YU91802A - Derivati 3-azabiciklo(3.1.0.)heksana koji imaju afinitet prema receptoru opijata - Google Patents

Derivati 3-azabiciklo(3.1.0.)heksana koji imaju afinitet prema receptoru opijata

Info

Publication number: YU91802A
Authority: YU; Yugoslavia
Prior art keywords: azabicyclo; opiate; pharmaceutically; opioid receptor; useful
Prior art date: 2000-06-23

Application number

YU91802A

Other languages

English (en)

Serbo-Croatian (sh)

Inventor

Bernard Joseph Banks

Douglas James Critcher

Ashley Edward Fenwick

David Morris Gethin

Graham Lunn

Original Assignee

Pfizer Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-23

Filing date

2001-06-07

Publication date

2006-05-25

2001-06-07 Application filed by Pfizer Inc. filed Critical Pfizer Inc.

2006-05-25 Publication of YU91802A publication Critical patent/YU91802A/sh

Links

108090000137 Opioid Receptors Proteins 0.000 title abstract 3
102000003840 Opioid Receptors Human genes 0.000 title abstract 3
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical class CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 title 1
208000007848 Alcoholism Diseases 0.000 abstract 1
206010003645 Atopy Diseases 0.000 abstract 1
206010010774 Constipation Diseases 0.000 abstract 1
206010012434 Dermatitis allergic Diseases 0.000 abstract 1
208000030814 Eating disease Diseases 0.000 abstract 1
208000019454 Feeding and Eating disease Diseases 0.000 abstract 1
206010019196 Head injury Diseases 0.000 abstract 1
206010028813 Nausea Diseases 0.000 abstract 1
208000012488 Opiate Overdose Diseases 0.000 abstract 1
101100244562 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) oprD gene Proteins 0.000 abstract 1
201000001880 Sexual dysfunction Diseases 0.000 abstract 1
206010047700 Vomiting Diseases 0.000 abstract 1
201000008937 atopic dermatitis Diseases 0.000 abstract 1
208000010668 atopic eczema Diseases 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
108700023159 delta Opioid Receptors Proteins 0.000 abstract 1
102000048124 delta Opioid Receptors Human genes 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
235000014632 disordered eating Nutrition 0.000 abstract 1
208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
102000048260 kappa Opioid Receptors Human genes 0.000 abstract 1
102000051367 mu Opioid Receptors Human genes 0.000 abstract 1
230000008693 nausea Effects 0.000 abstract 1
229940002612 prodrug Drugs 0.000 abstract 1
239000000651 prodrug Substances 0.000 abstract 1
230000001823 pruritic effect Effects 0.000 abstract 1
231100000872 sexual dysfunction Toxicity 0.000 abstract 1
230000035939 shock Effects 0.000 abstract 1
208000017520 skin disease Diseases 0.000 abstract 1
230000000391 smoking effect Effects 0.000 abstract 1
230000008673 vomiting Effects 0.000 abstract 1
108020001588 κ-opioid receptors Proteins 0.000 abstract 1
108020001612 μ-opioid receptors Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Addiction (AREA)
Psychiatry (AREA)
Reproductive Health (AREA)
Pain & Pain Management (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Otolaryngology (AREA)
Heart & Thoracic Surgery (AREA)
Gynecology & Obstetrics (AREA)
Nutrition Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

YU91802A 2000-06-23 2001-06-07 Derivati 3-azabiciklo(3.1.0.)heksana koji imaju afinitet prema receptoru opijata YU91802A (sh)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0015562.2A GB0015562D0 (en)	2000-06-23	2000-06-23	Heterocycles

Publications (1)

Publication Number	Publication Date
YU91802A true YU91802A (sh)	2006-05-25

Family

ID=9894368

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
YU91802A YU91802A (sh)	2000-06-23	2001-06-07	Derivati 3-azabiciklo(3.1.0.)heksana koji imaju afinitet prema receptoru opijata

Country Status (34)

