ZA984440B - Compounds their preparation and their use for the transfer of nucleic acids into cells - Google Patents

Compounds their preparation and their use for the transfer of nucleic acids into cells

Info

Publication number
ZA984440B
ZA984440B ZA984440A ZA984440A ZA984440B ZA 984440 B ZA984440 B ZA 984440B ZA 984440 A ZA984440 A ZA 984440A ZA 984440 A ZA984440 A ZA 984440A ZA 984440 B ZA984440 B ZA 984440B
Authority
ZA
South Africa
Prior art keywords
compounds
nucleic acids
cells
transfer
preparation
Prior art date
Application number
ZA984440A
Other languages
English (en)
Inventor
Daniel Scherman
Catherine Dubertret
Gerardo Byk
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of ZA984440B publication Critical patent/ZA984440B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/12—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
ZA984440A 1997-05-28 1998-05-25 Compounds their preparation and their use for the transfer of nucleic acids into cells ZA984440B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9706549A FR2763943B1 (fr) 1997-05-28 1997-05-28 Composes, leur preparation et leur utilisation pour le transfert d'acides nucleiques dans les cellules

Publications (1)

Publication Number Publication Date
ZA984440B true ZA984440B (en) 1998-12-10

Family

ID=9507333

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA984440A ZA984440B (en) 1997-05-28 1998-05-25 Compounds their preparation and their use for the transfer of nucleic acids into cells

Country Status (17)

