ZA958894B - Tricyclic amide compound process for their preparation and the pharmaceutical compositions which contain them - Google Patents

Tricyclic amide compound process for their preparation and the pharmaceutical compositions which contain them

Info

Publication number: ZA958894B
Authority: ZA; South Africa
Prior art keywords: alkyl; cycloalkyl; substd; alkoxy; alkenyl
Prior art date: 1994-10-21

Application number

ZA958894A

Other languages

English (en)

Inventor

Daniel Lesieur

Patrick Depreux

Veronique Leclerc

Mansour Hamid Ait

Philippe Delagrange

Pierre Renard

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-21

Filing date

1995-10-20

Publication date

1996-05-14

1995-10-20 Application filed by Adir filed Critical Adir

1996-05-14 Publication of ZA958894B publication Critical patent/ZA958894B/xx

Links

-1 amide compound Chemical class 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 9
125000003342 alkenyl group Chemical group 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 4
125000000304 alkynyl group Chemical group 0.000 abstract 3
125000000753 cycloalkyl group Chemical group 0.000 abstract 3
FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 abstract 2
SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 2
UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 abstract 2
125000002947 alkylene group Chemical group 0.000 abstract 2
238000006467 substitution reaction Methods 0.000 abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
125000004450 alkenylene group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004419 alkynylene group Chemical group 0.000 abstract 1
150000001408 amides Chemical class 0.000 abstract 1
RFRXIWQYSOIBDI-UHFFFAOYSA-N benzarone Chemical compound CCC=1OC2=CC=CC=C2C=1C(=O)C1=CC=C(O)C=C1 RFRXIWQYSOIBDI-UHFFFAOYSA-N 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 1
RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/92—Naphthofurans; Hydrogenated naphthofurans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
- C07C233/13—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/20—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/60—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Diabetes (AREA)
Psychiatry (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Transplantation (AREA)
Child & Adolescent Psychology (AREA)
Anesthesiology (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Furan Compounds (AREA)
Pyrane Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Indole Compounds (AREA)

ZA958894A 1994-10-21 1995-10-20 Tricyclic amide compound process for their preparation and the pharmaceutical compositions which contain them ZA958894B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9412581A FR2725985B1 (fr)	1994-10-21	1994-10-21	Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
ZA958894B true ZA958894B (en)	1996-05-14

Family

ID=9468074

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA958894A ZA958894B (en)	1994-10-21	1995-10-20	Tricyclic amide compound process for their preparation and the pharmaceutical compositions which contain them

Country Status (16)

