ZA984466B - Process for obtaining quinapril hydrochloride and solvates useful for the isolation and purification of quinapril hydrochloride - Google Patents

Process for obtaining quinapril hydrochloride and solvates useful for the isolation and purification of quinapril hydrochloride

Info

Publication number: ZA984466B
Authority: ZA; South Africa
Prior art keywords: quinapril hydrochloride; solvate; quinapril; obtaining; isolation
Prior art date: 1997-05-29

Application number

ZA984466A

Other languages

English (en)

Inventor

Montserrat Monsalva Liagostera

Marti Bartra Sanmarti

Jaime Tomas Navarro

Salvador Poug Torres

Original Assignee

Esteve Quimica Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-05-29

Filing date

1998-05-26

Publication date

1998-12-01

1998-05-26 Application filed by Esteve Quimica Sa filed Critical Esteve Quimica Sa

1998-12-01 Publication of ZA984466B publication Critical patent/ZA984466B/xx

Links

229960003042 quinapril hydrochloride Drugs 0.000 title abstract 6
IBBLRJGOOANPTQ-JKVLGAQCSA-N quinapril hydrochloride Chemical compound Cl.C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 IBBLRJGOOANPTQ-JKVLGAQCSA-N 0.000 title abstract 6
239000012453 solvate Substances 0.000 title abstract 5
238000000034 method Methods 0.000 title abstract 2
238000002955 isolation Methods 0.000 title 1
238000000746 purification Methods 0.000 title 1
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 6
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 3
239000002904 solvent Substances 0.000 abstract 3
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 2
238000001035 drying Methods 0.000 abstract 2
JSDRRTOADPPCHY-HSQYWUDLSA-N quinapril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](CC2=CC=CC=C2C1)C(O)=O)CC1=CC=CC=C1 JSDRRTOADPPCHY-HSQYWUDLSA-N 0.000 abstract 2
230000001476 alcoholic effect Effects 0.000 abstract 1
229940030600 antihypertensive agent Drugs 0.000 abstract 1
239000002220 antihypertensive agent Substances 0.000 abstract 1
-1 benzyl ester Chemical class 0.000 abstract 1
230000000593 degrading effect Effects 0.000 abstract 1
229910000041 hydrogen chloride Inorganic materials 0.000 abstract 1
IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 abstract 1
238000005984 hydrogenation reaction Methods 0.000 abstract 1
238000007327 hydrogenolysis reaction Methods 0.000 abstract 1
229960001455 quinapril Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Other In-Based Heterocyclic Compounds (AREA)

ZA984466A 1997-05-29 1998-05-26 Process for obtaining quinapril hydrochloride and solvates useful for the isolation and purification of quinapril hydrochloride ZA984466B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ES09701169A ES2122941B1 (es)	1997-05-29	1997-05-29	Procedimiento para la obtencion de quinapril clorhidrato y solvatos utiles para el aislamiento y purificacion de quinapril clorhidrato.

Publications (1)

Publication Number	Publication Date
ZA984466B true ZA984466B (en)	1998-12-01

Family

ID=8299498

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA984466A ZA984466B (en)	1997-05-29	1998-05-26	Process for obtaining quinapril hydrochloride and solvates useful for the isolation and purification of quinapril hydrochloride

Country Status (13)

Country	Link
US (2)	USRE39888E1 (da)
EP (1)	EP0992495B1 (da)
JP (1)	JP2002502386A (da)
KR (1)	KR100477713B1 (da)
AT (1)	ATE258920T1 (da)
AU (1)	AU730140B2 (da)
CA (1)	CA2293705C (da)
DE (1)	DE69821483T2 (da)
DK (1)	DK0992495T3 (da)
ES (1)	ES2122941B1 (da)
PT (1)	PT992495E (da)
WO (1)	WO1998054149A1 (da)
ZA (1)	ZA984466B (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20030225124A1 (en) *	1999-08-31	2003-12-04	Spiridon Spireas	Stable formulations of ACE inhibitors, and methods for preparation thereof
AU2002361494A1 (en)	2002-12-16	2004-07-09	Lupin Limited	Crystalline form of quinapril hydrochloride and process for preparing the same
CL2004000541A1 (es)	2003-03-31	2005-02-04	Warner Lambert Co	Procedimiento de preparacion de clorhidrato de quinapril por reaccion entre una 2,5-dioxo-oxazolidina y un ester terbutilico de una tetrahidro isoquinolina, util como principio activo para tratar la hipertension y la insuficiencia cardiaca congestiva
WO2007054966A2 (en) *	2005-09-13	2007-05-18	Aarti Healthcare Limited	A process for the preparation of highly pure crystalline quinapril hydrochloride
WO2007069268A2 (en) *	2005-10-14	2007-06-21	Sun Pharmaceutical Industries Limited	A process for the preparation of substantially pure 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives
WO2009053994A1 (en) *	2007-10-26	2009-04-30	Matrix Laboratories Limited	Process for preparing pure amorphous quinapril hydrochloride

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4344949A (en) *	1980-10-03	1982-08-17	Warner-Lambert Company	Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
IN156096B (da) *	1981-03-19	1985-05-11	Usv Pharma Corp
JPS58188857A (ja) *	1982-04-26	1983-11-04	Takeda Chem Ind Ltd	テトラヒドロイソキノリン誘導体
DE3333454A1 (de) *	1983-09-16	1985-04-11	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
DE3333455A1 (de) *	1983-09-16	1985-04-11	Hoechst Ag, 6230 Frankfurt	Verfahren zur herstellung n-alkylierter dipeptide und deren estern
US4761479A (en) *	1987-03-30	1988-08-02	Warner-Lambert Company	Crystalline quinapril and a process for producing the same
JPH01275546A (ja) *	1988-04-26	1989-11-06	Nisso Yuka Kogyo Kk	安息香酸ソーダの単離方法
DE4206697A1 (de) *	1992-03-04	1993-09-09	Hoechst Ag	Verfahren zur herstellung von modifizierten phenolharzen
JP3211396B2 (ja) *	1992-08-26	2001-09-25	住友化学工業株式会社	アクリル酸及び酢酸の回収方法

