NZ503485A - Aromatic sulfone hydroxamic acid metalloprotease inhibitor - Google Patents

Aromatic sulfone hydroxamic acid metalloprotease inhibitor

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Publication number
NZ503485A
NZ503485A NZ503485A NZ50348598A NZ503485A NZ 503485 A NZ503485 A NZ 503485A NZ 503485 A NZ503485 A NZ 503485A NZ 50348598 A NZ50348598 A NZ 50348598A NZ 503485 A NZ503485 A NZ 503485A
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NZ
New Zealand
Prior art keywords
alkyl
group
cycloalkyl
alkoxy
heteroaryl
Prior art date
Application number
NZ503485A
Other languages
English (en)
Inventor
Joseph J Mcdonald
John N Freskos
Daniel P Getman
Clara I Villamil
Thomas E Barta
Daniel P Becker
Terri L Boehm
Crescenzo Gary A De
Original Assignee
G
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Publication of NZ503485A publication Critical patent/NZ503485A/en

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    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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WO1999025687A1 (fr) 1999-05-27
ZA9810412B (en) 1999-12-09
EP1042290A1 (fr) 2000-10-11
NO20002469L (no) 2000-07-12
AU1373299A (en) 1999-06-07
US6541489B1 (en) 2003-04-01
US20040048852A1 (en) 2004-03-11
AR016010A1 (es) 2001-05-30
RU2250105C2 (ru) 2005-04-20
JP2001523662A (ja) 2001-11-27
BR9814643A (pt) 2000-10-03
US6890937B2 (en) 2005-05-10
AU756150B2 (en) 2003-01-02
AU756150C (en) 2004-03-04
NO20002469D0 (no) 2000-05-12
PL341379A1 (en) 2001-04-09
US20060084688A1 (en) 2006-04-20
CN1279669A (zh) 2001-01-10
IL135106A0 (en) 2001-05-20

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