ATE248593T1 - Mesembrin und verwandte verbindungen enthaltende pharmazeutische zusammensetzungen - Google Patents
Mesembrin und verwandte verbindungen enthaltende pharmazeutische zusammensetzungenInfo
- Publication number
- ATE248593T1 ATE248593T1 AT97924158T AT97924158T ATE248593T1 AT E248593 T1 ATE248593 T1 AT E248593T1 AT 97924158 T AT97924158 T AT 97924158T AT 97924158 T AT97924158 T AT 97924158T AT E248593 T1 ATE248593 T1 AT E248593T1
- Authority
- AT
- Austria
- Prior art keywords
- mesembrine
- pharmaceutical compositions
- related compounds
- compounds
- compositions containing
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- DAHIQPJTGIHDGO-UHFFFAOYSA-N mesembrine Natural products C1=C(OC)C(OC)=CC=C1C1(CCC(=O)C2)C2N(C)CC1 DAHIQPJTGIHDGO-UHFFFAOYSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- DAHIQPJTGIHDGO-IAGOWNOFSA-N mesembrine Chemical compound C1=C(OC)C(OC)=CC=C1[C@]1(CCC(=O)C2)[C@@H]2N(C)CC1 DAHIQPJTGIHDGO-IAGOWNOFSA-N 0.000 title 1
- DAHIQPJTGIHDGO-IRXDYDNUSA-N Mesembrine Chemical compound C1=C(OC)C(OC)=CC=C1[C@@]1(CCC(=O)C2)[C@H]2N(C)CC1 DAHIQPJTGIHDGO-IRXDYDNUSA-N 0.000 abstract 3
- KPMLOZVRLWHOBN-UHFFFAOYSA-N 3a-(3,4-dimethoxyphenyl)-1-methyl-3,4,5,6,7,7a-hexahydro-2h-indol-6-ol Chemical compound C1=C(OC)C(OC)=CC=C1C1(CCC(O)C2)C2N(C)CC1 KPMLOZVRLWHOBN-UHFFFAOYSA-N 0.000 abstract 2
- 208000020016 psychiatric disease Diseases 0.000 abstract 2
- 241000219479 Aizoaceae Species 0.000 abstract 1
- 208000007848 Alcoholism Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010006550 Bulimia nervosa Diseases 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 241000196324 Embryophyta Species 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 241001601435 Mesembryanthemum sect. Planifolia Species 0.000 abstract 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 abstract 1
- 201000007930 alcohol dependence Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 206010013663 drug dependence Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Child & Adolescent Psychology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ZA964595 | 1996-06-04 | ||
| PCT/GB1997/001493 WO1997046234A1 (en) | 1996-06-04 | 1997-06-03 | Pharmaceutical compositions containing mesembrine and related compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE248593T1 true ATE248593T1 (de) | 2003-09-15 |
Family
ID=25585724
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT97924158T ATE248593T1 (de) | 1996-06-04 | 1997-06-03 | Mesembrin und verwandte verbindungen enthaltende pharmazeutische zusammensetzungen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6288104B1 (de) |
| EP (1) | EP0910372B1 (de) |
| JP (2) | JP4315469B2 (de) |
| CN (1) | CN1227487A (de) |
| AT (1) | ATE248593T1 (de) |
| AU (1) | AU716611B2 (de) |
| DE (1) | DE69724618T2 (de) |
| WO (1) | WO1997046234A1 (de) |
| ZA (1) | ZA974576B (de) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7643874B2 (en) | 2001-10-24 | 2010-01-05 | Power Paper Ltd. | Dermal patch |
| JP4394444B2 (ja) | 2001-10-24 | 2010-01-06 | パワー ペーパー リミティド | 活性物質の制御された皮膚内デリバリーのためのデバイス及び方法 |
