AP2002002698A0 - 3-Azabicyclo[3.1.0] hexane derivatives useful in therapy. - Google Patents

3-Azabicyclo[3.1.0] hexane derivatives useful in therapy.

Info

Publication number: AP2002002698A0
Authority: AP; ARIPO
Prior art keywords: opiate; useful; pharmaceutically; azabicyclo; therapy
Prior art date: 2000-06-23

Application number

APAP/P/2002/002698A

Other languages

English (en)

Inventor

Bernard Joseph Banks

Douglas James Critcher

Ashley Edward Fenwick

David Morris Gethin

Paul Stephen Gibson

Graham Lunn

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-23

Filing date

2001-06-07

Publication date

2002-12-31

2001-06-07 Application filed by Pfizer filed Critical Pfizer

2002-12-31 Publication of AP2002002698A0 publication Critical patent/AP2002002698A0/en

Links

150000005228 3‐azabicyclo[3.1.0]hexanes Chemical class 0.000 title 1
238000002560 therapeutic procedure Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Nutrition Science (AREA)
Gynecology & Obstetrics (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

APAP/P/2002/002698A 2000-06-23 2001-06-07 3-Azabicyclo[3.1.0] hexane derivatives useful in therapy. AP2002002698A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0015562.2A GB0015562D0 (en)	2000-06-23	2000-06-23	Heterocycles
PCT/IB2001/001035 WO2001098267A1 (en)	2000-06-23	2001-06-07	3-azabicyclo (3.1.0) hexane derivatives having opioid receptor affinity

Publications (1)

Publication Number	Publication Date
AP2002002698A0 true AP2002002698A0 (en)	2002-12-31

Family

ID=9894368

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
APAP/P/2002/002698A AP2002002698A0 (en)	2000-06-23	2001-06-07	3-Azabicyclo[3.1.0] hexane derivatives useful in therapy.

Country Status (34)

Country	Link
EP (1)	EP1292574A1 (is)
JP (1)	JP2004512263A (is)
KR (1)	KR20040002386A (is)
CN (1)	CN1639121A (is)
AP (1)	AP2002002698A0 (is)
AR (1)	AR028969A1 (is)
AU (1)	AU781837B2 (is)
BG (1)	BG107329A (is)
BR (1)	BR0111867A (is)
CA (1)	CA2412188A1 (is)
CZ (1)	CZ20023967A3 (is)
DO (1)	DOP2001000187A (is)
DZ (1)	DZ3368A1 (is)
EA (1)	EA005117B1 (is)
GB (1)	GB0015562D0 (is)
HR (1)	HRP20020998A2 (is)
HU (1)	HUP0301228A3 (is)
IL (1)	IL153427A0 (is)
IS (1)	IS6637A (is)
MA (1)	MA26915A1 (is)
MX (1)	MXPA02012878A (is)
NO (1)	NO20026168L (is)
NZ (1)	NZ523141A (is)
OA (1)	OA12293A (is)
PA (1)	PA8519401A1 (is)
PE (1)	PE20020253A1 (is)
PL (1)	PL365956A1 (is)
SK (1)	SK17172002A3 (is)
TN (1)	TNSN01094A1 (is)
UA (1)	UA73176C2 (is)
UY (1)	UY26787A1 (is)
WO (1)	WO2001098267A1 (is)
YU (1)	YU91802A (is)
ZA (1)	ZA200210278B (is)

