ZA933940B - Preparation process for an 11-keto steroid derivative - Google Patents

Preparation process for an 11-keto steroid derivative

Info

Publication number: ZA933940B
Authority: ZA; South Africa
Prior art keywords: preparation process; keto; steroid derivative; compounds; keto steroid
Prior art date: 1992-06-04

Application number

ZA933940A

Other languages

English (en)

Inventor

Francis Brion

Jean Buendia

Christian Diolez

Michel Vivat

Original Assignee

Roussel Uclaf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-06-04

Filing date

1993-06-04

Publication date

1994-06-06

1993-06-04 Application filed by Roussel Uclaf filed Critical Roussel Uclaf

1994-06-06 Publication of ZA933940B publication Critical patent/ZA933940B/xx

Links

238000002360 preparation method Methods 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 4
150000002148 esters Chemical group 0.000 abstract 2
125000001033 ether group Chemical group 0.000 abstract 2
150000003944 halohydrins Chemical class 0.000 abstract 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000002345 steroid group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
- C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
- C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
- C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
- C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
- C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
- C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Cultivation Of Plants (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

ZA933940A 1992-06-04 1993-06-04 Preparation process for an 11-keto steroid derivative ZA933940B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR929206773A FR2691968B1 (fr)	1992-06-04	1992-06-04	Nouveau procede de preparation d'un derive sterouide 11-ceto.

Publications (1)

Publication Number	Publication Date
ZA933940B true ZA933940B (en)	1994-06-06

Family

ID=9430432

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA933940A ZA933940B (en)	1992-06-04	1993-06-04	Preparation process for an 11-keto steroid derivative

Country Status (16)

Country	Link
US (1)	US5585482A (de)
EP (1)	EP0573362B1 (de)
JP (1)	JP3328377B2 (de)
KR (1)	KR100274369B1 (de)
CN (1)	CN1039646C (de)
AT (1)	ATE144526T1 (de)
CA (1)	CA2097678C (de)
DE (1)	DE69305572T2 (de)
DK (1)	DK0573362T3 (de)
ES (1)	ES2093379T3 (de)
FR (1)	FR2691968B1 (de)
GR (1)	GR3021436T3 (de)
HU (1)	HU216638B (de)
MX (1)	MX9303139A (de)
RU (1)	RU2108340C1 (de)
ZA (1)	ZA933940B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2700339B1 (fr) *	1993-01-14	1995-03-03	Roussel Uclaf	Nouveaux dérivés 17,20-époxydes du pregnane, leur préparation, leur application à la préparation de dérivés cortisoniques et intermédiaires.
US5909921A (en) *	1997-04-11	1999-06-08	Nesbeth; Roleto E.	Lift device and system for a pick-up truck cargo cover
ATE473759T1 (de)	1998-05-22	2010-07-15	Univ Leland Stanford Junior	Bifunktionelle moleküle sowie darauf basierende therapien.
CN100428897C (zh) *	2002-08-16	2008-10-29	浙江寿峰堂生物工程有限公司	抗疲劳改善亚健康的保健食品及其制备方法
CN102379684B (zh)	2005-04-28	2014-11-19	普罗透斯数字保健公司	药物信息系统
US9062126B2 (en)	2005-09-16	2015-06-23	Raptor Pharmaceuticals Inc.	Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
EP2398500B1 (de)	2009-02-20	2019-03-13	2-BBB Medicines B.V.	Arzneiabgabesystem auf glutathion-basis
ES2942923T3 (es)	2009-05-06	2023-06-07	Laboratory Skin Care Inc	Composiciones de administración dérmica que comprenden complejos de agente activo-partículas de fosfato de calcio y métodos de uso de las mismas
CN103923145B (zh) *	2014-04-16	2015-04-01	江苏远大仙乐药业有限公司	一种醋酸可的松重要中间体的制备方法
CN106866765B (zh) *	2016-12-12	2019-01-15	河南利华制药有限公司	一种醋酸可的松的制备方法
CN107400153B (zh) *	2017-04-23	2019-08-27	浙江仙琚制药股份有限公司	一种醋酸氢化可的松的制备方法
CN108373492B (zh) *	2018-04-20	2021-12-21	江苏远大仙乐药业有限公司	一种醋酸可的松的制备方法
CN111333690B (zh) *	2018-12-18	2021-10-08	奥锐特药业股份有限公司	一种9-卤代甾体激素化合物9-位脱卤的制备方法
CN109942660B (zh) *	2019-04-17	2020-06-12	河南利华制药有限公司	一锅烩制备醋酸可的松的方法
CN110698528B (zh) *	2019-11-19	2022-08-26	湖南新合新生物医药有限公司	甲基泼尼松龙中间体脱溴物及其制备方法
CN113493484A (zh) *	2020-04-02	2021-10-12	河南利华制药有限公司	一种甲基泼尼松及其中间体的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA536948A (en) *		1957-02-05	S. Fonken Gunther	17.alpha.,21-DIHYDROXY-4-PREGNENE-3,11,20-TRIONE
US3057884A (en) *	1961-07-24	1962-10-09	Upjohn Co	Process for converting 11-hydroxy steroid compounds to corresponding keto derivatives
DE2950026C2 (de) *	1979-12-10	1982-05-19	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Verfahren zur Herstellung von 11-Ketosteroiden
DE3373189D1 (en) *	1982-06-21	1987-10-01	Dainippon Ink & Chemicals	Process for preparation of steroids
FR2681069B1 (fr) *	1991-09-06	1995-04-28	Roussel Uclaf	Nouveau procede de preparation de l'hydrocortisone et nouveaux intermediaires.

