ZA9810412B - Aromatic sulfone hydroxamic acid metalloprotease inhibitor. - Google Patents

Aromatic sulfone hydroxamic acid metalloprotease inhibitor.

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Publication number
ZA9810412B
ZA9810412B ZA9810412A ZA9810412A ZA9810412B ZA 9810412 B ZA9810412 B ZA 9810412B ZA 9810412 A ZA9810412 A ZA 9810412A ZA 9810412 A ZA9810412 A ZA 9810412A ZA 9810412 B ZA9810412 B ZA 9810412B
Authority
ZA
South Africa
Prior art keywords
hydroxamic acid
metalloprotease inhibitor
aromatic sulfone
sulfone hydroxamic
acid metalloprotease
Prior art date
Application number
ZA9810412A
Other languages
English (en)
Inventor
Thomas E Barta
Daniel P Becker
Terri L Boehm
Gary A De Crescenzo
Clara I Villamil
Joseph J Mcdonald
John N Freskos
Daniel P Getman
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of ZA9810412B publication Critical patent/ZA9810412B/xx

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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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ZA9810412A 1997-11-14 1998-11-13 Aromatic sulfone hydroxamic acid metalloprotease inhibitor. ZA9810412B (en)

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Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6747027B1 (en) 1996-07-22 2004-06-08 Pharmacia Corporation Thiol sulfonamide metalloprotease inhibitors
US6197791B1 (en) * 1997-02-27 2001-03-06 American Cyanamid Company N-hdroxy-2-(alkyl, aryl, or heteroaryl, sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors
US6638952B1 (en) 1997-03-04 2003-10-28 Pharmacia Corporation Aromatic sulfonyl alpha-cycloamino hydroxamic acid compounds
US6696449B2 (en) 1997-03-04 2004-02-24 Pharmacia Corporation Sulfonyl aryl hydroxamates and their use as matrix metalloprotease inhibitors
US6794511B2 (en) 1997-03-04 2004-09-21 G. D. Searle Sulfonyl aryl or heteroaryl hydroxamic acid compounds
US7115632B1 (en) 1999-05-12 2006-10-03 G. D. Searle & Co. Sulfonyl aryl or heteroaryl hydroxamic acid compounds
WO1999025687A1 (fr) * 1997-11-14 1999-05-27 G.D. Searle & Co. Inhibiteur de metalloprotease a base d'acide hydroxamique aromatique sulfone
US6750228B1 (en) * 1997-11-14 2004-06-15 Pharmacia Corporation Aromatic sulfone hydroxamic acid metalloprotease inhibitor
US20010039287A1 (en) * 1997-11-14 2001-11-08 Thomas E Barta Aromatic sulfone hydroxamic acid metalloprotease inhibitor
WO1999042436A1 (fr) * 1998-02-19 1999-08-26 American Cyanamid Company Alkyle, aryle ou heteroarylamides n-hydroxy-2-(alkyl, aryl ou heteroaryl sulfanyl, sulfinyl ou sulfonyl)-3-substitues en tant qu'inhibiteurs de la metalloproteinase matricielle
AU2592600A (en) * 1998-12-23 2000-07-31 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6358980B1 (en) * 1999-01-27 2002-03-19 American Cyanamid Company Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors
US6946473B2 (en) 1999-01-27 2005-09-20 Wyeth Holdings Corporation Preparation and use of acetylenic ortho-sulfonamido and phosphinic acid amido bicyclic heteroaryl hydroxamic acids as TACE inhibitors
US6753337B2 (en) 1999-01-27 2004-06-22 Wyeth Holdings Corporation Alkynyl containing hydroxamic acid compounds as matrix metalloproteinase/tace inhibitors
US6800646B1 (en) 1999-02-08 2004-10-05 Pharmacia Corporation Sulfamato hydroxamic acid metalloprotease inhibitor
HRP20010660A2 (en) 1999-02-08 2005-02-28 G.D. Searle & Co Sulfamato hydroxamic acid metalloprotease inhibitor
AU4589701A (en) * 2000-03-24 2001-10-08 Cocensys Inc Aryl substituted pyrazoles, triazoles and tetrazoles, and the use thereof