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DE60226161T2 (de) *	2001-10-22	2009-07-02	Pfizer Products Inc., Groton	3-azabicyclo[3.1.0]hexan derivative als antagonisten der opioid rezeptoren
CN100411618C (zh) *	2002-05-17	2008-08-20	迪欧加药品公司	有效的选择性阿片受体调制剂化合物的用途
DE10259245A1 (de)	2002-12-17	2004-07-01	Merck Patent Gmbh	Derivate des Asimadolins mit kovalent gebundenen Säuren
ATE451364T1 (de)	2004-02-23	2009-12-15	Glaxo Group Ltd	Als modulatoren des dopamin-d3-rezeptors geeignete azabicycloä3.1.0ühexanderivate
GB0507680D0 (en) *	2005-04-15	2005-05-25	Glaxo Group Ltd	Compounds
ATE484502T1 (de) *	2005-06-14	2010-10-15	Glaxo Group Ltd	Neue verbindungen
WO2007113258A1 (en) *	2006-04-03	2007-10-11	Glaxo Group Limited	Azabicyclo [3. 1. o] hexane derivatives as modulators of dopamine d3 receptors
EP2636407A3 (en)	2007-03-30	2013-11-06	Tioga Pharmaceuticals, Inc.	Kappa-opiate agonists for the treatment of diarrhea-predominant and alternating irritable bowel syndrome
TWI423801B (zh) *	2007-08-27	2014-01-21	Theravance Inc	作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
ES2645725T3 (es)	2010-06-11	2017-12-07	Rhodes Technologies	Procesos catalizados por metales de transición para la preparación de compuestos de N-alilo y uso de los mismos
BR112013007566A2 (pt)	2010-09-28	2016-08-02	Panacea Biotec Ltd	novos compostos bicíclicos
CA2927527C (en) *	2013-11-20	2021-06-01	Sanwa Kagaku Kenkyusho Co., Ltd.	Novel 3-azabicyclo[3.1.0]hexane derivative and use thereof as u-opioid receptor antagonist
HK1246778A1 (zh)	2015-05-20	2018-09-14	株式会社三和化学研究所	一种新型的3-氮杂双环[3.1.0]己烷衍生物的盐的晶体以及其医药应用
JP7185633B2 (ja)	2017-02-17	2022-12-07	トレベナ・インコーポレイテッド	７員アザ複素環を含有するデルタ－オピオイド受容体調節化合物、その使用方法及び製造方法
BR112019016827A2 (pt)	2017-02-17	2020-04-07	Trevena Inc	compostos moduladores de receptor delta-opioide contendo aza-heterocíclico com 5 membros, métodos de uso e produção dos mesmos
EP3590511A4 (en)	2017-03-02	2020-09-02	Sanwa Kagaku Kenkyusho Co., Ltd	THERAPEUTIC AGENT FOR DISORDERS RELATED TO THE CONSUMPTION OF ALCOHOL
CN108250088B (zh) *	2018-01-04	2020-10-30	四川之江高新材料股份有限公司	N，n，n′-三甲基-n′-羟乙基双氨基乙基醚的制备方法
CN115825305B (zh) *	2022-10-21	2024-09-20	昆明理工大学	一种分子印迹固相微萃取纤维及其制备方法与应用

Family Cites Families (6)

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Publication number	Priority date	Publication date	Assignee	Title
US3065230A (en) *	1959-03-16	1962-11-20	Burroughs Wellcome Co	Azabicyclohexanes and method of preparing them
ATE110057T1 (de) *	1987-04-16	1994-09-15	Lilly Co Eli	Piperidine als opioid-antagoniste.
US5159081A (en) *	1991-03-29	1992-10-27	Eli Lilly And Company	Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists
DE4341403A1 (de) *	1993-12-04	1995-06-08	Basf Ag	N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
PE20001420A1 (es) *	1998-12-23	2000-12-18	Pfizer	Moduladores de ccr5
TWI244481B (en) *	1998-12-23	2005-12-01	Pfizer	3-azabicyclo[3.1.0]hexane derivatives useful in therapy