Country	Link
US (1)	US5843986A (de)
EP (1)	EP0708099B1 (de)
JP (1)	JP2999143B2 (de)
CN (2)	CN1053662C (de)
AT (1)	ATE209641T1 (de)
AU (1)	AU688586B2 (de)
CA (1)	CA2160961C (de)
DE (1)	DE69524186T2 (de)
DK (1)	DK0708099T3 (de)
ES (1)	ES2169113T3 (de)
FI (1)	FI118565B (de)
FR (1)	FR2725985B1 (de)
NO (1)	NO314262B1 (de)
NZ (1)	NZ280298A (de)
PT (1)	PT708099E (de)
ZA (1)	ZA958894B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6071946A (en) *	1994-10-21	2000-06-06	Adir Et Compagnie	Tricyclic urea compounds
US5998461A (en) *	1994-10-21	1999-12-07	Adir Et Compagnie	Tricyclic amide compounds
FR2739379B1 (fr) *	1995-09-29	1997-10-24	Adir	Nouveaux composes amines de 5,6,7,8-tetrahydronaphto(2,3-b) furane et d'indano(5,6-b)furane, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
SK283970B9 (sk) *	1996-03-08	2004-10-05	Takeda Chemical Industries Ltd	Tricyklické zlúčeniny, spôsob výroby a farmaceutický prípravok ich obsahujúci
EP1199304A1 (de) *	1997-03-05	2002-04-24	Takeda Chemical Industries, Ltd.	Bizyklische Verbindungen und trizyklische Verbindung enthaltende pharmazeutische Zusammensetzung für die Behandlung von oder Vorbeugung gegen Schlafstörungen
US6034239A (en) *	1996-03-08	2000-03-07	Takeda Chemical Industries, Ltd.	Tricyclic compounds, their production and use
PT1027043E (pt) *	1996-12-10	2005-02-28	Bristol Myers Squibb Co	Benzodioxole benzofurano di-hidrobenzofurano e benzodioxano como agentes melatonergicos
FR2763335B1 (fr) *	1997-05-16	2000-11-24	Adir	Nouveaux composes heterocycliques substitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2772766B1 (fr) *	1997-12-24	2000-06-30	Adir	Nouveaux composes heterocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2773798B1 (fr)	1998-01-16	2001-02-02	Adir	Nouveaux composes tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US6214869B1 (en)	1998-06-05	2001-04-10	Bristol-Myers Squibb	Heterocyclic cis cyclopropane derivatives as melatonergic agents
EP1189900B1 (de)	1999-06-30	2004-01-14	Bristol-Myers Squibb Company	Heterocyclische aminopyrrolidon-derivate als melatonergene wirkstoffe
AU6595000A (en)	1999-08-20	2001-03-19	Takeda Chemical Industries Ltd.	Dihydrobenzofuran derivatives, process for the preparation thereof and agents
FR2805993B1 (fr) *	2000-03-08	2004-01-16	Adir	Utilisation de ligands melatoninergiques pour l'obtention de compositions pharmaceutiques destinees a la prevention ou au traitement du developpement de la tolerance aux composes nitres
US7012090B1 (en)	2000-03-17	2006-03-14	Alcon, Inc.	Pyranoindoles for treating glaucoma
TWI402261B (zh) *	2006-06-19	2013-07-21	Takeda Pharmaceutical	三環化合物及其醫藥組成物
KR20090086641A (ko) *	2006-12-08	2009-08-13	다케다 야쿠힌 고교 가부시키가이샤	삼환 화합물 및 이의 의학적 용도
GB201002372D0 (en)	2010-02-12	2010-03-31	Element Six Production Pty Ltd	A superhard multiphase material and method of using same
CN107325011A (zh) *	2016-04-30	2017-11-07	陕西合成药业股份有限公司	一种褪黑激素类化合物及其制备方法和用途
WO2022265993A1 (en)	2021-06-14	2022-12-22	Scorpion Therapeutics, Inc.	Urea derivatives which can be used to treat cancer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2613365B1 (fr) *	1987-04-01	1989-07-28	Adir	Nouveaux derives de l'amino tetrahydro-5, 6, 7, 8 naphto (2, 3b) furanne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2613364B1 (fr) *	1987-04-01	1989-06-09	Adir	Nouvelles amines tricycliques derivees du tetrahydro-5, 6, 7, 8 naphto (2, 3b) dihydro-2, 3 furanne, et du tetrahydro-6, 7, 8, 9 5h-benzocyclohepta (2, 3b) dihydro-2, 3 furanne, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent
FR2658818B1 (fr) *	1990-02-27	1993-12-31	Adir Cie	Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2680507B1 (fr) *	1991-08-23	1993-10-08	Adir Cie	Nouvelles naphtylethylurees et naphtylethylthiourees, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2689124A1 (fr) *	1992-03-27	1993-10-01	Adir	Nouvelles naphtylalkylamines, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
GB9407919D0 (en) *	1994-04-21	1994-06-15	Glaxo Group Ltd	Chemical compounds

1994
- 1994-10-21 FR FR9412581A patent/FR2725985B1/fr not_active Expired - Fee Related
1995
- 1995-10-18 NO NO19954149A patent/NO314262B1/no not_active IP Right Cessation
- 1995-10-19 AT AT95402331T patent/ATE209641T1/de not_active IP Right Cessation
- 1995-10-19 CA CA002160961A patent/CA2160961C/fr not_active Expired - Fee Related
- 1995-10-19 EP EP95402331A patent/EP0708099B1/de not_active Expired - Lifetime
- 1995-10-19 PT PT95402331T patent/PT708099E/pt unknown
- 1995-10-19 DK DK95402331T patent/DK0708099T3/da active
- 1995-10-19 ES ES95402331T patent/ES2169113T3/es not_active Expired - Lifetime
- 1995-10-19 US US08/545,395 patent/US5843986A/en not_active Expired - Fee Related
- 1995-10-19 DE DE69524186T patent/DE69524186T2/de not_active Expired - Fee Related
- 1995-10-20 NZ NZ280298A patent/NZ280298A/en not_active IP Right Cessation
- 1995-10-20 JP JP7272750A patent/JP2999143B2/ja not_active Expired - Fee Related
- 1995-10-20 CN CN95115980A patent/CN1053662C/zh not_active Expired - Fee Related
- 1995-10-20 AU AU34377/95A patent/AU688586B2/en not_active Ceased
- 1995-10-20 FI FI955023A patent/FI118565B/fi active IP Right Grant
- 1995-10-20 ZA ZA958894A patent/ZA958894B/xx unknown
1999
- 1999-12-15 CN CNB991261585A patent/CN1137889C/zh not_active Expired - Fee Related

