ZA978960B - Acridone derivatives and method of preparation of 8-hydroxy imidazoacridinone derivatives - Google Patents

Acridone derivatives and method of preparation of 8-hydroxy imidazoacridinone derivatives

Info

Publication number: ZA978960B
Authority: ZA; South Africa
Prior art keywords: hydroxy; derivatives; dialkylamino; omega; formula
Prior art date: 1996-10-07

Application number

ZA978960A

Other languages

English (en)

Inventor

Jerzy Kazimierz Konopa

Marek Tadeusz Konieczny

Original Assignee

British Tech Group

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-07

Filing date

1997-10-07

Publication date

1999-04-07

1997-10-07 Application filed by British Tech Group filed Critical British Tech Group

1999-04-07 Publication of ZA978960B publication Critical patent/ZA978960B/xx

Links

FZEYVTFCMJSGMP-UHFFFAOYSA-N acridone Chemical class C1=CC=C2C(=O)C3=CC=CC=C3NC2=C1 FZEYVTFCMJSGMP-UHFFFAOYSA-N 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
AGQRWJOCXVXWBB-UHFFFAOYSA-N 8-hydroxyimidazo[4,5-a]acridin-2-one Chemical class C1=CC2=NC(=O)N=C2C2=CC3=CC=C(O)C=C3N=C12 AGQRWJOCXVXWBB-UHFFFAOYSA-N 0.000 title 1
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 6
150000001875 compounds Chemical class 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 3
229910052763 palladium Inorganic materials 0.000 abstract 3
-1 1-chloro-7-(protected hydroxy)-4-nitroacridin-9(10H)-one Chemical class 0.000 abstract 2
238000010438 heat treatment Methods 0.000 abstract 2
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
150000003973 alkyl amines Chemical class 0.000 abstract 1
230000000118 anti-neoplastic effect Effects 0.000 abstract 1
DZBUGLKDJFMEHC-UHFFFAOYSA-N benzoquinolinylidene Natural products C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
235000019253 formic acid Nutrition 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1
238000007363 ring formation reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

ZA978960A 1996-10-07 1997-10-07 Acridone derivatives and method of preparation of 8-hydroxy imidazoacridinone derivatives ZA978960B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB9620751A GB2317888A (en)	1996-10-07	1996-10-07	Acridone derivatives and preparation of 8-hydroxy-imidazoacridinone derivatives

Publications (1)

Publication Number	Publication Date
ZA978960B true ZA978960B (en)	1999-04-07

Family

ID=10800965

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA978960A ZA978960B (en)	1996-10-07	1997-10-07	Acridone derivatives and method of preparation of 8-hydroxy imidazoacridinone derivatives

Country Status (11)

Country	Link
US (1)	US6229015B1 (fr)
EP (1)	EP0929552B1 (fr)
JP (1)	JP4138883B2 (fr)
AT (1)	ATE215542T1 (fr)
CA (1)	CA2268157C (fr)
DE (1)	DE69711654T2 (fr)
DK (1)	DK0929552T3 (fr)
ES (1)	ES2171993T3 (fr)
GB (1)	GB2317888A (fr)
WO (1)	WO1998015554A1 (fr)
ZA (1)	ZA978960B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2008528616A (ja) *	2005-01-28	2008-07-31	ザンサスファーマシューティカルズ，インコーポレイテッド	炎症性疾患および脱髄性疾患を処置するための化合物
US20080108641A1 (en) *	2006-02-08	2008-05-08	Ajami Alfred M	Compounds for treating inflammatory disorders, demyelinating disdorders and cancers
WO2007092436A2 (fr) *	2006-02-08	2007-08-16	Xanthus Pharmaceuticals, Inc.	Composes pour le traitement de troubles inflammatoires, de troubles de demyelinisation et de cancers
EP3070078B1 (fr)	2015-03-20	2017-10-04	Politechnika Gdanska	Bisacridines asymmetriques at leur utilisation en tant qu`agents anti-tumorales

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9104548D0 (en) *	1991-03-05	1991-04-17	Cholody Wienlaw M	Antineoplastic modified imidazoacridines

1996
- 1996-10-07 GB GB9620751A patent/GB2317888A/en not_active Withdrawn
1997
- 1997-09-10 WO PCT/GB1997/002470 patent/WO1998015554A1/fr not_active Ceased
- 1997-09-10 EP EP97939096A patent/EP0929552B1/fr not_active Expired - Lifetime
- 1997-09-10 DE DE69711654T patent/DE69711654T2/de not_active Expired - Fee Related
- 1997-09-10 ES ES97939096T patent/ES2171993T3/es not_active Expired - Lifetime
- 1997-09-10 CA CA002268157A patent/CA2268157C/fr not_active Expired - Fee Related
- 1997-09-10 DK DK97939096T patent/DK0929552T3/da active
- 1997-09-10 JP JP51727398A patent/JP4138883B2/ja not_active Expired - Fee Related
- 1997-09-10 AT AT97939096T patent/ATE215542T1/de not_active IP Right Cessation
- 1997-10-07 ZA ZA978960A patent/ZA978960B/xx unknown
1999
- 1999-04-06 US US09/286,655 patent/US6229015B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US6229015B1 (en)	2001-05-08
ATE215542T1 (de)	2002-04-15
WO1998015554A1 (fr)	1998-04-16
DK0929552T3 (da)	2002-07-22
GB2317888A (en)	1998-04-08
JP2001516339A (ja)	2001-09-25
DE69711654T2 (de)	2002-09-19
EP0929552B1 (fr)	2002-04-03
DE69711654D1 (de)	2002-05-08
CA2268157C (fr)	2006-01-10
CA2268157A1 (fr)	1998-04-16
EP0929552A1 (fr)	1999-07-21
JP4138883B2 (ja)	2008-08-27
ES2171993T3 (es)	2002-09-16
GB9620751D0 (en)	1996-11-20

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