ZA989228B - Method for preparing substituted 4-phenyl-4-cyanocyclo-hexanoic acids - Google Patents

Method for preparing substituted 4-phenyl-4-cyanocyclo-hexanoic acids

Info

Publication number: ZA989228B
Authority: ZA; South Africa
Prior art keywords: cyanocyclo; phenyl; preparing substituted; hexanoic acids; hexanoic
Prior art date: 1997-10-10

Application number

ZA989228A

Other languages

English (en)

Inventor

Kevin Webb

Wilford Mendelson

Jianhao Chen

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-10

Filing date

1998-10-09

Publication date

1999-04-12

1998-10-09 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

1999-04-12 Publication of ZA989228B publication Critical patent/ZA989228B/xx

Links

XWFKZQVEYDVFTA-UHFFFAOYSA-N 4-cyano-4-phenylcyclohexane-1-carboxylic acid Chemical class C1CC(C(=O)O)CCC1(C#N)C1=CC=CC=C1 XWFKZQVEYDVFTA-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
- C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pulmonology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

ZA989228A 1997-10-10 1998-10-09 Method for preparing substituted 4-phenyl-4-cyanocyclo-hexanoic acids ZA989228B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US6161397P	1997-10-10	1997-10-10

Publications (1)

Publication Number	Publication Date
ZA989228B true ZA989228B (en)	1999-04-12

Family

ID=22036929

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA989228A ZA989228B (en)	1997-10-10	1998-10-09	Method for preparing substituted 4-phenyl-4-cyanocyclo-hexanoic acids

Country Status (30)

Country	Link
EP (1)	EP1043930A4 (fr)
JP (1)	JP2001519363A (fr)
KR (1)	KR100560038B1 (fr)
CN (1)	CN1192025C (fr)
AP (1)	AP1335A (fr)
AR (1)	AR015952A1 (fr)
AU (1)	AU741832B2 (fr)
BG (1)	BG104302A (fr)
BR (1)	BR9814064A (fr)
CA (1)	CA2305614A1 (fr)
DZ (1)	DZ2619A1 (fr)
EA (1)	EA003609B1 (fr)
HU (1)	HUP0003905A3 (fr)
ID (1)	ID25536A (fr)
IL (1)	IL135434A (fr)
MA (1)	MA24670A1 (fr)
MY (1)	MY122105A (fr)
NO (1)	NO20001777L (fr)
NZ (1)	NZ503759A (fr)
OA (1)	OA11347A (fr)
PE (1)	PE121599A1 (fr)
PL (1)	PL191974B1 (fr)
SA (1)	SA99191000A (fr)
SK (1)	SK4902000A3 (fr)
TR (1)	TR200000945T2 (fr)
TW (1)	TW440557B (fr)
UA (1)	UA67753C2 (fr)
UY (2)	UY25201A1 (fr)
WO (1)	WO1999018793A1 (fr)
ZA (1)	ZA989228B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9920152D0 (en) *	1999-08-25	1999-10-27	Smithkline Beecham Plc	Novel process
EP1237851A4 (fr) *	1999-12-15	2004-06-23	Smithkline Beecham	SELS D'ACIDE CARBOXYLIQUE i Cis /i -4-CYANO-4- 3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]CYCLOHEXANE-1
DE60124221T2 (de) *	2000-01-26	2007-09-13	Smithkline Beecham Corp.	Monohydrat des cis-lithium-cyano-4-3-(cyclopentyloy)-4-methoxyphenyl/cyclohexancarboxylats
CA2402384A1 (fr)	2000-03-16	2001-09-20	Inflazyme Pharmaceuticals Ltd.	Inhibiteurs benzyles de pde4
ATE305467T1 (de)	2001-01-31	2005-10-15	Pfizer Prod Inc	Als inhibitoren von pde4-isozymen geeignete etherderivate
US7250518B2 (en)	2001-01-31	2007-07-31	Pfizer Inc.	Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
IL156413A0 (en)	2001-01-31	2004-01-04	Pfizer Prod Inc	Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes
WO2002060898A1 (fr)	2001-01-31	2002-08-08	Pfizer Products Inc.	Derives amide acide de thiazolyle, oxazolyle, pyrrolyle et imidazolyle utilises en tant qu'inhibiteurs des isozymes pde4
CN102491959B (zh) *	2011-12-19	2015-03-25	江苏澄扬作物科技有限公司	一种环氧乙烷衍生物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4021478A (en) *	1972-07-13	1977-05-03	The Upjohn Company	Preparation of carboxylic acids from glycidonitriles with ionic lewis acids
HU225869B1 (en) *	1992-04-02	2007-11-28	Smithkline Beecham Corp	Compounds with antiallergic and antiinflammatory activity and pharmaceutical compns. contg. them
US5524438A (en) *	1994-12-15	1996-06-11	United Technologies Corporation	Segmented bulkhead liner for a gas turbine combustor
AR012550A1 (es) *	1997-02-12	2000-11-08	Smithkline Beecham Corp	Metodo para preparar acidos 4-fenil-4-ciano-ciclohexanoicos sustituidos y compuestos intermediarios
US6452022B1 (en) *	1997-10-10	2002-09-17	Smithkline Beecham Corporation	Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

