ZA9810059B - Method for the preparation of citalopram - Google Patents

Method for the preparation of citalopram

Info

Publication number: ZA9810059B
Authority: ZA; South Africa
Prior art keywords: citalopram; preparation
Prior art date: 1997-11-10

Application number

ZA9810059A

Other languages

English (en)

Inventor

Hans Petersen

Michael Bech Sommer

Klaus Peter Bogeso

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-11-10

Filing date

1998-11-03

Publication date

1999-05-05

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37709809&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA9810059(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-11-03 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

1999-05-05 Publication of ZA9810059B publication Critical patent/ZA9810059B/xx

Links

WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 title 1
229960001653 citalopram Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Bioinformatics & Cheminformatics (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Furan Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

ZA9810059A 1997-11-10 1998-11-03 Method for the preparation of citalopram ZA9810059B (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PCT/DK1997/000511 WO1998019511A2 (en)	1997-11-10	1997-11-10	Method for the preparation of citalopram
CNB971825017A CN100338051C (zh)	1997-11-10	1997-11-10	西酞普兰的制备方法

Publications (1)

Publication Number	Publication Date
ZA9810059B true ZA9810059B (en)	1999-05-05

Family

ID=37709809

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9810059A ZA9810059B (en)	1997-11-10	1998-11-03	Method for the preparation of citalopram

Country Status (21)

