ZA964665B - Method of producing l-lysine - Google Patents

Method of producing l-lysine

Info

Publication number
ZA964665B
ZA964665B ZA964665A ZA964665A ZA964665B ZA 964665 B ZA964665 B ZA 964665B ZA 964665 A ZA964665 A ZA 964665A ZA 964665 A ZA964665 A ZA 964665A ZA 964665 B ZA964665 B ZA 964665B
Authority
ZA
South Africa
Prior art keywords
lysine
producing
Prior art date
Application number
ZA964665A
Other languages
English (en)
Inventor
Seiko Otsuna
Masakazu Sugimoto
Masako Izui
Atsushi Hayakawa
Eiichi Nakano
Masaki Kobayashi
Yasuhiko Yoshihara
Tsuyoshi Nakamatsu
Original Assignee
Ajinomoto Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Kk filed Critical Ajinomoto Kk
Publication of ZA964665B publication Critical patent/ZA964665B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0014—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4)
    • C12N9/0016—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on the CH-NH2 group of donors (1.4) with NAD or NADP as acceptor (1.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1217—Phosphotransferases with a carboxyl group as acceptor (2.7.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ZA964665A 1995-06-07 1996-06-05 Method of producing l-lysine ZA964665B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP14061495 1995-06-07

Publications (1)

Publication Number Publication Date
ZA964665B true ZA964665B (en) 1997-01-07

Family

ID=15272810

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA964665A ZA964665B (en) 1995-06-07 1996-06-05 Method of producing l-lysine

Country Status (17)

Country Link
US (3) US20020086370A1 (de)
EP (1) EP0841395B1 (de)
JP (1) JP3106501B2 (de)
KR (1) KR100268324B1 (de)
CN (1) CN1165619C (de)
AU (1) AU705550B2 (de)
BR (1) BR9606379A (de)
CA (1) CA2224058C (de)
CZ (1) CZ293268B6 (de)
DK (1) DK0841395T3 (de)
ES (1) ES2373863T3 (de)
HU (1) HU222503B1 (de)
MX (1) MX9709923A (de)
RU (1) RU2197528C2 (de)
SK (1) SK285013B6 (de)
WO (1) WO1996040934A1 (de)
ZA (1) ZA964665B (de)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0841395T3 (da) 1995-06-07 2012-01-09 Ajinomoto Kk Fremgangsmåde til at fremstille L-lysin
JP4035855B2 (ja) † 1996-06-05 2008-01-23 味の素株式会社 Ｌ−リジンの製造法
SK285201B6 (sk) * 1996-12-05 2006-08-03 Ajinomoto Co., Inc. Rekombinantná DNA, autonómne reprodukovaná v bunkách koryneformnej baktérie, koryneformná baktéria a spôsob výroby L-lyzínu, vektor pVK7
JP4075087B2 (ja) * 1996-12-05 2008-04-16 味の素株式会社 Ｌ−リジンの製造法
AU1619699A (en) 1997-12-05 1999-06-28 Human Genome Sciences, Inc. Synferon, a synthetic type i interferon
DE19931317A1 (de) * 1999-07-07 2001-01-11 Degussa L-Lysin produzierende coryneforme Bakterien und Verfahren zur Herstellung von L-Lysin
JP3965821B2 (ja) * 1999-03-09 2007-08-29 味の素株式会社 Ｌ−リジンの製造法
WO2000056859A1 (en) * 1999-03-19 2000-09-28 Ajinomoto Co., Inc. Process for producing l-amino acid
JP2003135066A (ja) * 1999-03-19 2003-05-13 Ajinomoto Co Inc Ｌ−リジンの製造法
DE19912384A1 (de) * 1999-03-19 2000-09-21 Degussa Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung coryneformer Bakterien
JP2003180348A (ja) * 1999-07-02 2003-07-02 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2003180355A (ja) * 1999-07-02 2003-07-02 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2003144161A (ja) * 1999-07-02 2003-05-20 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2003144160A (ja) * 1999-07-02 2003-05-20 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2003169674A (ja) * 1999-07-02 2003-06-17 Ajinomoto Co Inc Ｌ−リジンの製造法
DE19931314A1 (de) * 1999-07-07 2001-01-11 Degussa L-Lysin produzierende coryneforme Bakterien und Verfahren zur Herstellung von Lysin
JP2001046067A (ja) 1999-08-04 2001-02-20 Ajinomoto Co Inc 好熱性バチルス属細菌由来のｌ−リジン生合成系遺伝子
PL341895A1 (en) * 1999-08-12 2001-02-26 Ajinomoto Kk Plasmide autonomously replicable in corynebacter bacteria
US6927046B1 (en) 1999-12-30 2005-08-09 Archer-Daniels-Midland Company Increased lysine production by gene amplification using coryneform bacteria
AR032570A1 (es) 2001-02-08 2003-11-12 Archer Daniels Midland Co Construcciones de polinucleotidicas para aumentar la produccion de lisina
KR100943834B1 (ko) * 2001-08-06 2010-02-24 에보니크 데구사 게엠베하 Ｌ-리신을 생산하는 코리네형 세균 및 코리네형 세균을 사용하여 l-리신을 생산하는 방법
EP1424397B1 (de) 2002-11-26 2011-01-19 Ajinomoto Co., Inc. Methode für die Produktion von L-Glutamin und L-Glutamin-produzierendes Bakterium
JP4655539B2 (ja) * 2004-08-06 2011-03-23 味の素株式会社 アシラーゼを用いたβアミノ酸の製造方法
RU2350655C2 (ru) 2004-10-07 2009-03-27 Адзиномото Ко., Инк. Способ получения основного вещества
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BRPI0709628A2 (pt) * 2006-03-30 2011-07-19 Basf Se processo para produção de cadaverina, e de uma poliamida, e, microrganismo recombinante
JP2010041920A (ja) 2006-12-19 2010-02-25 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2010088301A (ja) 2007-02-01 2010-04-22 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2011067095A (ja) 2008-01-10 2011-04-07 Ajinomoto Co Inc 発酵法による目的物質の製造法
JP5526785B2 (ja) 2008-01-23 2014-06-18 味の素株式会社 Ｌ−アミノ酸の製造法
WO2009098046A1 (en) * 2008-02-04 2009-08-13 Basf Se Method for the production of dipicolinate
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JP2012029565A (ja) 2008-11-27 2012-02-16 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
JP2010142200A (ja) 2008-12-22 2010-07-01 Ajinomoto Co Inc Ｌ−リジンの製造法
JPWO2011013707A1 (ja) 2009-07-29 2013-01-10 味の素株式会社 Ｌ−アミノ酸の製造法
JP2012196144A (ja) 2009-08-03 2012-10-18 Ajinomoto Co Inc ビブリオ属細菌を用いたｌ−リジンの製造法
JP2012223091A (ja) 2009-08-25 2012-11-15 Ajinomoto Co Inc Ｌ−アミノ酸の製造法
KR101226384B1 (ko) * 2010-03-05 2013-01-25 씨제이제일제당 (주) 개량된 프로모터 및 이를 이용한 ｌ-라이신의 생산 방법
EP2374873A1 (de) * 2010-04-08 2011-10-12 Technische Universität Hamburg-Harburg Modifizierte Aspartatkinase aus dem Corynebacterium und ihre Verwendung bei der Aminosäureherstellung
RU2011134436A (ru) 2011-08-18 2013-10-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") Способ получения l-аминокислоты с использованием бактерии семейства enterobacteriaceae, обладающей повышенной экспрессией генов каскада образования флагелл и клеточной подвижности
MY171302A (en) * 2011-12-21 2019-10-08 Cj Cheiljedang Corp Method for producing l-lysine using microorganisms having ability to produce l-lysine
CN103667165B (zh) * 2012-09-12 2017-05-31 中国科学院上海生命科学研究院 高产l‑赖氨酸的生产菌株及其应用
JP2016192903A (ja) 2013-09-17 2016-11-17 味の素株式会社 海藻由来バイオマスからのｌ−アミノ酸の製造方法
CN106459857B (zh) 2013-10-02 2019-04-19 味之素株式会社 氨控制装置及氨控制方法
KR101518860B1 (ko) * 2013-10-11 2015-05-12 씨제이제일제당 (주) L-아미노산의 생산 방법
CN105821090B (zh) * 2015-01-08 2019-12-13 中国科学院天津工业生物技术研究所 嗜热共生杆菌meso-二氨基庚二酸脱氢酶突变体应用
EP3415622A1 (de) 2017-06-14 2018-12-19 Evonik Degussa GmbH Verfahren zur herstellung von feinchemikalien mittels eines corynebakteriums, welches modifizierte alpha-1,6-glucosidasen sezerniert
EP3456833A1 (de) 2017-09-18 2019-03-20 Evonik Degussa GmbH Methode zur fermentativen production von l-aminosäuren
EP3467099A1 (de) 2017-10-05 2019-04-10 Evonik Degussa GmbH Verfahren zur fermentativen herstellung von l-aminosäuren
EP3498853A1 (de) 2017-12-14 2019-06-19 Evonik Degussa GmbH Verfahren zur fermentativen herstellung von l-lysin
EP3594355A1 (de) 2018-07-12 2020-01-15 Evonik Operations GmbH Verfahren zur fermentativen herstellung von l-lysin
EP3599282B1 (de) 2018-07-24 2021-03-17 Evonik Operations GmbH Verfahren zur fermentativen herstellung von l-lysin
RU2019128538A (ru) 2018-09-26 2021-03-11 Эвоник Оперейшенс ГмбХ Способ ферментативного получения l-лизина
EP3660158A1 (de) 2018-11-29 2020-06-03 Evonik Operations GmbH Verfahren zur fermentativen herstellung von l-lysin
EP3670525A1 (de) 2018-12-18 2020-06-24 Evonik Operations GmbH Verfahren zur fermentativen herstellung von l-lysin unter verwendung von c.-glutamicum-stämmen mit einem mutierten kup-transporter
US10829746B2 (en) 2019-01-23 2020-11-10 Evonik Operations Gmbh Method for the fermentative production of L-lysine
US12258600B2 (en) 2021-09-20 2025-03-25 Evonik Operations Gmbh Method for the fermentative production of L-lysine using C. glutamicum strains expressing modified gluconate repressor proteins GntR1 and GntR2
CN116286807A (zh) * 2021-12-14 2023-06-23 廊坊梅花生物技术开发有限公司 突变的dapA启动子及其应用
US20250340893A1 (en) 2022-05-18 2025-11-06 Evonik Operations Gmbh Biotechnological production of desferrioxamines and analogs thereof
CN119212691A (zh) 2022-05-18 2024-12-27 赢创运营有限公司 比苏卡林、去铁胺及其类似物的生物技术生产
CN119212692A (zh) 2022-05-18 2024-12-27 赢创运营有限公司 比苏卡林、去铁胺及其类似物的单体的生物技术生产
EP4613854A1 (de) 2024-03-05 2025-09-10 Evonik Operations GmbH Verfahren zur fermentativen herstellung von l-lysin unter verwendung von c. glutamicum-stämmen die eine heterologe nicotinamid-nukleotid-transhydrogenase pntab exprimieren und eine erhöhte aktivität einer myo-inositol-permease aufweisen