1998
- 1998-07-10 UA UA2000041944A patent/UA67753C2/uk unknown
- 1998-10-02 MA MA25278A patent/MA24670A1/fr unknown
- 1998-10-07 ID IDW20000614A patent/ID25536A/id unknown
- 1998-10-07 NZ NZ503759A patent/NZ503759A/en unknown
- 1998-10-07 AP APAP/P/2000/001782A patent/AP1335A/en active
- 1998-10-07 UY UY25201A patent/UY25201A1/es not_active IP Right Cessation
- 1998-10-07 WO PCT/US1998/021061 patent/WO1999018793A1/fr not_active Ceased
- 1998-10-07 CN CNB988100304A patent/CN1192025C/zh not_active Expired - Fee Related
- 1998-10-07 BR BR9814064-7A patent/BR9814064A/pt not_active IP Right Cessation
- 1998-10-07 JP JP2000515437A patent/JP2001519363A/ja active Pending
- 1998-10-07 KR KR1020007003742A patent/KR100560038B1/ko not_active Expired - Fee Related
- 1998-10-07 TR TR2000/00945T patent/TR200000945T2/xx unknown
- 1998-10-07 AU AU96874/98A patent/AU741832B2/en not_active Ceased
- 1998-10-07 AR ARP980105002A patent/AR015952A1/es unknown
- 1998-10-07 EA EA200000406A patent/EA003609B1/ru not_active IP Right Cessation
- 1998-10-07 DZ DZ980229A patent/DZ2619A1/fr active
- 1998-10-07 CA CA002305614A patent/CA2305614A1/fr not_active Abandoned
- 1998-10-07 EP EP98950965A patent/EP1043930A4/fr not_active Withdrawn
- 1998-10-07 SK SK490-2000A patent/SK4902000A3/sk unknown
- 1998-10-07 IL IL13543498A patent/IL135434A/en not_active IP Right Cessation
- 1998-10-07 HU HU0003905A patent/HUP0003905A3/hu not_active Application Discontinuation
- 1998-10-07 PL PL339759A patent/PL191974B1/pl not_active IP Right Cessation
- 1998-10-08 MY MYPI98004606A patent/MY122105A/en unknown
- 1998-10-09 PE PE1998000955A patent/PE121599A1/es not_active Application Discontinuation
- 1998-10-09 ZA ZA989228A patent/ZA989228B/xx unknown
- 1998-12-01 TW TW087116680A patent/TW440557B/zh not_active IP Right Cessation
1999
- 1999-01-26 SA SA99191000A patent/SA99191000A/ar unknown
- 1999-05-25 UY UY25524A patent/UY25524A1/es not_active Application Discontinuation
2000
- 2000-04-05 BG BG104302A patent/BG104302A/xx unknown
- 2000-04-06 NO NO20001777A patent/NO20001777L/no not_active Application Discontinuation
- 2000-04-07 OA OA1200000100A patent/OA11347A/en unknown

Also Published As

Publication number	Publication date
HUP0003905A2 (en)	2001-03-28
AU741832B2 (en)	2001-12-13
EP1043930A4 (fr)	2004-09-15
MA24670A1 (fr)	1999-07-01
AP2000001782A0 (en)	2000-06-30
CN1275052A (zh)	2000-11-29
IL135434A0 (en)	2001-05-20
PE121599A1 (es)	2000-02-19
UA67753C2 (uk)	2004-07-15
BR9814064A (pt)	2000-09-26
AP1335A (en)	2004-11-29
CA2305614A1 (fr)	1999-04-22
TW440557B (en)	2001-06-16
SA99191000A (ar)	2005-12-03
TR200000945T2 (tr)	2000-10-23
EA200000406A1 (ru)	2000-10-30
CN1192025C (zh)	2005-03-09
EP1043930A1 (fr)	2000-10-18
PL191974B1 (pl)	2006-07-31
KR100560038B1 (ko)	2006-03-13
PL339759A1 (en)	2001-01-02
ID25536A (id)	2000-10-12
EA003609B1 (ru)	2003-06-26
BG104302A (en)	2001-08-31
HUP0003905A3 (en)	2002-01-28
MY122105A (en)	2006-03-31
DZ2619A1 (fr)	2003-03-08
AU9687498A (en)	1999-05-03
OA11347A (en)	2003-12-17
JP2001519363A (ja)	2001-10-23
KR20010015709A (ko)	2001-02-26
SK4902000A3 (en)	2000-11-07
NZ503759A (en)	2002-03-01
WO1999018793A1 (fr)	1999-04-22
NO20001777D0 (no)	2000-04-06
NO20001777L (no)	2000-05-03
UY25524A1 (es)	2000-02-23
AR015952A1 (es)	2001-05-30
IL135434A (en)	2004-12-15
UY25201A1 (es)	2001-08-27

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