ZA925098B - Process for the preparation of derivatives of baccatin iii and of 10-deacetylbaccatin iii - Google Patents

Process for the preparation of derivatives of baccatin iii and of 10-deacetylbaccatin iii

Info

Publication number: ZA925098B
Authority: ZA; South Africa
Prior art keywords: iii; preparation; derivatives; general formula; deacetylbaccatin
Prior art date: 1991-07-10

Application number

ZA925098A

Other languages

English (en)

Inventor

Augustin Hittinger

Hittinger Augustin

Original Assignee

Rhone Poulenc Rorer Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-07-10

Filing date

1992-07-08

Publication date

1993-04-28

1992-07-08 Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa

1993-04-28 Publication of ZA925098B publication Critical patent/ZA925098B/xx

Links

238000000034 method Methods 0.000 title abstract 2
YWLXLRUDGLRYDR-ZHPRIASZSA-N 5beta,20-epoxy-1,7beta,10beta,13alpha-tetrahydroxy-9-oxotax-11-ene-2alpha,4alpha-diyl 4-acetate 2-benzoate Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](O)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 YWLXLRUDGLRYDR-ZHPRIASZSA-N 0.000 title 2
OVMSOCFBDVBLFW-VHLOTGQHSA-N 5beta,20-epoxy-1,7beta,13alpha-trihydroxy-9-oxotax-11-ene-2alpha,4alpha,10beta-triyl 4,10-diacetate 2-benzoate Chemical class O([C@@H]1[C@@]2(C[C@H](O)C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)O)C(=O)C1=CC=CC=C1 OVMSOCFBDVBLFW-VHLOTGQHSA-N 0.000 title 1
CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
TUCNEACPLKLKNU-UHFFFAOYSA-N acetyl Chemical compound C[C]=O TUCNEACPLKLKNU-UHFFFAOYSA-N 0.000 abstract 2
125000006239 protecting group Chemical group 0.000 abstract 2
-1 t-butoxy Chemical group 0.000 abstract 2
DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Epoxy Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Peptides Or Proteins (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Cephalosporin Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Steroid Compounds (AREA)

ZA925098A 1991-07-10 1992-07-08 Process for the preparation of derivatives of baccatin iii and of 10-deacetylbaccatin iii ZA925098B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9108673A FR2678930B1 (fr)	1991-07-10	1991-07-10	Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii.

Publications (1)

Publication Number	Publication Date
ZA925098B true ZA925098B (en)	1993-04-28

Family

ID=9414931

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA925098A ZA925098B (en)	1991-07-10	1992-07-08	Process for the preparation of derivatives of baccatin iii and of 10-deacetylbaccatin iii

Country Status (25)

