PE86199A1 - Sulfonamida inhibidor de la enzima farnesilo transferasa - Google Patents
Sulfonamida inhibidor de la enzima farnesilo transferasaInfo
- Publication number
- PE86199A1 PE86199A1 PE1998000508A PE00050898A PE86199A1 PE 86199 A1 PE86199 A1 PE 86199A1 PE 1998000508 A PE1998000508 A PE 1998000508A PE 00050898 A PE00050898 A PE 00050898A PE 86199 A1 PE86199 A1 PE 86199A1
- Authority
- PE
- Peru
- Prior art keywords
- cells
- transferasa
- aryl
- alkyl
- farnesilo
- Prior art date
Links
- 229940125532 enzyme inhibitor Drugs 0.000 title 1
- 239000002532 enzyme inhibitor Substances 0.000 title 1
- 229940124530 sulfonamide Drugs 0.000 title 1
- 150000003456 sulfonamides Chemical class 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 210000004881 tumor cell Anatomy 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 abstract 1
- 230000002159 abnormal effect Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229950008696 farnesil Drugs 0.000 abstract 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- CBEQRNSPHCCXSH-UHFFFAOYSA-N iodine monobromide Chemical group IBr CBEQRNSPHCCXSH-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000001685 thyroid gland Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87705097A | 1997-06-17 | 1997-06-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE86199A1 true PE86199A1 (es) | 1999-09-24 |
Family
ID=25369146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1998000508A PE86199A1 (es) | 1997-06-17 | 1998-06-15 | Sulfonamida inhibidor de la enzima farnesilo transferasa |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0989980A1 (fr) |
| JP (1) | JP2002507192A (fr) |
| KR (1) | KR20010013826A (fr) |
| CN (1) | CN1267290A (fr) |
| AR (1) | AR012989A1 (fr) |
| AU (1) | AU8253698A (fr) |
| CA (1) | CA2293358C (fr) |
| CO (1) | CO4940475A1 (fr) |
| HU (1) | HUP0004627A2 (fr) |
| IL (1) | IL133393A0 (fr) |
| NZ (1) | NZ501619A (fr) |
| PE (1) | PE86199A1 (fr) |
| WO (1) | WO1998057949A1 (fr) |
| ZA (1) | ZA985218B (fr) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6689789B2 (en) | 1997-06-17 | 2004-02-10 | Schering Corporation | Compounds useful for inhibition of farnesyl protein transferase |
| US7517884B2 (en) | 1998-03-30 | 2009-04-14 | Kalypsys Inc. | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
| US7342016B2 (en) | 2000-08-30 | 2008-03-11 | Schering Corporation | Farnesyl protein transferase inhibitors as antitumor agents |
| EP1337522B1 (fr) * | 2000-11-29 | 2007-08-29 | Schering Corporation | Inhibiteurs de farnesyl proteine transferase |
| CA2585172C (fr) | 2004-10-29 | 2014-08-12 | Kalypsys, Inc. | Composes bicycliques a substitution sulfonyle, modulateurs des ppars |
| HUE040020T2 (hu) | 2005-10-25 | 2019-02-28 | Kalypsys Inc | PPAR modulátorok sói és eljárások metabolikus betegségek kezelésére |
| WO2008091863A1 (fr) | 2007-01-23 | 2008-07-31 | Kalypsys, Inc. | Composés bicycliques substitués par sulfonyle utilisés comme modulateurs de ppar dans le traitement de la stéatohépatite non alcoolique |
| US9796717B2 (en) * | 2013-02-19 | 2017-10-24 | Icahn School Of Medicine At Mount Sinai | Tricyclic heterocycles as anticancer agents |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL111257A0 (en) * | 1993-10-15 | 1994-12-29 | Schering Corp | Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases |
| IL117797A0 (en) * | 1995-04-07 | 1996-08-04 | Pharmacopeia Inc | Tricyclic compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
| IL117798A (en) * | 1995-04-07 | 2001-11-25 | Schering Plough Corp | Tricyclic compounds useful for inhibiting the function of protein - G and for the treatment of malignant diseases, and pharmaceutical preparations containing them |
-
1998
- 1998-06-15 AU AU82536/98A patent/AU8253698A/en not_active Abandoned
- 1998-06-15 NZ NZ501619A patent/NZ501619A/en unknown
- 1998-06-15 WO PCT/US1998/011508 patent/WO1998057949A1/fr not_active Ceased
- 1998-06-15 KR KR1019997011846A patent/KR20010013826A/ko not_active Withdrawn
- 1998-06-15 CN CN98808186A patent/CN1267290A/zh active Pending
- 1998-06-15 ZA ZA985218A patent/ZA985218B/xx unknown
- 1998-06-15 IL IL13339398A patent/IL133393A0/xx unknown
- 1998-06-15 CA CA002293358A patent/CA2293358C/fr not_active Expired - Fee Related
- 1998-06-15 HU HU0004627A patent/HUP0004627A2/hu unknown
- 1998-06-15 PE PE1998000508A patent/PE86199A1/es not_active Application Discontinuation
- 1998-06-15 EP EP98932718A patent/EP0989980A1/fr not_active Withdrawn
- 1998-06-15 JP JP54752198A patent/JP2002507192A/ja active Pending
- 1998-06-16 AR ARP980102859A patent/AR012989A1/es unknown
- 1998-06-16 CO CO98034142A patent/CO4940475A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR012989A1 (es) | 2000-11-22 |
| ZA985218B (en) | 1998-12-15 |
| IL133393A0 (en) | 2001-04-30 |
| HUP0004627A2 (hu) | 2001-10-28 |
| CA2293358C (fr) | 2008-08-05 |
| NZ501619A (en) | 2002-02-01 |
| EP0989980A1 (fr) | 2000-04-05 |
| CA2293358A1 (fr) | 1998-12-23 |
| JP2002507192A (ja) | 2002-03-05 |
| CO4940475A1 (es) | 2000-07-24 |
| WO1998057949A1 (fr) | 1998-12-23 |
| KR20010013826A (ko) | 2001-02-26 |
| CN1267290A (zh) | 2000-09-20 |
| AU8253698A (en) | 1999-01-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |