ZA92990B - Calcium channel antagonists and methodology for their identification - Google Patents

Calcium channel antagonists and methodology for their identification

Info

Publication number
ZA92990B
ZA92990B ZA92990A ZA92990A ZA92990B ZA 92990 B ZA92990 B ZA 92990B ZA 92990 A ZA92990 A ZA 92990A ZA 92990 A ZA92990 A ZA 92990A ZA 92990 B ZA92990 B ZA 92990B
Authority
ZA
South Africa
Prior art keywords
methodology
identification
calcium channel
channel antagonists
antagonists
Prior art date
Application number
ZA92990A
Other languages
English (en)
Inventor
Stanley M Goldin
M Goldin Stanley
Kazumi Kobayashi
Kobayashi Kazumi
Andrew G Knapp
G Knapp Andrew
Subbarao Katragadda
Katragadda Subbarao
Deborah Daly
Daly Deborah
Lain-Yen Hu
Hu Lain-Yen
N Laxma Reddy
Laxma Reddy N
Lee Margolin
Margolin Lee
Original Assignee
Cambridge Neuroscience Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cambridge Neuroscience Inc filed Critical Cambridge Neuroscience Inc
Publication of ZA92990B publication Critical patent/ZA92990B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA92990A 1991-02-11 1992-02-11 Calcium channel antagonists and methodology for their identification ZA92990B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/654,104 US5312928A (en) 1991-02-11 1991-02-11 Calcium channel antagonists and methodology for their identification

Publications (1)

Publication Number Publication Date
ZA92990B true ZA92990B (en) 1992-11-25

Family

ID=24623446

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA92990A ZA92990B (en) 1991-02-11 1992-02-11 Calcium channel antagonists and methodology for their identification

Country Status (6)

Country Link
US (1) US5312928A (fr)
AU (1) AU1530692A (fr)
IE (1) IE920327A1 (fr)
PT (1) PT100117A (fr)
WO (1) WO1992014709A2 (fr)
ZA (1) ZA92990B (fr)

