ZA954892B - Novel cell system having specific interaction of peptide binding pairs - Google Patents

Novel cell system having specific interaction of peptide binding pairs

Info

Publication number
ZA954892B
ZA954892B ZA954892A ZA954892A ZA954892B ZA 954892 B ZA954892 B ZA 954892B ZA 954892 A ZA954892 A ZA 954892A ZA 954892 A ZA954892 A ZA 954892A ZA 954892 B ZA954892 B ZA 954892B
Authority
ZA
South Africa
Prior art keywords
peptide
transcriptional activation
fusion protein
protein
host cell
Prior art date
Application number
ZA954892A
Other languages
English (en)
Inventor
Kathleen H Young
Bradley A Ozenberger
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of ZA954892B publication Critical patent/ZA954892B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Mobile Radio Communication Systems (AREA)
ZA954892A 1994-06-14 1995-06-13 Novel cell system having specific interaction of peptide binding pairs ZA954892B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/259,609 US5989808A (en) 1994-06-14 1994-06-14 Identification of compounds affecting specific interaction of peptide binding pairs

Publications (1)

Publication Number Publication Date
ZA954892B true ZA954892B (en) 1996-01-30

Family

ID=22985626

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA954892A ZA954892B (en) 1994-06-14 1995-06-13 Novel cell system having specific interaction of peptide binding pairs

Country Status (18)

Country Link
US (3) US5989808A (lt)
EP (1) EP0765389B1 (lt)
AT (1) ATE245189T1 (lt)
AU (1) AU706173B2 (lt)
CA (1) CA2195083A1 (lt)
DE (1) DE69531302T2 (lt)
DK (1) DK0765389T3 (lt)
ES (1) ES2202366T3 (lt)
GE (1) GEP20022619B (lt)
IL (1) IL114118A0 (lt)
LT (1) LT4230B (lt)
LV (1) LV11906B (lt)
NZ (1) NZ287372A (lt)
PT (1) PT765389E (lt)
RU (1) RU2208646C2 (lt)
SI (1) SI9520073B (lt)
WO (1) WO1995034646A1 (lt)
ZA (1) ZA954892B (lt)

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US7226761B2 (en) * 1992-11-05 2007-06-05 Danisco Sweeteners Oy Manufacture of five-carbon sugars and sugar alcohols
US6891021B2 (en) 1993-02-12 2005-05-10 Board Of Trustees Of The Leland Stanford Junior University Regulated apoptosis
US6972193B1 (en) * 1993-02-12 2005-12-06 Board Of Trustees Of Leland Stanford Junior University Regulated transcription of targeted genes and other biological events
US6770446B1 (en) * 1994-06-14 2004-08-03 Wyeth Cell systems having specific interaction of peptide binding pairs
US5610015A (en) * 1995-03-23 1997-03-11 Wisconsin Alumni Research Foundation System to detect protein-RNA interactions
DE69636866D1 (en) * 1995-04-11 2007-03-15 Gen Hospital Corp Reverse "two-hybrid"-systeme
US6171800B1 (en) 1995-06-07 2001-01-09 Biogen, Inc. Method of making and binding CAIP polypeptides
US6423824B1 (en) 1995-06-07 2002-07-23 Biogen, Inc. CAIP-like gene family
US5837844A (en) * 1995-06-07 1998-11-17 Biogen, Inc. CAIP-like gene family
DE29724617U1 (de) * 1996-04-26 2002-06-13 Massachusetts Institute Of Technology, Cambridge, Mass. Drei-Hybrid-Kit zur Molekülauswahl
CA2252886C (en) * 1996-04-26 2008-02-12 Massachusetts Institute Of Technology Three-hybrid screening assay
US6696251B1 (en) 1996-05-31 2004-02-24 Board Of Trustees Of The University Of Illinois Yeast cell surface display of proteins and uses thereof
WO1997049808A1 (en) * 1996-06-27 1997-12-31 Biogen, Inc. The caip-like gene family
FR2761697B1 (fr) * 1997-04-03 1999-05-28 Inst Nat Sante Rech Med Methodes de detection d'interactions entre plusieurs proteines
DE19715683C2 (de) * 1997-04-15 1999-11-11 Max Planck Gesellschaft Neue Reportervektoren für One-Hybrid und Two-Hybrid Systeme
US7005295B1 (en) 1997-04-16 2006-02-28 Wyeth β-amyloid peptide-binding proteins and polynucleotides encoding the same
US6787319B2 (en) 1997-04-16 2004-09-07 American Home Products Corp. β-amyloid peptide-binding proteins and polynucleotides encoding the same
WO1998049297A1 (en) 1997-04-25 1998-11-05 American Home Products Corporation Neuronal mort1 isoforms
US6479653B1 (en) 1997-08-26 2002-11-12 Ariad Gene Therapeutics, Inc. Compositions and method for regulation of transcription
JP4296608B2 (ja) * 1997-08-27 2009-07-15 田辺三菱製薬株式会社 Ｐｐａｒのアゴニスト及びアンタゴニストのスクリーニング方法
CA2315819A1 (en) 1997-10-15 1999-04-22 Diversa Corporation Screening for novel compounds which regulate biological interactions
EP1149920A1 (en) * 1997-10-15 2001-10-31 Diversa, Inc. Screening for novel compounds which regulate biological interactions
US6261842B1 (en) 1997-10-23 2001-07-17 Wisconsin Alumni Research Foundation Microorganism genomics, compositions and methods related thereto
JP2002502585A (ja) * 1997-11-14 2002-01-29 ロシュ ダイアグノスティックス コーポレイション 抗原存在下においてエフェクター複合体を形成する可変領域融合ペプチド
CA2317816C (en) 1998-01-09 2009-02-17 Tvw Telethon Institute For Child Health Research Peptide detection method
EP0974649A1 (en) 1998-06-22 2000-01-26 Universität Zürich Screening system
US7166475B2 (en) 1999-02-26 2007-01-23 Cyclacel Ltd. Compositions and methods for monitoring the modification state of a pair of polypeptides
GB9907687D0 (en) * 1999-04-01 1999-05-26 Kudos Pharm Ltd Assays methods and means
NZ514710A (en) 1999-04-21 2004-07-30 Wyeth Corp Methods of identifying compounds which affect binding between two key regulatory regions of voltage-gated sodium and potassium ion channels
JP2004527204A (ja) * 2000-04-24 2004-09-09 ワイエス ペプチド結合対の特異的相互作用を有する新規な細胞系
EP1349946B1 (en) 2000-08-25 2011-01-26 BASF Plant Science GmbH Plant polynucleotides encoding prenyl proteases
AU2002220275A1 (en) * 2000-12-08 2002-06-18 The Board Of Trustees Of The University Of Illinois Mutated class ii major histocompatibility proteins
DK1534819T3 (da) 2002-08-21 2010-04-19 Revivicor Inc Griselignende dyr, som mangler enhver ekspression af funktionel alfa-1,3-galactosyltransferase
US9453251B2 (en) 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
DE60333228D1 (de) 2002-12-02 2010-08-12 Amgen Fremont Inc Gegen den tumor nekrose faktor gerichtete antikörper und deren verwendungen
WO2005049804A2 (en) * 2003-11-17 2005-06-02 Georgia Tech Research Corporation Engineering enzymes through genetic selection
EP1544307A1 (en) * 2003-12-18 2005-06-22 AXXAM S.r.l. LAC9 chimeric receptor and uses thereof
US8603824B2 (en) 2004-07-26 2013-12-10 Pfenex, Inc. Process for improved protein expression by strain engineering
CA2909775A1 (en) 2005-08-09 2007-03-29 Revivicor, Inc. Transgenic ungulates expressing ctla4-ig and uses thereof
CA2635906A1 (en) * 2006-02-07 2007-08-16 Wyeth Materials and methods for identifying agents that modulate norrin. norrin mimetics, and agents identified thereby
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
JP5444553B2 (ja) 2007-04-27 2014-03-19 フェネックス インコーポレイテッド 微生物宿主を迅速にスクリーニングして、異種タンパク質発現の収率および／または質が改善されている特定の株を同定する方法
CN101131363B (zh) * 2007-09-30 2010-12-01 南京大学 一种基于酵母三杂交的小分子化合物检测方法
US10603174B2 (en) 2015-03-24 2020-03-31 Osiris Therapeutics, Inc. Compositions comprising meniscal tissues and uses thereof

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US5283173A (en) * 1990-01-24 1994-02-01 The Research Foundation Of State University Of New York System to detect protein-protein interactions
US5322801A (en) * 1990-04-19 1994-06-21 The General Hospital Corporation Protein partner screening assays and uses thereof
EP1362913B1 (en) * 1992-10-30 2006-01-25 The General Hospital Corporation Interaction trap system for isolating proteins
US5512473A (en) * 1993-01-29 1996-04-30 Brent; Roger Max-interacting proteins and related molecules and methods
US5582995A (en) * 1993-06-11 1996-12-10 The General Hospital Corporation Methods of screening for compounds which inhibit the direct binding of Ras to Raf
CA2180271A1 (en) * 1993-12-30 1995-07-06 Ronald M. Evans Novel uses for gal4-receptor constructs
ES2146749T3 (es) * 1994-01-21 2000-08-16 Icos Corp Materiales y metodos en relacion con proteinas que interaccionan con la caseina quinasa i.
US5525490A (en) * 1994-03-29 1996-06-11 Onyx Pharmaceuticals, Inc. Reverse two-hybrid method
US5691147A (en) * 1994-06-02 1997-11-25 Mitotix, Inc. CDK4 binding assay

Also Published As

Publication number Publication date
AU2606695A (en) 1996-01-05
EP0765389A1 (en) 1997-04-02
AU706173B2 (en) 1999-06-10
SI9520073B (sl) 2004-06-30
ES2202366T3 (es) 2004-04-01
DK0765389T3 (da) 2003-10-27
LT97004A (en) 1997-07-25
US6251602B1 (en) 2001-06-26
IL114118A0 (en) 1995-10-31
DE69531302D1 (de) 2003-08-21
WO1995034646A1 (en) 1995-12-21
CA2195083A1 (en) 1995-12-21
RU2208646C2 (ru) 2003-07-20
LV11906A (lv) 1997-12-20
DE69531302T2 (de) 2004-04-22
ATE245189T1 (de) 2003-08-15
US6284519B1 (en) 2001-09-04
LV11906B (en) 1998-06-20
EP0765389B1 (en) 2003-07-16
US5989808A (en) 1999-11-23
PT765389E (pt) 2003-11-28
NZ287372A (en) 1997-11-24
GEP20022619B (en) 2002-01-25
LT4230B (en) 1997-10-27
SI9520073A (sl) 1998-02-28

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