ZA96100B - Substituted oxazolidine calpain and/or cathepsin b inhibitors - Google Patents

Substituted oxazolidine calpain and/or cathepsin b inhibitors

Info

Publication number
ZA96100B
ZA96100B ZA96100A ZA96100A ZA96100B ZA 96100 B ZA96100 B ZA 96100B ZA 96100 A ZA96100 A ZA 96100A ZA 96100 A ZA96100 A ZA 96100A ZA 96100 B ZA96100 B ZA 96100B
Authority
ZA
South Africa
Prior art keywords
calpain
cathepsin
inhibitors
substituted oxazolidine
oxazolidine
Prior art date
Application number
ZA96100A
Other languages
English (en)
Inventor
Norton Paul Peet
Shujaath Mehdi
Matthew David Linnik
Michael Richard Angelastro
Hwa-Ok Kim
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of ZA96100B publication Critical patent/ZA96100B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA96100A 1995-01-11 1996-01-08 Substituted oxazolidine calpain and/or cathepsin b inhibitors ZA96100B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37119295A 1995-01-11 1995-01-11

Publications (1)

Publication Number Publication Date
ZA96100B true ZA96100B (en) 1996-07-24

Family

ID=23462894

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA96100A ZA96100B (en) 1995-01-11 1996-01-08 Substituted oxazolidine calpain and/or cathepsin b inhibitors

Country Status (23)

Country Link
US (1) US5691368A (fr)
EP (1) EP0802909B1 (fr)
JP (1) JP4157601B2 (fr)
KR (1) KR100393701B1 (fr)
CN (1) CN1088456C (fr)
AR (1) AR001787A1 (fr)
AT (1) ATE206413T1 (fr)
AU (1) AU692044B2 (fr)
CA (1) CA2210258C (fr)
DE (1) DE69523072T2 (fr)
DK (1) DK0802909T3 (fr)
ES (1) ES2165441T3 (fr)
FI (1) FI972935L (fr)
HU (1) HUT77649A (fr)
IL (1) IL116724A (fr)
MX (1) MX9705235A (fr)
NO (1) NO309267B1 (fr)
NZ (1) NZ298999A (fr)
PT (1) PT802909E (fr)
SI (1) SI0802909T1 (fr)
TW (1) TW454001B (fr)
WO (1) WO1996021655A2 (fr)
ZA (1) ZA96100B (fr)

