ZA923607B - Vaccines and methods for their production - Google Patents

Vaccines and methods for their production

Info

Publication number: ZA923607B
Authority: ZA; South Africa
Prior art keywords: virus; vaccines; production; methods; treating
Prior art date: 1991-05-17

Application number

ZA923607A

Other languages

English (en)

Inventor

John Sidney Oxford

Sidney Oxford John

Original Assignee

Retroscreen Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-05-17

Filing date

1992-05-18

Publication date

1993-02-24

1992-05-18 Application filed by Retroscreen Ltd filed Critical Retroscreen Ltd

1993-02-24 Publication of ZA923607B publication Critical patent/ZA923607B/xx

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
229960005486 vaccine Drugs 0.000 title abstract 2
241000700605 Viruses Species 0.000 abstract 4
239000003795 chemical substances by application Substances 0.000 abstract 2
230000000415 inactivating effect Effects 0.000 abstract 2
229940124718 AIDS vaccine Drugs 0.000 abstract 1
239000003431 cross linking reagent Substances 0.000 abstract 1
239000003599 detergent Substances 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
230000003019 stabilising effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55588—Adjuvants of undefined constitution
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16061—Methods of inactivation or attenuation
- C12N2760/16063—Methods of inactivation or attenuation by chemical treatment

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Virology (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Immunology (AREA)
Microbiology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Mycology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Communicable Diseases (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Hematology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
Pulmonology (AREA)
Oncology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Telephone Function (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

ZA923607A 1991-05-17 1992-05-18 Vaccines and methods for their production ZA923607B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB919110808A GB9110808D0 (en)	1991-05-17	1991-05-17	Aids vaccine and method for its production

Publications (1)

Publication Number	Publication Date
ZA923607B true ZA923607B (en)	1993-02-24

Family

ID=10695252

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA923607A ZA923607B (en)	1991-05-17	1992-05-18	Vaccines and methods for their production

Country Status (16)

Country	Link
US (1)	US5698432A (pt)
EP (1)	EP0514199B1 (pt)
JP (1)	JPH05328967A (pt)
KR (1)	KR0149182B1 (pt)
AT (1)	ATE172642T1 (pt)
AU (1)	AU652447B2 (pt)
BR (1)	BR9201848A (pt)
CA (1)	CA2068817A1 (pt)
DE (1)	DE69227400T2 (pt)
ES (1)	ES2127203T3 (pt)
GB (1)	GB9110808D0 (pt)
IE (1)	IE921556A1 (pt)
IN (1)	IN174080B (pt)
NZ (1)	NZ242780A (pt)
SG (1)	SG49763A1 (pt)
ZA (1)	ZA923607B (pt)