Country	Link
EP (1)	EP1292574A1 (is)
JP (1)	JP2004512263A (is)
KR (1)	KR20040002386A (is)
CN (1)	CN1639121A (is)
AP (1)	AP2002002698A0 (is)
AR (1)	AR028969A1 (is)
AU (1)	AU781837B2 (is)
BG (1)	BG107329A (is)
BR (1)	BR0111867A (is)
CA (1)	CA2412188A1 (is)
CZ (1)	CZ20023967A3 (is)
DO (1)	DOP2001000187A (is)
DZ (1)	DZ3368A1 (is)
EA (1)	EA005117B1 (is)
GB (1)	GB0015562D0 (is)
HR (1)	HRP20020998A2 (is)
HU (1)	HUP0301228A3 (is)
IL (1)	IL153427A0 (is)
IS (1)	IS6637A (is)
MA (1)	MA26915A1 (is)
MX (1)	MXPA02012878A (is)
NO (1)	NO20026168L (is)
NZ (1)	NZ523141A (is)
OA (1)	OA12293A (is)
PA (1)	PA8519401A1 (is)
PE (1)	PE20020253A1 (is)
PL (1)	PL365956A1 (is)
SK (1)	SK17172002A3 (is)
TN (1)	TNSN01094A1 (is)
UA (1)	UA73176C2 (is)
UY (1)	UY26787A1 (is)
WO (1)	WO2001098267A1 (is)
YU (1)	YU91802A (is)
ZA (1)	ZA200210278B (is)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4155522B2 (ja) *	2001-10-22	2008-09-24	ファイザー・プロダクツ・インク	オピオイド受容体アンタゴニストとしての３−アザビシクロ（３．１．０）ヘキサン誘導体
US20050176746A1 (en) *	2002-05-17	2005-08-11	Frank Weber	Use of compounds that are effective as selective opiate receptor modulators
DE10259245A1 (de)	2002-12-17	2004-07-01	Merck Patent Gmbh	Derivate des Asimadolins mit kovalent gebundenen Säuren
ATE451364T1 (de) *	2004-02-23	2009-12-15	Glaxo Group Ltd	Als modulatoren des dopamin-d3-rezeptors geeignete azabicycloä3.1.0ühexanderivate
GB0507680D0 (en) *	2005-04-15	2005-05-25	Glaxo Group Ltd	Compounds
JP5068747B2 (ja) *	2005-06-14	2012-11-07	グラクソグループリミテッド	ドーパミンｄ３受容体のモジュレーターとしてのアザビシクロ［３．１．０］ヘキサン誘導体
ATE498619T1 (de) *	2006-04-03	2011-03-15	Glaxo Group Ltd	Azabicycloä3.1.0ühexanderivate als modulatoren von dopamin-d3-rezeptoren
CN101677997B (zh)	2007-03-30	2012-05-09	泰奥加制药公司	用于治疗腹泻型和交替型肠易激综合征的κ-阿片剂激动剂
TWI423801B (zh) *	2007-08-27	2014-01-21	Theravance Inc	作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
CA2936749C (en) *	2010-06-11	2019-07-09	Rhodes Technologies	Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
BR112013007566A2 (pt)	2010-09-28	2016-08-02	Panacea Biotec Ltd	novos compostos bicíclicos
DK3072884T3 (da) *	2013-11-20	2020-03-09	Sanwa Kagaku Kenkyusho Co	3-azabicyclo[3.1.0]hexanderivat og anvendelse deraf til medicinske formål
MX388953B (es)	2015-05-20	2025-03-20	Ube Industries	Cristal de sal de derivado de 3-azabiciclo[3.1.0]hexano novedoso y usos medicionales del mismo.
CN110446495B (zh)	2017-02-17	2023-09-05	特维娜有限公司	含有7元氮杂杂环的δ阿片受体调节化合物及其使用和制备方法
CN110520129A (zh) *	2017-02-17	2019-11-29	特维娜有限公司	含有5元氮杂杂环的δ阿片受体调节化合物及其使用和制备方法
KR20190120212A (ko)	2017-03-02	2019-10-23	가부시키가이샤산와카가쿠켄큐쇼	알코올 사용 장해의 치료약
CN108250088B (zh) *	2018-01-04	2020-10-30	四川之江高新材料股份有限公司	N，n，n′-三甲基-n′-羟乙基双氨基乙基醚的制备方法
CN116406268A (zh)	2020-10-27	2023-07-07	特维娜有限公司	δ-阿片样物质调节剂的结晶和无定形形式
CN115825305B (zh) *	2022-10-21	2024-09-20	昆明理工大学	一种分子印迹固相微萃取纤维及其制备方法与应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3065230A (en) *	1959-03-16	1962-11-20	Burroughs Wellcome Co	Azabicyclohexanes and method of preparing them
NZ224236A (en) *	1987-04-16	1990-08-28	Lilly Co Eli	Trans 3,4 pyridine derivatives and pharmaceutical compositions
US5159081A (en) *	1991-03-29	1992-10-27	Eli Lilly And Company	Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists
DE4341403A1 (de) *	1993-12-04	1995-06-08	Basf Ag	N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
TWI244481B (en) *	1998-12-23	2005-12-01	Pfizer	3-azabicyclo[3.1.0]hexane derivatives useful in therapy
PE20001420A1 (es) *	1998-12-23	2000-12-18	Pfizer	Moduladores de ccr5

