ATE229022T1 - 9-amino und 9-nitrocamptothecinderivate, verfahren zu ihrer herstellung unf ihre verwendung als antitumormittel - Google Patents

9-amino und 9-nitrocamptothecinderivate, verfahren zu ihrer herstellung unf ihre verwendung als antitumormittel

Info

Publication number: ATE229022T1
Authority: AT; Austria
Prior art keywords: formula; compound; chem; amino; nitrocamptothecine
Prior art date: 1993-09-28

Application number

AT99202203T

Other languages

English (en)

Inventor

Walter Cabri

Ilaria Candiani

Franco Zarini

Angelo Bedeschi

Sergio Penco

Original Assignee

Pharmacia Italia Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-09-28

Filing date

1994-09-15

Publication date

2002-12-15

1994-09-15 Application filed by Pharmacia Italia Spa filed Critical Pharmacia Italia Spa

2002-12-15 Application granted granted Critical

2002-12-15 Publication of ATE229022T1 publication Critical patent/ATE229022T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
XLHNAFUKOSPOAT-FQEVSTJZSA-N (s)-4-ethyl-4-hydroxy-9-nitro-1h-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4h,12h)-dione Chemical class C1=C([N+]([O-])=O)C=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 XLHNAFUKOSPOAT-FQEVSTJZSA-N 0.000 title 1
239000002246 antineoplastic agent Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 8
FUXVKZWTXQUGMW-FQEVSTJZSA-N 9-Aminocamptothecin Chemical compound C1=CC(N)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 FUXVKZWTXQUGMW-FQEVSTJZSA-N 0.000 abstract 2
230000000259 anti-tumor effect Effects 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
230000000802 nitrating effect Effects 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F23—COMBUSTION APPARATUS; COMBUSTION PROCESSES
- F23C—METHODS OR APPARATUS FOR COMBUSTION USING FLUID FUEL OR SOLID FUEL SUSPENDED IN A CARRIER GAS OR AIR
- F23C5/00—Disposition of burners with respect to the combustion chamber or to one another; Mounting of burners in combustion apparatus
- F23C5/02—Structural details of mounting

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Combustion & Propulsion (AREA)
Mechanical Engineering (AREA)
General Engineering & Computer Science (AREA)
Oncology (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT99202203T 1993-09-28 1994-09-15 9-amino und 9-nitrocamptothecinderivate, verfahren zu ihrer herstellung unf ihre verwendung als antitumormittel ATE229022T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939319944A GB9319944D0 (en)	1993-09-28	1993-09-28	Process for the preparation of 9-amino camptothecin
EP94927618A EP0670839B1 (de)	1993-09-28	1994-09-15	Verfahren zur herstellung von 9-amino camptothecin

Publications (1)

Publication Number	Publication Date
ATE229022T1 true ATE229022T1 (de)	2002-12-15

Family

ID=10742611

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT94927618T ATE189221T1 (de)	1993-09-28	1994-09-15	Verfahren zur herstellung von 9-amino camptothecin
AT99202203T ATE229022T1 (de)	1993-09-28	1994-09-15	9-amino und 9-nitrocamptothecinderivate, verfahren zu ihrer herstellung unf ihre verwendung als antitumormittel

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
AT94927618T ATE189221T1 (de)	1993-09-28	1994-09-15	Verfahren zur herstellung von 9-amino camptothecin

Country Status (21)