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US5858684A (en) * 1991-08-23 1999-01-12 The Brigham And Women's Hospital, Inc. Method of screening calcium receptor-active molecules
US6001884A (en) * 1991-08-23 1999-12-14 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5688938A (en) * 1991-08-23 1997-11-18 The Brigham & Women's Hospital, Inc. Calcium receptor-active molecules
US6031003A (en) * 1991-08-23 2000-02-29 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5763569A (en) * 1991-08-23 1998-06-09 The Brigham And Women's Hospital, Inc Calcium receptor-active molecules
US6313146B1 (en) 1991-08-23 2001-11-06 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6017965A (en) * 1993-02-08 2000-01-25 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US6750244B2 (en) 1993-02-08 2004-06-15 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US6211245B1 (en) 1993-02-08 2001-04-03 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US6071970A (en) * 1993-02-08 2000-06-06 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
US7087765B2 (en) 1995-06-07 2006-08-08 Nps Pharmaceuticals, Inc. Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
DE69333527T2 (de) * 1993-02-23 2005-06-16 Brigham & Women's Hospital, Inc., Boston Calciumrezeptoraktive moleküle
US5962314A (en) * 1993-02-23 1999-10-05 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
JPH09505058A (ja) * 1993-11-15 1997-05-20 ベイカー・メディカル・リサーチ・インスティテュート 心機能不全の治療方法およびそのために有用な医薬組成物
DE69434889D1 (de) 1994-02-08 2007-01-11 Nps Pharma Inc An einer neuen Stelle von Rezeptorabhängigen Kalziumkanälen wirkende Verbindungen zur Behandlung von neurologischen Erkrankungen
NZ281431A (en) * 1994-02-22 1997-09-22 Merrell Pharma Inc Alkylamide-substituted indole derivatives
ES2285707T3 (es) 1994-10-21 2007-11-16 Nps Pharmaceuticals, Inc. Compuestos activos frente al receptor de calcio.
US5981525A (en) * 1995-01-10 1999-11-09 Smithkline Beecham Corporation Indole derivatives useful in the treatment of osteoporosis
WO1997041090A1 (fr) 1996-05-01 1997-11-06 Nps Pharmaceuticals, Inc. Composes servant a declencher l'activite d'un recepteur d'ions inorganiques
GB9614366D0 (en) * 1996-07-09 1996-09-04 Smithkline Beecham Spa Novel compounds
GB9614347D0 (en) * 1996-07-09 1996-09-04 Smithkline Beecham Spa Novel compounds
US6458806B1 (en) 1996-08-15 2002-10-01 Millennium Pharmaceuticals, Inc. Aryl alkenamides derivatives as MCP-1 antagonists
JP4044728B2 (ja) 1997-07-15 2008-02-06 メディクエスト セラピューティックス インク 治療および診断薬剤としての新規なポリアミンアナログ
US6646149B1 (en) 1997-07-15 2003-11-11 Nicolaas M. J. Vermeulin Polyamine analogues as therapeutic and diagnostic agents
US7208528B1 (en) 1997-07-15 2007-04-24 Mediquest Therapeutics, Inc. Polyamine analogues as therapeutic and diagnostic agents
WO2000007590A1 (fr) * 1998-08-03 2000-02-17 Eli Lilly And Company INHIBITEURS DE sPLA2 DE TYPE INDOLE
DE69922997T2 (de) * 1998-12-04 2005-12-15 Neurosearch A/S Verwendung von isatinderivaten als ionenkanalaktivierende mittel
US6441156B1 (en) * 1998-12-30 2002-08-27 The United States Of America As Represented By The Department Of Health And Human Services Calcium channel compositions and methods of use thereof
USRE43327E1 (en) 2001-01-08 2012-04-24 Aminex Therapeutics, Inc. Hydrophobic polyamine analogs and methods for their use
FR2820136A1 (fr) * 2001-01-26 2002-08-02 Aventis Pharma Sa Nouveaux derives de l'uree, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation
US7166463B2 (en) * 2001-11-16 2007-01-23 The Regents Of The University Of Colorado Nucleic acids encoding modified olfactory cyclic nucleotide gated ion channels
JP2007505095A (ja) * 2003-09-12 2007-03-08 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー うつ病及び不安障害の治療のためのアルファ−２−デルタリガンド及びｓｓｒｉ及び／又はｓｎｒｉを含む組み合わせ
US20080248040A1 (en) * 2003-10-02 2008-10-09 Menghang Xia Nucleic Acid Molecules Encoding Novel Human Low-Voltage Activated Calcium Channel Proteins, Designed-Alpha 1I-1 and Alpha 1I-2, Encoded Proteins and Methods of Use Thereof
US20070178462A1 (en) * 2004-02-18 2007-08-02 Uebele Victor N Nucleic acid molecules encoding novel murine low-voltage activated calcium channel proteins, designated-alpha1h, encoded proteins and methods of use thereof
FR2885129B1 (fr) * 2005-04-29 2007-06-15 Proskelia Sas Nouveaux derives de l'ureee substituee parun thiazole ou benzothiazole, leur procede de preparation, leur application a titre de medicaments, les compositions pharmaceutiques les renfermant et utilisation.
ATE450262T1 (de) * 2005-11-25 2009-12-15 Galapagos Sas Harnstoff-derivate als calcium-rezeptor- modulatoren
GB0613674D0 (en) * 2006-07-10 2006-08-16 Proskelia Sas Derivatives of urea and related diamines, methods for their manufacture, and uses therefor
HUE052620T2 (hu) 2016-03-25 2021-05-28 Aminex Therapeutics Inc Biológiailag hozzáférhetõ poliaminok
AU2021280970B2 (en) 2020-05-29 2023-10-05 Unilever Global Ip Limited A liquid laundry composition
ES2983533T3 (es) 2020-05-29 2024-10-23 Basf Se Etoxilatos de oligopropilenimina modificados anfotéricamente para mejorar la eliminación de manchas de los detergentes para ropa
JP2023545674A (ja) 2020-09-30 2023-10-31 アミネックス セラピューティクス， インコーポレイテッド ポリアミン輸送阻害剤およびｄｆｍｏの配合原薬
CN118318027A (zh) 2021-11-29 2024-07-09 巴斯夫欧洲公司 用于改善衣物洗涤剂污渍去除的两性改性三亚烷基四胺乙氧基化物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925664A (en) * 1986-10-20 1990-05-15 University Of Utah Spider toxins and methods for their use as blockers of calcium channels and amino acid receptor function
US4950739A (en) * 1988-02-10 1990-08-21 New York University Membrane calcium channels and factors and methods for blocking, isolating and purifying calcium channels
DD298412A5 (de) * 1989-04-28 1992-02-20 ������@���Kk�� Verfahren zur herstellung von polypeptiden, die geeignet sind als antagonisten exzitatorischer aminosaeure-neurotransmitter und/oder blocker der calciumkanaele
US5037846A (en) * 1990-01-02 1991-08-06 Pfizer Inc. Indolyl-3 polyamines and their use as antagonists of excitatory amino acid neurotransmitters

Also Published As

Publication number Publication date
PT100117A (pt) 1993-08-31
US5312928A (en) 1994-05-17
WO1992014709A3 (fr) 1992-12-10
IE920327A1 (en) 1992-08-12
AU1530692A (en) 1992-09-15
WO1992014709A2 (fr) 1992-09-03

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