Country	Link
US (1)	US6291689B1 (is)
EP (1)	EP1032566B9 (is)
JP (1)	JP2002530296A (is)
CN (1)	CN100338051C (is)
AR (1)	AR029604A2 (is)
AT (1)	ATE232524T1 (is)
AU (1)	AU738526C (is)
BR (1)	BR9714924A (is)
CA (1)	CA2291068C (is)
CZ (1)	CZ296533B6 (is)
DE (2)	DE1032566T1 (is)
DK (1)	DK1032566T5 (is)
EA (1)	EA003132B1 (is)
ES (1)	ES2149141T4 (is)
IL (1)	IL135813A (is)
IS (1)	IS5473A (is)
SK (1)	SK6812000A3 (is)
TR (1)	TR200001314T2 (is)
UA (1)	UA62985C2 (is)
WO (1)	WO1998019511A2 (is)
ZA (1)	ZA9810059B (is)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA62985C2 (en)	1997-11-10	2004-01-15	Lunnbeck As H	A method for the preparation of citalopram
EA002770B1 (ru)	1997-11-11	2002-08-29	Х.Лундбекк А/С	Способ получения циталопрама
PL199423B1 (pl) *	1998-10-20	2008-09-30	Lundbeck & Co As H	Sposób wytwarzania citalopramu
IL143422A0 (en)	1998-12-23	2002-04-21	Lundbeck & Co As H	Method for the preparation of 5-cyanophthalide
AR022329A1 (es) *	1999-01-29	2002-09-04	Lundbeck & Co As H	Metodo para la preparacion de 5-cianoftalida
DK1173431T4 (da)	1999-04-14	2010-01-04	Lundbeck & Co As H	Fremgangsmåde til fremstilling af citalopram
ITMI991579A1 (it)	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
ITMI991581A1 (it) *	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
GB2360281B (en)	1999-10-25	2002-01-16	Lundbeck & Co As H	Method for the preparation of citalopram
HRP20020344B1 (hr)	1999-10-25	2010-10-31	H. Lundbeck A/S	Način priprave citaloprama
AR026063A1 (es)	1999-11-01	2002-12-26	Lundbeck & Co As H	Metodo para la preparacion de 5-carboxiftalida.
US6310222B1 (en) *	1999-11-01	2001-10-30	Sumika Fine Chemicals Co., Ltd.	Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
HUP0203635A3 (en)	1999-12-28	2005-02-28	Lundbeck & Co As H	Method for the preparation of citalopram
PT1246813E (pt) *	1999-12-30	2004-02-27	Lundbeck & Co As H	Metodo para a preparacao de citalopram
CN1195749C (zh)	2000-01-14	2005-04-06	H.隆德贝克有限公司	制备5－氰基2－苯并[c]呋喃酮的方法
US6433196B1 (en) *	2000-02-17	2002-08-13	Sumika Fine Chemicals Co., Ltd.	Production method of citalopram, intermediate therefor and production method of the intermediate
NL1017415C1 (nl) *	2000-02-24	2001-05-18	Lundbeck & Co As H	Werkwijze voor de bereiding van Citalopram.
IES20010143A2 (en) *	2000-02-24	2001-07-25	Lundbeck & Co As H	Method for the preparation of citalopram
NL1017417C1 (nl)	2000-03-03	2001-03-16	Lundbeck & Co As H	Werkwijze voor de bereiding van Citalopram.
GB0005477D0 (en)	2000-03-07	2000-04-26	Resolution Chemicals Limited	Process for the preparation of citalopram
KR20020080481A (ko)	2000-03-13	2002-10-23	하. 룬트벡 아크티에 셀스카브	시탈로프람의 제조 방법
IES20010206A2 (en) *	2000-03-13	2002-03-06	Lundbeck & Co As H	Method for the preparation of citalopram
GR1004072B (el) *	2000-03-13	2002-12-02	H.Lundbeck A/S	Μεθοδος παρασκευης της σιταλοπραμης
GB2357762B (en)	2000-03-13	2002-01-30	Lundbeck & Co As H	Crystalline base of citalopram
CN1427835A (zh)	2000-03-13	2003-07-02	H·隆德贝克有限公司	5－取代的1－(4－氟苯基)－1,3－二氢异苯并呋喃的分步烷基化
TR200202155T2 (tr) *	2000-03-14	2002-12-23	H. Lundbeck A/S	Sitalopramin preparasyon metodu