Country	Link
US (2)	US5614628A (de)
EP (2)	EP0670839B1 (de)
JP (3)	JP3754068B2 (de)
KR (1)	KR950704323A (de)
CN (2)	CN1046283C (de)
AT (2)	ATE189221T1 (de)
AU (1)	AU676089B2 (de)
CA (1)	CA2150382C (de)
DE (2)	DE69422795T2 (de)
DK (2)	DK0670839T3 (de)
ES (2)	ES2189345T3 (de)
FI (1)	FI952549A7 (de)
GB (1)	GB9319944D0 (de)
GR (1)	GR3033197T3 (de)
HU (1)	HUT71267A (de)
IL (3)	IL111066A (de)
MY (1)	MY131618A (de)
PT (2)	PT982307E (de)
RU (1)	RU2137774C1 (de)
WO (1)	WO1995009169A1 (de)
ZA (1)	ZA947522B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9319944D0 (en) *	1993-09-28	1993-11-17	Erba Carlo Spa	Process for the preparation of 9-amino camptothecin
GB9410388D0 (en) *	1994-05-24	1994-07-13	Erba Carlo Spa	Method for the preparation of 9-amino camptothecin
IL117684A (en) *	1995-04-07	2002-02-10	Pharmacia & Upjohn Inc	Intermediates and Process for Production of History of Kempotocin (CPT-11) and Related Compounds
US6504029B1 (en) *	1995-04-10	2003-01-07	Daiichi Pharmaceutical Co., Ltd.	Condensed-hexacyclic compounds and a process therefor
GB9510716D0 (en) *	1995-05-26	1995-07-19	Pharmacia Spa	Substituted camptothecin derivatives and process for their preparation
GB9600438D0 (en) *	1996-01-10	1996-03-13	Pharmacia Spa	Hexacyclic camptothecin analogues, and process for preparing them
GB9601779D0 (en) *	1996-01-30	1996-04-03	Pharmacia Spa	9, 10 Disubstituted camptothecin derivatives
US5731316A (en) *	1996-01-30	1998-03-24	The Stehlin Foundation For Cancer Research	Derivatives of camptothecin and methods of treating cancer using these derivatives
US6395541B1 (en)	1996-05-23	2002-05-28	The Rockefeller University	Methods for the identification of compounds capable of inhibiting HIV-1 viral replication employing murine cell lines expressing human topoisomerase I
GB9702807D0 (en)	1997-02-12	1997-04-02	Pharmacia & Upjohn Spa	Alkynyl-substituted camptothecins and process for their preparation
GB9715821D0 (en) *	1997-07-25	1997-10-01	Pharmacia & Upjohn Spa	Amidino-camptothecin derivatives
US5922877A (en) *	1997-08-05	1999-07-13	The Stehlin Foundation For Cancer Research	Methods of preparing and purifying 9-nitro-20-camptothecin
USRE38408E1 (en)	1997-08-05	2004-01-27	The Stehlin Foundation For Cancer Research	Methods of preparing and purifying 9-nitro-20-camptothecin
JP4776843B2 (ja)	1999-10-01	2011-09-21	イムノゲンインコーポレーティッド	免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
US7049322B2 (en) *	2002-02-21	2006-05-23	Supergen, Inc.	Compositions and formulations of 9-nitrocamptothecin polymorphs and methods of use therefor
CN100334089C (zh) *	2004-07-21	2007-08-29	王洋	一种9－硝基喜树碱的生产方法
US20060135546A1 (en) *	2004-12-16	2006-06-22	Jagadevappa Basavaraja	Methods for the purification of 20(S)- camptothecin
CN1312155C (zh) *	2005-01-21	2007-04-25	华东理工大学	一种分离纯化9－硝基喜树碱的方法
AU2010265863C1 (en)	2009-06-26	2012-11-01	Taris Biomedical Llc	Implantable drug delivery devices and methods of making the same
JP7859260B2 (ja) *	2022-08-31	2026-05-15	トヨタ自動車株式会社	銀ナノ粒子の製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4894456A (en) *	1987-03-31	1990-01-16	Research Triangle Institute	Synthesis of camptothecin and analogs thereof
US5053512A (en) *	1987-04-14	1991-10-01	Research Triangle Institute	Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives
US4981968A (en) *	1987-03-31	1991-01-01	Research Triangle Institute	Synthesis of camptothecin and analogs thereof
GB9316352D0 (en) *	1993-08-06	1993-09-22	Erba Carlo Spa	Process for the preparation of 9-amino camptothecin
GB9319944D0 (en) *	1993-09-28	1993-11-17	Erba Carlo Spa	Process for the preparation of 9-amino camptothecin
GB9402934D0 (en) *	1994-02-16	1994-04-06	Erba Carlo Spa	Camptothecin derivatives and process for their preparation