US6683093B2 (en) * 2000-05-12 2004-01-27 Pharmacia Corporation Aromatic sulfone hydroxamic acids and their use as protease inhibitors
EP1282614B1 (fr) * 2000-05-15 2003-11-12 Darwin Discovery Limited Derives d'acide hydroxamique
US6444685B1 (en) 2000-07-17 2002-09-03 Wyeth N-(4-sulfonylaryl)Cyclylamine 2-hydroxyethylamines as beta-3 adrenergic receptor agonists
FR2821356A1 (fr) * 2001-02-23 2002-08-30 Cerep Nouveaux derives d'arylcarbamates et d'arylurees, preparations et utilisations
US20040024024A1 (en) * 2001-05-11 2004-02-05 Freskos John N. Aromatic sulfone hydroxamates and their use as protease inhibitors
YU85403A (sh) * 2001-05-11 2006-03-03 Pharmacia Corporation Aromatični sulfonski hidroksamati i njihova upotreba kao proteaznih inhibitora
US6683078B2 (en) 2001-07-19 2004-01-27 Pharmacia Corporation Use of sulfonyl aryl or heteroaryl hydroxamic acids and derivatives thereof as aggrecanase inhibitors
DE60231425D1 (de) * 2001-11-13 2009-04-16 Shiseido Co Ltd Azabicycloverbindung, matrixmetallproteaseinhibitor und zubereitung für haut
WO2003091247A2 (fr) 2002-04-25 2003-11-06 Pharmacia Corporation Acides piperidinylsulfonylmethylhydroxamiques et piperazinylsulfonylmethylhydroxamiques et leur utilisation comme inhibiteurs de protease
KR100701811B1 (ko) * 2002-05-29 2007-04-02 머크 앤드 캄파니 인코포레이티드 탄저병의 치료 및 치사 인자의 억제에 유용한 화합물
JP2006502980A (ja) * 2002-06-25 2006-01-26 ファルマシア・コーポレーション アリールスルホニルヒドロキサム酸およびアミド誘導体、ならびにプロテアーゼ阻害薬としてのそれらの使用
BR0316506A (pt) * 2002-11-25 2005-10-04 Pharmacia Corp Midas e ácidos heteroarilsulfonilmetil hidroxâmicos e sua aplicação como inibidores da protease
US20050043533A1 (en) * 2003-03-25 2005-02-24 Babiak Kevin A. Process for making alpha-substituted hydroxamic acids
US8088737B2 (en) 2003-04-04 2012-01-03 Incyte Corporation Compositions, methods and kits relating to Her-2 cleavage
WO2005105133A2 (fr) * 2004-04-23 2005-11-10 Massachusetts Eye And Ear Infirmary Methodes et compositions de conservation de la viabilite de cellules photoreceptrices
AU2005250351A1 (en) * 2004-05-11 2005-12-15 Merck & Co., Inc. Process for making n-sulfonated-amino acid derivatives
US7638553B2 (en) * 2004-06-14 2009-12-29 Hoffmann-La Roche Inc. Hydroxamates, their manufacture and use as pharmaceutical agents
DE102004031620A1 (de) * 2004-06-30 2006-02-02 Sanofi-Aventis Deutschland Gmbh 4-Trifluormethoxyphenoxybenzol-4`-sulfonsäuren, Verfahren zu ihrer Herstellung und Verwendung in Arzneimitteln
US20100003276A1 (en) * 2004-12-07 2010-01-07 Hermes Jeffery D Methods for treating anthrax and inhibiting lethal factor
WO2008063639A2 (fr) * 2006-11-21 2008-05-29 Massachusetts Eye And Ear Infirmary Compositions et procédés pour préserver des cellules de l'oeil
ES2313841B1 (es) * 2007-06-26 2010-01-12 Proyecto De Biomedicina Cima, S.L. Composiciones para tratamiento anti-fibrinolitico.
CA2896053A1 (fr) 2012-12-21 2014-06-26 Ocata Therapeutics, Inc. Procedes de production de plaquettes a partir de cellules souches pluripotentes, et compositions associees
US9840520B2 (en) 2014-05-14 2017-12-12 The Regents Of The University Of Colorado, A Body Corporate Heterocyclic hydroxamic acids as protein deacetylase inhibitors and dual protein deacetylase-protein kinase inhibitors and methods of use thereof
WO2020006384A1 (fr) * 2018-06-29 2020-01-02 Loyola University Of Chicago Inhibiteurs de métalloprotéinase matricielle d'acide hydroxamique carborane et agents pour une thérapie par capture de neutrons par le bore