Country	Link
US (1)	US5578739A (de)
EP (2)	EP0522958A1 (de)
JP (1)	JP3085710B2 (de)
KR (1)	KR100206458B1 (de)
AT (1)	ATE132145T1 (de)
AU (1)	AU662346B2 (de)
CA (1)	CA2111319C (de)
CZ (1)	CZ281288B6 (de)
DE (1)	DE69207194T2 (de)
DK (1)	DK0593641T3 (de)
ES (1)	ES2081120T3 (de)
FI (1)	FI109792B (de)
FR (1)	FR2678930B1 (de)
GR (1)	GR3018543T3 (de)
HU (1)	HU217115B (de)
IE (1)	IE73637B1 (de)
MX (1)	MX9204029A (de)
NO (2)	NO934485D0 (de)
NZ (1)	NZ243491A (de)
PL (1)	PL169780B1 (de)
RU (1)	RU2088578C1 (de)
SK (1)	SK281560B6 (de)
WO (1)	WO1993001179A1 (de)
YU (1)	YU49175B (de)
ZA (1)	ZA925098B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6794523B2 (en)	1991-09-23	2004-09-21	Florida State University	Taxanes having t-butoxycarbonyl substituted side-chains and pharmaceutical compositions containing them
US5272171A (en) *	1992-02-13	1993-12-21	Bristol-Myers Squibb Company	Phosphonooxy and carbonate derivatives of taxol
US5294637A (en) *	1992-07-01	1994-03-15	Bristol-Myers Squibb Company	Fluoro taxols
US5380751A (en) *	1992-12-04	1995-01-10	Bristol-Myers Squibb Company	6,7-modified paclitaxels
MX9308012A (es) *	1992-12-24	1994-08-31	Bristol Myers Squibb Co	Eteres fosfonooximetilicos de derivados de taxano, solubles en agua y composiciones farmaceuticas que los incluyen.
US5646176A (en)	1992-12-24	1997-07-08	Bristol-Myers Squibb Company	Phosphonooxymethyl ethers of taxane derivatives
FR2703049B1 (fr) *	1993-03-22	1995-04-21	Rhone Poulenc Rorer Sa	Procédé de purification des taxoïdes.
CA2129288C (en) *	1993-08-17	2000-05-16	Jerzy Golik	Phosphonooxymethyl esters of taxane derivatives
FR2718135B1 (fr) *	1994-04-05	1996-04-26	Rhone Poulenc Rorer Sa	Procédé de préparation d'hydroxy-7 taxanes.
US5580899A (en)	1995-01-09	1996-12-03	The Liposome Company, Inc.	Hydrophobic taxane derivatives
US6107332A (en)	1995-09-12	2000-08-22	The Liposome Company, Inc.	Hydrolysis-promoting hydrophobic taxane derivatives
US6051600A (en) *	1995-09-12	2000-04-18	Mayhew; Eric	Liposomal hydrolysis-promoting hydrophobic taxane derivatives
FR2740451B1 (fr) *	1995-10-27	1998-01-16	Seripharm	Nouveaux intermediaires pour l'hemisynthese de taxanes, leurs procedes de preparation et leur utilisation dans la synthese generale des taxanes
FR2742751B1 (fr) *	1995-12-22	1998-01-30	Rhone Poulenc Rorer Sa	Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
US7288665B1 (en) *	1997-08-18	2007-10-30	Florida State University	Process for selective derivatization of taxanes
US6111144A (en)	1997-08-21	2000-08-29	Florida State University	Method for the synthesis of a taxane intermediate
US5917062A (en) *	1997-11-21	1999-06-29	Indena S.P.A	Intermediates and methods useful in the semisynthesis of paclitaxel and analogs
ES2178369T3 (es) *	1998-01-14	2002-12-16	Bristol Myers Squibb Co	Nuevos complejos cristalinos dce baccatina iii con imidazol, 2-metilimidazol o isopropanol.
ATE269854T1 (de)	1998-05-01	2004-07-15	Napro Biotherapeutics Inc	Verfahren und verwendbare zwischenprodukte für paclitaxel synthese von c-7,c-10 di-cbz baccatin iii
AU775373B2 (en)	1999-10-01	2004-07-29	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
IT1319168B1 (it) *	2000-03-17	2003-09-26	Indena Spa	Derivati di condensazione ad attivita' antitumorale, loro metodo dipreparazione e formulazioni che li contengono.
RU2008141912A (ru)	2006-03-23	2010-04-27	Новартис АГ (CH)	Противоопухолевые лекарства на основе антител к клеточным антигенам
DE102008013929B3 (de) *	2008-03-12	2009-04-09	Wieland-Werke Ag	Verdampferrohr mit optimierten Hinterschneidungen am Nutengrund
CN101531645B (zh) *	2009-04-29	2012-08-22	深圳万乐药业有限公司	一种多西他赛的合成方法
EP2861256B1 (de)	2012-06-15	2019-10-23	The Brigham and Women's Hospital, Inc.	Zusammensetzungen zur behandlung von krebs und verfahren zur herstellung davon
BR112016022499A2 (pt)	2014-04-03	2017-08-15	Invictus Oncology Pvt Ltd	Produtos terapêuticos combinatórios supramoleculares

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2601675B1 (fr) *	1986-07-17	1988-09-23	Rhone Poulenc Sante	Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
FR2629818B1 (fr) *	1988-04-06	1990-11-16	Centre Nat Rech Scient	Procede de preparation du taxol
FR2629819B1 (fr) *	1988-04-06	1990-11-16	Rhone Poulenc Sante	Procede de preparation de derives de la baccatine iii et de la desacetyl-10 baccatine iii

1991
- 1991-07-10 FR FR9108673A patent/FR2678930B1/fr not_active Expired - Fee Related
1992
- 1992-07-08 CA CA002111319A patent/CA2111319C/fr not_active Expired - Lifetime
- 1992-07-08 DK DK92915477.1T patent/DK0593641T3/da active
- 1992-07-08 AU AU23280/92A patent/AU662346B2/en not_active Expired
- 1992-07-08 EP EP92401958A patent/EP0522958A1/de active Pending
- 1992-07-08 SK SK17-94A patent/SK281560B6/sk not_active IP Right Cessation
- 1992-07-08 EP EP92915477A patent/EP0593641B1/de not_active Expired - Lifetime
- 1992-07-08 KR KR1019940700046A patent/KR100206458B1/ko not_active Expired - Lifetime
- 1992-07-08 PL PL92302030A patent/PL169780B1/pl unknown
- 1992-07-08 ZA ZA925098A patent/ZA925098B/xx unknown
- 1992-07-08 JP JP05502037A patent/JP3085710B2/ja not_active Expired - Lifetime
- 1992-07-08 CZ CZ9431A patent/CZ281288B6/cs not_active IP Right Cessation
- 1992-07-08 RU RU9294016161A patent/RU2088578C1/ru active
- 1992-07-08 HU HU9400062A patent/HU217115B/hu unknown
- 1992-07-08 AT AT92915477T patent/ATE132145T1/de active
- 1992-07-08 ES ES92915477T patent/ES2081120T3/es not_active Expired - Lifetime
- 1992-07-08 DE DE69207194T patent/DE69207194T2/de not_active Expired - Lifetime
- 1992-07-08 WO PCT/FR1992/000649 patent/WO1993001179A1/fr not_active Ceased
- 1992-07-09 NZ NZ243491A patent/NZ243491A/en not_active IP Right Cessation
- 1992-07-09 MX MX9204029A patent/MX9204029A/es unknown
- 1992-07-09 IE IE922234A patent/IE73637B1/en not_active IP Right Cessation
- 1992-07-10 YU YU68792A patent/YU49175B/sh unknown
1993
- 1993-12-08 NO NO934485D patent/NO934485D0/no unknown
- 1993-12-08 NO NO934485A patent/NO302521B1/no not_active IP Right Cessation
1994
- 1994-01-07 FI FI940075A patent/FI109792B/fi not_active IP Right Cessation
1995
- 1995-07-06 US US08/498,613 patent/US5578739A/en not_active Expired - Lifetime
- 1995-12-28 GR GR950402328T patent/GR3018543T3/el unknown

