ZA932840B - 1-piperazino-1,3-dihydroindene derivatives - Google Patents

1-piperazino-1,3-dihydroindene derivatives

Info

Publication number: ZA932840B
Authority: ZA; South Africa
Prior art keywords: alkyl; hydrogen; cycloalkylalkyl; cycloalkyl; alkenyl
Prior art date: 1992-04-28

Application number

ZA932840A

Other languages

English (en)

Inventor

Klaus Bogeso

Peter Bregnedal

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-04-28

Filing date

1993-04-22

Publication date

1993-11-23

1993-04-22 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

1993-11-23 Publication of ZA932840B publication Critical patent/ZA932840B/xx

Links

PWOUAMWQYHOLIB-UHFFFAOYSA-N 1-(2,3-dihydro-1h-inden-1-yl)piperazine Chemical class C1CC2=CC=CC=C2C1N1CCNCC1 PWOUAMWQYHOLIB-UHFFFAOYSA-N 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 4
229910052739 hydrogen Inorganic materials 0.000 abstract 4
239000001257 hydrogen Substances 0.000 abstract 4
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 4
125000003342 alkenyl group Chemical group 0.000 abstract 3
125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 3
125000000753 cycloalkyl group Chemical group 0.000 abstract 3
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000004193 piperazinyl group Chemical group 0.000 abstract 2
125000001960 7 membered carbocyclic group Chemical group 0.000 abstract 1
125000003341 7 membered heterocyclic group Chemical group 0.000 abstract 1
208000019901 Anxiety disease Diseases 0.000 abstract 1
208000022497 Cocaine-Related disease Diseases 0.000 abstract 1
102000004076 Dopamine D1 Receptors Human genes 0.000 abstract 1
108090000511 Dopamine D1 Receptors Proteins 0.000 abstract 1
206010013654 Drug abuse Diseases 0.000 abstract 1
208000019695 Migraine disease Diseases 0.000 abstract 1
208000018737 Parkinson disease Diseases 0.000 abstract 1
208000028017 Psychotic disease Diseases 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
230000036506 anxiety Effects 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
201000001272 cocaine abuse Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
125000002541 furyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
206010027599 migraine Diseases 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
201000000980 schizophrenia Diseases 0.000 abstract 1
208000019116 sleep disease Diseases 0.000 abstract 1
208000022925 sleep disturbance Diseases 0.000 abstract 1
208000024891 symptom Diseases 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1
125000005034 trifluormethylthio group Chemical group FC(S*)(F)F 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Psychology (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)

ZA932840A 1992-04-28 1993-04-22 1-piperazino-1,3-dihydroindene derivatives ZA932840B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK92551A DK55192D0 (da)	1992-04-28	1992-04-28	1-piperazino-1,2-dihydroindenderivater

Publications (1)

Publication Number	Publication Date
ZA932840B true ZA932840B (en)	1993-11-23

Family

ID=8094828

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA932840A ZA932840B (en)	1992-04-28	1993-04-22	1-piperazino-1,3-dihydroindene derivatives

Country Status (23)

Country	Link
US (1)	US5807855A (de)
EP (1)	EP0638073B1 (de)
JP (1)	JP3255416B2 (de)
KR (1)	KR100267635B1 (de)
AT (1)	ATE194003T1 (de)
AU (1)	AU669709B2 (de)
CA (1)	CA2134566C (de)
CL (1)	CL2003002050A1 (de)
CZ (1)	CZ281676B6 (de)
DE (1)	DE69328901T2 (de)
DK (2)	DK55192D0 (de)
ES (1)	ES2148227T3 (de)
FI (1)	FI113862B (de)
GR (1)	GR3034396T3 (de)
HU (2)	HUT71419A (de)
IL (1)	IL105464A (de)
NO (1)	NO306946B1 (de)
NZ (1)	NZ252098A (de)
PT (1)	PT638073E (de)
RU (1)	RU2114106C1 (de)
SK (1)	SK281613B6 (de)
WO (1)	WO1993022293A1 (de)
ZA (1)	ZA932840B (de)

