ZA985352B - Barbituric acid derivatives with antimetastatic and antitumor activity. - Google Patents

Barbituric acid derivatives with antimetastatic and antitumor activity.

Info

Publication number: ZA985352B
Authority: ZA; South Africa
Prior art keywords: antimetastatic; acid derivatives; antitumor activity; barbituric acid; barbituric
Prior art date: 1997-06-21

Application number

ZA9805352A

Other languages

English (en)

Inventor

Ambrogio Oliva

Gianpiero De Cillis

Frank Grams

Valeria Livi

Gerd Zimmermann

Ernesto Menta

Hans-Willi Krell

Original Assignee

Roche Diagnostics Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-06-21

Filing date

1998-06-19

Publication date

1999-12-20

1998-06-19 Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh

1999-12-20 Publication of ZA985352B publication Critical patent/ZA985352B/xx

Links

230000002001 anti-metastasis Effects 0.000 title 1
230000000259 anti-tumor effect Effects 0.000 title 1
150000007656 barbituric acids Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- C07D239/62—Barbituric acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Hematology (AREA)
Oncology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

ZA9805352A 1997-06-21 1998-06-19 Barbituric acid derivatives with antimetastatic and antitumor activity. ZA985352B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP97110200		1997-06-21

Publications (1)

Publication Number	Publication Date
ZA985352B true ZA985352B (en)	1999-12-20

Family

ID=8226939

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9805352A ZA985352B (en)	1997-06-21	1998-06-19	Barbituric acid derivatives with antimetastatic and antitumor activity.

Country Status (18)

Country	Link
US (1)	US6335332B1 (de)
EP (1)	EP0989982B1 (de)
JP (1)	JP2002504916A (de)
KR (1)	KR20010014020A (de)
CN (1)	CN1295227C (de)
AR (1)	AR018997A1 (de)
AT (1)	ATE302200T1 (de)
AU (1)	AU746853B2 (de)
BR (1)	BR9810450A (de)
CA (1)	CA2294259A1 (de)
CO (1)	CO4940451A1 (de)
DE (1)	DE69831233T2 (de)
ES (1)	ES2247707T3 (de)
HR (1)	HRP980340A2 (de)
MA (1)	MA24573A1 (de)
TR (1)	TR199903148T2 (de)
WO (1)	WO1998058925A1 (de)
ZA (1)	ZA985352B (de)

Families Citing this family (31)

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AUPO190596A0 (en)	1996-08-26	1996-09-19	Alchemia Pty Ltd	Oligosaccharide synthesis
AUPO937597A0 (en) *	1997-09-24	1997-10-16	Alchemia Pty Ltd	Protecting and linking groups for organic synthesis
US6265578B1 (en) *	1999-02-12	2001-07-24	Hoffmann-La Roche Inc.	Pyrimidine-2,4,6-triones
HN2000000137A (es) *	1999-08-12	2001-02-02	Pfizer Prod Inc	Pirimidina-2,4,6-trionas inhibidores de metaloproteinasas
EP1276728A2 (de)	2000-04-24	2003-01-22	ARYx Therapeutics	Ultrakurz wirksame hypnotische barbiturate
US6841671B2 (en)	2000-10-26	2005-01-11	Pfizer Inc.	Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors
AP2001002319A0 (en) *	2000-10-26	2001-12-31	Pfizer Prod Inc	Pyrimidine-2,4,6-trione metalloproteinase inhibitors.
CZ20031083A3 (cs) *	2000-10-26	2004-03-17	Pfizer Products Inc.	5-Spiropyrimidin-2, 4, 6-trionové inhibitory metaloproteinasy
SE0100902D0 (sv)	2001-03-15	2001-03-15	Astrazeneca Ab	Compounds
CN100338041C (zh) *	2001-05-03	2007-09-19	霍夫曼-拉罗奇有限公司	明胶酶抑制剂与抗肿瘤剂的组合以及其应用
NI200300045A (es) *	2002-04-26	2005-07-08	Pfizer Prod Inc	Inhibidores de triariloxiariloxipirimidin-2,4,6-triona de metaloproteinasa.
AU2003216660A1 (en)	2002-04-26	2003-11-10	Pfizer Products Inc.	N-substituted-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors
JP2005527598A (ja)	2002-04-26	2005-09-15	ファイザー・プロダクツ・インク	トリアリール−オキシ−アリール−スピロ−ピリミジン−２，４，６−トリオンメタロプロテイナーゼ阻害剤
MXPA04010550A (es)	2002-04-26	2005-01-25	Pfizer Prod Inc	Inhibidores de metaloproteinasa de pirimidina-2,4,6-triona.
WO2005097133A1 (en) *	2004-04-01	2005-10-20	F. Hoffmann-La Roche Ag	Use of a trioxopyrimidine for the treatment and prevention of bronchial inflammatory diseases
KR100837137B1 (ko) *	2004-04-01	2008-06-11	에프. 호프만-라 로슈 아게	기관지 염증성 질환의 치료 및 예방을 위한트리옥소피리미딘의 용도
US10022352B2 (en)	2006-04-07	2018-07-17	Vertex Pharmaceuticals Incorporated	Modulators of ATP-binding cassette transporters
USRE50453E1 (en)	2006-04-07	2025-06-10	Vertex Pharmaceuticals Incorporated	Indole derivatives as CFTR modulators
JP5420395B2 (ja)	2006-04-07	2014-02-19	バーテックスファーマシューティカルズインコーポレイテッド	Ａｔｐ結合カセット輸送体の調節剤
US7645789B2 (en)	2006-04-07	2010-01-12	Vertex Pharmaceuticals Incorporated	Indole derivatives as CFTR modulators
US8563573B2 (en)	2007-11-02	2013-10-22	Vertex Pharmaceuticals Incorporated	Azaindole derivatives as CFTR modulators
KR100862969B1 (ko)	2007-03-05	2008-10-13	바이오스펙트럼 주식회사	바르비투르산을 유효성분으로 포함하는 피부 미백제
US8802868B2 (en)	2010-03-25	2014-08-12	Vertex Pharmaceuticals Incorporated	Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
RU2569678C2 (ru)	2010-04-22	2015-11-27	Вертекс Фармасьютикалз Инкорпорейтед	Способ получения циклоалкилкарбоксамидо-индольных соединений
AU2013290444B2 (en)	2012-07-16	2018-04-26	Vertex Pharmaceuticals Incorporated	Pharmaceutical compositions of (R)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl) cyclopropanecarboxamide and administration thereof
US10093631B2 (en)	2014-02-14	2018-10-09	Acquist Llc	Bifunctional compounds and use for reducing uric acid levels
PL3925607T5 (pl)	2014-04-15	2026-06-01	Vertex Pharmaceuticals Incorporated	Kompozycje farmaceutyczne do leczenia chorób, w których pośredniczy mukowiscydozowy przezbłonowy regulator przewodnictwa
CN107108526A (zh)	2015-01-22	2017-08-29	R·P·小沃勒尔	双功能化合物及用于降低尿酸水平的用途
TWI771303B (zh)	2016-06-30	2022-07-21	美商艾克奎斯特有限責任公司	化合物及其於降低尿酸位準之用途(一)
EP3481819B1 (de)	2016-07-06	2022-06-01	Acquist LLC	Verbindungen und deren verwendung zur reduzierung des harnsäurespiegels
LV15384B (lv)	2017-07-24	2019-05-20	Latvijas Organiskās Sintēzes Institūts	1-Acetil-5-nitro-4-fenil-3-pirolin-2-ons pielietošanai vēža ārstēšanā

