ZA962009B - Esters and amides of di-substituted 1,4-piperidine. - Google Patents

Esters and amides of di-substituted 1,4-piperidine.

Info

Publication number
ZA962009B
ZA962009B ZA9602009A ZA962009A ZA962009B ZA 962009 B ZA962009 B ZA 962009B ZA 9602009 A ZA9602009 A ZA 9602009A ZA 962009 A ZA962009 A ZA 962009A ZA 962009 B ZA962009 B ZA 962009B
Authority
ZA
South Africa
Prior art keywords
piperidine
amides
esters
substituted
Prior art date
Application number
ZA9602009A
Other languages
English (en)
Inventor
Enzo Cereda
Maura Bignotti
Vincenzo Martino
Giovanni Battista Schiavi
Angelo Sagrada
Original Assignee
Boehringer Ingelheim Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Italia filed Critical Boehringer Ingelheim Italia
Publication of ZA962009B publication Critical patent/ZA962009B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA9602009A 1995-03-14 1996-03-13 Esters and amides of di-substituted 1,4-piperidine. ZA962009B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95MI000491A IT1275903B1 (it) 1995-03-14 1995-03-14 Esteri e ammidi della 1,4-piperidina disostituita

Publications (1)

Publication Number Publication Date
ZA962009B true ZA962009B (en) 1997-09-15

Family

ID=11370883

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9602009A ZA962009B (en) 1995-03-14 1996-03-13 Esters and amides of di-substituted 1,4-piperidine.

Country Status (27)

Country Link
US (1) US6002009A (cs)
EP (1) EP0815080B1 (cs)
JP (1) JP4021477B2 (cs)
KR (1) KR19980702972A (cs)
AR (1) AR002967A1 (cs)
AT (1) ATE269304T1 (cs)
AU (1) AU5101096A (cs)
BG (1) BG101711A (cs)
BR (1) BR9607347A (cs)
CA (1) CA2209904C (cs)
CO (1) CO4700521A1 (cs)
CZ (1) CZ285997A3 (cs)
DE (1) DE69632724T2 (cs)
EE (1) EE9700202A (cs)
ES (1) ES2224159T3 (cs)
HR (1) HRP960116A2 (cs)
IL (1) IL117446A0 (cs)
IT (1) IT1275903B1 (cs)
NO (1) NO974236D0 (cs)
NZ (1) NZ303941A (cs)
PE (1) PE7698A1 (cs)
PL (1) PL322211A1 (cs)
SK (1) SK121397A3 (cs)
TR (1) TR199700948T1 (cs)
WO (1) WO1996028424A1 (cs)
YU (1) YU14196A (cs)
ZA (1) ZA962009B (cs)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT832065E (pt) * 1995-06-06 2002-02-28 Pfizer N-(indole-2-carbonil)-glicinamidas e seus derivados como agentes antidiabeticos
AU7001796A (en) * 1995-09-22 1997-04-09 Yoshitomi Pharmaceutical Industries, Ltd. Benzoic acid compounds and medicinal use thereof
TW445263B (en) 1996-02-29 2001-07-11 Janssen Pharmaceutica Nv Novel esters of 1,4-disubstituted piperidine derivatives
IL125658A0 (en) 1997-08-18 1999-04-11 Hoffmann La Roche Ccr-3 receptor antagonists
US6339087B1 (en) 1997-08-18 2002-01-15 Syntex (U.S.A.) Llc Cyclic amine derivatives-CCR-3 receptor antagonists
TW570920B (en) 1998-12-22 2004-01-11 Janssen Pharmaceutica Nv 4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders
GB0211230D0 (en) * 2002-05-16 2002-06-26 Medinnova Sf Treatment of heart failure
PL1664036T3 (pl) * 2003-09-03 2012-04-30 Pfizer Związki benzimidazolonu wykazujące działanie agonistyczne względem receptora 5-ht4
TW200533348A (en) * 2004-02-18 2005-10-16 Theravance Inc Indazole-carboxamide compounds as 5-ht4 receptor agonists
US7728006B2 (en) * 2004-04-07 2010-06-01 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
US8309575B2 (en) 2004-04-07 2012-11-13 Theravance, Inc. Quinolinone-carboxamide compounds as 5-HT4 receptor agonists
US7737163B2 (en) * 2004-06-15 2010-06-15 Pfizer Inc. Benzimidazolone carboxylic acid derivatives
EA200801607A1 (ru) * 2004-06-15 2008-10-30 Пфайзер Инк. Производные бензимидазолонкарбоновой кислоты
AP2418A (en) * 2004-06-15 2012-06-04 Pfizer Benzimidazolone carboxylic acid derivatives.
JP2008509088A (ja) * 2004-09-02 2008-03-27 ファイザー株式会社 ベンズイミダゾロンカルボン酸誘導体
DE602005016446D1 (de) * 2004-11-05 2009-10-15 Theravance Inc 5-HT4-Rezeptoragonistenverbindungen
DE602005014566D1 (de) * 2004-11-05 2009-07-02 Theravance Inc Chinolinon-carboxamid-verbindungen
ATE469897T1 (de) * 2004-12-22 2010-06-15 Theravance Inc Indazolcarbonsäureamidverbindungen
AU2006217534B8 (en) * 2005-02-22 2011-12-08 Pfizer Inc. Oxyindole derivatives as 5HT4 receptor agonists
BRPI0608392A2 (pt) * 2005-03-02 2009-12-29 Theravance Inc compostos de quinolinona como agonistas do receptor 5-ht4
US7317022B2 (en) * 2005-06-07 2008-01-08 Theravance, Inc. Benzoimidazolone-carboxamide compounds as 5-HT4 receptors agonists
MY143574A (en) * 2005-11-22 2011-05-31 Theravance Inc Carbamate compounds as 5-ht4 receptor agonists
US8642772B2 (en) * 2008-10-14 2014-02-04 Sk Biopharmaceuticals Co., Ltd. Piperidine compounds, pharmaceutical composition comprising the same and its use
US8232315B2 (en) * 2009-06-26 2012-07-31 Sk Biopharmaceuticals Co., Ltd. Methods for treating drug addiction and improving addiction-related behavior
ES2447295T3 (es) 2009-11-06 2014-03-11 Sk Biopharmaceuticals Co., Ltd. Métodos para el tratamiento del trastorno de déficit de atención/hiperactividad
EP2496227B1 (en) 2009-11-06 2019-05-22 SK Biopharmaceuticals Co., Ltd. Methods for treating fibromyalgia syndrome
NZ604423A (en) 2010-06-24 2015-01-30 Alkermes Pharma Ireland Ltd Prodrugs of nh-acidic compounds: ester, carbonate, carbamate and phosphonate derivatives
US9610274B2 (en) 2010-06-30 2017-04-04 Sk Biopharmaceuticals Co., Ltd. Methods for treating bipolar disorder
US8623913B2 (en) 2010-06-30 2014-01-07 Sk Biopharmaceuticals Co., Ltd. Methods for treating restless legs syndrome

