ATE229022T1 - 9-amino und 9-nitrocamptothecinderivate, verfahren zu ihrer herstellung unf ihre verwendung als antitumormittel - Google Patents

9-amino und 9-nitrocamptothecinderivate, verfahren zu ihrer herstellung unf ihre verwendung als antitumormittel

Info

Publication number: ATE229022T1
Authority: AT; Austria
Prior art keywords: formula; compound; chem; amino; nitrocamptothecine
Prior art date: 1993-09-28

Application number

AT99202203T

Other languages

English (en)

Inventor

Walter Cabri

Ilaria Candiani

Franco Zarini

Angelo Bedeschi

Sergio Penco

Original Assignee

Pharmacia Italia Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-09-28

Filing date

1994-09-15

Publication date

2002-12-15

1994-09-15 Application filed by Pharmacia Italia Spa filed Critical Pharmacia Italia Spa

2002-12-15 Application granted granted Critical

2002-12-15 Publication of ATE229022T1 publication Critical patent/ATE229022T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
XLHNAFUKOSPOAT-FQEVSTJZSA-N (s)-4-ethyl-4-hydroxy-9-nitro-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione Chemical class C1=C([N+]([O-])=O)C=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 XLHNAFUKOSPOAT-FQEVSTJZSA-N 0.000 title 1
239000002246 antineoplastic agent Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 8
FUXVKZWTXQUGMW-FQEVSTJZSA-N 9-Aminocamptothecin Chemical compound C1=CC(N)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 FUXVKZWTXQUGMW-FQEVSTJZSA-N 0.000 abstract 2
230000000259 anti-tumor effect Effects 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000000802 nitrating effect Effects 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F23—COMBUSTION APPARATUS; COMBUSTION PROCESSES
- F23C—METHODS OR APPARATUS FOR COMBUSTION USING FLUID FUEL OR SOLID FUEL SUSPENDED IN A CARRIER GAS OR AIR
- F23C5/00—Disposition of burners with respect to the combustion chamber or to one another; Mounting of burners in combustion apparatus
- F23C5/02—Structural details of mounting

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Combustion & Propulsion (AREA)
Mechanical Engineering (AREA)
General Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Oncology (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT99202203T 1993-09-28 1994-09-15 9-amino und 9-nitrocamptothecinderivate, verfahren zu ihrer herstellung unf ihre verwendung als antitumormittel ATE229022T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939319944A GB9319944D0 (en)	1993-09-28	1993-09-28	Process for the preparation of 9-amino camptothecin
EP94927618A EP0670839B1 (de)	1993-09-28	1994-09-15	Verfahren zur herstellung von 9-amino camptothecin

Publications (1)

Publication Number	Publication Date
ATE229022T1 true ATE229022T1 (de)	2002-12-15

Family

ID=10742611

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT99202203T ATE229022T1 (de)	1993-09-28	1994-09-15	9-amino und 9-nitrocamptothecinderivate, verfahren zu ihrer herstellung unf ihre verwendung als antitumormittel
AT94927618T ATE189221T1 (de)	1993-09-28	1994-09-15	Verfahren zur herstellung von 9-amino camptothecin

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT94927618T ATE189221T1 (de)	1993-09-28	1994-09-15	Verfahren zur herstellung von 9-amino camptothecin

Country Status (21)

