TR200000945T2 - İkameli 4-fenil-4-siyanosikloheksanoik asitlerin hazırlanması için metod - Google Patents

İkameli 4-fenil-4-siyanosikloheksanoik asitlerin hazırlanması için metod

Info

Publication number
TR200000945T2
TR200000945T2 TR2000/00945T TR200000945T TR200000945T2 TR 200000945 T2 TR200000945 T2 TR 200000945T2 TR 2000/00945 T TR2000/00945 T TR 2000/00945T TR 200000945 T TR200000945 T TR 200000945T TR 200000945 T2 TR200000945 T2 TR 200000945T2
Authority
TR
Turkey
Prior art keywords
phenyl
substituted
preparation
group
cyanocyclohexanoic
Prior art date
Application number
TR2000/00945T
Other languages
English (en)
Turkish (tr)
Inventor
Webb Kevin
Mendelson Wilford
Jianhoa Chen
Original Assignee
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation
Publication of TR200000945T2 publication Critical patent/TR200000945T2/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/48Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/45Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00Compounds having —CHO groups
    • C07C47/52Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TR2000/00945T 1997-10-10 1998-10-07 İkameli 4-fenil-4-siyanosikloheksanoik asitlerin hazırlanması için metod TR200000945T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6161397P 1997-10-10 1997-10-10

Publications (1)

Publication Number Publication Date
TR200000945T2 true TR200000945T2 (tr) 2000-10-23

Family

ID=22036929

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/00945T TR200000945T2 (tr) 1997-10-10 1998-10-07 İkameli 4-fenil-4-siyanosikloheksanoik asitlerin hazırlanması için metod

Country Status (30)

Country Link
EP (1) EP1043930A4 (fr)
JP (1) JP2001519363A (fr)
KR (1) KR100560038B1 (fr)
CN (1) CN1192025C (fr)
AP (1) AP1335A (fr)
AR (1) AR015952A1 (fr)
AU (1) AU741832B2 (fr)
BG (1) BG104302A (fr)
BR (1) BR9814064A (fr)
CA (1) CA2305614A1 (fr)
DZ (1) DZ2619A1 (fr)
EA (1) EA003609B1 (fr)
HU (1) HUP0003905A3 (fr)
ID (1) ID25536A (fr)
IL (1) IL135434A (fr)
MA (1) MA24670A1 (fr)
MY (1) MY122105A (fr)
NO (1) NO20001777L (fr)
NZ (1) NZ503759A (fr)
OA (1) OA11347A (fr)
PE (1) PE121599A1 (fr)
PL (1) PL191974B1 (fr)
SA (1) SA99191000A (fr)
SK (1) SK4902000A3 (fr)
TR (1) TR200000945T2 (fr)
TW (1) TW440557B (fr)
UA (1) UA67753C2 (fr)
UY (2) UY25201A1 (fr)
WO (1) WO1999018793A1 (fr)
ZA (1) ZA989228B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920152D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel process
WO2001043692A2 (fr) * 1999-12-15 2001-06-21 Smithkline Beecham Corporation SELS D'ACIDE CARBOXYLIQUE Cis-4-CYANO-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]CYCLOHEXANE-1
HK1051030A1 (zh) * 2000-01-26 2003-07-18 Smithkline Beecham Corporation 顺-锂-腈-4-[3-(环戊氧基)-4-甲氧苯基]环己烷羧酸酯的单水合物
US6555572B2 (en) 2000-03-16 2003-04-29 Inflazyme Pharmaceuticals Ltd. Benzylated PDE4 inhibitors
PL364135A1 (en) 2001-01-31 2004-12-13 Pfizer Products Inc. Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes
BR0116850A (pt) 2001-01-31 2004-02-25 Pfizer Prod Inc Derivados de amida de ácido tiazolil-, oxazolil-, pirrolil- e imidazolil- úteis como inibidores de isoenzimas de pde4
CN1527830A (zh) 2001-01-31 2004-09-08 �Ʒ� 用作pde4同工酶的抑制剂的醚衍生物
US7250518B2 (en) 2001-01-31 2007-07-31 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
CN102491959B (zh) * 2011-12-19 2015-03-25 江苏澄扬作物科技有限公司 一种环氧乙烷衍生物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021478A (en) * 1972-07-13 1977-05-03 The Upjohn Company Preparation of carboxylic acids from glycidonitriles with ionic lewis acids
CA2133439C (fr) * 1992-04-02 2005-07-26 Siegfried Benjamin Christensen, Iv Composes utiles pour le traitement des maladies d'origine allergique et inflammatoire
US5524438A (en) * 1994-12-15 1996-06-11 United Technologies Corporation Segmented bulkhead liner for a gas turbine combustor
UY24882A1 (es) * 1997-02-12 2001-08-27 Smithkline Beecham Corp Ácidos 4-fenil-4-ciano-ciclohexanoicos sustituidos
US6452022B1 (en) * 1997-10-10 2002-09-17 Smithkline Beecham Corporation Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Also Published As

Publication number Publication date
IL135434A (en) 2004-12-15
TW440557B (en) 2001-06-16
ID25536A (id) 2000-10-12
UA67753C2 (uk) 2004-07-15
AU741832B2 (en) 2001-12-13
NO20001777D0 (no) 2000-04-06
PL339759A1 (en) 2001-01-02
EA200000406A1 (ru) 2000-10-30
EP1043930A4 (fr) 2004-09-15
BG104302A (en) 2001-08-31
BR9814064A (pt) 2000-09-26
EP1043930A1 (fr) 2000-10-18
PL191974B1 (pl) 2006-07-31
AP2000001782A0 (en) 2000-06-30
SA99191000A (ar) 2005-12-03
HUP0003905A2 (en) 2001-03-28
MA24670A1 (fr) 1999-07-01
PE121599A1 (es) 2000-02-19
CN1192025C (zh) 2005-03-09
IL135434A0 (en) 2001-05-20
WO1999018793A1 (fr) 1999-04-22
AR015952A1 (es) 2001-05-30
MY122105A (en) 2006-03-31
KR100560038B1 (ko) 2006-03-13
HUP0003905A3 (en) 2002-01-28
AU9687498A (en) 1999-05-03
JP2001519363A (ja) 2001-10-23
ZA989228B (en) 1999-04-12
KR20010015709A (ko) 2001-02-26
NO20001777L (no) 2000-05-03
AP1335A (en) 2004-11-29
UY25201A1 (es) 2001-08-27
UY25524A1 (es) 2000-02-23
NZ503759A (en) 2002-03-01
EA003609B1 (ru) 2003-06-26
CA2305614A1 (fr) 1999-04-22
OA11347A (en) 2003-12-17
CN1275052A (zh) 2000-11-29
DZ2619A1 (fr) 2003-03-08
SK4902000A3 (en) 2000-11-07

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