| AU2002347567B2 (en) | 2001-10-24 | 2008-07-17 | Power Paper Ltd. | Dermal patch |
| US7785324B2 (en) | 2005-02-25 | 2010-08-31 | Endoscopic Technologies, Inc. (Estech) | Clamp based lesion formation apparatus and methods configured to protect non-target tissue |
| WO2005051381A1 (en) * | 2003-11-26 | 2005-06-09 | Biovitrum Ab | Substituted urea-octatydroindols as antagonists of melanin concentrating hormone receptor 1 (MCH1R) |
| WO2005051380A1 (en) * | 2003-11-26 | 2005-06-09 | Biovitrum Ab | Substituted urea-octahydroindols as antagonists of melanin concentrating hormone receptor 1 (mch1r) |
| TW200640529A (en) * | 2005-02-28 | 2006-12-01 | Thomas Christian Lines | Composition for treating mental health disorders |
| US20070149600A1 (en) * | 2005-04-25 | 2007-06-28 | Andrew Browning | Substituted octahydroisoindoles |
| WO2010106494A1 (en) * | 2009-03-20 | 2010-09-23 | H.L. Hall & Sons Limited | Use of pharmaceutical compositions containing mesembrenone |
| AU2010224486B2 (en) * | 2009-03-20 | 2014-04-24 | Hg&H Pharmaceuticals (Pty) Ltd | Sceletium extract and uses thereof |
| WO2011092547A1 (en) | 2010-01-29 | 2011-08-04 | Council Of Scientific & Industrial Research | Triazine-aryl-bis-indoles and process for preparation thereof |
| US9752932B2 (en) | 2010-03-10 | 2017-09-05 | Drexel University | Tunable electro-optic filter stack |
| US9576694B2 (en) | 2010-09-17 | 2017-02-21 | Drexel University | Applications for alliform carbon |
| US20160038551A1 (en) | 2013-03-28 | 2016-02-11 | Botanical Resource Holdings Proprietary Limited | Stabilized mesembrine compositions |
| WO2015130994A1 (en) | 2014-02-28 | 2015-09-03 | Tripp Matthew L | Phosphodiesterase-4 inhibiting phytochemical compositions |
| US20220031660A1 (en) * | 2015-03-27 | 2022-02-03 | Botanical Resource Holdings (Proprietary) Limited | Cancer treatment composition |
| WO2016157045A1 (en) * | 2015-03-27 | 2016-10-06 | Botanical Resource Holdings (Proprietary) Limited | Cancer treatment composition |
| CN106866496B (zh) * | 2017-04-21 | 2019-10-15 | 中国科学院上海有机化学研究所 | 六氢苯并喹啉-6-酮和六氢苯并吲哚-5-酮化合物、合成方法及用途 |
| EP3658167A1 (de) * | 2017-07-26 | 2020-06-03 | HG&H Pharmaceuticals (Pty) Limited | Mesembrenol und / oder mesembranol zur prophylaxe und behandlung von patienten mit epilepsie und assoziierten krankheiten |
| CA3202844A1 (en) * | 2020-12-21 | 2022-06-30 | Ryan PROTZKO | Methods for delay of ejaculation in human males |
| CN113072576B (zh) * | 2021-04-07 | 2022-04-26 | 四川大学 | 一类手性硅代松叶菊碱、合成方法及用途 |
| EP4373575A1 (de) * | 2021-07-22 | 2024-05-29 | Kanna Health Ltd. | Neue verbindungen und ihre verwendungen |
| CA3233930A1 (en) * | 2021-10-19 | 2023-04-27 | Justin KIRKLAND | Mesembrine derivatives |
| US20250051277A1 (en) | 2021-10-29 | 2025-02-13 | Sensorium Therapeutics, Inc. | Delivery of therapeutic alkaloid compounds |
| WO2023076533A1 (en) * | 2021-10-29 | 2023-05-04 | Sensorium Therapeutics, Inc. | Solid forms of mesembrine and therapeutic uses thereof |
| WO2023166304A1 (en) * | 2022-03-02 | 2023-09-07 | Kanna Health Ltd | Compounds for the use in the treatment of mood disorders |
| GB2616343A (en) * | 2022-03-02 | 2023-09-06 | Kanna Health Ltd | Compounds for the use in the treatment of mood disorders |
| GB2619907A (en) | 2022-04-01 | 2023-12-27 | Kanna Health Ltd | Novel crystalline salt forms of mesembrine |
| US12410128B1 (en) | 2022-04-15 | 2025-09-09 | Sensorium Therapeutics, Inc. | Therapeutic alkaloid compounds |
| WO2023225773A1 (en) * | 2022-05-23 | 2023-11-30 | Sensorium Therapeutics, Inc. | Solid forms of mesembrine and therapeutic uses thereof |
| WO2024015559A2 (en) * | 2022-07-15 | 2024-01-18 | Sensorium Therapeutics, Inc. | Solid forms of mesembrine and therapeutic uses thereof |
| GB2623122A (en) * | 2022-10-07 | 2024-04-10 | Kanna Health Ltd | Preparation of mesembrine |
| WO2024102991A1 (en) * | 2022-11-11 | 2024-05-16 | Sensorium Therapeutics, Inc. | Therapeutic alkaloid compounds |
| WO2024102461A1 (en) * | 2022-11-11 | 2024-05-16 | Sensorium Therapeutics, Inc. | Alkyl-substituted derivatives of mesembrine and mesembrenone and therapeutic uses thereof |
| AU2023413043A1 (en) * | 2022-12-22 | 2025-07-03 | Sensorium Therapeutics, Inc. | Delivery of therapeutic alkaloid compounds |
| WO2024173800A2 (en) * | 2023-02-17 | 2024-08-22 | Sensorium Therapeutics, Inc. | Solid forms of mesembranol and therapeutic uses thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3604112A1 (de) | 1986-02-10 | 1987-08-13 | Bernhard Dr Janiak | Pflanzenextrakte von mesembryanthemaceen sowie solche enthaltende schaedlingsbekaempfungsmittel und arzneimittel |
-
1997
- 1997-05-26 ZA ZA9704576A patent/ZA974576B/xx unknown
- 1997-06-03 EP EP97924158A patent/EP0910372B1/de not_active Expired - Lifetime
- 1997-06-03 WO PCT/GB1997/001493 patent/WO1997046234A1/en not_active Ceased
- 1997-06-03 DE DE69724618T patent/DE69724618T2/de not_active Expired - Lifetime
- 1997-06-03 AU AU29722/97A patent/AU716611B2/en not_active Expired
- 1997-06-03 CN CN97197056A patent/CN1227487A/zh active Pending
- 1997-06-03 US US09/194,836 patent/US6288104B1/en not_active Expired - Lifetime
- 1997-06-03 JP JP50031498A patent/JP4315469B2/ja not_active Expired - Fee Related
- 1997-06-03 AT AT97924158T patent/ATE248593T1/de not_active IP Right Cessation
-
2008
- 2008-10-22 JP JP2008272215A patent/JP2009062387A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP0910372B1 (de) | 2003-09-03 |
| JP2000511896A (ja) | 2000-09-12 |
| DE69724618D1 (de) | 2003-10-09 |
| US6288104B1 (en) | 2001-09-11 |
| ZA974576B (en) | 1998-02-04 |
| AU2972297A (en) | 1998-01-05 |
| DE69724618T2 (de) | 2005-04-21 |
| AU716611B2 (en) | 2000-03-02 |
| JP2009062387A (ja) | 2009-03-26 |
| CN1227487A (zh) | 1999-09-01 |
| EP0910372A1 (de) | 1999-04-28 |
| WO1997046234A1 (en) | 1997-12-11 |
| JP4315469B2 (ja) | 2009-08-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69724618D1 (de) | Mesembrin und verwandte verbindungen enthaltende pharmazeutische zusammensetzungen | |
| MX9704777A (es) | Compuestos espiro tetraciclicos, procedimiento para su preparacion y composiciones que los contienen. | |
| MX9702865A (es) | Agentes estrogenicos. | |
| LU92146I2 (fr) | Dasatinib et ses sels pharmaceutiquement acceptables | |