Country	Link
US (2)	US5614628A (de)
EP (2)	EP0982307B1 (de)
JP (3)	JP3754068B2 (de)
KR (1)	KR950704323A (de)
CN (2)	CN1046283C (de)
AT (2)	ATE229022T1 (de)
AU (1)	AU676089B2 (de)
CA (1)	CA2150382C (de)
DE (2)	DE69422795T2 (de)
DK (2)	DK0982307T3 (de)
ES (2)	ES2189345T3 (de)
FI (1)	FI952549A7 (de)
GB (1)	GB9319944D0 (de)
GR (1)	GR3033197T3 (de)
HU (1)	HUT71267A (de)
IL (3)	IL120073A (de)
MY (1)	MY131618A (de)
PT (2)	PT670839E (de)
RU (1)	RU2137774C1 (de)
WO (1)	WO1995009169A1 (de)
ZA (1)	ZA947522B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9319944D0 (en) *	1993-09-28	1993-11-17	Erba Carlo Spa	Process for the preparation of 9-amino camptothecin
GB9410388D0 (en) *	1994-05-24	1994-07-13	Erba Carlo Spa	Method for the preparation of 9-amino camptothecin
TW438775B (en) *	1995-04-07	2001-06-07	Pharmacia & Upjohn Co Llc	Novel intermediates and process for the manufacture of camptothecin derivatives (CPT-11) and related compounds
US6504029B1 (en) *	1995-04-10	2003-01-07	Daiichi Pharmaceutical Co., Ltd.	Condensed-hexacyclic compounds and a process therefor
GB9510716D0 (en) *	1995-05-26	1995-07-19	Pharmacia Spa	Substituted camptothecin derivatives and process for their preparation
GB9600438D0 (en) *	1996-01-10	1996-03-13	Pharmacia Spa	Hexacyclic camptothecin analogues, and process for preparing them
GB9601779D0 (en) *	1996-01-30	1996-04-03	Pharmacia Spa	9, 10 Disubstituted camptothecin derivatives
US5731316A (en) *	1996-01-30	1998-03-24	The Stehlin Foundation For Cancer Research	Derivatives of camptothecin and methods of treating cancer using these derivatives
US6395541B1 (en)	1996-05-23	2002-05-28	The Rockefeller University	Methods for the identification of compounds capable of inhibiting HIV-1 viral replication employing murine cell lines expressing human topoisomerase I
GB9702807D0 (en)	1997-02-12	1997-04-02	Pharmacia & Upjohn Spa	Alkynyl-substituted camptothecins and process for their preparation
GB9715821D0 (en) *	1997-07-25	1997-10-01	Pharmacia & Upjohn Spa	Amidino-camptothecin derivatives
USRE38408E1 (en)	1997-08-05	2004-01-27	The Stehlin Foundation For Cancer Research	Methods of preparing and purifying 9-nitro-20-camptothecin
US5922877A (en) *	1997-08-05	1999-07-13	The Stehlin Foundation For Cancer Research	Methods of preparing and purifying 9-nitro-20-camptothecin
AU775373B2 (en)	1999-10-01	2004-07-29	Immunogen, Inc.	Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6756381B2 (en) *	2002-02-21	2004-06-29	Supergen, Inc.	Compositions and formulations of 9-nitrocamptothecin polymorphs and methods of use thereof
CN100334089C (zh) *	2004-07-21	2007-08-29	王洋	一种9－硝基喜树碱的生产方法
US20060135546A1 (en) *	2004-12-16	2006-06-22	Jagadevappa Basavaraja	Methods for the purification of 20(S)- camptothecin
CN1312155C (zh) *	2005-01-21	2007-04-25	华东理工大学	一种分离纯化9－硝基喜树碱的方法
DK2445570T3 (da)	2009-06-26	2013-02-25	Taris Biomedical Inc	Implanterbare lægemiddelafgivelsesindretninger samt fremgangsmåder til deres fremstilling
JP2024033912A (ja) *	2022-08-31	2024-03-13	トヨタ自動車株式会社	銀ナノ粒子の製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4981968A (en) *	1987-03-31	1991-01-01	Research Triangle Institute	Synthesis of camptothecin and analogs thereof
US5053512A (en) *	1987-04-14	1991-10-01	Research Triangle Institute	Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives
US4894456A (en) *	1987-03-31	1990-01-16	Research Triangle Institute	Synthesis of camptothecin and analogs thereof
GB9316352D0 (en) *	1993-08-06	1993-09-22	Erba Carlo Spa	Process for the preparation of 9-amino camptothecin
GB9319944D0 (en) *	1993-09-28	1993-11-17	Erba Carlo Spa	Process for the preparation of 9-amino camptothecin
GB9402934D0 (en) *	1994-02-16	1994-04-06	Erba Carlo Spa	Camptothecin derivatives and process for their preparation