DE10190485T1 (de) *	2000-03-16	2002-03-21	Lundbeck & Co As H	Verfahren zur Herstellung von 5-Cyano-1-(4-fluorphenyl)-1,3-dihydroisobenzofuranen
AR032455A1 (es) *	2000-05-12	2003-11-12	Lundbeck & Co As H	Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
CA2354877C (en) *	2000-08-18	2006-05-02	H. Lundbeck A/S	Method for the preparation of citalopram
US6491947B2 (en)	2000-11-03	2002-12-10	Chemlink Laboratories, Llc	Expanded perborate salt, use, and method of production
IT1319686B1 (it) *	2000-12-12	2003-10-23	C D Farmasint S R L	Procedimento di preparazione di citalopram.
WO2001045483A2 (en)	2000-12-22	2001-06-28	H. Lundbeck A/S	Method for the preparation of pure citalopram
JP2003519121A (ja)	2000-12-28	2003-06-17	ハー・ルンドベック・アクチエゼルスカベット	純粋なシタロプラムの製造方法
EP1355897A1 (en)	2001-01-30	2003-10-29	Orion Corporation Fermion	Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
BG65271B1 (bg) *	2001-06-18	2007-11-30	H. Lundbeck A/S	Метод за получаване на циталопрам
IL159326A0 (en)	2001-07-31	2004-06-01	Lundbeck & Co As H	Crystalline composition containing escitalopram
TWI332938B (en) *	2002-03-27	2010-11-11	Bando Chemical Ind	Novel 1,3,5-tris(arylamino)benzenes
BG65515B1 (bg) *	2002-07-26	2008-10-31	H. Lundbeck A/S	Метод за получаване на 5-цианофталид
FI20021421A0 (fi) *	2002-07-30	2002-07-30	Orion Corp Fermion	Valmistusmenetelmä
AR040970A1 (es)	2002-08-12	2005-04-27	Lundbeck & Co As H	Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram
WO2004016602A1 (en) *	2002-08-14	2004-02-26	Natco Pharma Limited	Process for the preparation of high purity citalopram and its pharmaceutically acceptable salts
GB2385051B (en) *	2002-08-29	2003-12-24	Max India Ltd	Improved process for the preparation of 5-substituted-1 (4-fluorophenyl)-1,3-dihydro isobenzofurans
WO2004026855A1 (en) *	2002-09-20	2004-04-01	H. Lundbeck A/S	Method for manufacture of dihydroisobenzofuran derivatives
US6812355B2 (en)	2002-10-22	2004-11-02	Sekhsaria Chemicals Limited	Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
ITMI20030479A1 (it) *	2003-03-13	2004-09-14	Adorkem Technology S P A	Procedimento per la preparazione di un ciano-isobenzofurano.
EP1611118A2 (en)	2003-03-21	2006-01-04	H. Lundbeck A/S	Intermediates for the preparation of citalopram and escitalopram
AU2003238676A1 (en) *	2003-04-21	2004-11-19	Podile Khadgapathi	An improved process for the preparation of citalopram hydrobromide
US6781003B1 (en) *	2003-06-09	2004-08-24	Aurobindo Pharma Ltd.	Preparation of pure citalopram
PT1506963E (pt) *	2003-10-28	2005-08-31	Adorkem Technology Spa	Processo para a preparacao de citalopram
CN100569765C (zh)	2003-12-19	2009-12-16	杭州民生药业集团有限公司	西酞普兰中间体晶体碱
EP1723133A1 (en) *	2004-02-16	2006-11-22	Jubilant Organosys Limited	One pot synthesis of citalopram from 5-cyanophthalide
ES2285972T1 (es)	2004-08-23	2007-12-01	Sun Pharmaceutical Industries Limited	Procedimiento de fabricacion de citalopram y enantiomeros.
GB0601286D0 (en)	2006-01-23	2006-03-01	Sandoz Ag	Asymmetric synthesis
US9339500B2 (en) *	2008-03-04	2016-05-17	Intra-Cellular Therapies, Inc.	Methods of treating vasomotor symptoms