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WO2000021550A2 (fr) * 1998-10-13 2000-04-20 President And Fellows Of Harvard College Methodes et compositions de traitement des maladies neurodegeneratives
US6458760B1 (en) * 1998-11-12 2002-10-01 Henry Ford Health System Method for treating tissue damaged from ischemia
CA2360740A1 (fr) * 1999-03-02 2000-09-08 Boehringer Ingelheim Pharmaceuticals, Inc. Composes utiles en tant qu'inhibiteurs reversibles de la cathepsine s
TW200404789A (en) * 1999-03-15 2004-04-01 Axys Pharm Inc Novel compounds and compositions as protease inhibitors
HK1039110A1 (zh) 1999-03-15 2002-04-12 Axys Pharmaceuticals, Inc. 以新颖的合成物及组分作为蛋白酶抑制剂
EP1516877A1 (fr) * 1999-03-15 2005-03-23 Axys Pharmaceuticals, Inc. Derivés d'amine comme inhibiteurs de protease
US6420364B1 (en) * 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
ES2259617T3 (es) 1999-11-05 2006-10-16 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Compuestos heterociclicos y su aplicacion como medicamentos.
FR2800737B1 (fr) * 1999-11-05 2006-06-30 Sod Conseils Rech Applic Nouveaux composes heterocycliques et leur application a titre de medicaments
WO2002010768A2 (fr) * 2000-07-31 2002-02-07 The Regents Of The University Of California Modele pour la maladie d'alzheimer et autres maladies neurodegenerative
WO2002051983A2 (fr) 2000-12-22 2002-07-04 Axys Pharmaceuticals, Inc. Composes et compositions en tant qu'inhibiteurs de cathepsine
US7030116B2 (en) 2000-12-22 2006-04-18 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
MXPA04002282A (es) 2001-09-14 2005-03-07 Axis Pharmaceutical Inc Nuevos compuestos y preparaciones como inhibidores de la catepsina.
EP1446392A1 (fr) 2001-11-14 2004-08-18 Aventis Pharmaceuticals, Inc. Nouveaux composes et compositions jouant le role d'inhibiteurs de cathepsine s
WO2004084830A2 (fr) * 2003-03-21 2004-10-07 Buck Institute Méthode de traitement de la maladie d'alzheimer
US7384970B2 (en) * 2003-03-24 2008-06-10 Irm Llc Inhibitors of cathepsin S
US7109243B2 (en) * 2003-03-24 2006-09-19 Irm Llc Inhibitors of cathepsin S
WO2004089395A2 (fr) * 2003-04-01 2004-10-21 Aventis Pharmaceuticals Inc. Utilisation d'un inhibiteur de la cathepsine-s ou -b afin de traiter ou de prevenir les maladies pulmonaires obstructives chroniques
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
US7173051B2 (en) * 2003-06-13 2007-02-06 Irm, Llc Inhibitors of cathepsin S
US7256207B2 (en) * 2003-08-20 2007-08-14 Irm Llc Inhibitors of cathepsin S
FR2863268B1 (fr) * 2003-12-09 2006-02-24 Sod Conseils Rech Applic Nouveaux derives du 2-hydroxytetrahydrofuranne et leur application a titre de medicaments
US8278345B2 (en) 2006-11-09 2012-10-02 Probiodrug Ag Inhibitors of glutaminyl cyclase
ATE554085T1 (de) 2006-11-30 2012-05-15 Probiodrug Ag Neue inhibitoren von glutaminylcyclase
JP5930573B2 (ja) 2007-03-01 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤の新規使用
WO2008128985A1 (fr) 2007-04-18 2008-10-30 Probiodrug Ag Dérivés de thio-urée utilisés comme inhibiteurs de la glutaminyl cyclase
EP2300000A1 (fr) * 2008-07-03 2011-03-30 University of Massachusetts Procédés et compositions pour réduire une inflammation et traiter des troubles inflammatoires
PL2475428T3 (pl) 2009-09-11 2015-12-31 Probiodrug Ag Pochodne heterocykliczne jako inhibitory cyklazy glutaminowej
ES2586231T3 (es) 2010-03-03 2016-10-13 Probiodrug Ag Inhibidores de glutaminil ciclasa
MX2012010470A (es) 2010-03-10 2012-10-09 Probiodrug Ag Inhibidores heterociclicos d ciclasa de glutaminilo (qc, ec .3 2. 5).
US8541596B2 (en) 2010-04-21 2013-09-24 Probiodrug Ag Inhibitors
EP2686313B1 (fr) 2011-03-16 2016-02-03 Probiodrug AG Dérivés de benzimidazole en tant qu'inhibiteurs de la glutaminyl cyclase
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej
WO2024018245A1 (fr) 2022-07-22 2024-01-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Utilisation d'inhibiteurs de calpaïne pour le traitement de la maladie rénale diabétique
WO2024153744A1 (fr) 2023-01-20 2024-07-25 Institut National de la Santé et de la Recherche Médicale Activateurs d'autophagie pour le traitement de la rhabdomyolyse
WO2025153685A1 (fr) * 2024-01-18 2025-07-24 Firmenich Sa Pro-parfums de 3-acyl-oxazolidin-5-one

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Also Published As

Publication number Publication date
WO1996021655A2 (fr) 1996-07-18
KR100393701B1 (ko) 2003-11-28
DE69523072T2 (de) 2002-06-20
JPH10512257A (ja) 1998-11-24
AR001787A1 (es) 1997-12-10
CA2210258A1 (fr) 1996-07-18
NO309267B1 (no) 2001-01-08
CA2210258C (fr) 2002-10-01
ATE206413T1 (de) 2001-10-15
NZ298999A (en) 1999-01-28
CN1088456C (zh) 2002-07-31
JP4157601B2 (ja) 2008-10-01
FI972935A0 (fi) 1997-07-10
ES2165441T3 (es) 2002-03-16
HUT77649A (hu) 1998-07-28
WO1996021655A3 (fr) 1996-09-06
CN1173174A (zh) 1998-02-11
EP0802909A2 (fr) 1997-10-29
NO973216L (no) 1997-09-09
IL116724A (en) 2000-08-31
PT802909E (pt) 2002-03-28
AU692044B2 (en) 1998-05-28
NO973216D0 (no) 1997-07-10
MX9705235A (es) 1997-10-31
SI0802909T1 (en) 2002-02-28
EP0802909B1 (fr) 2001-10-04
TW454001B (en) 2001-09-11
US5691368A (en) 1997-11-25
FI972935A7 (fi) 1997-07-10
AU4473196A (en) 1996-07-31
FI972935L (fi) 1997-07-10
DE69523072D1 (en) 2001-11-08
IL116724A0 (en) 1996-05-14
DK0802909T3 (da) 2002-01-28

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