1993
- 1993-09-28 GB GB939319944A patent/GB9319944D0/en active Pending
1994
- 1994-09-15 EP EP94927618A patent/EP0670839B1/de not_active Expired - Lifetime
- 1994-09-15 KR KR1019950702120A patent/KR950704323A/ko not_active Ceased
- 1994-09-15 FI FI952549A patent/FI952549A7/fi unknown
- 1994-09-15 RU RU95112485A patent/RU2137774C1/ru active
- 1994-09-15 EP EP99202203A patent/EP0982307B1/de not_active Expired - Lifetime
- 1994-09-15 AT AT94927618T patent/ATE189221T1/de not_active IP Right Cessation
- 1994-09-15 DE DE69422795T patent/DE69422795T2/de not_active Expired - Fee Related
- 1994-09-15 HU HU9501898A patent/HUT71267A/hu unknown
- 1994-09-15 CN CN94190731A patent/CN1046283C/zh not_active Expired - Fee Related
- 1994-09-15 ES ES99202203T patent/ES2189345T3/es not_active Expired - Lifetime
- 1994-09-15 DE DE69431856T patent/DE69431856T2/de not_active Expired - Fee Related
- 1994-09-15 DK DK94927618T patent/DK0670839T3/da active
- 1994-09-15 WO PCT/EP1994/003098 patent/WO1995009169A1/en not_active Ceased
- 1994-09-15 CA CA002150382A patent/CA2150382C/en not_active Expired - Fee Related
- 1994-09-15 PT PT99202203T patent/PT982307E/pt unknown
- 1994-09-15 AT AT99202203T patent/ATE229022T1/de not_active IP Right Cessation
- 1994-09-15 AU AU76969/94A patent/AU676089B2/en not_active Ceased
- 1994-09-15 PT PT94927618T patent/PT670839E/pt unknown
- 1994-09-15 JP JP51008495A patent/JP3754068B2/ja not_active Expired - Fee Related
- 1994-09-15 DK DK99202203T patent/DK0982307T3/da active
- 1994-09-15 ES ES94927618T patent/ES2144059T3/es not_active Expired - Lifetime
- 1994-09-26 IL IL11106694A patent/IL111066A/xx not_active IP Right Cessation
- 1994-09-26 IL IL12007394A patent/IL120073A/xx not_active IP Right Cessation
- 1994-09-27 ZA ZA947522A patent/ZA947522B/xx unknown
- 1994-09-28 US US08/313,906 patent/US5614628A/en not_active Expired - Fee Related
- 1994-09-28 MY MYPI94002582A patent/MY131618A/en unknown
1996
- 1996-12-31 US US08/775,605 patent/US5916897A/en not_active Expired - Fee Related
1997
- 1997-01-24 IL IL12007397A patent/IL120073A0/xx unknown
1999
- 1999-01-06 CN CN99100920A patent/CN1273974A/zh active Pending
2000
- 2000-04-12 GR GR20000400891T patent/GR3033197T3/el not_active IP Right Cessation
2004
- 2004-07-14 JP JP2004206841A patent/JP2005036003A/ja not_active Withdrawn
- 2004-07-14 JP JP2004206842A patent/JP2005036004A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
JP2005036003A (ja)	2005-02-10
RU95112485A (ru)	1997-04-20
ZA947522B (en)	1995-05-29
GB9319944D0 (en)	1993-11-17
DE69422795D1 (de)	2000-03-02
CN1115181A (zh)	1996-01-17
DK0982307T3 (da)	2003-03-24
DE69431856T2 (de)	2003-08-21
AU676089B2 (en)	1997-02-27
CN1273974A (zh)	2000-11-22
GR3033197T3 (en)	2000-08-31
IL111066A (en)	1999-12-31
DK0670839T3 (da)	2002-12-23
EP0982307B1 (de)	2002-12-04
EP0670839B1 (de)	2000-01-26
FI952549A7 (fi)	1995-07-21
US5916897A (en)	1999-06-29
ATE189221T1 (de)	2000-02-15
ES2144059T3 (es)	2000-06-01
KR950704323A (ko)	1995-11-17
FI952549A0 (fi)	1995-05-24
PT670839E (pt)	2000-05-31
HU9501898D0 (en)	1995-08-28
MY131618A (en)	2007-08-30
WO1995009169A1 (en)	1995-04-06
JP3754068B2 (ja)	2006-03-08
IL120073A0 (en)	1997-04-15
ES2189345T3 (es)	2003-07-01
IL120073A (en)	1999-07-14
AU7696994A (en)	1995-04-18
IL111066A0 (en)	1994-12-29
US5614628A (en)	1997-03-25
EP0982307A2 (de)	2000-03-01
CA2150382A1 (en)	1995-04-06
CA2150382C (en)	2006-12-05
DE69431856D1 (de)	2003-01-16
PT982307E (pt)	2003-04-30
JPH08506834A (ja)	1996-07-23
EP0670839A1 (de)	1995-09-13
JP2005036004A (ja)	2005-02-10
CN1046283C (zh)	1999-11-10
DE69422795T2 (de)	2000-07-20
HUT71267A (en)	1995-11-28
RU2137774C1 (ru)	1999-09-20
EP0982307A3 (de)	2000-07-26

Legal Events

Date

Code

Title

Description

2003-06-15

UEP

Publication of translation of european patent specification

Ref document number: 0982307

Country of ref document: EP

2008-06-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69431856D1 (de)	2003-01-16	9-Amino und 9-Nitrocamptothecinderivate, Verfahren zu ihrer Herstellung unf ihre Verwendung als Antitumormittel
NZ306664A (en)	1999-11-29	Intermediates of camptothecin (CPT-11) or mappicine and their manufacture
CA2241666A1 (en)	1997-09-12	Tricyclic compounds, their production and use
IE881837L (en)	1988-12-19	Process
EP0655448A4 (de)	1995-06-07
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DE3770359D1 (de)	1991-07-04	6-amino-anthracycline, verfahren zu ihrer herstellung und ihre verwendung.
CA2197467A1 (en)	1997-01-09	Method for the preparation of taxol and its derivatives
ATE146476T1 (de)	1997-01-15	Cephalosporinverbindungen und verfahren zu ihrer herstellung
IL110553A (en)	1997-03-18	Process for the preparation of 9-amino camptothecin from the 12-nitro derivative, pharmaceutical compositions containing it and certain intermediates
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CA2276310A1 (en)	1998-07-16	Process for the production of tetrazolylbenzopyrans
AU7206898A (en)	1998-10-20	Method for producing 1,3-di-substituted 2-nitroguanidines
ES8609250A1 (es)	1986-07-16	Un procedimiento para la preparacion de nuevos derivados de ftalimida.
DE2720113A1 (de)	1977-12-15	Thiazolo-rifamycin-derivate sowie verfahren zu deren herstellung
MX9701396A (es)	1998-04-30	Procedimiento para preparar derivado de 1,5-benzotiazepina.
DE68922670D1 (de)	1995-06-22	Mischung, die eine makrocyclische Verbindung und eine organische Säure enthält, und deren Verwendung für die Gewinnung von Metallen.
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DE3772852D1 (de)	1991-10-17	Thiadiazolylacetamid-derivate, verfahren zu ihrer herstellung und ihre verwendung.
JPS5718641A (en)	1982-01-30	Preparation of quinone