1997
- 1997-05-29 ES ES09701169A patent/ES2122941B1/es not_active Expired - Fee Related
1998
- 1998-05-25 US US11/022,424 patent/USRE39888E1/en not_active Expired - Fee Related
- 1998-05-25 EP EP98920547A patent/EP0992495B1/en not_active Expired - Lifetime
- 1998-05-25 CA CA002293705A patent/CA2293705C/en not_active Expired - Fee Related
- 1998-05-25 JP JP50027999A patent/JP2002502386A/ja active Pending
- 1998-05-25 DE DE1998621483 patent/DE69821483T2/de not_active Expired - Lifetime
- 1998-05-25 US US09/424,673 patent/US6617457B1/en not_active Ceased
- 1998-05-25 AT AT98920547T patent/ATE258920T1/de not_active IP Right Cessation
- 1998-05-25 DK DK98920547T patent/DK0992495T3/da active
- 1998-05-25 PT PT98920547T patent/PT992495E/pt unknown
- 1998-05-25 KR KR10-1999-7011151A patent/KR100477713B1/ko not_active Expired - Fee Related
- 1998-05-25 AU AU73365/98A patent/AU730140B2/en not_active Ceased
- 1998-05-25 WO PCT/ES1998/000145 patent/WO1998054149A1/es not_active Ceased
- 1998-05-26 ZA ZA984466A patent/ZA984466B/xx unknown

Also Published As

Publication number	Publication date
EP0992495A1 (en)	2000-04-12
USRE39888E1 (en)	2007-10-16
DK0992495T3 (da)	2004-06-01
ATE258920T1 (de)	2004-02-15
EP0992495B1 (en)	2004-02-04
ES2122941A1 (es)	1998-12-16
PT992495E (pt)	2004-06-30
AU7336598A (en)	1998-12-30
DE69821483D1 (de)	2004-03-11
CA2293705A1 (en)	1998-12-03
ES2122941B1 (es)	1999-07-01
AU730140B2 (en)	2001-03-01
JP2002502386A (ja)	2002-01-22
KR100477713B1 (ko)	2005-03-18
KR20010013167A (ko)	2001-02-26
DE69821483T2 (de)	2005-01-13
CA2293705C (en)	2008-03-18
US6617457B1 (en)	2003-09-09
WO1998054149A1 (es)	1998-12-03

Publication	Publication Date	Title
ATE231496T1 (de)	2003-02-15	Saccharinderivate als proteolytische enzyminhibitoren
NO20022251L (no)	2002-07-05	Interferon-gamma-konjugater
WO2003030886A3 (en)	2003-08-07	Allylamides useful in the treatment of alzheimer's disease
FI955855A0 (fi)	1995-12-05	Menetelmä ksylitolin tuottamiseksi
ZA984466B (en)	1998-12-01	Process for obtaining quinapril hydrochloride and solvates useful for the isolation and purification of quinapril hydrochloride
BR9003011A (pt)	1991-08-20	Processo para purificacao de triptofano
EP1348712A4 (en)	2008-04-02	L-NUCLEIC ACID DERIVATIVES AND METHOD FOR THEIR SYNTHESIS
EP1327626A4 (en)	2004-08-18	PRAVASTATIN PURIFICATION PROCESS
GB2336365B (en)	2000-09-06	Woolgrease
ID26210A (id)	2000-12-07	Proses pemurnian turunan sefalosporin
IL146746A0 (en)	2002-07-25	New process for the purification of aldehyde impurities
PT763047E (pt)	2002-07-31	Novo processo para a preparacao de nucleosidos
ES2149281T3 (es)	2000-11-01	Derivado opticamente activo de imidazolidinona y su proceso de fabricacion.
AU1725401A (en)	2001-07-16	Process for the recovery of purified terephthalic acid (pta)
HUP0002119A2 (hu)	2000-11-28	Eljárás nehézfémek eltávolítására
ES2193524T3 (es)	2003-11-01	Procedimiento de preparacion de acido azetidino-2-carboxilico.
BRPI9807312B8 (pt)	2016-09-13	derivados de (4-piperidinil)-1h-2-benzopirano úteis como agentes antipsicóticos, composição farmacêutica e processo para a preparação dos referidos derivados
IL150155A0 (en)	2002-12-01	Process for the recovery and recycle of d-tartaric acid
DK0985680T3 (da)	2003-01-06	Fremgangsmåde til oprensning af roxithromycin
TW374758B (en)	1999-11-21	The process for preparing an optical active erythro-3-amino-2-hydroxyl butyrate
HUP0004840A2 (hu)	2001-04-28	Eljárás kolchikon vegyületeknek a megfelelő 3-glikozil származékokká történő biotranszformációjára
DK1214315T5 (da)	2004-06-21	1,4-Dihydropyridin-5-carboxylsyreesterderivater og fremgangsmåde til fremstilling af samme
EP0984017A3 (en)	2001-05-16	Improved process for the production of an N-acyl derivative of O,S-dialkyl phosphoroamidothioate
NO20004278L (no)	2000-08-25	Fremstilling av 2-oksopiperaziner pÕ en fast bærer
PT102116B (pt)	2002-06-28	Processo de producao de sulfoxido benzimidazolicos por oxidacao de tioeteres utilizando o sistema peroxido de hidrogenio/ alquiltrioxido de renio/base