2000
- 2000-06-23 GB GBGB0015562.2A patent/GB0015562D0/en not_active Ceased
2001
- 2001-06-06 DO DO2001000187A patent/DOP2001000187A/es unknown
- 2001-06-07 HR HR20020998A patent/HRP20020998A2/hr not_active Application Discontinuation
- 2001-06-07 CZ CZ20023967A patent/CZ20023967A3/cs unknown
- 2001-06-07 KR KR1020027017503A patent/KR20040002386A/ko not_active Ceased
- 2001-06-07 BR BR0111867-6A patent/BR0111867A/pt not_active IP Right Cessation
- 2001-06-07 EP EP01936728A patent/EP1292574A1/en not_active Withdrawn
- 2001-06-07 AP APAP/P/2002/002698A patent/AP2002002698A0/en unknown
- 2001-06-07 HU HU0301228A patent/HUP0301228A3/hu unknown
- 2001-06-07 MX MXPA02012878A patent/MXPA02012878A/es unknown
- 2001-06-07 DZ DZ013368A patent/DZ3368A1/xx active
- 2001-06-07 IL IL15342701A patent/IL153427A0/xx unknown
- 2001-06-07 WO PCT/IB2001/001035 patent/WO2001098267A1/en not_active Ceased
- 2001-06-07 EA EA200201269A patent/EA005117B1/ru not_active IP Right Cessation
- 2001-06-07 JP JP2002504223A patent/JP2004512263A/ja not_active Withdrawn
- 2001-06-07 CA CA002412188A patent/CA2412188A1/en not_active Abandoned
- 2001-06-07 YU YU91802A patent/YU91802A/sh unknown
- 2001-06-07 OA OA1200200386A patent/OA12293A/en unknown
- 2001-06-07 AU AU62591/01A patent/AU781837B2/en not_active Ceased
- 2001-06-07 NZ NZ523141A patent/NZ523141A/en unknown
- 2001-06-07 CN CNA018116086A patent/CN1639121A/zh active Pending
- 2001-06-07 PL PL01365956A patent/PL365956A1/xx not_active Application Discontinuation
- 2001-06-07 SK SK1717-2002A patent/SK17172002A3/sk unknown
- 2001-06-12 PA PA20018519401A patent/PA8519401A1/es unknown
- 2001-06-21 PE PE2001000604A patent/PE20020253A1/es not_active Application Discontinuation
- 2001-06-21 AR ARP010102957A patent/AR028969A1/es unknown
- 2001-06-21 UY UY26787A patent/UY26787A1/es not_active Application Discontinuation
- 2001-06-22 TN TNTNSN01094A patent/TNSN01094A1/fr unknown
- 2001-07-06 UA UA20021210406A patent/UA73176C2/uk unknown
2002
- 2002-11-28 BG BG107329A patent/BG107329A/xx unknown
- 2002-11-28 IS IS6637A patent/IS6637A/is unknown
- 2002-12-16 MA MA26955A patent/MA26915A1/fr unknown
- 2002-12-19 ZA ZA200210278A patent/ZA200210278B/xx unknown
- 2002-12-20 NO NO20026168A patent/NO20026168L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
TNSN01094A1 (fr)	2005-11-10
HUP0301228A2 (hu)	2003-08-28
AU781837B2 (en)	2005-06-16
MXPA02012878A (es)	2003-05-14
UY26787A1 (es)	2002-01-31
NZ523141A (en)	2005-06-24
HRP20020998A2 (en)	2004-02-29
CA2412188A1 (en)	2001-12-27
PA8519401A1 (es)	2002-12-30
KR20040002386A (ko)	2004-01-07
GB0015562D0 (en)	2000-08-16
SK17172002A3 (sk)	2004-09-08
NO20026168D0 (no)	2002-12-20
PL365956A1 (en)	2005-01-24
AU6259101A (en)	2002-01-02
IL153427A0 (en)	2003-07-06
BG107329A (en)	2003-07-31
ZA200210278B (en)	2003-12-19
BR0111867A (pt)	2003-07-01
CZ20023967A3 (cs)	2004-02-18
AR028969A1 (es)	2003-05-28
OA12293A (en)	2004-03-18
HUP0301228A3 (en)	2005-08-29
CN1639121A (zh)	2005-07-13
EA005117B1 (ru)	2004-10-28
JP2004512263A (ja)	2004-04-22
WO2001098267A8 (en)	2003-02-27
EA200201269A1 (ru)	2003-06-26
UA73176C2 (en)	2005-06-15
NO20026168L (no)	2003-02-18
DZ3368A1 (fr)	2001-12-27
MA26915A1 (fr)	2004-12-20
AP2002002698A0 (en)	2002-12-31
DOP2001000187A (es)	2002-03-30
PE20020253A1 (es)	2002-04-08
WO2001098267A1 (en)	2001-12-27
EP1292574A1 (en)	2003-03-19
IS6637A (is)	2002-11-28