1992
- 1992-06-04 FR FR929206773A patent/FR2691968B1/fr not_active Expired - Fee Related
1993
- 1993-04-21 RU RU93036551A patent/RU2108340C1/ru active
- 1993-05-27 MX MX9303139A patent/MX9303139A/es unknown
- 1993-05-31 KR KR1019930009652A patent/KR100274369B1/ko not_active Expired - Lifetime
- 1993-06-03 DE DE69305572T patent/DE69305572T2/de not_active Expired - Lifetime
- 1993-06-03 DK DK93401419.2T patent/DK0573362T3/da active
- 1993-06-03 EP EP93401419A patent/EP0573362B1/de not_active Expired - Lifetime
- 1993-06-03 AT AT93401419T patent/ATE144526T1/de active
- 1993-06-03 HU HU9301633A patent/HU216638B/hu unknown
- 1993-06-03 CA CA002097678A patent/CA2097678C/fr not_active Expired - Lifetime
- 1993-06-03 ES ES93401419T patent/ES2093379T3/es not_active Expired - Lifetime
- 1993-06-04 ZA ZA933940A patent/ZA933940B/xx unknown
- 1993-06-04 CN CN93106670A patent/CN1039646C/zh not_active Expired - Lifetime
- 1993-06-04 JP JP15819393A patent/JP3328377B2/ja not_active Expired - Lifetime
1995
- 1995-10-19 US US08/545,518 patent/US5585482A/en not_active Expired - Lifetime
1996
- 1996-10-24 GR GR950403164T patent/GR3021436T3/el unknown

Also Published As

Publication number	Publication date
US5585482A (en)	1996-12-17
ATE144526T1 (de)	1996-11-15
RU2108340C1 (ru)	1998-04-10
HUT64770A (en)	1994-02-28
EP0573362A1 (de)	1993-12-08
ES2093379T3 (es)	1996-12-16
AU666938B2 (en)	1996-02-29
CN1039646C (zh)	1998-09-02
HU216638B (hu)	1999-07-28
MX9303139A (es)	1994-06-30
JPH0665286A (ja)	1994-03-08
KR100274369B1 (ko)	2001-02-01
DK0573362T3 (da)	1997-01-13
DE69305572T2 (de)	1997-03-06
CA2097678C (fr)	2004-05-04
FR2691968B1 (fr)	1994-07-29
CN1083069A (zh)	1994-03-02
FR2691968A1 (fr)	1993-12-10
DE69305572D1 (de)	1996-11-28
AU4001893A (en)	1993-12-09
GR3021436T3 (en)	1997-01-31
HU9301633D0 (en)	1993-09-28
JP3328377B2 (ja)	2002-09-24
CA2097678A1 (fr)	1993-12-05
EP0573362B1 (de)	1996-10-23

Publication	Publication Date	Title
CA2097678A1 (fr)	1993-12-05	Procede de preparation d'un derive steroide 11-ceto
IL109917A0 (en)	1994-10-07	Lipopeptides from Actinoplanes sp. with pharmacological action, process for their preparation and the use thereof
DE3563970D1 (en)	1988-09-01	6,6-ethylene-15,16-methylene-3-oxo-17-alpha-pregn-4-ene 21-17 carbolactone, process for their preparation and pharmaceutical compositions containing them
CA2115015A1 (fr)	1994-08-06	Procede de preparation de steroides 6alpha, 9alpha-difluores et nouveaux intermediaires obtenus
NZ513881A (en)	2002-10-25	Pharmaceutical compositions of tizoxanide and nitazoxanide
TW427997B (en)	2001-04-01	New preparation process for a 16 β-methyl steroid and new intermediates
GR3020751T3 (en)	1996-11-30	New 16-alpha steroid-methylation process.
AU668161B2 (en)	1996-04-26	Novel process and intermediates
AU5344094A (en)	1994-05-09	Process for intensification of fermentations
AU5637890A (en)	1991-01-07	Conversion of delta16-steroid to a delta17(20)-20-silyl ether
DE3161634D1 (en)	1984-01-19	Alkyl-4-methyl-3-formyl pentenoates, their preparation, their use in the preparation of the 4-methyl-3-formyl-3-pentenoic acid and the intermediates
ZA937665B (en)	1994-05-16	Process for intensification of fermentations
SI0879242T1 (en)	2000-08-31	Preparation of (11beta, 16beta)-21-(3-carboxy-3-oxopropoxy)-11-hydroxy-2'-methyl-5'h-pregna-1,4-dieno(17,16-d)oxazole-3,20-dione