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4595700A (en) 1984-12-21 1986-06-17 G. D. Searle & Co. Thiol based collagenase inhibitors
US4792633A (en) 1986-05-19 1988-12-20 E. I. Du Pont De Nemours And Company Preparation of ortho-(alkyl- or arylthio)phenols
US4882434A (en) * 1986-10-29 1989-11-21 Takeda Chemical Industries, Ltd. Gamma-lactonecarboxylic acid derivatives and their use as antibacterial agents or intermediates
GB8827305D0 (en) 1988-11-23 1988-12-29 British Bio Technology Compounds
JP3122161B2 (ja) * 1991-05-16 2001-01-09 武田薬品工業株式会社 γ−ラクトン免疫抑制剤
AU3899193A (en) 1992-04-07 1993-11-08 British Bio-Technology Limited Hydroxamic acid based collagenase and cytokine inhibitors
US5376664A (en) 1992-07-27 1994-12-27 The Du Pont Merck Pharmaceutical Company Unsymmetrical mono-3-nitro bis-naphthalimides as anticancer agents
US5455258A (en) 1993-01-06 1995-10-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
GB9307956D0 (en) 1993-04-17 1993-06-02 Walls Alan J Hydroxamic acid derivatives
GB9320660D0 (en) 1993-10-07 1993-11-24 British Bio Technology Inhibition of cytokine production
CA2175057A1 (fr) 1993-11-04 1995-05-11 Robert P. Lenk Formulations de liposome multilamellaire contenant un metabolite d'acide arachidonique
GB9323165D0 (en) 1993-11-10 1994-01-05 Chiros Ltd Compounds
WO1995029892A1 (fr) 1994-04-28 1995-11-09 The Du Pont Merck Pharmaceutical Company Derives d'acides hydroxamiques et d'acides amines et leur utilisation comme agents antiarthritiques
GB9416897D0 (en) 1994-08-20 1994-10-12 British Biotech Pharm Metalloproteinase inhibitors
CZ288436B6 (en) 1994-10-05 2001-06-13 Darwin Discovery Ltd Peptidyl derivatives, their therapeutic use as inhibitors of metalloproteinases and pharmaceutical preparation in which they are comprised
NO300877B1 (no) 1995-12-07 1997-08-11 Elkem Materials Anordning ved granulering av metall og slagg
ES2233275T3 (es) 1995-12-08 2005-06-16 Agouron Pharmaceuticals, Inc. Intermediarios que sirven para la preparacion de inhibidores de metaloproteinasas.
ATE225343T1 (de) 1995-12-20 2002-10-15 Hoffmann La Roche Matrix-metalloprotease inhibitoren
PT871439E (pt) * 1996-01-02 2004-08-31 Aventis Pharma Inc Compostos do acido hidroxamico substituidos (arilo heteroarilo arilmetilo ou heteroarilmetilo)
WO1997027117A1 (fr) * 1996-01-24 1997-07-31 Pettoma Division Of 1098604 Ontario Limited Boite-boisson refermable
JP2001505869A (ja) * 1996-07-22 2001-05-08 モンサント カンパニー チオールスルホン メタロプロテアーゼ阻害剤
YU40999A (sh) * 1997-02-27 2002-06-19 American Cyanamid Company N-hidroksi-2-(alkil,aril ili heteroaril sulfanil,sulfinil ili sulfonil)-3-supstituisani alkil,aril ili heteroarilamidi, kao inhibitori za matrične metaloproteinaze
US6300514B1 (en) * 1997-06-25 2001-10-09 Ono Pharmaceutical Co., Ltd. Aryl (sulfide, sulfoxide and sulfone) derivatives and drugs containing the same as the active ingredient
US6576664B1 (en) 1997-08-18 2003-06-10 Bristol-Myers Squibb Pharma Company Inhibitors of aggrecanase and matrix metalloproteinases for the treatment of arthritis
WO1999025687A1 (fr) * 1997-11-14 1999-05-27 G.D. Searle & Co. Inhibiteur de metalloprotease a base d'acide hydroxamique aromatique sulfone
US6750228B1 (en) * 1997-11-14 2004-06-15 Pharmacia Corporation Aromatic sulfone hydroxamic acid metalloprotease inhibitor
US20010014688A1 (en) * 1997-11-14 2001-08-16 Thomas E. Barta Aromatic sulfone hydroxamic acid metalloprotease inhibitor
US20010039287A1 (en) * 1997-11-14 2001-11-08 Thomas E Barta Aromatic sulfone hydroxamic acid metalloprotease inhibitor
IL127496A0 (en) 1997-12-19 1999-10-28 Pfizer Prod Inc The use of MMP inhibitors for the treatment of ocular angiogenesis
WO1999042436A1 (fr) 1998-02-19 1999-08-26 American Cyanamid Company Alkyle, aryle ou heteroarylamides n-hydroxy-2-(alkyl, aryl ou heteroaryl sulfanyl, sulfinyl ou sulfonyl)-3-substitues en tant qu'inhibiteurs de la metalloproteinase matricielle
AU4074799A (en) * 1998-05-14 1999-11-29 Du Pont Pharmaceuticals Company Substituted aryl hydroxamic acids as metalloproteinase inhibitors
HRP20010660A2 (en) 1999-02-08 2005-02-28 G.D. Searle & Co Sulfamato hydroxamic acid metalloprotease inhibitor
EP1165500A1 (fr) 1999-04-02 2002-01-02 Du Pont Pharmaceuticals Company Nouveaux derives d'amides faisant office d'inhibiteurs de metalloproteases matricielles, de tnf-alpha, et de l'aggrecanase
US6683093B2 (en) * 2000-05-12 2004-01-27 Pharmacia Corporation Aromatic sulfone hydroxamic acids and their use as protease inhibitors
YU85403A (sh) * 2001-05-11 2006-03-03 Pharmacia Corporation Aromatični sulfonski hidroksamati i njihova upotreba kao proteaznih inhibitora
US20040024024A1 (en) * 2001-05-11 2004-02-05 Freskos John N. Aromatic sulfone hydroxamates and their use as protease inhibitors
US6998390B2 (en) * 2002-04-25 2006-02-14 Zhenkun Ma Oxolide antibacterials
JP2006502980A (ja) * 2002-06-25 2006-01-26 ファルマシア・コーポレーション アリールスルホニルヒドロキサム酸およびアミド誘導体、ならびにプロテアーゼ阻害薬としてのそれらの使用
BR0316506A (pt) * 2002-11-25 2005-10-04 Pharmacia Corp Midas e ácidos heteroarilsulfonilmetil hidroxâmicos e sua aplicação como inibidores da protease

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NO20002469L (no) 2000-07-12
AU1373299A (en) 1999-06-07
US6541489B1 (en) 2003-04-01
US20040048852A1 (en) 2004-03-11
AR016010A1 (es) 2001-05-30
RU2250105C2 (ru) 2005-04-20
JP2001523662A (ja) 2001-11-27
BR9814643A (pt) 2000-10-03
US6890937B2 (en) 2005-05-10
AU756150B2 (en) 2003-01-02
AU756150C (en) 2004-03-04
NO20002469D0 (no) 2000-05-12
PL341379A1 (en) 2001-04-09
US20060084688A1 (en) 2006-04-20
CN1279669A (zh) 2001-01-10
IL135106A0 (en) 2001-05-20

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