ZA97850B - New 2,3-Benzodiazepine derivatives, their production and use as pharmaceutical agents. - Google Patents

New 2,3-Benzodiazepine derivatives, their production and use as pharmaceutical agents.

Info

Publication number: ZA97850B
Authority: ZA; South Africa
Prior art keywords: alkyl; hydrogen; optionally substituted; cycloalkyl; group
Prior art date: 1996-02-01

Application number

ZA9700850A

Other languages

English (en)

Inventor

Istvan Ling

Gizella Abraham

Sandor Solyom

Tamas Hamori

Istvan Tarnawa

Pal Berzsenyi

Ferenc Andrasi

Emese Csuzdi

Marta Szoellosy

Antal Simay

Istvan Pallagi

Katalin Horvath

Original Assignee

Schering Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-02-01

Filing date

1997-01-31

Publication date

1997-08-04

1997-01-31 Application filed by Schering Ag filed Critical Schering Ag

1997-08-04 Publication of ZA97850B publication Critical patent/ZA97850B/xx

Links

RPBDCDQMCRHNLM-UHFFFAOYSA-N C1=NNC=C2C=CC=CC2=C1 Chemical class C1=NNC=C2C=CC=CC2=C1 RPBDCDQMCRHNLM-UHFFFAOYSA-N 0.000 title 1
239000008177 pharmaceutical agent Substances 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 8
229910052739 hydrogen Inorganic materials 0.000 abstract 7
239000001257 hydrogen Substances 0.000 abstract 7
150000002431 hydrogen Chemical class 0.000 abstract 5
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
125000000041 C6-C10 aryl group Chemical group 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052736 halogen Inorganic materials 0.000 abstract 2
150000002367 halogens Chemical class 0.000 abstract 2
PQJIYKDSOWPZSW-UHFFFAOYSA-N 1-(3-chlorophenyl)-8-methoxy-4-methyl-5h-2,3-benzodiazepine Chemical compound C12=CC(OC)=CC=C2CC(C)=NN=C1C1=CC=CC(Cl)=C1 PQJIYKDSOWPZSW-UHFFFAOYSA-N 0.000 abstract 1
125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Neurology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ZA9700850A 1996-02-01 1997-01-31 New 2,3-Benzodiazepine derivatives, their production and use as pharmaceutical agents. ZA97850B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19604920A DE19604920A1 (de)	1996-02-01	1996-02-01	Neue 2,3-Benzodiazepinderivate, deren Herstellung und Verwendung als Arzneimittel

Publications (1)

Publication Number	Publication Date
ZA97850B true ZA97850B (en)	1997-08-04

Family

ID=7785065

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9700850A ZA97850B (en)	1996-02-01	1997-01-31	New 2,3-Benzodiazepine derivatives, their production and use as pharmaceutical agents.

Country Status (14)

Country	Link
US (1)	US6200970B1 (fr)
EP (1)	EP0888313B1 (fr)
JP (1)	JP2000505793A (fr)
AT (1)	ATE216373T1 (fr)
AU (1)	AU2285997A (fr)
CA (1)	CA2244777C (fr)
DE (2)	DE19604920A1 (fr)
DK (1)	DK0888313T3 (fr)
ES (1)	ES2175386T3 (fr)
HU (1)	HUP9901473A3 (fr)
MX (1)	MX9806171A (fr)
PT (1)	PT888313E (fr)
WO (1)	WO1997028135A1 (fr)
ZA (1)	ZA97850B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5891871A (en) *	1996-03-21	1999-04-06	Cocensys, Inc.	Substituted 2,3-benzodiazepin-4-ones and the use thereof
ES2320973T3 (es)	2000-06-12	2009-06-01	EISAI R&D MANAGEMENT CO., LTD.	Compuestos de 1,2-dihidropiridina, procedimiento para su preparacion y uso de los mismos.
WO2001098280A2 (fr) *	2000-06-16	2001-12-27	Annovis, Inc.	Antagonistes 5h-2,3-benzodiazepine de recepteurs d'acide amine excitateurs
US6432944B1 (en)	2000-07-06	2002-08-13	Bristol-Myers Squibb Company	Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives
HU225100B1 (hu) *	2000-12-21	2006-06-28	Egyt Gyogyszervegyeszeti Gyar	2,3-Benzodiazepinszármazékok, ilyen hatóanyagot tartalmazó gyógyászati készítmények és alkalmazásuk
CA2446696A1 (fr) *	2001-06-07	2002-12-12	Neuro3D	Inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations de ces inhibiteurs
GB0129260D0 (en)	2001-12-06	2002-01-23	Eisai London Res Lab Ltd	Pharmaceutical compositions and their uses
DE60313005T2 (de) *	2002-09-13	2007-12-20	Motac Neuroscience Ltd.	Behandlung von dyskinesie mit 2,3-benzodiazepinen
ES2286453T3 (es) *	2002-09-17	2007-12-01	Motac Neuroscience Limited	Tratamiento de la discinesia.
US20040141152A1 (en) *	2002-09-27	2004-07-22	Marino Joseph A.	Apparatus and method for conducting vision screening
US6858605B2 (en)	2003-02-04	2005-02-22	Ivax Drug Research Institute, Ltd.	Substituted 2,3-benzodiazepine derivatives
HUP0302449A3 (en) *	2003-08-04	2005-06-28	Egis Gyogyszergyar Nyilvanosan	8-chloro-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for producing them
MY148809A (en)	2004-07-06	2013-05-31	Eisai R&D Man Co Ltd	Crystals of 1,2-dihydropyridine compound and their production process
EA016087B1 (ru) *	2005-12-30	2012-02-28	Эгиш Дьёдьсердьяр Ньильваношан Мюкёдё Ресвеньтаршашаг	Оптические изомеры дигидро-2,3-бензодиазепинов и их стереоселективный синтез
TW200902024A (en) *	2007-04-02	2009-01-16	Teva Pharma	Novel 2,3-benzodiazepine derivatives and their use as antipsychotic agents
EP2885286B1 (fr) *	2012-08-16	2017-03-22	Bayer Pharma Aktiengesellschaft	2,3-benzodiazépines
SG11201505979UA (en)	2013-02-19	2015-09-29	Bayer Pharma AG	Bicyclo 2,3-benzodiazepines and spirocyclically substituted 2,3-benzodiazepines
WO2015121268A1 (fr) *	2014-02-14	2015-08-20	Bayer Pharma Aktiengesellschaft	1-phényl-3h-2,3-benzodiazépines et leur utilisation comme inhibiteurs de bromodomaine
MA54460A (fr)	2018-12-14	2021-10-20	Eisai R&D Man Co Ltd	Formulations pharmaceutiques à base d'eau de composés de 1,2-dihydropyridine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU179018B (en)	1978-10-19	1982-08-28	Gyogyszerkutato Intezet	Process for producing new 5h-2,3-benzodiazepine derivatives
HU186760B (en)	1981-03-12	1985-09-30	Gyogyszerkutato Intezet	Process for preparing 3,4-dihydro-5h-2,3-aenzodiazepine derivatives
HU191698B (en)	1984-07-27	1987-03-30	Gyogyszerkutato Intezet	Process for producing new 1-aryl-5h-2beta-benzodiazepines
HU208429B (en)	1991-05-03	1993-10-28	Gyogyszerkutato Intezet	Process for producing 1-/3-chloro-phenyl/-4-methyl-7,8-dimethoxy-5h-2,3-benzodiazepine of high purity
US5891871A (en) *	1996-03-21	1999-04-06	Cocensys, Inc.	Substituted 2,3-benzodiazepin-4-ones and the use thereof

1996
- 1996-02-01 DE DE19604920A patent/DE19604920A1/de not_active Withdrawn
1997
- 1997-01-29 ES ES97915277T patent/ES2175386T3/es not_active Expired - Lifetime
- 1997-01-29 US US09/125,008 patent/US6200970B1/en not_active Expired - Fee Related
- 1997-01-29 AT AT97915277T patent/ATE216373T1/de not_active IP Right Cessation
- 1997-01-29 AU AU22859/97A patent/AU2285997A/en not_active Abandoned
- 1997-01-29 EP EP97915277A patent/EP0888313B1/fr not_active Expired - Lifetime
- 1997-01-29 WO PCT/DE1997/000225 patent/WO1997028135A1/fr not_active Ceased
- 1997-01-29 JP JP9527247A patent/JP2000505793A/ja not_active Ceased
- 1997-01-29 DK DK97915277T patent/DK0888313T3/da active
- 1997-01-29 DE DE59707062T patent/DE59707062D1/de not_active Expired - Fee Related
- 1997-01-29 HU HU9901473A patent/HUP9901473A3/hu unknown
- 1997-01-29 PT PT97915277T patent/PT888313E/pt unknown
- 1997-01-29 CA CA002244777A patent/CA2244777C/fr not_active Expired - Fee Related
- 1997-01-31 ZA ZA9700850A patent/ZA97850B/xx unknown
1998
- 1998-07-31 MX MX9806171A patent/MX9806171A/es not_active IP Right Cessation

Also Published As

Publication number	Publication date
CA2244777A1 (fr)	1997-08-07
HUP9901473A3 (en)	2001-07-30
PT888313E (pt)	2002-09-30
DE59707062D1 (de)	2002-05-23
DK0888313T3 (da)	2002-07-15
MX9806171A (es)	1998-10-31
DE19604920A1 (de)	1997-08-07
JP2000505793A (ja)	2000-05-16
US6200970B1 (en)	2001-03-13
EP0888313A1 (fr)	1999-01-07
HUP9901473A2 (hu)	1999-09-28
EP0888313B1 (fr)	2002-04-17
ATE216373T1 (de)	2002-05-15
ES2175386T3 (es)	2002-11-16
AU2285997A (en)	1997-08-22
CA2244777C (fr)	2006-11-07
WO1997028135A1 (fr)	1997-08-07

Publication	Publication Date	Title
ZA97850B (en)	1997-08-04	New 2,3-Benzodiazepine derivatives, their production and use as pharmaceutical agents.
EP0144986A3 (en)	1985-07-24	Indole-3-carboxamide derivatives
AU2267495A (en)	1995-11-16	Benzamide derivatives as vasopressin antagonists
NZ503912A (en)	2002-09-27	Piperidinylaminomethyl trifluoromethyl cyclic ether compounds and their use as substance P antagonists
AU587057B2 (en)	1989-08-03	1,4-dihydro-3-oxo-2-(substituted phenyl)-benzothiazine derivatives
MY129176A (en)	2007-03-30	Tetrahydro gamma-carbolines
ES2175328T3 (es)	2002-11-16	Piperidonas como antagonistas de la taquiquinina.
TW340109B (en)	1998-09-11	Amide derivatives and their therapeutic use
CA1271747C (fr)	1990-07-17	Derives de benzazepines
HRP20010885B1 (en)	2010-07-31	Ethanesulfonyl-piperidine derivatives
NO950360L (no)	1995-08-02	Nytt legemiddel som inneholder 3-fenylsulfonyl-3,7-diazabisyklo[3,3,1Ånonan-forbindelser
UA41350C2 (uk)	2001-09-17	Похідна морфоліну або її фармацевтично прийнятна сіль та фармацевтична композиція на її основі
GB9916374D0 (en)	1999-09-15	Chemical compounds
HU0103912D0 (en)	2001-12-28	Use of substituted alkylpyridazinone derivatives for the preparation of pharmaceutical compositions with anxiolytic activity
DE3375784D1 (en)	1988-04-07	1,3,4,6,7,11b-hexahydro-7-aryl-2h-pyrazino (2,1-alpha) isoquinolines useful as intermediates and pharmaceutical compounds and methods of preparation
DE60122350D1 (de)	2006-09-28	Benzoesaüre derivate und deren verwendung
ES2027492A6 (es)	1992-06-01	Procedimiento de preparacion de nuevos derivados dihidropirimidotiazinos y de sus sales de adicion acidas farmaceuticamente aceptables.
ES8800942A1 (es)	1987-12-01	Un procedimiento para preparar derivados de isoquinolina
ES2191283T3 (es)	2003-09-01	Una camptotecina sustituida con alquinilo y su procedimiento de preparacion.
ES2018977A6 (es)	1991-05-16	Procedimiento de preparacion de n-ciclopropil-4-fluoroanilinas.