| BR0009830A (pt) | Composições para cuidados com a pele contendo uma combinação de substâncias ativas para cuidados com a pele | |
| ATE269846T1 (de) | N-substituierte aminotetraline als neuropeptid y y5 rezeptor-liganden und ihre anwendung zur behandlung von fettleibigkeit und anderen erkrankungen | |
| DE69427704D1 (de) | Neue (r)-5-carbamoyl-8-fluor-3-n,n-disubstituierte-amino-3,4-dihydro-2h-1-benzopyrane | |
| GEP20063885B (en) | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use | |
| DE69725608D1 (de) | Indolin-2-one derivate, verfahren zu ihrer herstellung und dieseenthaltende arzneimittel | |
| CO5180642A1 (es) | Compuestos sustituidos de piperidina, procesos para su prepa racion, composiciones farmaceuticas que los contienen y su utilizacion | |
| DK256890D0 (da) | Benzo-piperidin-, -piperidyliden- og piperazinforbindelser, kompositioner indeholdende forbindelserne og fremgangsmaader til forbindelsernes fremstilling og anvendelse | |
| ATE396174T1 (de) | Hydroxyalkylaminderivate als beta-secretase- inhibitoren und deren verwendung zur behandlung der alzheimerschen krankheit oder ähnlicher krankheiten | |
| UA66861C2 (uk) | 2-феніл-1-[4-(2-аміноетокси)бензил]індол в комбінації з естрогенами, способи лікування та продукт для лікування | |
| DK0564350T3 (da) | 3, 5-di-tert-butyl-4-hydroxyflavoner, fremgangsmåde til deres fremstilling og farmaceutiske sammensætninger med antioxidant- og anti-vasokonstriktorisk virkning | |
| MX9704037A (es) | 1,1-dioxidos de 1,2,5-tiadiazolidin-3-ona 2-substituida y composiciones y metodo de uso de los mismos. | |
| AU2001271987A1 (en) | Non-genotoxic metalloporphyrins as synthetic catalytic scavengers of reactive oxygen species | |
| DE69229339D1 (de) | Kristallines tiagabinehydrochlorid-monohydrat, seine herstellung und verwendung | |
| EA199800692A1 (ru) | Изолируемые смеси из семян eugenia jambolana lamarck, способы их получения, способ получения оксамата натрия, лекарственные средства для профилактики и лечения диабета и применение указанных смесей, их компонентов и оксамата натрия для получения этих лекарственных средств | |
| ATE247645T1 (de) | Neue piperazinylalkylthiopyrimidine derivate, diese enthaltende pharmazeutische zusammenstellungen und verfahren zu deren herstellung | |
| ATE369348T1 (de) | Zyklisierte benzamid-neurokinin-antagonisten zur verwendung in therapie | |
| ATE290857T1 (de) | Bretyliumhaltige zusammensetzungen und kits und deren verwendung zur vorbeugung und behandlung cardiovaskulärer erkrankungen | |
| ATE124681T1 (de) | Arzneimittelzusammensetzungen zur behandlung von psoriasis. | |
| MX9704034A (es) | Derivados y composiciones de 1,1-dioxido de 2-arilcarboniloximetil-1,2,5-tiadiazolidin-3-ona substituido y metodo de uso. | |
| ATE264309T1 (de) | Substituierte caprolactam-derivate, diese enthaltende pharmazeutische zubereitungen sowie ihre verwendung zur behandlung von tumoren | |
| ATE266027T1 (de) | Optisch aktives pyridyl-4h-1,2,4-oxadiazinderivat und seine verwendung zur behandlung von gefässkrankheiten |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |