ATE179700T1 - Tricyclische benzodiazepine, ihr verwendung und herstellung - Google Patents
Tricyclische benzodiazepine, ihr verwendung und herstellungInfo
- Publication number
- ATE179700T1 ATE179700T1 AT94908289T AT94908289T ATE179700T1 AT E179700 T1 ATE179700 T1 AT E179700T1 AT 94908289 T AT94908289 T AT 94908289T AT 94908289 T AT94908289 T AT 94908289T AT E179700 T1 ATE179700 T1 AT E179700T1
- Authority
- AT
- Austria
- Prior art keywords
- dihydrofuran
- cyclopentene
- furan
- cyano
- nitro
- Prior art date
Links
- 229940049706 benzodiazepine Drugs 0.000 title 1
- 150000001557 benzodiazepines Chemical class 0.000 title 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 4
- LPIQUOYDBNQMRZ-UHFFFAOYSA-N cyclopentene Chemical compound C1CC=CC1 LPIQUOYDBNQMRZ-UHFFFAOYSA-N 0.000 abstract 4
- ABADUMLIAZCWJD-UHFFFAOYSA-N 1,3-dioxole Chemical group C1OC=CO1 ABADUMLIAZCWJD-UHFFFAOYSA-N 0.000 abstract 2
- JKTCBAGSMQIFNL-UHFFFAOYSA-N 2,3-dihydrofuran Chemical compound C1CC=CO1 JKTCBAGSMQIFNL-UHFFFAOYSA-N 0.000 abstract 2
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 abstract 2
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- HGCIXCUEYOPUTN-UHFFFAOYSA-N cyclohexene Chemical compound C1CCC=CC1 HGCIXCUEYOPUTN-UHFFFAOYSA-N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- RGSFGYAAUTVSQA-UHFFFAOYSA-N pentamethylene Natural products C1CCCC1 RGSFGYAAUTVSQA-UHFFFAOYSA-N 0.000 abstract 2
- VSWICNJIUPRZIK-UHFFFAOYSA-N 2-piperideine Chemical compound C1CNC=CC1 VSWICNJIUPRZIK-UHFFFAOYSA-N 0.000 abstract 1
- RSEBUVRVKCANEP-UHFFFAOYSA-N 2-pyrroline Chemical compound C1CC=CN1 RSEBUVRVKCANEP-UHFFFAOYSA-N 0.000 abstract 1
- MGADZUXDNSDTHW-UHFFFAOYSA-N 2H-pyran Chemical compound C1OC=CC=C1 MGADZUXDNSDTHW-UHFFFAOYSA-N 0.000 abstract 1
- BUDQDWGNQVEFAC-UHFFFAOYSA-N Dihydropyran Chemical compound C1COC=CC1 BUDQDWGNQVEFAC-UHFFFAOYSA-N 0.000 abstract 1
- 208000012661 Dyskinesia Diseases 0.000 abstract 1
- ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000008038 benzoazepines Chemical class 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- -1 cyano, hydroxy Chemical group 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- ZVJHJDDKYZXRJI-UHFFFAOYSA-N pyrroline Natural products C1CC=NC1 ZVJHJDDKYZXRJI-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000019116 sleep disease Diseases 0.000 abstract 1
- 208000022925 sleep disturbance Diseases 0.000 abstract 1
- 229930192474 thiophene Natural products 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK93267A DK26793D0 (da) | 1993-03-10 | 1993-03-10 | Benzofuranyl- eller dihydrobenzofuranyl-substituerede tricycliske benzazepiner, der anvendelse og fremstilling |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE179700T1 true ATE179700T1 (de) | 1999-05-15 |
Family
ID=8091615
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94908289T ATE179700T1 (de) | 1993-03-10 | 1994-02-18 | Tricyclische benzodiazepine, ihr verwendung und herstellung |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US5512562A (de) |
| EP (1) | EP0688320B1 (de) |
| JP (1) | JP3779319B2 (de) |
| KR (1) | KR960701022A (de) |
| CN (1) | CN1045957C (de) |
| AT (1) | ATE179700T1 (de) |
| AU (1) | AU682494B2 (de) |
| CA (1) | CA2157668C (de) |
| DE (1) | DE69418321T2 (de) |
| DK (2) | DK26793D0 (de) |
| ES (1) | ES2133542T3 (de) |
| FI (1) | FI111944B (de) |
| GR (1) | GR3030864T3 (de) |
| IL (1) | IL108730A (de) |
| NO (1) | NO953543D0 (de) |
| NZ (1) | NZ262098A (de) |
| TW (1) | TW279861B (de) |
| WO (1) | WO1994020472A1 (de) |
| ZA (1) | ZA941377B (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0888324A1 (de) * | 1996-03-08 | 1999-01-07 | Synthelabo | 2-aminoäthyl-benzofuran-derivate, deren herstellung und verwendung in therapie |
| FR2745815B1 (fr) * | 1996-03-08 | 1998-06-26 | Synthelabo | Derives de benzofurane, leur preparations et compositions pharmaceutiques les comprenant |
| FR2752840A1 (fr) * | 1996-08-29 | 1998-03-06 | Synthelabo | Derives de benzothiophene, leur preparation et leur application en therapeutique |
| IL131670A (en) * | 1997-03-12 | 2005-07-25 | Addex Pharmaceuticals Sa | Use of 2,3,4,5-tetrahydro-1h-3-benzazepines for the manufacture of a pharmaceutical composition for the treatment of sleep disorders |
| US6528529B1 (en) * | 1998-03-31 | 2003-03-04 | Acadia Pharmaceuticals Inc. | Compounds with activity on muscarinic receptors |
| AU4727799A (en) * | 1998-06-30 | 2000-01-17 | Eli Lilly And Company | Azepine derivatives having effects on serotonin related systems |
| MXPA04000358A (es) | 2001-07-13 | 2004-05-04 | Pharmacia & Up John Company | Hexahidroazepino (4,5-g) indoles e indolinas como ligandos del receptor 5-ht. |
| GB0412314D0 (en) * | 2004-06-02 | 2004-07-07 | Glaxo Group Ltd | Compounds |
| GB0414795D0 (en) * | 2004-07-01 | 2004-08-04 | Glaxo Group Ltd | Compounds |
| KR101781789B1 (ko) * | 2010-01-27 | 2017-09-26 | 에이비 파르마 리미티드. | C형 간염 바이러스 억제제로 사용되는 다환 헤테로사이클릭 화합물 |
| CA2894552A1 (en) * | 2012-12-21 | 2014-06-26 | Abt Holding Company | Benzazepines as serotonin 5-ht2c receptor ligands and uses thereof |
| CN105566262B (zh) * | 2016-01-11 | 2017-10-27 | 华东理工大学 | 苯并呋喃‑7‑烷基胺类化合物及其用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4255445A (en) * | 1980-03-07 | 1981-03-10 | Smithkline Corporation | 8-Hydroxy-6,7-(2-methyl-2,3-dihydrofuro)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines |
| CA1234110A (en) * | 1983-08-12 | 1988-03-15 | Joel G. Berger | Benzazepine derivatives, pharmaceutical compositions containing them and processes for the preparation of such compounds and compositions |
| DK180485D0 (da) * | 1985-04-22 | 1985-04-23 | Novo Industri As | Nitrogenholdige forbindelser |
| DK157925C (da) * | 1985-04-22 | 1990-08-27 | Novo Industri As | 2,3,4,5-tetrahydro-1h-3-benzazepinderivater og farmaceutiske praeparater indeholdende disse |
-
1993
- 1993-03-10 DK DK93267A patent/DK26793D0/da not_active Application Discontinuation
-
1994
- 1994-02-18 NZ NZ262098A patent/NZ262098A/en not_active IP Right Cessation
- 1994-02-18 DE DE69418321T patent/DE69418321T2/de not_active Expired - Lifetime
- 1994-02-18 AT AT94908289T patent/ATE179700T1/de not_active IP Right Cessation
- 1994-02-18 DK DK94908289T patent/DK0688320T3/da active
- 1994-02-18 WO PCT/DK1994/000069 patent/WO1994020472A1/en not_active Ceased
- 1994-02-18 CN CN94191882A patent/CN1045957C/zh not_active Expired - Fee Related
- 1994-02-18 EP EP94908289A patent/EP0688320B1/de not_active Expired - Lifetime
- 1994-02-18 CA CA002157668A patent/CA2157668C/en not_active Expired - Fee Related
- 1994-02-18 KR KR1019950703762A patent/KR960701022A/ko not_active Ceased
- 1994-02-18 JP JP51947094A patent/JP3779319B2/ja not_active Expired - Fee Related
- 1994-02-18 ES ES94908289T patent/ES2133542T3/es not_active Expired - Lifetime
- 1994-02-18 AU AU61386/94A patent/AU682494B2/en not_active Ceased
- 1994-02-22 IL IL10873094A patent/IL108730A/en not_active IP Right Cessation
- 1994-02-22 TW TW083101509A patent/TW279861B/zh active
- 1994-02-24 US US08/202,401 patent/US5512562A/en not_active Expired - Lifetime
- 1994-02-28 ZA ZA941377A patent/ZA941377B/xx unknown
-
1995
- 1995-09-08 NO NO953543A patent/NO953543D0/no not_active Application Discontinuation
- 1995-09-08 FI FI954229A patent/FI111944B/fi not_active IP Right Cessation
-
1999
- 1999-07-27 GR GR990401950T patent/GR3030864T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW279861B (de) | 1996-07-01 |
| WO1994020472A1 (en) | 1994-09-15 |
| AU6138694A (en) | 1994-09-26 |
| CA2157668C (en) | 2006-05-30 |
| AU682494B2 (en) | 1997-10-09 |
| JP3779319B2 (ja) | 2006-05-24 |
| ES2133542T3 (es) | 1999-09-16 |
| ZA941377B (en) | 1995-08-28 |
| GR3030864T3 (en) | 1999-11-30 |
| JPH08507498A (ja) | 1996-08-13 |
| DE69418321T2 (de) | 1999-12-30 |
| CN1045957C (zh) | 1999-10-27 |
| FI954229L (fi) | 1995-09-08 |
| NZ262098A (en) | 1996-11-26 |
| KR960701022A (ko) | 1996-02-24 |
| US5512562A (en) | 1996-04-30 |
| NO953543L (no) | 1995-09-08 |
| CA2157668A1 (en) | 1994-09-15 |
| FI954229A0 (fi) | 1995-09-08 |
| DK26793D0 (da) | 1993-03-10 |
| DK0688320T3 (da) | 1999-11-01 |
| IL108730A (en) | 1999-08-17 |
| EP0688320A1 (de) | 1995-12-27 |
| CN1121710A (zh) | 1996-05-01 |
| EP0688320B1 (de) | 1999-05-06 |
| FI111944B (fi) | 2003-10-15 |
| NO953543D0 (no) | 1995-09-08 |
| IL108730A0 (en) | 1994-05-30 |
| DE69418321D1 (de) | 1999-06-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EEIH | Change in the person of patent owner | ||
| EEIH | Change in the person of patent owner | ||
| REN | Ceased due to non-payment of the annual fee |