ZA985218B - Novel sulfonamide inhibitors of farnesyl-protein transferase - Google Patents

Novel sulfonamide inhibitors of farnesyl-protein transferase

Info

Publication number
ZA985218B
ZA985218B ZA985218A ZA985218A ZA985218B ZA 985218 B ZA985218 B ZA 985218B ZA 985218 A ZA985218 A ZA 985218A ZA 985218 A ZA985218 A ZA 985218A ZA 985218 B ZA985218 B ZA 985218B
Authority
ZA
South Africa
Prior art keywords
farnesyl
protein transferase
novel sulfonamide
sulfonamide inhibitors
inhibitors
Prior art date
Application number
ZA985218A
Other languages
English (en)
Inventor
F George Njoroge
Bancha Vibulbhan
Arthur G Taveras
Ronald J Doll
Viyyoor M Girijavallabhan
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of ZA985218B publication Critical patent/ZA985218B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D221/00Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04Ortho- or peri-condensed ring systems
    • C07D221/06Ring systems of three rings
    • C07D221/16Ring systems of three rings containing carbocyclic rings other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
ZA985218A 1997-06-17 1998-06-15 Novel sulfonamide inhibitors of farnesyl-protein transferase ZA985218B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87705097A 1997-06-17 1997-06-17

Publications (1)

Publication Number Publication Date
ZA985218B true ZA985218B (en) 1998-12-15

Family

ID=25369146

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA985218A ZA985218B (en) 1997-06-17 1998-06-15 Novel sulfonamide inhibitors of farnesyl-protein transferase

Country Status (14)

Country Link
EP (1) EP0989980A1 (fr)
JP (1) JP2002507192A (fr)
KR (1) KR20010013826A (fr)
CN (1) CN1267290A (fr)
AR (1) AR012989A1 (fr)
AU (1) AU8253698A (fr)
CA (1) CA2293358C (fr)
CO (1) CO4940475A1 (fr)
HU (1) HUP0004627A2 (fr)
IL (1) IL133393A0 (fr)
NZ (1) NZ501619A (fr)
PE (1) PE86199A1 (fr)
WO (1) WO1998057949A1 (fr)
ZA (1) ZA985218B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6689789B2 (en) 1997-06-17 2004-02-10 Schering Corporation Compounds useful for inhibition of farnesyl protein transferase
US7517884B2 (en) 1998-03-30 2009-04-14 Kalypsys Inc. Sulfonyl-substituted bicyclic compounds as modulators of PPAR
US7342016B2 (en) 2000-08-30 2008-03-11 Schering Corporation Farnesyl protein transferase inhibitors as antitumor agents
EP1337522B1 (fr) * 2000-11-29 2007-08-29 Schering Corporation Inhibiteurs de farnesyl proteine transferase
CA2585172C (fr) 2004-10-29 2014-08-12 Kalypsys, Inc. Composes bicycliques a substitution sulfonyle, modulateurs des ppars
HUE040020T2 (hu) 2005-10-25 2019-02-28 Kalypsys Inc PPAR modulátorok sói és eljárások metabolikus betegségek kezelésére
WO2008091863A1 (fr) 2007-01-23 2008-07-31 Kalypsys, Inc. Composés bicycliques substitués par sulfonyle utilisés comme modulateurs de ppar dans le traitement de la stéatohépatite non alcoolique
US9796717B2 (en) * 2013-02-19 2017-10-24 Icahn School Of Medicine At Mount Sinai Tricyclic heterocycles as anticancer agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL111257A0 (en) * 1993-10-15 1994-12-29 Schering Corp Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
IL117797A0 (en) * 1995-04-07 1996-08-04 Pharmacopeia Inc Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL117798A (en) * 1995-04-07 2001-11-25 Schering Plough Corp Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them

Also Published As

Publication number Publication date
AR012989A1 (es) 2000-11-22
IL133393A0 (en) 2001-04-30
HUP0004627A2 (hu) 2001-10-28
PE86199A1 (es) 1999-09-24
CA2293358C (fr) 2008-08-05
NZ501619A (en) 2002-02-01
EP0989980A1 (fr) 2000-04-05
CA2293358A1 (fr) 1998-12-23
JP2002507192A (ja) 2002-03-05
CO4940475A1 (es) 2000-07-24
WO1998057949A1 (fr) 1998-12-23
KR20010013826A (ko) 2001-02-26
CN1267290A (zh) 2000-09-20
AU8253698A (en) 1999-01-04

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