1993
- 1993-09-28 GB GB939319944A patent/GB9319944D0/en active Pending
1994
- 1994-09-15 DE DE69422795T patent/DE69422795T2/de not_active Expired - Fee Related
- 1994-09-15 EP EP99202203A patent/EP0982307B1/de not_active Expired - Lifetime
- 1994-09-15 WO PCT/EP1994/003098 patent/WO1995009169A1/en not_active Ceased
- 1994-09-15 ES ES99202203T patent/ES2189345T3/es not_active Expired - Lifetime
- 1994-09-15 AU AU76969/94A patent/AU676089B2/en not_active Ceased
- 1994-09-15 PT PT94927618T patent/PT670839E/pt unknown
- 1994-09-15 ES ES94927618T patent/ES2144059T3/es not_active Expired - Lifetime
- 1994-09-15 FI FI952549A patent/FI952549A7/fi unknown
- 1994-09-15 DK DK99202203T patent/DK0982307T3/da active
- 1994-09-15 CA CA002150382A patent/CA2150382C/en not_active Expired - Fee Related
- 1994-09-15 AT AT99202203T patent/ATE229022T1/de not_active IP Right Cessation
- 1994-09-15 HU HU9501898A patent/HUT71267A/hu unknown
- 1994-09-15 DK DK94927618T patent/DK0670839T3/da active
- 1994-09-15 KR KR1019950702120A patent/KR950704323A/ko not_active Ceased
- 1994-09-15 JP JP51008495A patent/JP3754068B2/ja not_active Expired - Fee Related
- 1994-09-15 EP EP94927618A patent/EP0670839B1/de not_active Expired - Lifetime
- 1994-09-15 CN CN94190731A patent/CN1046283C/zh not_active Expired - Fee Related
- 1994-09-15 PT PT99202203T patent/PT982307E/pt unknown
- 1994-09-15 AT AT94927618T patent/ATE189221T1/de not_active IP Right Cessation
- 1994-09-15 DE DE69431856T patent/DE69431856T2/de not_active Expired - Fee Related
- 1994-09-15 RU RU95112485A patent/RU2137774C1/ru active
- 1994-09-26 IL IL12007394A patent/IL120073A/xx not_active IP Right Cessation
- 1994-09-26 IL IL11106694A patent/IL111066A/xx not_active IP Right Cessation
- 1994-09-27 ZA ZA947522A patent/ZA947522B/xx unknown
- 1994-09-28 US US08/313,906 patent/US5614628A/en not_active Expired - Fee Related
- 1994-09-28 MY MYPI94002582A patent/MY131618A/en unknown
1996
- 1996-12-31 US US08/775,605 patent/US5916897A/en not_active Expired - Fee Related
1997
- 1997-01-24 IL IL12007397A patent/IL120073A0/xx unknown
1999
- 1999-01-06 CN CN99100920A patent/CN1273974A/zh active Pending
2000
- 2000-04-12 GR GR20000400891T patent/GR3033197T3/el not_active IP Right Cessation
2004
- 2004-07-14 JP JP2004206841A patent/JP2005036003A/ja not_active Withdrawn
- 2004-07-14 JP JP2004206842A patent/JP2005036004A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
PT982307E (pt)	2003-04-30
DE69422795T2 (de)	2000-07-20
DK0670839T3 (da)	2002-12-23
CA2150382A1 (en)	1995-04-06
ES2144059T3 (es)	2000-06-01
IL111066A (en)	1999-12-31
IL111066A0 (en)	1994-12-29
GB9319944D0 (en)	1993-11-17
US5916897A (en)	1999-06-29
EP0982307B1 (de)	2002-12-04
FI952549A7 (fi)	1995-07-21
CN1046283C (zh)	1999-11-10
KR950704323A (ko)	1995-11-17
ES2189345T3 (es)	2003-07-01
FI952549A0 (fi)	1995-05-24
JP2005036004A (ja)	2005-02-10
EP0670839B1 (de)	2000-01-26
CN1115181A (zh)	1996-01-17
RU95112485A (ru)	1997-04-20
EP0982307A2 (de)	2000-03-01
JPH08506834A (ja)	1996-07-23
WO1995009169A1 (en)	1995-04-06
GR3033197T3 (en)	2000-08-31
EP0982307A3 (de)	2000-07-26
CN1273974A (zh)	2000-11-22
JP3754068B2 (ja)	2006-03-08
AU7696994A (en)	1995-04-18
JP2005036003A (ja)	2005-02-10
ATE189221T1 (de)	2000-02-15
MY131618A (en)	2007-08-30
DE69431856T2 (de)	2003-08-21
IL120073A (en)	1999-07-14
US5614628A (en)	1997-03-25
DE69422795D1 (de)	2000-03-02
DE69431856D1 (de)	2003-01-16
PT670839E (pt)	2000-05-31
ZA947522B (en)	1995-05-29
RU2137774C1 (ru)	1999-09-20
EP0670839A1 (de)	1995-09-13
CA2150382C (en)	2006-12-05
AU676089B2 (en)	1997-02-27
HUT71267A (en)	1995-11-28
HU9501898D0 (en)	1995-08-28
DK0982307T3 (da)	2003-03-24
IL120073A0 (en)	1997-04-15

Legal Events

Date

Code

Title

Description

2003-06-15

UEP

Publication of translation of european patent specification

Ref document number: 0982307

Country of ref document: EP

2008-06-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE229022T1 (de)	2002-12-15	9-amino und 9-nitrocamptothecinderivate, verfahren zu ihrer herstellung unf ihre verwendung als antitumormittel
CA2241666A1 (en)	1997-09-12	Tricyclic compounds, their production and use
ATE212342T1 (de)	2002-02-15	Zwischerprodukte für die hemisynthese von taxanen und deren verfahren zu herstellung
IE881837L (en)	1988-12-19	Process
CA2298548A1 (en)	1999-02-11	Method for producing 2-(3-pyrazolyl-oxymethylene) nitrobenzenes
TW258735B (de)	1995-10-01
ATE170865T1 (de)	1998-09-15	Festfase bei oligonukleotidsynthese
DE69010874D1 (de)	1994-08-25	Fluornaphthacendione, deren glycosilierte Abkömmlinge und Verfahren zu deren Herstellung.
DE3770359D1 (de)	1991-07-04	6-amino-anthracycline, verfahren zu ihrer herstellung und ihre verwendung.
CA2197467A1 (en)	1997-01-09	Method for the preparation of taxol and its derivatives
ATE146476T1 (de)	1997-01-15	Cephalosporinverbindungen und verfahren zu ihrer herstellung
IL110553A (en)	1997-03-18	Process for the preparation of 9-amino camptothecin from the 12-nitro derivative, pharmaceutical compositions containing it and certain intermediates
ATE239017T1 (de)	2003-05-15	1,4-dihydropyridin-5-carbonsäureester-derivate und verfahren zu ihrer herstellung
CA2276310A1 (en)	1998-07-16	Process for the production of tetrazolylbenzopyrans
IL131513A0 (en)	2001-01-28	Method for producing 1,3-di-substituted 2-nitroguanidines
MX9701396A (es)	1998-04-30	Procedimiento para preparar derivado de 1,5-benzotiazepina.
BG103737A (en)	2000-06-30	Method for the preparation of derivatives of 4h-4-oxo-quinolysine-3-carboxylic acid
CA2364862A1 (en)	2000-09-08	Process for preparing derivatives of biphenyl-2-carboxylic acid
TW326043B (en)	1998-02-01	Method for preparing coumarin and derivatives thereof
DE3772852D1 (de)	1991-10-17	Thiadiazolylacetamid-derivate, verfahren zu ihrer herstellung und ihre verwendung.
JPS5610150A (en)	1981-02-02	Preparation of nitrotoluene derivative
JPS57192341A (en)	1982-11-26	Isoprenylamine derivative
JPS5782357A (en)	1982-05-22	Preparation of oligopeptide
JPS646275A (en)	1989-01-10	Mitomycin derivative
JPS6468391A (en)	1989-03-14	Production of novel n-acetyl-beta-d-hexosamine derivative