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1143703A (is) *	1965-03-18
GB1526331A (en) *	1976-01-14	1978-09-27	Kefalas As	Phthalanes
GB8419963D0 (en)	1984-08-06	1984-09-12	Lundbeck & Co As H	Intermediate compound and method
GB8814057D0 (en) *	1988-06-14	1988-07-20	Lundbeck & Co As H	New enantiomers & their isolation
US5814636A (en) *	1994-07-15	1998-09-29	Meiji Seika Kabushiki Kaisha	Compounds with platelet aggregation inhibitor activity
ES2148120T3 (es)	1997-07-08	2002-01-16	Lundbeck & Co As H	Metodo para la preparacion de citalopram.
UA62985C2 (en)	1997-11-10	2004-01-15	Lunnbeck As H	A method for the preparation of citalopram
EA002770B1 (ru)	1997-11-11	2002-08-29	Х.Лундбекк А/С	Способ получения циталопрама

1997
- 1997-10-11 UA UA2000052907A patent/UA62985C2/uk unknown
- 1997-11-10 JP JP2000583316A patent/JP2002530296A/ja active Pending
- 1997-11-10 ES ES97945798T patent/ES2149141T4/es not_active Expired - Lifetime
- 1997-11-10 IL IL13581397A patent/IL135813A/xx not_active IP Right Cessation
- 1997-11-10 EA EA200000509A patent/EA003132B1/ru not_active IP Right Cessation
- 1997-11-10 DE DE1032566T patent/DE1032566T1/de active Pending
- 1997-11-10 CZ CZ20001713A patent/CZ296533B6/cs not_active IP Right Cessation
- 1997-11-10 SK SK681-2000A patent/SK6812000A3/sk unknown
- 1997-11-10 CA CA002291068A patent/CA2291068C/en not_active Expired - Fee Related
- 1997-11-10 CN CNB971825017A patent/CN100338051C/zh not_active Expired - Fee Related
- 1997-11-10 EP EP97945798A patent/EP1032566B9/en not_active Revoked
- 1997-11-10 DE DE69719098T patent/DE69719098T2/de not_active Revoked
- 1997-11-10 AT AT97945798T patent/ATE232524T1/de not_active IP Right Cessation
- 1997-11-10 BR BR9714924-1A patent/BR9714924A/pt not_active Application Discontinuation
- 1997-11-10 DK DK97945798T patent/DK1032566T5/da active
- 1997-11-10 TR TR2000/01314T patent/TR200001314T2/xx unknown
- 1997-11-10 WO PCT/DK1997/000511 patent/WO1998019511A2/en not_active Ceased
- 1997-11-10 AU AU51167/98A patent/AU738526C/en not_active Ceased
1998
- 1998-11-03 ZA ZA9810059A patent/ZA9810059B/xx unknown
1999
- 1999-10-22 AR ARP990105341A patent/AR029604A2/es unknown
2000
- 2000-04-26 IS IS5473A patent/IS5473A/is unknown
- 2000-05-03 US US09/565,061 patent/US6291689B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU738526C (en)	2004-03-25
EP1032566B9 (en)	2003-10-22
CN1286688A (zh)	2001-03-07
EA200000509A1 (ru)	2000-10-30
WO1998019511A2 (en)	1998-05-14
SK6812000A3 (en)	2000-10-09
CA2291068C (en)	2002-10-29
DE69719098T2 (de)	2004-02-12
ES2149141T3 (es)	2003-10-01
IS5473A (is)	2000-04-26
US6291689B1 (en)	2001-09-18
TR200001314T2 (tr)	2000-11-21
UA62985C2 (en)	2004-01-15
AR029604A2 (es)	2003-07-10
DE69719098D1 (de)	2003-03-20
DE1032566T1 (de)	2001-03-15
DK1032566T5 (da)	2004-06-28
IL135813A (en)	2003-07-31
JP2002530296A (ja)	2002-09-17
ATE232524T1 (de)	2003-02-15
IL135813A0 (en)	2001-05-20
DK1032566T3 (da)	2003-06-10
CA2291068A1 (en)	1998-05-14
CZ296533B6 (cs)	2006-04-12
BR9714924A (pt)	2000-09-26
CN100338051C (zh)	2007-09-19
EA003132B1 (ru)	2003-02-27
WO1998019511A3 (en)	1998-08-06
ES2149141T1 (es)	2000-11-01
EP1032566B1 (en)	2003-02-12
AU5116798A (en)	1998-05-29
EP1032566A2 (en)	2000-09-06
CZ20001713A3 (cs)	2000-10-11
ES2149141T4 (es)	2004-11-16
AU738526B2 (en)	2001-09-20

Publication	Publication Date	Title
IL135813A (en)	2003-07-31	Method for the preparation of citalopram
PL347189A1 (en)	2002-03-25	Method for the preparation of citalopram
GB2354240B (en)	2001-05-23	Method for the preparation of citalopram
GB2354239B (en)	2001-06-06	Method for the preparation of citalopram
IL145615A0 (en)	2002-06-30	Method for the preparation of citalopram
GB2360281B (en)	2002-01-16	Method for the preparation of citalopram
HUP0104856A3 (en)	2003-01-28	Method for the preparation of 5-cyanophthalide
ZA984538B (en)	1998-12-07	Method for the preparation of carbamates
HUP0203635A3 (en)	2005-02-28	Method for the preparation of citalopram
HUP0203840A3 (en)	2005-02-28	Method for the preparation of citalopram
ZA981885B (en)	1998-09-10	Method for the preparation of alpha-bromo-lactam derivatives
HUP0200169A3 (en)	2002-11-28	Method for the preparation of citalopram
ZA984534B (en)	1998-12-07	Method for the preparation of carbamates
IL135641A (en)	2005-08-31	Method for the preparation of citalopram
ZA985981B (en)	1999-01-28	Method for the preparation of citalopram
IL153125A0 (en)	2003-06-24	Method for the preparation of citalopram
IL152953A0 (en)	2003-06-24	Method for the preparation of citalopram
SI1042310T1 (en)	2002-12-31	Method for the preparation of citalopram
SI1032566T1 (en)	2003-06-30	Method for the preparation of citalopram
AU6887198A (en)	1998-11-27	Improved method for the preparation of benzyluracils
SI1123284T1 (en)	2003-08-31	Method for the preparation of citalopram
ZA200102822B (en)	2001-10-08	Method for the preparation of citalopram.
LT97134A (en)	1998-04-27	Method for the preparation of zeolites