ZA974576B - Pharmaceutical composition. - Google Patents
Pharmaceutical composition.Info
- Publication number
- ZA974576B ZA974576B ZA9704576A ZA974576A ZA974576B ZA 974576 B ZA974576 B ZA 974576B ZA 9704576 A ZA9704576 A ZA 9704576A ZA 974576 A ZA974576 A ZA 974576A ZA 974576 B ZA974576 B ZA 974576B
- Authority
- ZA
- South Africa
- Prior art keywords
- compounds
- mesembrine
- disclosed
- pharmaceutical composition
- mesembranol
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- DAHIQPJTGIHDGO-IRXDYDNUSA-N Mesembrine Chemical compound C1=C(OC)C(OC)=CC=C1[C@@]1(CCC(=O)C2)[C@H]2N(C)CC1 DAHIQPJTGIHDGO-IRXDYDNUSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- KPMLOZVRLWHOBN-UHFFFAOYSA-N 3a-(3,4-dimethoxyphenyl)-1-methyl-3,4,5,6,7,7a-hexahydro-2h-indol-6-ol Chemical compound C1=C(OC)C(OC)=CC=C1C1(CCC(O)C2)C2N(C)CC1 KPMLOZVRLWHOBN-UHFFFAOYSA-N 0.000 abstract 2
- 208000020016 psychiatric disease Diseases 0.000 abstract 2
- 241000219479 Aizoaceae Species 0.000 abstract 1
- 208000007848 Alcoholism Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010006550 Bulimia nervosa Diseases 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 241000196324 Embryophyta Species 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 241001601435 Mesembryanthemum sect. Planifolia Species 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- 201000007930 alcohol dependence Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 206010013663 drug dependence Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- DAHIQPJTGIHDGO-UHFFFAOYSA-N mesembrine Natural products C1=C(OC)C(OC)=CC=C1C1(CCC(=O)C2)C2N(C)CC1 DAHIQPJTGIHDGO-UHFFFAOYSA-N 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Anesthesiology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ZA9704576A ZA974576B (en) | 1996-06-04 | 1997-05-26 | Pharmaceutical composition. |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ZA964595 | 1996-06-04 | ||
| ZA9704576A ZA974576B (en) | 1996-06-04 | 1997-05-26 | Pharmaceutical composition. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA974576B true ZA974576B (en) | 1998-02-04 |
Family
ID=25585724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA9704576A ZA974576B (en) | 1996-06-04 | 1997-05-26 | Pharmaceutical composition. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6288104B1 (de) |
| EP (1) | EP0910372B1 (de) |
| JP (2) | JP4315469B2 (de) |
| CN (1) | CN1227487A (de) |
| AT (1) | ATE248593T1 (de) |
| AU (1) | AU716611B2 (de) |
| DE (1) | DE69724618T2 (de) |
| WO (1) | WO1997046234A1 (de) |
| ZA (1) | ZA974576B (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7643874B2 (en) | 2001-10-24 | 2010-01-05 | Power Paper Ltd. | Dermal patch |
| CN1607970B (zh) | 2001-10-24 | 2010-11-10 | 纸型电池有限公司 | 皮肤贴片 |
| CN1606461B (zh) * | 2001-10-24 | 2011-03-23 | 纸型电池有限公司 | 一种用制剂作皮肤治疗的装置、一种成套器具及皮肤贴片 |
| US7785324B2 (en) | 2005-02-25 | 2010-08-31 | Endoscopic Technologies, Inc. (Estech) | Clamp based lesion formation apparatus and methods configured to protect non-target tissue |
| WO2005051380A1 (en) * | 2003-11-26 | 2005-06-09 | Biovitrum Ab | Substituted urea-octahydroindols as antagonists of melanin concentrating hormone receptor 1 (mch1r) |
| WO2005051381A1 (en) * | 2003-11-26 | 2005-06-09 | Biovitrum Ab | Substituted urea-octatydroindols as antagonists of melanin concentrating hormone receptor 1 (MCH1R) |
| US20060216331A1 (en) | 2005-02-28 | 2006-09-28 | Lines Thomas C | Composition for treating mental health disorders |
| WO2006114402A1 (en) * | 2005-04-25 | 2006-11-02 | Biovitrum Ab (Publ) | Substituted octahydroisoindoles as antagonists of melanin concentrating hormone receptor 1 (mch1r) |
| PL2408446T3 (pl) * | 2009-03-20 | 2020-03-31 | Hg&H Pharmaceuticals (Pty) Limited | Zastosowanie kompozycji farmaceutycznych zawierających mesembrenon |
| EP2408460B1 (de) | 2009-03-20 | 2018-09-26 | HG&H Pharmaceuticals (Pty) Limited | Sceletium extrakt und verwendungen davon |
| EP2417129B1 (de) | 2010-01-29 | 2016-03-23 | Council of Scientific & Industrial Research | Triazin-aryl-bis-indole als pde-4 hemmer verwendbar für die behandlung von asthma |
| US9752932B2 (en) | 2010-03-10 | 2017-09-05 | Drexel University | Tunable electro-optic filter stack |
| US9576694B2 (en) | 2010-09-17 | 2017-02-21 | Drexel University | Applications for alliform carbon |
| US20160038551A1 (en) | 2013-03-28 | 2016-02-11 | Botanical Resource Holdings Proprietary Limited | Stabilized mesembrine compositions |
| WO2015130994A1 (en) | 2014-02-28 | 2015-09-03 | Tripp Matthew L | Phosphodiesterase-4 inhibiting phytochemical compositions |
| WO2016157045A1 (en) * | 2015-03-27 | 2016-10-06 | Botanical Resource Holdings (Proprietary) Limited | Cancer treatment composition |
| US20220031660A1 (en) * | 2015-03-27 | 2022-02-03 | Botanical Resource Holdings (Proprietary) Limited | Cancer treatment composition |
| CN106866496B (zh) * | 2017-04-21 | 2019-10-15 | 中国科学院上海有机化学研究所 | 六氢苯并喹啉-6-酮和六氢苯并吲哚-5-酮化合物、合成方法及用途 |
| AU2018307730B9 (en) | 2017-07-26 | 2024-02-15 | Hg&H Pharmaceuticals (Pty) Ltd | Mesembrenol and/or mesembranol for prophylaxis and treatment of patients suffering from epilepsy and associated diseases |
| CA3202844A1 (en) | 2020-12-21 | 2022-06-30 | Ryan PROTZKO | Methods for delay of ejaculation in human males |
| CN113072576B (zh) * | 2021-04-07 | 2022-04-26 | 四川大学 | 一类手性硅代松叶菊碱、合成方法及用途 |
| WO2023004428A1 (en) * | 2021-07-22 | 2023-01-26 | Kanna Health Ltd. | Novel compounds and uses thereof |
| CA3233930A1 (en) * | 2021-10-19 | 2023-04-27 | Justin KIRKLAND | Mesembrine derivatives |
| US20250073206A1 (en) * | 2021-10-29 | 2025-03-06 | Sensorium Therapeutics, Inc. | Solid forms of mesembrine and therapeutic uses thereof |
| US20250051277A1 (en) | 2021-10-29 | 2025-02-13 | Sensorium Therapeutics, Inc. | Delivery of therapeutic alkaloid compounds |
| EP4486339A1 (de) * | 2022-03-02 | 2025-01-08 | Kanna Health Ltd. | Verbindungen zur verwendung bei der behandlung von stimmungsstörungen |
| GB2616343A (en) * | 2022-03-02 | 2023-09-06 | Kanna Health Ltd | Compounds for the use in the treatment of mood disorders |
| GB2619907A (en) | 2022-04-01 | 2023-12-27 | Kanna Health Ltd | Novel crystalline salt forms of mesembrine |
| US12410128B1 (en) | 2022-04-15 | 2025-09-09 | Sensorium Therapeutics, Inc. | Therapeutic alkaloid compounds |
| WO2023225773A1 (en) * | 2022-05-23 | 2023-11-30 | Sensorium Therapeutics, Inc. | Solid forms of mesembrine and therapeutic uses thereof |
| WO2024015559A2 (en) * | 2022-07-15 | 2024-01-18 | Sensorium Therapeutics, Inc. | Solid forms of mesembrine and therapeutic uses thereof |
| GB2623122A (en) * | 2022-10-07 | 2024-04-10 | Kanna Health Ltd | Preparation of mesembrine |
| WO2024102461A1 (en) * | 2022-11-11 | 2024-05-16 | Sensorium Therapeutics, Inc. | Alkyl-substituted derivatives of mesembrine and mesembrenone and therapeutic uses thereof |
| WO2024102991A1 (en) * | 2022-11-11 | 2024-05-16 | Sensorium Therapeutics, Inc. | Therapeutic alkaloid compounds |
| JP2025541878A (ja) * | 2022-12-22 | 2025-12-23 | センソリアム セラピューティクス インコーポレイテッド | 治療用アルカロイド化合物の送達 |
| WO2024173800A2 (en) * | 2023-02-17 | 2024-08-22 | Sensorium Therapeutics, Inc. | Solid forms of mesembranol and therapeutic uses thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3604112A1 (de) | 1986-02-10 | 1987-08-13 | Bernhard Dr Janiak | Pflanzenextrakte von mesembryanthemaceen sowie solche enthaltende schaedlingsbekaempfungsmittel und arzneimittel |
-
1997
- 1997-05-26 ZA ZA9704576A patent/ZA974576B/xx unknown
- 1997-06-03 CN CN97197056A patent/CN1227487A/zh active Pending
- 1997-06-03 JP JP50031498A patent/JP4315469B2/ja not_active Expired - Fee Related
- 1997-06-03 DE DE69724618T patent/DE69724618T2/de not_active Expired - Lifetime
- 1997-06-03 WO PCT/GB1997/001493 patent/WO1997046234A1/en not_active Ceased
- 1997-06-03 US US09/194,836 patent/US6288104B1/en not_active Expired - Lifetime
- 1997-06-03 AT AT97924158T patent/ATE248593T1/de not_active IP Right Cessation
- 1997-06-03 EP EP97924158A patent/EP0910372B1/de not_active Expired - Lifetime
- 1997-06-03 AU AU29722/97A patent/AU716611B2/en not_active Expired
-
2008
- 2008-10-22 JP JP2008272215A patent/JP2009062387A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU716611B2 (en) | 2000-03-02 |
| CN1227487A (zh) | 1999-09-01 |
| WO1997046234A1 (en) | 1997-12-11 |
| JP2000511896A (ja) | 2000-09-12 |
| EP0910372B1 (de) | 2003-09-03 |
| US6288104B1 (en) | 2001-09-11 |
| JP4315469B2 (ja) | 2009-08-19 |
| DE69724618T2 (de) | 2005-04-21 |
| DE69724618D1 (de) | 2003-10-09 |
| EP0910372A1 (de) | 1999-04-28 |
| AU2972297A (en) | 1998-01-05 |
| JP2009062387A (ja) | 2009-03-26 |
| ATE248593T1 (de) | 2003-09-15 |
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