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9103862D0 (en) * 1991-02-25 1991-04-10 Glaxo Group Ltd Chemical compounds
GB9204565D0 (en) * 1992-03-03 1992-04-15 Smithkline Beecham Plc Pharmaceuticals
WO1994008965A1 (en) * 1992-10-16 1994-04-28 Smithkline Beecham Plc N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-ht4 receptor antagonists
KR970702247A (ko) * 1994-03-30 1997-05-13 고야 마사시 벤조산 화합물 및 이들의 약제로서의 용도(benzoic acid compound and use thereof as medicine)

Also Published As

Publication number Publication date
EE9700202A (et) 1998-02-16
ITMI950491A0 (it) 1995-03-14
IL117446A0 (en) 1996-07-23
TR199700948T1 (xx) 1998-03-21
NO974236L (no) 1997-09-12
PL322211A1 (en) 1998-01-19
CA2209904C (en) 2007-11-13
AU5101096A (en) 1996-10-02
JPH11501640A (ja) 1999-02-09
CZ285997A3 (cs) 1998-02-18
ATE269304T1 (de) 2004-07-15
HRP960116A2 (en) 1997-10-31
US6002009A (en) 1999-12-14
KR19980702972A (ko) 1998-09-05
JP4021477B2 (ja) 2007-12-12
EP0815080B1 (en) 2004-06-16
NO974236D0 (no) 1997-09-12
NZ303941A (en) 1998-11-25
ES2224159T3 (es) 2005-03-01
MX9706826A (es) 1997-11-29
PE7698A1 (es) 1998-03-11
YU14196A (sh) 1999-03-04
DE69632724T2 (de) 2005-07-07
WO1996028424A1 (en) 1996-09-19
CA2209904A1 (en) 1996-09-19
IT1275903B1 (it) 1997-10-24
BR9607347A (pt) 1997-12-30
ITMI950491A1 (it) 1996-09-14
AR002967A1 (es) 1998-05-27
DE69632724D1 (de) 2004-07-22
EP0815080A1 (en) 1998-01-07
SK121397A3 (en) 1998-02-04
BG101711A (en) 1998-02-27
CO4700521A1 (es) 1998-12-29

Similar Documents

Publication Publication Date Title
IL117446A0 (en) Esters and amides of disubstituted 1,4-piperidine
GR3031759T3 (en) Toothbrush and the process for its manufacture
HUP9801633A3 (en) Heterotelechelic block copolymers and process for producing the same
HUP9801697A3 (en) Modified mp52-protein and process for producing thereof
GB2303127B (en) Sulfide-oxidizing bacteria and process therewith
GR3029933T3 (en) Process for producing n-arylhydroxylamines and n-hetarylhydroxylamines
GB9509424D0 (en) "An improved product"
EP0709420A3 (en) Block copolymers of polyesters and polycarbonates and process for their preparation
KR970000398B1 (en) Process for the preparation of 1,1,1,2-tetrafluoro-2-chloroethan and pentafluorethane
EP0714890A3 (de) Verfahren zur Herstellung von 4-Amino-2,2,6,6-tetramethyl-piperidin
ZA966757B (en) Novel compounds and process.
IL114305A0 (en) 2,4,6-triiodo-5-substituted-amino-isophthalate esters and their use
GB9501017D0 (en) Microencapsulation process and product
GB2307192B (en) Pipe-coating method and product
GB9522558D0 (en) Novel product and process
HUP9802570A3 (en) Process for producing dolastatin 15 and intermediates thereof
HU9403239D0 (en) Selfsticking tearing stkipe and process for making thereof
ZA987326B (en) Process for the preparation of heteroarylcarboxylic amides and esters.
HUP9603080A2 (en) Novel carboxylic ester derivatives, process for producing the same, and insecticide or insectifuge containing the same
HUP9601636A3 (en) N-substituted cis-n-propenyl-acetamides and process for producing thereof
EP0830336A4 (en) PROCESS FOR THE PREPARATION OF TERTIARY AMINOCARBONATES AND AMINOETHERS
PL324340A1 (en) Novel quinoxalinophosphonic and quinoxalinoalkanophosphonic acids
EP0862626A4 (en) PILOSULIN 2
GB9525652D0 (en) Improved electrosurgical instrument and method for the production thereof
EP0731172A3 (en) Process for the preparation of galactosyltrehalose and food containing it