Also Published As

Publication number	Publication date
NO954149D0 (no)	1995-10-18
DE69524186D1 (de)	2002-01-10
CN1137889C (zh)	2004-02-11
DK0708099T3 (da)	2002-02-11
JPH08239377A (ja)	1996-09-17
FI955023A0 (fi)	1995-10-20
FI118565B (fi)	2007-12-31
PT708099E (pt)	2002-05-31
CN1053662C (zh)	2000-06-21
CA2160961A1 (fr)	1996-04-22
EP0708099A1 (de)	1996-04-24
JP2999143B2 (ja)	2000-01-17
FI955023L (fi)	1996-04-22
FR2725985B1 (fr)	1996-11-15
AU688586B2 (en)	1998-03-12
CA2160961C (fr)	2001-07-17
AU3437795A (en)	1996-05-02
CN1130184A (zh)	1996-09-04
CN1263095A (zh)	2000-08-16
NO314262B1 (no)	2003-02-24
NO954149L (no)	1996-04-22
US5843986A (en)	1998-12-01
HK1029116A1 (en)	2001-03-23
ATE209641T1 (de)	2001-12-15
NZ280298A (en)	1996-10-28
EP0708099B1 (de)	2001-11-28
ES2169113T3 (es)	2002-07-01
FR2725985A1 (fr)	1996-04-26
DE69524186T2 (de)	2002-07-04

Publication	Publication Date	Title
AU688586B2 (en)	1998-03-12	New tricyclic amide compounds, processes for their preparation and the pharmaceutical compositions which contain them
ES2034893A1 (es)	1993-04-01	Procedimiento para la obtencion de nuevos pregna-1,4-diene-3,20-dione-16-17-acetal-21 esteres.
EP0422596A3 (en)	1992-03-11	Tricyclic carbapenem compounds
CA2011587A1 (en)	1991-02-24	Nerve growth factor secretion inducing composition
CA2275166A1 (en)	1998-06-18	Novel benzopyran derivatives
AU660469B2 (en)	1995-06-29	Pharmacologically active hydrazine derivatives and processes for the preparation thereof
AU5455996A (en)	1996-12-12	New alkoxyaryl compounds, their processes of preparation and the pharmaceutical compositions which contain them
DK0462009T3 (da)	1999-07-05	Nye cephalosporiner, der i 3-stilling omfatter en propenylgruppe substitueret med en kvaternær ammoniumforbindelse, fremgan
HU9802757D0 (en)	1999-01-28	New naphthalene compounds, a process for their preparation and pharmaceutical compositions containing them
AU4872793A (en)	1994-04-14	New ellipticine compounds, a process for their preparation and pharmaceutical compositions containing them
EP0397511A3 (de)	1992-03-04	Cephalosporinverbindungen und Verfahren zu ihrer Herstellung
BR1100306A (pt)	2002-04-02	Compostos, composições farmacêuticas, uso de um composto e processo para preparação de compostos
EP0669336A4 (de)	1996-04-10	Neue cephem-derivate.
ATE135694T1 (de)	1996-04-15	Alkylthiopoly(ethylimidazolium)verbindungen, verfahren zur herstellung und deren verwendung als biozidemittel
HU9400094D0 (en)	1994-05-30	New 17,20-epoxy-pregnane derivatives process for producing them and use of them for producing cortizone derivatives and intermadeiates
DK0955286T3 (da)	2002-11-25	Dihydro- eller tetrahydronaphthalenderivater med (anti) østrogen virkning
BG100887A (en)	1998-01-30	Process for the preparation of 7-hydroxy taxanes
TW198031B (de)	1993-01-11
ES2128572T3 (es)	1999-05-16	Utilizacion de los derivados de cefem como agentes antimetastaticos.
CA2027542A1 (en)	1990-08-24	Uv-absorbing cyclic enaminoketones
DE69326767D1 (de)	1999-11-18	Verfahren und zwischenprodukte zur herstellung von bis-aza-bicyclischen anxiolytica
IE891895L (en)	1989-12-14	2-amino-7-hydroxytetraline ethers
ATE52501T1 (de)	1990-05-15	Cyclohexan-1,3-dionderivate, diese enthaltende zusammensetzungen, verfahren zu deren herstellung und deren verwendung als herbizide und pflanzenwachstumsregulatoren.
SE8401064D0 (sv)	1984-02-27	Neue isoxazole und verfahren zu ihrer herstellung