Also Published As

Publication number	Publication date
HUT66018A (en)	1994-08-29
JPH06509082A (ja)	1994-10-13
AU662346B2 (en)	1995-08-31
JP3085710B2 (ja)	2000-09-11
FR2678930B1 (fr)	1995-01-13
DE69207194T2 (de)	1996-09-05
NO934485L (no)	1993-12-08
RU2088578C1 (ru)	1997-08-27
US5578739A (en)	1996-11-26
EP0593641A1 (de)	1994-04-27
CA2111319A1 (fr)	1993-01-21
IE73637B1 (en)	1997-06-18
YU49175B (sh)	2004-07-15
AU2328092A (en)	1993-02-11
ES2081120T3 (es)	1996-02-16
FI940075L (fi)	1994-01-07
NZ243491A (en)	1995-05-26
EP0593641B1 (de)	1995-12-27
FI109792B (fi)	2002-10-15
HU9400062D0 (en)	1994-05-30
DK0593641T3 (da)	1996-01-29
FI940075A0 (fi)	1994-01-07
IE922234A1 (en)	1993-01-13
YU68792A (sh)	1995-10-03
KR100206458B1 (ko)	1999-07-01
HU217115B (hu)	1999-11-29
NO934485D0 (no)	1993-12-08
ATE132145T1 (de)	1996-01-15
EP0522958A1 (de)	1993-01-13
CA2111319C (fr)	2003-04-08
PL169780B1 (pl)	1996-08-30
SK281560B6 (sk)	2001-05-10
GR3018543T3 (en)	1996-03-31
CZ281288B6 (cs)	1996-08-14
FR2678930A1 (fr)	1993-01-15
DE69207194D1 (de)	1996-02-08
NO302521B1 (no)	1998-03-16
CZ3194A3 (en)	1994-04-13
SK1794A3 (en)	1994-11-09
MX9204029A (es)	1993-01-01
WO1993001179A1 (fr)	1993-01-21

Publication	Publication Date	Title
ZA925098B (en)	1993-04-28	Process for the preparation of derivatives of baccatin iii and of 10-deacetylbaccatin iii
NO923679D0 (no)	1992-09-22	Nye substituerte taksaner og farmasoeytiske preparater sominneholder slike
HU9203304D0 (en)	1992-12-28	3-benzylidene-1-carbamoyl-2-pyrrolidone analogues
HU9203016D0 (en)	1992-12-28	New taxane compounds substituted with alkoxy and pharmaceutical preparatives containing these compounds
TW234122B (de)	1994-11-11
IL122123A0 (en)	1998-04-05	Atherosclerosis treatment
YU89691A (sh)	1994-01-20	Postupak za dobijanje stereoselektivnih derivata fenilizoserina
FI904162A0 (fi)	1990-08-22	Foerfarande foer enantioselektiv framstaellning av fenyl-isoserinderivat.
HU9302315D0 (en)	1993-11-29	Method for producing acetyhlene derivatives and one for preparting plant protective preparatives containing said compounds
FI932992A0 (fi)	1993-06-29	Fungisida fenylbenzamider och foerfaranden foer framstaellning daerav
GR3018036T3 (en)	1996-02-29	Process for the preparation of taxane derivatives.
DK0623620T3 (da)	1999-06-07	5-HT3-pyrrolopyrazinderivater
ZA924888B (en)	1993-04-28	Process for the synthesis of enantiomers of 3-aminochroman compounds
EP0481289B1 (de)	1995-08-02	N-Fumaramidsäurederivate und diese enthaltende Fungizide.