ZA935660B - Modified proteases. - Google Patents

Modified proteases.

Info

Publication number
ZA935660B
ZA935660B ZA935660A ZA935660A ZA935660B ZA 935660 B ZA935660 B ZA 935660B ZA 935660 A ZA935660 A ZA 935660A ZA 935660 A ZA935660 A ZA 935660A ZA 935660 B ZA935660 B ZA 935660B
Authority
ZA
South Africa
Prior art keywords
pct
modified
date feb
proteases
sec
Prior art date
Application number
ZA935660A
Other languages
English (en)
Inventor
Keith Martyn Dawson
Richard James Gilbert
Original Assignee
British Biotech Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Biotech Pharm filed Critical British Biotech Pharm
Publication of ZA935660B publication Critical patent/ZA935660B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
ZA935660A 1992-08-04 1993-08-14 Modified proteases. ZA935660B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929216558A GB9216558D0 (en) 1992-08-04 1992-08-04 Modified proteases

Publications (1)

Publication Number Publication Date
ZA935660B true ZA935660B (en) 1994-03-17

Family

ID=10719807

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA935660A ZA935660B (en) 1992-08-04 1993-08-14 Modified proteases.

Country Status (10)

Country Link
US (2) US5645833A (de)
EP (1) EP0658206B1 (de)
JP (1) JP3449717B2 (de)
AT (1) ATE282089T1 (de)
AU (1) AU4720093A (de)
DE (1) DE69333689T2 (de)
ES (1) ES2232812T3 (de)
GB (1) GB9216558D0 (de)
WO (1) WO1994003614A1 (de)
ZA (1) ZA935660B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7278094A (en) * 1994-06-07 1996-01-04 M D Serv Europe S.A. Intravasal thrombolysis
GB9412131D0 (en) * 1994-06-17 1994-08-10 British Bio Technology Thrombolytic composition
US6942978B1 (en) * 1999-03-03 2005-09-13 The Board Of Trustees Of The University Of Arkansas Transmembrane serine protease overexpressed in ovarian carcinoma and uses thereof
US7700341B2 (en) * 2000-02-03 2010-04-20 Dendreon Corporation Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon
JP2001275677A (ja) * 2000-03-30 2001-10-09 Canon Inc 核酸断片プライマーまたはプローブ、およびこれを用いたポリヒドロキシアルカノエート合成微生物の検出方法
WO2002094864A2 (en) 2001-05-25 2002-11-28 Genset S.A. Human cdnas and proteins and uses thereof
DE102006053404A1 (de) * 2006-11-10 2008-05-15 Hydro Aluminium Alucast Gmbh Gießform zum Gießen eines Gussteils und Verwendung einer solchen Gießform
AU2016358796A1 (en) * 2015-11-25 2018-06-21 Academisch Ziekenhuis Leiden Recombinant serine proteases
JP7604376B2 (ja) 2018-12-28 2024-12-23 バーテックス ファーマシューティカルズ インコーポレイテッド 改変ウロキナーゼ型プラスミノゲンアクティベータポリペプチドおよび使用方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2007364A1 (en) * 1989-01-17 1990-07-17 David J. Livingston Gene sequences encoding modified residues situated in the protease domain of tpa
US5304482A (en) * 1989-03-06 1994-04-19 The Board Of Regents Of The University Of Texas System Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors
WO1990010649A1 (en) * 1989-03-06 1990-09-20 The Board Of Regents Of The University Of Texas System Serpin resistant chymotrypsin superfamily proteases, particularly pai-1 resistant +-pa, complementary inhibitor mutants; compositions; genes; expression
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids

Also Published As

Publication number Publication date
JP3449717B2 (ja) 2003-09-22
ATE282089T1 (de) 2004-11-15
ES2232812T3 (es) 2005-06-01
US5645833A (en) 1997-07-08
EP0658206B1 (de) 2004-11-10
JPH07509610A (ja) 1995-10-26
EP0658206A1 (de) 1995-06-21
GB9216558D0 (en) 1992-09-16
DE69333689D1 (de) 2004-12-16
DE69333689T2 (de) 2005-11-03
WO1994003614A1 (en) 1994-02-17
US5932213A (en) 1999-08-03
AU4720093A (en) 1994-03-03

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