2000
- 2000-06-23 GB GBGB0015562.2A patent/GB0015562D0/en not_active Ceased
2001
- 2001-06-06 DO DO2001000187A patent/DOP2001000187A/es unknown
- 2001-06-07 WO PCT/IB2001/001035 patent/WO2001098267A1/en not_active Ceased
- 2001-06-07 YU YU91802A patent/YU91802A/sh unknown
- 2001-06-07 JP JP2002504223A patent/JP2004512263A/ja not_active Withdrawn
- 2001-06-07 AU AU62591/01A patent/AU781837B2/en not_active Ceased
- 2001-06-07 DZ DZ013368A patent/DZ3368A1/xx active
- 2001-06-07 HU HU0301228A patent/HUP0301228A3/hu unknown
- 2001-06-07 EA EA200201269A patent/EA005117B1/ru not_active IP Right Cessation
- 2001-06-07 BR BR0111867-6A patent/BR0111867A/pt not_active IP Right Cessation
- 2001-06-07 IL IL15342701A patent/IL153427A0/xx unknown
- 2001-06-07 SK SK1717-2002A patent/SK17172002A3/sk unknown
- 2001-06-07 AP APAP/P/2002/002698A patent/AP2002002698A0/en unknown
- 2001-06-07 MX MXPA02012878A patent/MXPA02012878A/es unknown
- 2001-06-07 PL PL01365956A patent/PL365956A1/xx not_active Application Discontinuation
- 2001-06-07 CA CA002412188A patent/CA2412188A1/en not_active Abandoned
- 2001-06-07 NZ NZ523141A patent/NZ523141A/en unknown
- 2001-06-07 OA OA1200200386A patent/OA12293A/en unknown
- 2001-06-07 CN CNA018116086A patent/CN1639121A/zh active Pending
- 2001-06-07 EP EP01936728A patent/EP1292574A1/en not_active Withdrawn
- 2001-06-07 KR KR1020027017503A patent/KR20040002386A/ko not_active Ceased
- 2001-06-07 HR HR20020998A patent/HRP20020998A2/hr not_active Application Discontinuation
- 2001-06-07 CZ CZ20023967A patent/CZ20023967A3/cs unknown
- 2001-06-12 PA PA20018519401A patent/PA8519401A1/es unknown
- 2001-06-21 PE PE2001000604A patent/PE20020253A1/es not_active Application Discontinuation
- 2001-06-21 UY UY26787A patent/UY26787A1/es not_active Application Discontinuation
- 2001-06-21 AR ARP010102957A patent/AR028969A1/es unknown
- 2001-06-22 TN TNTNSN01094A patent/TNSN01094A1/fr unknown
- 2001-07-06 UA UA20021210406A patent/UA73176C2/uk unknown
2002
- 2002-11-28 IS IS6637A patent/IS6637A/is unknown
- 2002-11-28 BG BG107329A patent/BG107329A/xx unknown
- 2002-12-16 MA MA26955A patent/MA26915A1/fr unknown
- 2002-12-19 ZA ZA200210278A patent/ZA200210278B/xx unknown
- 2002-12-20 NO NO20026168A patent/NO20026168L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
EA200201269A1 (ru)	2003-06-26
SK17172002A3 (sk)	2004-09-08
MXPA02012878A (es)	2003-05-14
WO2001098267A1 (en)	2001-12-27
HUP0301228A3 (en)	2005-08-29
WO2001098267A8 (en)	2003-02-27
CZ20023967A3 (cs)	2004-02-18
IL153427A0 (en)	2003-07-06
HUP0301228A2 (hu)	2003-08-28
BR0111867A (pt)	2003-07-01
UA73176C2 (en)	2005-06-15
JP2004512263A (ja)	2004-04-22
AU781837B2 (en)	2005-06-16
YU91802A (sh)	2006-05-25
UY26787A1 (es)	2002-01-31
ZA200210278B (en)	2003-12-19
AR028969A1 (es)	2003-05-28
IS6637A (is)	2002-11-28
AU6259101A (en)	2002-01-02
DOP2001000187A (es)	2002-03-30
GB0015562D0 (en)	2000-08-16
NO20026168D0 (no)	2002-12-20
TNSN01094A1 (fr)	2005-11-10
HRP20020998A2 (en)	2004-02-29
MA26915A1 (fr)	2004-12-20
BG107329A (en)	2003-07-31
EP1292574A1 (en)	2003-03-19
CA2412188A1 (en)	2001-12-27
PE20020253A1 (es)	2002-04-08
EA005117B1 (ru)	2004-10-28
PA8519401A1 (es)	2002-12-30
NZ523141A (en)	2005-06-24
NO20026168L (no)	2003-02-18
KR20040002386A (ko)	2004-01-07
DZ3368A1 (fr)	2001-12-27
OA12293A (en)	2004-03-18
CN1639121A (zh)	2005-07-13
PL365956A1 (en)	2005-01-24

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YU91802A (sh)	2006-05-25	Derivati 3-azabiciklo(3.1.0.)heksana koji imaju afinitet prema receptoru opijata
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DE602004024188D1 (de)	2009-12-31	Des opioid-rezeptors
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AP2001002306A0 (en)	2001-12-31	Bridged piperazine derivatives.
WO2005075450A3 (en)	2006-03-30	Spiro-benzodioxoles and their use as cb1 antagonists
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WO2004089908A3 (en)	2004-12-23	3-azabicyclo[3.2.1]octane derivatives
MX2007006754A (es)	2007-07-09	Derivados de indenilo y uso de los mismos para el tratamiento de trastornos neurologicos.
AU2007288444A8 (en)	2013-05-09	Process for the synthesis of (+) and (-)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane
UA81464C2 (en)	2008-01-10	NOVEL AMINOPYRIDINE DERIVATIVES AS mGIuR5 ANTAGONISTS
WO2005030148A3 (en)	2005-06-30	Tetrahydroindolone derivatives for treatment of neurological conditions