ZA947863B - Stable solvates of avermectin compounds - Google Patents

Stable solvates of avermectin compounds

Info

Publication number: ZA947863B
Authority: ZA; South Africa
Prior art keywords: avermectin compounds; avermectin; compounds; disclosed; solvates
Prior art date: 1993-10-08

Application number

ZA947863A

Other languages

English (en)

Inventor

Joseph S Amato

Raymond Cvetovich

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-10-08

Filing date

1994-10-07

Publication date

1995-05-22

1994-10-07 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1995-05-22 Publication of ZA947863B publication Critical patent/ZA947863B/xx

Links

RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical class C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 title abstract 5
239000012453 solvate Substances 0.000 title abstract 2
239000005660 Abamectin Substances 0.000 abstract 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
239000000921 anthelmintic agent Substances 0.000 abstract 1
229940124339 anthelmintic agent Drugs 0.000 abstract 1
230000002141 anti-parasite Effects 0.000 abstract 1
239000003096 antiparasitic agent Substances 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
230000000749 insecticidal effect Effects 0.000 abstract 1
239000002917 insecticide Substances 0.000 abstract 1
230000007774 longterm Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/14—Ectoparasiticides, e.g. scabicides

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Tropical Medicine & Parasitology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
External Artificial Organs (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Separation Of Suspended Particles By Flocculating Agents (AREA)

ZA947863A 1993-10-08 1994-10-07 Stable solvates of avermectin compounds ZA947863B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/133,494 US5380838A (en)	1993-10-08	1993-10-08	Stable solvates of avermectin compounds

Publications (1)

Publication Number	Publication Date
ZA947863B true ZA947863B (en)	1995-05-22

Family

ID=22458871

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA947863A ZA947863B (en)	1993-10-08	1994-10-07	Stable solvates of avermectin compounds

Country Status (10)

Country	Link
US (1)	US5380838A (de)
EP (1)	EP0722454B1 (de)
JP (1)	JP2938974B2 (de)
AT (1)	ATE179985T1 (de)
AU (1)	AU681916B2 (de)
CA (1)	CA2171871C (de)
DE (1)	DE69418469T2 (de)
ES (1)	ES2131219T3 (de)
WO (1)	WO1995010525A1 (de)
ZA (1)	ZA947863B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9716567D0 (en)	1997-08-05	1997-10-08	Pfizer	Process
DE69824632T2 (de)	1997-11-12	2005-06-09	Mitsubishi Chemical Corp.	Purinderivate und medikamente, welche dieselben als aktiven bestandteil enthalten
KR100747106B1 (ko)	1999-05-11	2007-08-08	미쯔비시 가가꾸 가부시끼가이샤	퓨린 유도체 이수화물, 이를 유효성분으로 함유하는 의약및 이의 제조 중간체
WO2004063147A1 (en) *	2003-01-10	2004-07-29	Novo Nordisk A/S	Salts and solvates of glucagon antagonists

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE434277B (sv) *	1976-04-19	1984-07-16	Merck & Co Inc	Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
NZ188459A (en) *	1977-10-03	1982-09-07	Merck & Co Inc	Derivatives of c-076 compounds and pesticidal compositions
PH15982A (en) *	1977-10-03	1983-05-18	Merck & Co Inc	Selective hydrogenation producta of c-076 compounds and derivatives thereof
US4199569A (en) *	1977-10-03	1980-04-22	Merck & Co., Inc.	Selective hydrogenation products of C-076 compounds and derivatives thereof
US4206205A (en) *	1977-10-03	1980-06-03	Merck & Co., Inc.	Monosaccharide and aglycone derivatives of C-076
US4171314A (en) *	1977-12-19	1979-10-16	Merck & Co., Inc.	13-Halo and 13-deoxy C-076 compounds
US4734375A (en) *	1980-05-27	1988-03-29	Miles Laboratories, Inc.	Ion specific test method
US4457920A (en) *	1981-09-03	1984-07-03	Merck & Co., Inc.	4a-Substituted avermectin compounds
US4657854A (en) *	1983-05-05	1987-04-14	Ivan Endre Modrovich	Assay systems based on magnesium-responsive enzymes
DE3669515D1 (de) *	1985-09-13	1990-04-19	Biotechnolog Forschung Gmbh	Makrozyklische antibiotika.
US4812400A (en) *	1986-07-14	1989-03-14	Steinman Gary D	Process for measuring sodium levels in biological fluids
JPH0612999B2 (ja) *	1986-11-17	1994-02-23	関東化学株式会社	塩素イオン定量用試薬

1993
- 1993-10-08 US US08/133,494 patent/US5380838A/en not_active Expired - Lifetime
1994
- 1994-10-04 ES ES94931307T patent/ES2131219T3/es not_active Expired - Lifetime
- 1994-10-04 CA CA002171871A patent/CA2171871C/en not_active Expired - Lifetime
- 1994-10-04 DE DE69418469T patent/DE69418469T2/de not_active Expired - Lifetime
- 1994-10-04 WO PCT/US1994/011247 patent/WO1995010525A1/en not_active Ceased
- 1994-10-04 AT AT94931307T patent/ATE179985T1/de not_active IP Right Cessation
- 1994-10-04 EP EP94931307A patent/EP0722454B1/de not_active Expired - Lifetime
- 1994-10-04 JP JP7511881A patent/JP2938974B2/ja not_active Expired - Lifetime
- 1994-10-04 AU AU80130/94A patent/AU681916B2/en not_active Expired
- 1994-10-07 ZA ZA947863A patent/ZA947863B/xx unknown

Also Published As

Publication number	Publication date
DE69418469D1 (de)	1999-06-17
ATE179985T1 (de)	1999-05-15
US5380838A (en)	1995-01-10
EP0722454A1 (de)	1996-07-24
DE69418469T2 (de)	1999-12-16
CA2171871C (en)	1999-08-03
JPH09503521A (ja)	1997-04-08
AU8013094A (en)	1995-05-04
WO1995010525A1 (en)	1995-04-20
ES2131219T3 (es)	1999-07-16
EP0722454B1 (de)	1999-05-12
JP2938974B2 (ja)	1999-08-25
AU681916B2 (en)	1997-09-11
CA2171871A1 (en)	1995-04-20

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