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EP1882740B1 (de) 2006-07-26 2010-04-14 Ajinomoto Co., Inc. N-Acetyl-(R,S)-B-Aminosäuren-Acylase-Gene

Also Published As

Publication number Publication date
RU2197528C2 (ru) 2003-01-27
CZ293268B6 (cs) 2004-03-17
CA2224058A1 (en) 1996-12-19
WO1996040934A1 (en) 1996-12-19
SK285013B6 (sk) 2006-04-06
AU5910796A (en) 1996-12-30
US20110065153A1 (en) 2011-03-17
CZ390397A3 (cs) 1998-06-17
HUP9802666A3 (en) 2001-08-28
HU222503B1 (hu) 2003-07-28
KR19990022521A (ko) 1999-03-25
EP0841395A4 (de) 2005-07-27
US20030054506A1 (en) 2003-03-20
CN1165619C (zh) 2004-09-08
BR9606379A (pt) 1997-08-12
EP0841395A1 (de) 1998-05-13
KR100268324B1 (ko) 2000-10-16
CA2224058C (en) 2011-09-13
US7846698B2 (en) 2010-12-07
US8183017B2 (en) 2012-05-22
HUP9802666A2 (hu) 1999-02-01
CN1192242A (zh) 1998-09-02
SK164097A3 (en) 1998-07-08
MX9709923A (es) 1998-03-31
DK0841395T3 (da) 2012-01-09
US20020086370A1 (en) 2002-07-04
ES2373863T3 (es) 2012-02-09
EP0841395B1 (de) 2011-11-02
JP3106501B2 (ja) 2000-11-06
AU705550B2 (en) 1999-05-27

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