-26	The Board Of Regents, The University Of Texas System	Vmp-ähnliche sequenzen von pathogener borrelia
US5846946A (en) *	1996-06-14	1998-12-08	Pasteur Merieux Serums Et Vaccins	Compositions and methods for administering Borrelia DNA
AU722630B2 (en) *	1997-02-14	2000-08-10	Higeta Shoyu Co., Ltd.	Modified Treponema pallidum-derived antigen protein
US6060082A (en) *	1997-04-18	2000-05-09	Massachusetts Institute Of Technology	Polymerized liposomes targeted to M cells and useful for oral or mucosal drug delivery
US6689573B1 (en) *	1999-05-24	2004-02-10	New England Biolabs, Inc.	Method for screening restriction endonucleases
EP1311540B1 (fr) *	2000-08-18	2007-12-19	Research Foundation Of State University Of New York	Ospa du borrelia burgdorferi modifie
US7729322B2 (en) *	2002-02-28	2010-06-01	Qualcomm Incorporated	HDLC hardware accelerator
AU2003299872A1 (en)	2002-12-20	2004-07-22	Board Of Regents, The University Of Texas System	Vmp-like sequences of pathogenic borrelia species and strains
WO2009135118A2 (fr) *	2008-05-02	2009-11-05	Virginia Commonwealth University	Vaccin contre la maladie de lyme
CN112584858A (zh) *	2018-04-03	2021-03-30	赛诺菲	抗原性ospa多肽
US12631635B2 (en) *	2021-01-15	2026-05-19	Id-Fish Technology, Inc.	Species-specific antigen sequences for tick-borne relapsing fever (TBRF) and methods of use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK590288D0 (da) *	1988-10-24	1988-10-24	Symbicom Ab	Kemiske forbindelser
DE4015911A1 (de) *	1989-09-19	1991-03-28	Max Planck Gesellschaft	Impfstoff gegen die lyme-krankheit
SG122738A1 (en) *	1990-06-15	2006-06-29	Univ Yale	Compositions and methods for the prevention and diagnosis of lyme disease
IE912303A1 (en) *	1990-07-06	1992-01-15	American Home Prod	Vaccine against lyme disease and a challenge model for¹evaluating vaccine efficiency

1991
- 1991-12-12 CA CA002057536A patent/CA2057536C/fr not_active Expired - Fee Related
- 1991-12-18 ZA ZA919965A patent/ZA919965B/xx unknown
- 1991-12-18 DK DK91311758T patent/DK0492964T3/da active
- 1991-12-18 AU AU89834/91A patent/AU656159B2/en not_active Ceased
- 1991-12-18 DE DE69132681T patent/DE69132681T2/de not_active Expired - Lifetime
- 1991-12-18 AT AT91311758T patent/ATE204020T1/de not_active IP Right Cessation
- 1991-12-18 EP EP91311758A patent/EP0492964B1/fr not_active Expired - Lifetime
- 1991-12-19 IL IL100422A patent/IL100422A0/xx unknown
- 1991-12-19 IE IE444991A patent/IE66473B1/en not_active IP Right Cessation
- 1991-12-19 FI FI916023A patent/FI105924B/fi not_active IP Right Cessation
- 1991-12-20 NO NO915051A patent/NO303453B1/no unknown
- 1991-12-20 PT PT99918A patent/PT99918B/pt not_active IP Right Cessation
- 1991-12-21 JP JP3361129A patent/JP2706397B2/ja not_active Expired - Fee Related
1992
- 1992-09-08 US US07/941,523 patent/US5571718A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2057536C (fr)	1999-10-26
IE66473B1 (en)	1995-12-27
AU8983491A (en)	1992-06-25
FI105924B (fi)	2000-10-31
JP2706397B2 (ja)	1998-01-28
EP0492964A2 (fr)	1992-07-01
DE69132681D1 (de)	2001-09-13
IL100422A0 (en)	1992-09-06
JPH0641195A (ja)	1994-02-15
PT99918A (pt)	1992-12-31
EP0492964A3 (en)	1993-02-24
FI916023A0 (fi)	1991-12-19
DE69132681T2 (de)	2001-11-22
IE914449A1 (en)	1992-07-01
DK0492964T3 (da)	2001-10-08
NO915051L (no)	1992-06-22
AU656159B2 (en)	1995-01-27
NO915051D0 (no)	1991-12-20
PT99918B (pt)	1999-08-31
US5571718A (en)	1996-11-05
FI916023L (fi)	1992-06-22
CA2057536A1 (fr)	1992-06-22
NO303453B1 (no)	1998-07-13
EP0492964B1 (fr)	2001-08-08
ATE204020T1 (de)	2001-08-15

Publication	Publication Date	Title
EP0492964A3 (en)	1993-02-24	Cloning and expression of borrelia lipoproteins
AU566348B2 (en)	1987-10-15	Yeast hybrid vectors and their use for the production of polypeptides
PH11995051386B1 (en)	2002-09-18	Novel pesticidal proteins and strains
IL76762A (en)	1991-08-16	Autonomous replication sequences for yeast strains of the species pichia pastoris
WO1995033818A3 (fr)	1995-12-28	Genes pour la synthese des substances antipathogenes
FR2637612B1 (fr)	1993-09-10	Sequences de nucleotides codant pour une proteine a activite ureasique
CA2066370A1 (fr)	1992-10-27	Production favorisee par la secretion de proteines a ponts disulfures
Lingnau et al.	1996	Identification and purification of novel internalin-related proteins in Listeria monocytogenes and Listeria ivanovii
WO1989007144A3 (fr)	1989-09-08	Systeme de production d'une proteine avec un rendement eleve
AU551529B2 (en)	1986-05-01	Method and vector organism for controlled accumulation of cloned heterologous gene products in bacillus subtilis ii
AU3475495A (en)	1996-03-29	Process for producing recombinant proteins, plasmids and modified cells
EP2172214A3 (fr)	2011-03-16	Antigènes de Chlamydia et fragments d'ADN correspondants, et leurs utilisations
DK595187D0 (da)	1987-11-13	Minactivin og fremgangsmaade til fremstilling deraf
DK612889A (da)	1990-06-08	Enzym og fremgangsmaade til fremstilling deraf
AU6999287A (en)	1987-09-17	Insecticidal proteinaceous substance
WO1998044094A3 (fr)	1999-01-07	POLYPEPTIDES DE L'AMIDASE ALIPHATIQUE AmiE D'HELICOBACTERET SEQUENCES D'ADN CODANT LESDITS POLYPEPTIDES
EP0591697B8 (fr)	2001-11-14	Clonage et caractérisation des récepteurs de la GHRH
ES8506800A1 (es)	1985-08-01	Un metodo de fabricar un vector de plasmido recombinante deseado.
EP1241186A3 (fr)	2003-05-21	Protéine gas-6 (growth arrest-specific gene 6) humaine et acides nucléiques le codant
MX9605938A (es)	1998-05-31	Promotor de actinomicetos.
IT1251680B (it)	1995-05-19	Clonaggio e sequenziamento dell'operone srfa di bacillus subtilis che codifica il complesso multienzimatico surfattina sintetasi