DK0929552T3 - Acridonderivater og fremgangsmåde til fremstilling af 8-hydroxy-imidazoacridinonderivater - Google Patents

Acridonderivater og fremgangsmåde til fremstilling af 8-hydroxy-imidazoacridinonderivater

Info

Publication number: DK0929552T3
Authority: DK; Denmark
Prior art keywords: hydroxy; derivatives; dialkylamino; omega; formula
Prior art date: 1996-10-07

Application number

DK97939096T

Other languages

Danish (da)

English (en)

Inventor

Jerzy Kazimierz Konopa

Marek Tadeusz Konieczny

Original Assignee

Btg Int Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-07

Filing date

1997-09-10

Publication date

2002-07-22

1997-09-10 Application filed by Btg Int Ltd filed Critical Btg Int Ltd

2002-07-22 Application granted granted Critical

2002-07-22 Publication of DK0929552T3 publication Critical patent/DK0929552T3/da

Links

FZEYVTFCMJSGMP-UHFFFAOYSA-N acridone Chemical class C1=CC=C2C(=O)C3=CC=CC=C3NC2=C1 FZEYVTFCMJSGMP-UHFFFAOYSA-N 0.000 title abstract 2
AGQRWJOCXVXWBB-UHFFFAOYSA-N 8-hydroxyimidazo[4,5-a]acridin-2-one Chemical class C1=CC2=NC(=O)N=C2C2=CC3=CC=C(O)C=C3N=C12 AGQRWJOCXVXWBB-UHFFFAOYSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 6
150000001875 compounds Chemical class 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 3
229910052763 palladium Inorganic materials 0.000 abstract 3
-1 1-chloro-7-(protected hydroxy)-4-nitroacridin-9(10H)-one Chemical class 0.000 abstract 2
238000010438 heat treatment Methods 0.000 abstract 2
BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
150000003973 alkyl amines Chemical class 0.000 abstract 1
230000000118 anti-neoplastic effect Effects 0.000 abstract 1
DZBUGLKDJFMEHC-UHFFFAOYSA-N benzoquinolinylidene Natural products C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
235000019253 formic acid Nutrition 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1
238000007363 ring formation reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Oncology (AREA)
Hematology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK97939096T 1996-10-07 1997-09-10 Acridonderivater og fremgangsmåde til fremstilling af 8-hydroxy-imidazoacridinonderivater DK0929552T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB9620751A GB2317888A (en)	1996-10-07	1996-10-07	Acridone derivatives and preparation of 8-hydroxy-imidazoacridinone derivatives
PCT/GB1997/002470 WO1998015554A1 (fr)	1996-10-07	1997-09-10	Derives d'acridone et procede de preparation de derives de 8-hydroxy imidazoacridinone

Publications (1)

Publication Number	Publication Date
DK0929552T3 true DK0929552T3 (da)	2002-07-22

Family

ID=10800965

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK97939096T DK0929552T3 (da)	1996-10-07	1997-09-10	Acridonderivater og fremgangsmåde til fremstilling af 8-hydroxy-imidazoacridinonderivater

Country Status (11)

Country	Link
US (1)	US6229015B1 (fr)
EP (1)	EP0929552B1 (fr)
JP (1)	JP4138883B2 (fr)
AT (1)	ATE215542T1 (fr)
CA (1)	CA2268157C (fr)
DE (1)	DE69711654T2 (fr)
DK (1)	DK0929552T3 (fr)
ES (1)	ES2171993T3 (fr)
GB (1)	GB2317888A (fr)
WO (1)	WO1998015554A1 (fr)
ZA (1)	ZA978960B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU2006209225A1 (en) *	2005-01-28	2006-08-03	Xanthus Pharmaceuticals, Inc.	Compounds for treating inflammatory and demyelinating diseases
WO2007092436A2 (fr) *	2006-02-08	2007-08-16	Xanthus Pharmaceuticals, Inc.	Composes pour le traitement de troubles inflammatoires, de troubles de demyelinisation et de cancers
US20080108641A1 (en) *	2006-02-08	2008-05-08	Ajami Alfred M	Compounds for treating inflammatory disorders, demyelinating disdorders and cancers
PL3070078T3 (pl)	2015-03-20	2018-02-28	Politechnika Gdańska	Niesymetryczne bisakrydyny o działaniu przeciwnowotworowym i ich zastosowania

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9104548D0 (en) *	1991-03-05	1991-04-17	Cholody Wienlaw M	Antineoplastic modified imidazoacridines

1996
- 1996-10-07 GB GB9620751A patent/GB2317888A/en not_active Withdrawn
1997
- 1997-09-10 EP EP97939096A patent/EP0929552B1/fr not_active Expired - Lifetime
- 1997-09-10 DK DK97939096T patent/DK0929552T3/da active
- 1997-09-10 ES ES97939096T patent/ES2171993T3/es not_active Expired - Lifetime
- 1997-09-10 AT AT97939096T patent/ATE215542T1/de not_active IP Right Cessation
- 1997-09-10 WO PCT/GB1997/002470 patent/WO1998015554A1/fr not_active Ceased
- 1997-09-10 DE DE69711654T patent/DE69711654T2/de not_active Expired - Fee Related
- 1997-09-10 JP JP51727398A patent/JP4138883B2/ja not_active Expired - Fee Related
- 1997-09-10 CA CA002268157A patent/CA2268157C/fr not_active Expired - Fee Related
- 1997-10-07 ZA ZA978960A patent/ZA978960B/xx unknown
1999
- 1999-04-06 US US09/286,655 patent/US6229015B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP4138883B2 (ja)	2008-08-27
ES2171993T3 (es)	2002-09-16
EP0929552B1 (fr)	2002-04-03
ATE215542T1 (de)	2002-04-15
EP0929552A1 (fr)	1999-07-21
GB9620751D0 (en)	1996-11-20
DE69711654D1 (de)	2002-05-08
DE69711654T2 (de)	2002-09-19
CA2268157C (fr)	2006-01-10
GB2317888A (en)	1998-04-08
ZA978960B (en)	1999-04-07
WO1998015554A1 (fr)	1998-04-16
CA2268157A1 (fr)	1998-04-16
US6229015B1 (en)	2001-05-08
JP2001516339A (ja)	2001-09-25

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