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Publication number	Priority date	Publication date	Assignee	Title
CA2068224C (en) *	1989-11-14	2005-01-25	Paul A. Marks	Novel potent inducers of terminal differentiation and method of use thereof
ATE155893T1 (de) *	1990-05-16	1997-08-15	Abbott Lab	Test für barbiturate, tracer, immunogene, antikörper und testsatz dafür
DE19548624A1 (de)	1995-12-23	1997-06-26	Boehringer Mannheim Gmbh	Neue Barbitursäure-Derivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel

1998
- 1998-06-18 EP EP98936361A patent/EP0989982B1/de not_active Expired - Lifetime
- 1998-06-18 DE DE69831233T patent/DE69831233T2/de not_active Expired - Fee Related
- 1998-06-18 TR TR1999/03148T patent/TR199903148T2/xx unknown
- 1998-06-18 CN CNB988083558A patent/CN1295227C/zh not_active Expired - Fee Related
- 1998-06-18 KR KR19997012049A patent/KR20010014020A/ko not_active Ceased
- 1998-06-18 JP JP50374899A patent/JP2002504916A/ja not_active Ceased
- 1998-06-18 WO PCT/EP1998/003677 patent/WO1998058925A1/en not_active Ceased
- 1998-06-18 AT AT98936361T patent/ATE302200T1/de not_active IP Right Cessation
- 1998-06-18 BR BR9810450-0A patent/BR9810450A/pt not_active IP Right Cessation
- 1998-06-18 CA CA002294259A patent/CA2294259A1/en not_active Abandoned
- 1998-06-18 AU AU85391/98A patent/AU746853B2/en not_active Ceased
- 1998-06-18 ES ES98936361T patent/ES2247707T3/es not_active Expired - Lifetime
- 1998-06-18 US US09/445,461 patent/US6335332B1/en not_active Expired - Fee Related
- 1998-06-19 ZA ZA9805352A patent/ZA985352B/xx unknown
- 1998-06-19 AR ARP980102928A patent/AR018997A1/es not_active Application Discontinuation
- 1998-06-19 MA MA25126A patent/MA24573A1/fr unknown
- 1998-06-19 HR HR97110200.9A patent/HRP980340A2/hr not_active Application Discontinuation
- 1998-06-23 CO CO98035555A patent/CO4940451A1/es unknown

Also Published As

Publication number	Publication date
CA2294259A1 (en)	1998-12-30
MA24573A1 (fr)	1998-12-31
JP2002504916A (ja)	2002-02-12
CN1295227C (zh)	2007-01-17
ATE302200T1 (de)	2005-09-15
EP0989982A1 (de)	2000-04-05
TR199903148T2 (xx)	2000-04-21
AU746853B2 (en)	2002-05-02
WO1998058925A1 (en)	1998-12-30
CN1267296A (zh)	2000-09-20
EP0989982B1 (de)	2005-08-17
US6335332B1 (en)	2002-01-01
DE69831233T2 (de)	2006-06-01
ES2247707T3 (es)	2006-03-01
BR9810450A (pt)	2000-09-05
AU8539198A (en)	1999-01-04
DE69831233D1 (de)	2005-09-22
CO4940451A1 (es)	2000-07-24
AR018997A1 (es)	2001-12-26
HRP980340A2 (en)	1999-02-28
KR20010014020A (ko)	2001-02-26

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ZA200006632B (en)	2001-06-01	Quinoline-aminomethyl-pyridyl derivatives with anti-helicobacter activity.
AU8526198A (en)	1999-02-22	Compounds with anti-ks and anti-hiv activity
AU8808098A (en)	1999-02-22	Bis-acridinecarboxamides having antitumor activity
GB0005108D0 (en)	2000-04-26	Glucose responsive -cell line