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AUPN030794A0 (en)	1994-12-22	1995-01-27	Aruba International Pty Ltd	Discontinuous plasma or serum delipidation
DE19520216C2 (de) *	1995-06-01	1997-04-10	Frey Rainer H	Vakzine zur Prophylaxe und Therapie von AIDS, und Verfahren zur Herstellung
US20040053208A1 (en) *	1995-08-29	2004-03-18	V. I. TECHNOLOGIES, Inc.	Methods to selectively inactivate parasites in biological compositions
US6352695B1 (en) *	1997-10-03	2002-03-05	V.I. Technologies, Inc.	Methods and compositions for the selective modification of nucleic acids
US6093564A (en) *	1997-10-03	2000-07-25	V.I. Technologies, Inc.	Methods and compositions for the selective modification of nucleic acids
US6403359B1 (en)	1998-09-25	2002-06-11	V. I. TECHNOLOGIES, Inc.	Solid phase quenching systems
US6617100B2 (en)	1998-09-25	2003-09-09	V.I. Technologies, Inc.	Solid phase quenching systems
DE19916085A1 (de) *	1998-10-28	2000-05-04	Sonntag Hans Guenther	Verfahren zur Herstellung eines antiviralen Mittels
US6649170B1 (en) *	1999-05-12	2003-11-18	Statens Serum Institut	Adjuvant combinations for immunization composition and vaccines
TR200202104T2 (tr) *	1999-12-20	2002-12-23	Agricultural Research Council	Mikroorganizmaların etkisiz hale getirilmesi yöntemi.
AUPQ846900A0 (en) *	2000-06-29	2000-07-27	Aruba International Pty Ltd	A vaccine
US7407662B2 (en) *	2000-06-29	2008-08-05	Lipid Sciences, Inc.	Modified viral particles with immunogenic properties and reduced lipid content
US7439052B2 (en)	2000-06-29	2008-10-21	Lipid Sciences	Method of making modified immunodeficiency virus particles
US7407663B2 (en) *	2000-06-29	2008-08-05	Lipid Sciences, Inc.	Modified immunodeficiency virus particles
US20090017069A1 (en)	2000-06-29	2009-01-15	Lipid Sciences, Inc.	SARS Vaccine Compositions and Methods of Making and Using Them
US6991727B2 (en)	2001-06-25	2006-01-31	Lipid Sciences, Inc.	Hollow fiber contactor systems for removal of lipids from fluids
US7033500B2 (en) *	2001-06-25	2006-04-25	Lipid Sciences, Inc.	Systems and methods using multiple solvents for the removal of lipids from fluids
US20060060520A1 (en)	2001-06-25	2006-03-23	Bomberger David C	Systems and methods using a solvent for the removal of lipids from fluids
DE10144906B4 (de) *	2001-09-12	2013-11-28	Novartis Vaccines And Diagnostics Gmbh	Verfahren zur großtechnischen Herstellung von Impfstoffen
WO2003048366A1 (en) *	2001-12-07	2003-06-12	Postech Foundation	Sivmac239 immunogenic plasmids and aids dna vaccine containing the same
JP2007527387A (ja)	2003-07-03	2007-09-27	リピッドサイエンシーズ，インコーポレイテッド	脂質含量の低下したｈｄｌの粒子誘導体を製造するための方法及び装置
US7393826B2 (en)	2003-07-03	2008-07-01	Lipid Sciences, Inc.	Methods and apparatus for creating particle derivatives of HDL with reduced lipid content
SG10201404101RA (en) *	2007-08-28	2014-09-26	Baxter Int	Method For Producing Viral Vaccines
CN102858961A (zh) *	2010-05-03	2013-01-02	葛兰素史密丝克莱恩生物有限公司	新方法
US9370562B2 (en)	2012-06-01	2016-06-21	Boehringer Ingelheim Vetmedica Gmbh	Schmallenberg virus (SBV) vaccine, methods of production, and uses thereof
NZ702392A (en)	2012-06-08	2017-03-31	Aduro Biotech	Compositions and methods for cancer immunotherapy
EA201590396A1 (ru)	2012-12-13	2015-12-30	Адуро Биотек, Инк.	Композиция, содержащая циклические пуриновые динуклеотиды с определенной стереохимией, и способ ее получения и применения
ES2982836T3 (es)	2013-04-29	2024-10-17	Memorial Sloan Kettering Cancer Center	Composiciones y métodos para alterar la señalización de segundos mensajeros
EP2992000B1 (en)	2013-05-03	2020-07-08	The Regents of The University of California	Cyclic di-nucleotide induction of type i interferon
ME03586B (me)	2013-05-18	2020-07-20	Univ California	Sastavi i metode za aktiviranje signaliziranja koje je zavisno od .,stimulatora gena za interferon"
US9549944B2 (en)	2013-05-18	2017-01-24	Aduro Biotech, Inc.	Compositions and methods for inhibiting “stimulator of interferon gene”—dependent signalling
US10176292B2 (en)	2013-07-31	2019-01-08	Memorial Sloan-Kettering Cancer Center	STING crystals and modulators
JP5865942B2 (ja)	2014-04-16	2016-02-17	三菱電機株式会社	内燃機関のシリンダ吸入空気量推定装置および推定方法
JO3746B1 (ar)	2015-03-10	2021-01-31	Aduro Biotech Inc	تركيبات وطرق لتنشيط الإشارات المعتمدة على "منبه أو تحفيز جين انترفيرون"
EP3507367A4 (en)	2016-07-05	2020-03-25	Aduro BioTech, Inc.	CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF
UY37695A (es)	2017-04-28	2018-11-30	Novartis Ag	Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo
WO2019104237A1 (en)	2017-11-22	2019-05-31	Hdl Therapeutics, Inc.	Systems and methods for priming fluid circuits of a plasma processing system
EP3731814A4 (en)	2017-12-28	2021-09-29	HDL Therapeutics, Inc.	METHOD OF PRESERVATION AND ADMINISTRATION OF HIGH DENSITY PRE-BETA LIPOPROTEIN EXTRACTED FROM HUMAN PLASMA
WO2019143955A1 (en)	2018-01-22	2019-07-25	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Broadly protective inactivated influenza virus vaccine
US11643641B2 (en) *	2021-03-04	2023-05-09	Malireddy S. Reddy	Prevention of viral transmission by naked genetic material

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DE1617457A1 (de) *	1966-12-16	1972-04-20	Erba Carlo Spa	Verfahren zur Stabilisierung von Zubereitungen interferierender Virusprodukte
US4036952A (en) *	1973-02-24	1977-07-19	Bayer Aktiengesellschaft	Ethyleneimine inactivated microorganisms
DE2321951C2 (de) *	1973-05-02	1975-05-07	Behringwerke Ag, 3550 Marburg	Verfahren zur Herstellung einer Diphtherie-Vaccine
US4086134A (en) *	1973-09-18	1978-04-25	University Of Glasgow	Method for preparation of vaccine against feline leukemia
GB1503388A (en) *	1975-07-01	1978-03-08	Inverni Della Beffa Spa	Pharmaceutically active complexes and pharmaceutical compositions containing them
US4452734A (en) *	1980-02-11	1984-06-05	Merck & Co., Inc.	Herpes subunit vaccine
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US4645666A (en) *	1982-06-08	1987-02-24	The Regents Of The University Of California	Vaccine for bluetongue disease employing platinum compounds
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US4806350A (en) *	1986-04-18	1989-02-21	Norden Laboratories, Inc.	Vaccine formulation
EP0250128A3 (en) *	1986-06-18	1988-06-08	American Registry of Pathology	Novel virus isolated from patients with aids
DE3707987A1 (de) *	1987-03-12	1988-09-22	Behringwerke Ag	Inaktivierung von human immunodeficiency virus (hiv) in proteinhaltigen loesungen durch phenole
GB8906794D0 (en) *	1989-03-23	1989-05-10	Carroll Noel	Preparation of vaccines

1991
- 1991-05-17 GB GB919110808A patent/GB9110808D0/en active Pending
1992
- 1992-05-15 IN IN294MA1992 patent/IN174080B/en unknown
- 1992-05-15 DE DE69227400T patent/DE69227400T2/de not_active Expired - Fee Related
- 1992-05-15 ES ES92304422T patent/ES2127203T3/es not_active Expired - Lifetime
- 1992-05-15 AU AU16340/92A patent/AU652447B2/en not_active Ceased
- 1992-05-15 BR BR929201848A patent/BR9201848A/pt not_active Application Discontinuation
- 1992-05-15 CA CA002068817A patent/CA2068817A1/en not_active Abandoned
- 1992-05-15 EP EP92304422A patent/EP0514199B1/en not_active Expired - Lifetime
- 1992-05-15 AT AT92304422T patent/ATE172642T1/de not_active IP Right Cessation
- 1992-05-15 SG SG1996004956A patent/SG49763A1/en unknown
- 1992-05-18 ZA ZA923607A patent/ZA923607B/xx unknown
- 1992-05-18 NZ NZ24278092A patent/NZ242780A/en not_active IP Right Cessation
- 1992-05-18 KR KR1019920008346A patent/KR0149182B1/ko not_active Expired - Fee Related
- 1992-05-18 JP JP4168187A patent/JPH05328967A/ja active Pending
- 1992-07-01 IE IE155692A patent/IE921556A1/en not_active IP Right Cessation
1996
- 1996-10-11 US US08/729,135 patent/US5698432A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
BR9201848A (pt)	1993-01-05
JPH05328967A (ja)	1993-12-14
NZ242780A (en)	1994-07-26
EP0514199A3 (en)	1993-11-10
ATE172642T1 (de)	1998-11-15
DE69227400T2 (de)	1999-07-01
AU1634092A (en)	1992-12-17
CA2068817A1 (en)	1992-11-18
KR920021162A (ko)	1992-12-18
EP0514199B1 (en)	1998-10-28
US5698432A (en)	1997-12-16
AU652447B2 (en)	1994-08-25
SG49763A1 (en)	1998-06-15
DE69227400D1 (de)	1998-12-03
GB9110808D0 (en)	1991-07-10
EP0514199A2 (en)	1992-11-19
ES2127203T3 (es)	1999-04-16
IE921556A1 (en)	1992-11-18
IN174080B (pt)	1994-09-10
KR0149182B1 (ko)	1998-10-15

Publication	Publication Date	Title
EP0514199A3 (en)	1993-11-10	Vaccines and methods for their production
DE69434820D1 (de)	2006-09-21	Nukleinsäurevektor, einen solchen vektor enthaltene verbindung und impfstoff zur immunisierung gegen hepatitis
DE69737886D1 (de)	2007-08-16	Infektioese rna virus-klone, vakzine und davon abgeleitete diagnostische assays
PT97754A (pt)	1992-04-30	Processo para a preparacao de composicoes farmaceuticas contendo pelo menos um agente inibidor da poli-(adp-ribose)-polimerase nomeadamente, uma amida aromatica, para o tratamento de infeccoes provocadas por virus
PL325338A1 (en)	1998-07-20	Methods of and compositions for selectivel;y modifying nucleic acids
DK0702085T4 (da)	2010-04-06	Rekombinant infektiøs ikke-segmenteret negativ-strenget RNA-virus
PT92931A (pt)	1990-07-31	Metodo para tratar uma celula hospedeira ex-vivo para desordens hiperproliferativas ou infeccoes e respectiva construcao poli-nucleotidica
NO20001768D0 (no)	2000-04-06	Viruskapsomervaksine, fremgangsmåte til fremstilling samt anvendelse derav
DE69935714D1 (de)	2007-05-16	Anti-virale vektoren
BR7908410A (pt)	1980-09-09	Meio para deteccao de anticorpos de vhb no soro do sangue,e processo para deteccao da presenca da infeccao por virus da hepatite b em seres humanos
DE3684255D1 (de)	1992-04-16	Thymidinkinase-deletionsmutanten von bovinem herpesvirus-1, diese enthaltende impfstoffe gegen bovine rhinotracheitis und verfahren zu deren herstellung und verwendung.
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