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US6251893B1 (en) *	1998-06-15	2001-06-26	Nps Allelix Corp.	Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity
DE10041478A1 (de)	2000-08-24	2002-03-14	Sanol Arznei Schwarz Gmbh	Neue pharmazeutische Zusammensetzung
PL364625A1 (en) *	2001-02-23	2004-12-13	Merck & Co, Inc.	N-substituted nonaryl-heterocyclic nmda/nr2b antagonists
IS7282A (is) *	2001-12-21	2004-05-21	H. Lundbeck A/S	Amínóindan afleiður sem serótónín og noradrenalínupptökuhindrar
EP1458704A1 (de) *	2001-12-21	2004-09-22	H. Lundbeck A/S	Aminoindanderivate als serotonin- und norepinephrinaufnahmehemmer
PL199016B1 (pl) †	2002-06-20	2008-08-29	Adamed Sp Z Oo	Sposób wytwarzania olanzapiny
DE10334187A1 (de) *	2003-07-26	2005-03-03	Schwarz Pharma Ag	Substituierte 2-Aminotetraline zur Behandlung von Depressionen
DE10334188B4 (de) *	2003-07-26	2007-07-05	Schwarz Pharma Ag	Verwendung von Rotigotin zur Behandlung von Depressionen
BRPI0413595B8 (pt) *	2003-08-18	2021-05-25	H Lundbeck As	sal de malonato, composição farmacêutica, uso de um sal de malonato, e, método de fabricação de um composto
RS53369B (sr) *	2003-08-18	2014-10-31	H.Lundbeck A/S	Sukcinat i malonat soli trans-4-((1r,3s)-6-hloro-3- fenilindan-1-il)-1,2,2-trimetilpiperazin i njihova upotreba kao medikamenta
DE10361258A1 (de) *	2003-12-24	2005-07-28	Schwarz Pharma Ag	Verwendung von substituierten 2-Aminotetralinen zur vorbeugenden Behandlung von Morbus Parkinson
US20050197385A1 (en) *	2004-02-20	2005-09-08	Schwarz Pharma Ag	Use of rotigotine for treatment or prevention of dopaminergic neuron loss
DE102004014841B4 (de) *	2004-03-24	2006-07-06	Schwarz Pharma Ag	Verwendung von Rotigotin zur Behandlung und Prävention des Parkinson-Plus-Syndroms
TWI376373B (en) *	2005-02-16	2012-11-11	Lundbeck & Co As H	Crystalline base of a pharmaceutical compound
US20080269248A1 (en) *	2005-02-16	2008-10-30	H. Lundbeck A/S	Tartrate and Malate Salts of Trans-1-((1R,3S)-6-Chloro-3-Phenylindan-1-Yl)-3,3-Dimethylpiperazine
TWI453198B (zh) *	2005-02-16	2014-09-21	Lundbeck & Co As H	製造反式-1-((1r,3s)-6-氯基-3-苯基茚滿-1-基) -3 , 3 -二甲基六氫吡與其鹽類之方法及製造4-((1r , 3s）-6 -氯基-3-苯基茚滿-1-基 )-1,2,2-三甲基六氫吡與其鹽類之方法
TW200819426A (en)	2006-08-31	2008-05-01	Lundbeck & Co As H	Novel indane compounds
EA018927B1 (ru) *	2008-05-07	2013-11-29	Х. Лундбекк А/С	Способ лечения когнитивного расстройства, ассоциированного с шизофренией
AU2009298264A1 (en) *	2008-10-03	2010-04-08	H. Lundbeck A/S	Oral formulation
TW201102370A (en)	2009-07-07	2011-01-16	Lundbeck & Co As H	Manufacture of 4-((1R,3S)-6-chloro-3-phenyl-indan-1-yl)-1,2,2-trimethyl-piperazine and 1-((1R,3S)-6-chloro-3-phenyl-indan-1-yl)-3,3-dimethyl piperazine
EP2639216B1 (de)	2010-11-09	2018-07-11	Kaneka Corporation	Halogenierte indenone und verfahren zur herstellung optisch aktiver indanone oder optisch aktiver indanole unter verwendung dieser
JP2014501771A (ja) *	2011-01-07	2014-01-23	ハー・ルンドベック・アクチエゼルスカベット	４−（（１ｒ，３ｓ）−６−クロロ−３−フェニル−インダン−１−イル）−１，２，２−トリメチル−ピペラジンと１−（（１ｒ，３ｓ）−６−クロロ−３−フェニル−インダン，１−イル）−３，３−ジメチル−ピペラジンとを分割するための方法
PL3135656T3 (pl)	2011-06-20	2019-07-31	H. Lundbeck A/S	Deuterowane 1-piperazyno-3-fenyloindany do leczenia schizofrenii
JO3421B1 (ar)	2011-06-20	2019-10-20	H Lundbeck As	طريقة لإعطاء 1-((1ار.3س)-6-كلورو-3-فينيل-اندان-1-ايل)-1.2.2-ترايميثيل- بيبيرازين واملاجها لمعالجة انفصام الشخصية
JP2021520382A (ja) *	2018-04-06	2021-08-19	ハー・ルンドベック・アクチエゼルスカベット	２，２−ジメチルピペラジンの調製方法
EP3873885A1 (de)	2018-10-29	2021-09-08	H. Lundbeck A/S	Amorphe verbindungen der formel (i) und amorphe verbindungen von formel-(i)-salzen
EP3891134A1 (de)	2018-12-03	2021-10-13	H. Lundbeck A/S	Prodrugs von 4-((1r,3s)-6-chlor-3-phenyl-2,3-dihydro-1h-inden-1-yl)-1,2,2-trimethylpiperazin und 4-((1/r,3s)-6-chlor-3-(phenyl-d5)-2,3-dihydro-1h-inden-1-yl)-2,2-dimethy-1-(methyl-d3)piperazin

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GB1469108A (en) *	1973-06-25	1977-03-30	Kefalas As	Thiaxanthene derivative
US4038395A (en) *	1973-06-25	1977-07-26	Kefalas A/S	Compositions of and method of treating with the alpha-isomer of 2-chloro-9-[3'-(N'-2-hydroxyethylpiperazino-N)-propylidene]-thiaxanthene, carboxylic acid esters thereof and acid addition salts of these compounds
IE50867B1 (en) *	1980-02-29	1986-08-06	Kefalas As	Indane derivatives
IE55972B1 (en) *	1982-10-07	1991-03-13	Kefalas As	Phenylindene derivatives,acid addition salts thereof,and methods of preparation
HU198036B (en) *	1983-08-22	1989-07-28	Hoechst Roussel Pharma	Process for production of derivatives of 3-piperidil-/1h/-indasole and medical preparatives containing them
GB8427125D0 (en) *	1984-10-26	1984-12-05	Lundbeck & Co As H	Organic compounds
DE3582795D1 (de) *	1984-12-03	1991-06-13	Hughes Aircraft Co	Variabler linsen- und doppelbrechungskompensator fuer kontinuierlichen betrieb.
IE58370B1 (en) *	1985-04-10	1993-09-08	Lundbeck & Co As H	Indole derivatives
DE3521761A1 (de) *	1985-06-19	1987-01-02	Bayer Ag	Neue 1,4-dihydropyridine, verfahren zur herstellung und ihre verwendung in arzneimitteln
GB8628644D0 (en) *	1986-12-01	1987-01-07	Lunbeck A S H	Intermediates
GB8704572D0 (en) *	1987-02-26	1987-04-01	Lundbeck & Co As H	Organic compounds
MX173362B (es) *	1987-03-02	1994-02-23	Pfizer	Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
EP0302423A3 (de) *	1987-08-07	1991-01-09	Hoechst-Roussel Pharmaceuticals Incorporated	1-Phenyl-3-(1-piperazinyl)-1H-Indazole, Verfahren und Zwischenprodukte zu deren Herstellung und deren Anwendung als Arzneimittel
US4831031A (en) *	1988-01-22	1989-05-16	Pfizer Inc.	Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
GB8830312D0 (en) *	1988-12-28	1989-02-22	Lundbeck & Co As H	Heterocyclic compounds
EP0507863A4 (en) *	1989-12-28	1993-07-07	Virginia Commonwealth University	Sigma receptor ligands and the use thereof
DK152090D0 (da) *	1990-06-22	1990-06-22	Lundbaek A S H	Piperidylsubstituerede indolderivater
DK158590D0 (da) *	1990-07-02	1990-07-02	Lundbeck & Co As H	Indolderivater
DK286990D0 (da) *	1990-12-04	1990-12-04	Lundbeck & Co As H	Indanderivater
US5643784A (en) *	1990-12-04	1997-07-01	H, Lundbeck A/S	Indan derivatives

1992
- 1992-04-28 DK DK92551A patent/DK55192D0/da not_active Application Discontinuation
1993
- 1993-04-20 IL IL105464A patent/IL105464A/en not_active IP Right Cessation
- 1993-04-22 ZA ZA932840A patent/ZA932840B/xx unknown
- 1993-04-23 RU RU94045948A patent/RU2114106C1/ru active
- 1993-04-23 JP JP51884593A patent/JP3255416B2/ja not_active Expired - Lifetime
- 1993-04-23 WO PCT/DK1993/000136 patent/WO1993022293A1/en not_active Ceased
- 1993-04-23 HU HU9403098A patent/HUT71419A/hu unknown
- 1993-04-23 NZ NZ252098A patent/NZ252098A/en not_active IP Right Cessation
- 1993-04-23 PT PT93909807T patent/PT638073E/pt unknown
- 1993-04-23 DK DK93909807T patent/DK0638073T3/da active
- 1993-04-23 KR KR1019940703815A patent/KR100267635B1/ko not_active Expired - Lifetime
- 1993-04-23 CZ CZ942619A patent/CZ281676B6/cs not_active IP Right Cessation
- 1993-04-23 AU AU40599/93A patent/AU669709B2/en not_active Expired
- 1993-04-23 CA CA002134566A patent/CA2134566C/en not_active Expired - Lifetime
- 1993-04-23 AT AT93909807T patent/ATE194003T1/de active
- 1993-04-23 ES ES93909807T patent/ES2148227T3/es not_active Expired - Lifetime
- 1993-04-23 EP EP93909807A patent/EP0638073B1/de not_active Expired - Lifetime
- 1993-04-23 SK SK1293-94A patent/SK281613B6/sk not_active IP Right Cessation
- 1993-04-23 DE DE69328901T patent/DE69328901T2/de not_active Expired - Lifetime
1994
- 1994-10-26 FI FI945042A patent/FI113862B/fi not_active IP Right Cessation
- 1994-10-27 NO NO944090A patent/NO306946B1/no not_active IP Right Cessation
- 1994-10-28 US US08/331,213 patent/US5807855A/en not_active Expired - Lifetime
1995
- 1995-06-29 HU HU95P/P00587P patent/HU211909A9/hu unknown
2000
- 2000-09-13 GR GR20000402086T patent/GR3034396T3/el unknown
2003
- 2003-10-10 CL CL200302050A patent/CL2003002050A1/es unknown

Also Published As

Publication number	Publication date
SK129394A3 (en)	1995-05-10
HU211909A9 (en)	1996-01-29
CA2134566C (en)	2004-08-10
RU94045948A (ru)	1996-09-10
CL2003002050A1 (es)	2005-01-07
EP0638073A1 (de)	1995-02-15
HUT71419A (en)	1995-11-28
SK281613B6 (sk)	2001-05-10
NO944090D0 (no)	1994-10-27
GR3034396T3 (en)	2000-12-29
DK0638073T3 (da)	2000-11-06
NZ252098A (en)	1996-05-28
IL105464A0 (en)	1993-08-18
DE69328901D1 (de)	2000-07-27
DE69328901T2 (de)	2001-01-11
ATE194003T1 (de)	2000-07-15
JPH07505895A (ja)	1995-06-29
PT638073E (pt)	2000-11-30
AU4059993A (en)	1993-11-29
IL105464A (en)	1998-01-04
NO306946B1 (no)	2000-01-17
JP3255416B2 (ja)	2002-02-12
FI945042A7 (fi)	1994-10-26
NO944090L (no)	1994-12-20
KR950701323A (ko)	1995-03-23
HU9403098D0 (en)	1994-12-28
DK55192D0 (da)	1992-04-28
AU669709B2 (en)	1996-06-20
US5807855A (en)	1998-09-15
WO1993022293A1 (en)	1993-11-11
HK1013816A1 (en)	1999-09-10
KR100267635B1 (ko)	2000-11-01
CZ281676B6 (cs)	1996-12-11
EP0638073B1 (de)	2000-06-21
RU2114106C1 (ru)	1998-06-27
CA2134566A1 (en)	1993-11-11
FI113862B (fi)	2004-06-30
ES2148227T3 (es)	2000-10-16
FI945042A0 (fi)	1994-10-26
CZ261994A3 (en)	1995-05-17

Publication	Publication Date	Title
IL105464A0 (en)	1993-08-18	1-piperazino-1,2-dihydroindene derivatives
AR016129A1 (es)	2001-06-20	Compuestos derivados de 5h-tiazolo[3,2-a]pirimidina; su uso, un procedimiento para prepararlos, medicamentos que los contienen y compuestos utiles comointermediarios
BR9206500A (pt)	1995-10-03	Heterociclos contendo, nitrogênio tricíclico condensado como antagonistas de substancia receptora P
DK0856003T3 (da)	2001-01-22	Heterocykliske analoger af 1,2,4-triazolo[1,5-c]pyrimidin med antagonistisk virkning på adenosin A2a-receptorer
NO912301L (no)	1992-01-03	Nye indolderivater.
KR920018030A (ko)	1992-10-21	치환된 이미다졸-2-온의 유도체 및 이의 제조방법
PT99673A (pt)	1992-10-30	Processo para a preparacao de derivados de 1-piperazino-indano e de composicoes farmaceuticas que os contem
ATE179700T1 (de)	1999-05-15	Tricyclische benzodiazepine, ihr verwendung und herstellung
ATE102626T1 (de)	1994-03-15	Heterocyclische verbindungen, ihre darstellung und verwendung.
ES2111326T3 (es)	1998-03-01	Derivados de imidazolona y oxazolona como antagonistas de dopamina.
ATE294780T1 (de)	2005-05-15	Arylpiperidin- und aryl-1,2,5,6- tetrahydropyridinamid-derivate mit 5ht1a rezeptor aktivität
AU1201195A (en)	1995-07-17	Novel benzodiazepine derivative
MX9703671A (es)	1997-12-31	Compuesto de aminometil arilo y ligandos selectivos del subtipo de receptor de la dopamina.
BR9506763A (pt)	1997-10-07	Derivados de carbamoil metil uréia
ES2188155T3 (es)	2003-06-16	N-ariloxietilindolilalquilaminas para el tratamiento de la depresion.