Publication	Publication Date	Title
BG107329A (en)	2003-07-31	3-azabicyclo(3.1.0) hexane derivatives having opioid receptor affinity
TW200503713A (en)	2005-02-01	Novel compounds
MY138478A (en)	2009-06-30	Benzazepine derivatives for the treatment of neurological disorders
TW200505921A (en)	2005-02-16	Pyrrolopyrimidine and pyrrolopyridine derivatives substituted with cyclic amino group
UA84930C2 (ru)	2008-12-10	Пиррольные соединения как ингибиторы протеинкиназ erk, их синтез и соответствующие промежуточные соединения
GEP20043366B (en)	2004-04-13	Benzothiophene Derivative Compounds Process of Preparation and Use Thereof
TW200624432A (en)	2006-07-16	Imidazo [1,2-a] pyridine compounds, compositions, uses and methods related thereto
WO2006116218A8 (en)	2007-02-22	Crystal forms of {[(2r)-7-(2,6-dichlorophenyl)-5-fluoro-2,3-dihydro-1-benzofuran-2-yl]methyl}amine hydrochloride
MA29623B1 (fr)	2008-07-01	Derives de pyrazolo [3, 4-d] azepine comme antagonistes d'histamine h3
DE602004024188D1 (de)	2009-12-31	Des opioid-rezeptors
MXPA05011018A (es)	2005-12-12	Compuestos de 4-fenil piperidna y sus usos como moduladores de receptores opioides.
EP1725536B8 (en)	2009-04-22	Imidazoline derivatives having cb1-antagonistic activity
WO2005075450A3 (en)	2006-03-30	Spiro-benzodioxoles and their use as cb1 antagonists
WO2002011732A8 (en)	2002-06-20	Novel bicyclic and tricyclic pyrrolidine derivatives as gnrh antagonists
WO2004089908A3 (en)	2004-12-23	3-azabicyclo[3.2.1]octane derivatives
BR0318521A (pt)	2006-09-12	arilindenopiridinas e arilindenopirimidinas e métodos terapêuticos e profiláticos relacionados
MX2007006754A (es)	2007-07-09	Derivados de indenilo y uso de los mismos para el tratamiento de trastornos neurologicos.
WO2004050616A3 (en)	2004-09-10	Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
IL156201A0 (en)	2003-12-23	Pyrazinoquioxaline derivatives and pharmaceutical compositions containing the same
SI1893589T1 (sl)	2012-01-31	Substituirani N-benzo(d)izoksazol-3-il-aminski derivati kot inhibitorji mGluR5, serotonin-(5-HT) in noradrenalinskih receptorjev in njihova uporaba za pripravo zdravil
AU2007288444A8 (en)	2013-05-09	Process for the synthesis of (+) and (-)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane
WO2006029210A3 (en)	2006-05-04	Acyclic 1,3-diamines and uses therefor
UA81464C2 (en)	2008-01-10	NOVEL AMINOPYRIDINE DERIVATIVES AS mGIuR5 ANTAGONISTS
WO2002048105A3 (en)	2002-10-31	Aryloxy piperidinyl derivatives for the treatment of depression
MY139224A (en)	2009-08-28	Mcm-41 from rice husk