Country Link
US (1) US6300321B1 (de)
EP (1) EP0984925B1 (de)
JP (1) JP4467084B2 (de)
KR (1) KR20010013029A (de)
CN (1) CN1131208C (de)
AT (1) ATE284383T1 (de)
AU (1) AU738320B2 (de)
BR (1) BR9809506A (de)
CA (1) CA2290664C (de)
DE (1) DE69828045T2 (de)
FR (1) FR2763943B1 (de)
HU (1) HUP0001937A3 (de)
IL (1) IL132951A0 (de)
NO (1) NO314497B1 (de)
PL (1) PL336983A1 (de)
WO (1) WO1998054130A1 (de)
ZA (1) ZA984440B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7314926B1 (en) 1999-04-08 2008-01-01 Antisoma Research Limited Antiproliferative activity of g-rich oligonucleotides and method of using same to bind to nucleolin
US8114850B2 (en) 1999-04-08 2012-02-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US7960540B2 (en) 1999-04-08 2011-06-14 Advanced Cancer Therapeutics, Llc Antiproliferative activity of G-rich oligonucleotides and method of using same to bind to nucleolin
US20020091242A1 (en) 2000-10-11 2002-07-11 Michel Bessodes Acid-sensitive compounds, their preparation and uses
WO2002043769A2 (en) * 2000-11-29 2002-06-06 Gencell S.A. Neutral and anionic colloidal particles for gene delivery
US20030134423A1 (en) * 2002-01-04 2003-07-17 Chu Yong Liang Compounds for delivering substances into cells
EP1513538A4 (de) * 2002-06-14 2007-08-22 Mirus Bio Corp Neuartige verfahren zum einbringen von polynukleotiden in zellen
AU2004246904B2 (en) * 2003-06-18 2010-02-04 Biolab Ltd. Sphingolipids polyalkylamine conjugates for use in transfection
US7906122B2 (en) * 2003-06-18 2011-03-15 Yissum Research Development Company Of The Hebrew University Of Jersusalem Sphingoid polyalkylamine conjugates for Hepatitis B virus vaccination
GB0413613D0 (en) * 2004-06-17 2004-07-21 Univ London Small molecule carriers
US7973084B2 (en) 2005-04-28 2011-07-05 Postech Academy-Industrial Foundation Molecular transporters based on alditol or inositol and processes for the preparation thereof
KR100699279B1 (ko) 2005-04-28 2007-03-23 학교법인 포항공과대학교 당 또는 당 유사체를 골격으로 하는 분자 수송체 및 그의제조방법
KR20080088570A (ko) * 2005-08-10 2008-10-02 더 존스 홉킨스 유니버시티 항기생충 및 항암 치료제 및 라이신-특이적인 디메틸라제억제제로 유용한 폴리아민
GB0613753D0 (en) * 2006-07-11 2006-08-23 Norwegian Radium Hospital Res Method
ES3065854T3 (en) 2011-12-07 2026-05-08 Alnylam Pharmaceuticals Inc Biodegradable lipids for the delivery of active agents
IL316479A (en) 2014-06-25 2024-12-01 Acuitas Therapeutics Inc Novel lipids and lipid nanoparticle compositions for nucleic acid delivery
HUE067372T2 (hu) 2015-06-29 2024-10-28 Acuitas Therapeutics Inc Lipidek és nanoszemcsés lipid formulázások nukleinsavak beadására
RS63986B1 (sr) 2015-10-28 2023-03-31 Acuitas Therapeutics Inc Novi lipidi i lipidne formulacije nanočestica za isporuku nukleinskih kiselina
US12491261B2 (en) 2016-10-26 2025-12-09 Acuitas Therapeutics, Inc. Lipid nanoparticle formulations
WO2018191657A1 (en) 2017-04-13 2018-10-18 Acuitas Therapeutics, Inc. Lipids for delivery of active agents
ES2981244T3 (es) 2017-04-28 2024-10-07 Acuitas Therapeutics Inc Novedosas formulaciones de nanopartículas de lípidos de carbonilo y lípidos para la administración de ácidos nucleicos
US11639329B2 (en) 2017-08-16 2023-05-02 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations
WO2019036030A1 (en) 2017-08-17 2019-02-21 Acuitas Therapeutics, Inc. LIPIDS FOR USE IN LIPID NANOPARTICLE FORMULATIONS
US11542225B2 (en) 2017-08-17 2023-01-03 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations
EP4501322A3 (de) 2017-08-17 2025-04-16 Acuitas Therapeutics, Inc. Lipide zur verwendung in lipidnanopartikelformulierungen
IL281615B2 (en) 2018-09-21 2026-01-01 Acuitas Therapeutics Inc Systems and methods for producing lipid nanoparticles and liposomes
US12583816B2 (en) 2018-10-18 2026-03-24 Acuitas Therapeutics, Inc. Lipids for lipid nanoparticle delivery of active agents
JP7523449B2 (ja) 2019-01-11 2024-07-26 アクイタス セラピューティクス インコーポレイテッド 活性剤の脂質ナノ粒子送達のための脂質
JP7798855B2 (ja) 2020-07-16 2026-01-14 アクイタス セラピューティクス インコーポレイテッド 脂質ナノ粒子に使用するためのカチオン性脂質
CA3242402A1 (en) 2021-12-16 2023-06-22 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0730405A4 (de) * 1993-11-24 1997-02-19 Megabios Corp Amphiphile guanidin-derivate
US5777153A (en) * 1994-07-08 1998-07-07 Gilead Sciences, Inc. Cationic lipids
FR2727679B1 (fr) * 1994-12-05 1997-01-03 Rhone Poulenc Rorer Sa Nouveaux agents de transfection et leurs applications pharmaceutiques
FR2730637B1 (fr) * 1995-02-17 1997-03-28 Rhone Poulenc Rorer Sa Composition pharmaceutique contenant des acides nucleiques, et ses utilisations
FR2741066B1 (fr) * 1995-11-14 1997-12-12 Rhone Poulenc Rorer Sa Nouveaux agents de transfection et leurs applications pharmaceutiques
DE69703878T2 (de) * 1996-03-01 2001-04-26 Centre National De La Recherche Scientifique (C.N.R.S.), Paris Guanidinium-verbindungen, pharmazeutische präparate davon und ihre verwendungen

Also Published As

Publication number Publication date
JP4467084B2 (ja) 2010-05-26
EP0984925B1 (de) 2004-12-08
KR20010013029A (ko) 2001-02-26
IL132951A0 (en) 2001-03-19
PL336983A1 (en) 2000-07-31
EP0984925A1 (de) 2000-03-15
CN1131208C (zh) 2003-12-17
DE69828045D1 (de) 2005-01-13
WO1998054130A1 (fr) 1998-12-03
CA2290664C (fr) 2010-04-13
NO314497B1 (no) 2003-03-31
AU738320B2 (en) 2001-09-13
CA2290664A1 (fr) 1998-12-03
NO995808D0 (no) 1999-11-26
AU8022198A (en) 1998-12-30
ATE284383T1 (de) 2004-12-15
FR2763943B1 (fr) 1999-07-09
US6300321B1 (en) 2001-10-09
HUP0001937A2 (hu) 2000-10-28
CN1257480A (zh) 2000-06-21
JP2002502388A (ja) 2002-01-22
FR2763943A1 (fr) 1998-12-04
HUP0001937A3 (en) 2003-10-28
BR9809506A (pt) 2000-06-20
DE69828045T2 (de) 2005-12-01
NO995808L (no) 1999-11-26

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