DZ3368A1 - Derives 3-azabicyclo[3.1.0] hexane ayant une affinite pour le recepteur opioide - Google Patents

Derives 3-azabicyclo[3.1.0] hexane ayant une affinite pour le recepteur opioide

Info

Publication number
DZ3368A1
DZ3368A1 DZ013368A DZ013368A DZ3368A1 DZ 3368 A1 DZ3368 A1 DZ 3368A1 DZ 013368 A DZ013368 A DZ 013368A DZ 013368 A DZ013368 A DZ 013368A DZ 3368 A1 DZ3368 A1 DZ 3368A1
Authority
DZ
Algeria
Prior art keywords
hexane
affinity
opioid receptor
azabicyclo derivatives
azabicyclo
Prior art date
Application number
DZ013368A
Other languages
English (en)
Inventor
Bernard Joseph Banks
Douglas James Critcher
Ashley Edward Fenwick
David Morris Gethin
Stephen Paul Gibson
Graham Lunn
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Application granted granted Critical
Publication of DZ3368A1 publication Critical patent/DZ3368A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nutrition Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DZ013368A 2000-06-23 2001-06-07 Derives 3-azabicyclo[3.1.0] hexane ayant une affinite pour le recepteur opioide DZ3368A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0015562.2A GB0015562D0 (en) 2000-06-23 2000-06-23 Heterocycles
PCT/IB2001/001035 WO2001098267A1 (fr) 2000-06-23 2001-06-07 Derives 3-azabicyclo[3.1.0] hexane ayant une affinite pour le recepteur opioide

Publications (1)

Publication Number Publication Date
DZ3368A1 true DZ3368A1 (fr) 2001-12-27

Family

ID=9894368

Family Applications (1)

Application Number Title Priority Date Filing Date
DZ013368A DZ3368A1 (fr) 2000-06-23 2001-06-07 Derives 3-azabicyclo[3.1.0] hexane ayant une affinite pour le recepteur opioide

Country Status (34)

Country Link
EP (1) EP1292574A1 (fr)
JP (1) JP2004512263A (fr)
KR (1) KR20040002386A (fr)
CN (1) CN1639121A (fr)
AP (1) AP2002002698A0 (fr)
AR (1) AR028969A1 (fr)
AU (1) AU781837B2 (fr)
BG (1) BG107329A (fr)
BR (1) BR0111867A (fr)
CA (1) CA2412188A1 (fr)
CZ (1) CZ20023967A3 (fr)
DO (1) DOP2001000187A (fr)
DZ (1) DZ3368A1 (fr)
EA (1) EA005117B1 (fr)
GB (1) GB0015562D0 (fr)
HR (1) HRP20020998A2 (fr)
HU (1) HUP0301228A3 (fr)
IL (1) IL153427A0 (fr)
IS (1) IS6637A (fr)
MA (1) MA26915A1 (fr)
MX (1) MXPA02012878A (fr)
NO (1) NO20026168L (fr)
NZ (1) NZ523141A (fr)
OA (1) OA12293A (fr)
PA (1) PA8519401A1 (fr)
PE (1) PE20020253A1 (fr)
PL (1) PL365956A1 (fr)
SK (1) SK17172002A3 (fr)
TN (1) TNSN01094A1 (fr)
UA (1) UA73176C2 (fr)
UY (1) UY26787A1 (fr)
WO (1) WO2001098267A1 (fr)
YU (1) YU91802A (fr)
ZA (1) ZA200210278B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL368919A1 (en) * 2001-10-22 2005-04-04 Pfizer Products Inc. 3-azabicyclo (3.1.0) hexane derivatives as opioid receptor antagonists
CN101310723A (zh) * 2002-05-17 2008-11-26 迪欧加药品公司 有效的选择性阿片受体调制剂化合物的用途
DE10259245A1 (de) 2002-12-17 2004-07-01 Merck Patent Gmbh Derivate des Asimadolins mit kovalent gebundenen Säuren
TW200538113A (en) * 2004-02-23 2005-12-01 Glaxo Group Ltd Compounds
GB0507680D0 (en) * 2005-04-15 2005-05-25 Glaxo Group Ltd Compounds
WO2006133945A1 (fr) * 2005-06-14 2006-12-21 Glaxo Group Limited Nouveaux composés
DE602007012531D1 (de) * 2006-04-03 2011-03-31 Glaxo Group Ltd Azabicycloä3.1.0ühexanderivate als modulatoren von dopamin-d3-rezeptoren
AU2008232954A1 (en) 2007-03-30 2008-10-09 Tioga Pharmaceuticals Inc. Kappa-opiate agonists for the treatment of diarrhea-predominant and alternating irritable bowel syndrome
TWI423801B (zh) * 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
EP2580201B1 (fr) 2010-06-11 2017-08-02 Rhodes Technologies Procédés catalysés par métal de transition pour la préparation de composés de n-allyle et utilisation de ceux-ci
EP2621902B1 (fr) 2010-09-28 2017-04-12 Panacea Biotec Ltd Dérivés de 3-azabicyclo[3.1.0]hexane utiles pour le traitement de troubles du snc
KR102305244B1 (ko) * 2013-11-20 2021-09-27 우베 고산 가부시키가이샤 신규 3-아자비사이클로[3.1.0]헥산 유도체 및 그 의약 용도
KR20180004734A (ko) 2015-05-20 2018-01-12 가부시키가이샤산와카가쿠켄큐쇼 신규 3-아자비시클로［3.1.0］헥산 유도체의 염의 결정 및 그의 의약 용도
KR102662065B1 (ko) 2017-02-17 2024-05-07 트레베나, 인코포레이티드. 7-원 아자-헤테로고리 함유 델타-오피오이드 수용체 조절 화합물, 및 그의 사용 및 제조 방법
WO2018152293A1 (fr) 2017-02-17 2018-08-23 Trevena, Inc. Composés modulateurs du récepteur delta des opioïdes contenant des aza-hétérocycles à 5 chaînons, leurs procédés d'utilisation et de fabrication
CA3054122A1 (fr) 2017-03-02 2018-09-07 Ube Industries, Ltd. Agent therapeutique pour troubles lies a la consommation d'alcool
CN108250088B (zh) * 2018-01-04 2020-10-30 四川之江高新材料股份有限公司 N，n，n′-三甲基-n′-羟乙基双氨基乙基醚的制备方法
CN115825305B (zh) * 2022-10-21 2024-09-20 昆明理工大学 一种分子印迹固相微萃取纤维及其制备方法与应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3065230A (en) * 1959-03-16 1962-11-20 Burroughs Wellcome Co Azabicyclohexanes and method of preparing them
IL86061A (en) * 1987-04-16 1992-07-15 Lilly Co Eli Derivatives of trans-3,4-isomer of 4-methyl-4-phenyl-piperidines,process for their preparation and pharmaceutical compositions containing them
US5159081A (en) * 1991-03-29 1992-10-27 Eli Lilly And Company Intermediates of peripherally selective n-carbonyl-3,4,4-trisubstituted piperidine opioid antagonists
DE4341403A1 (de) * 1993-12-04 1995-06-08 Basf Ag N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
PE20001420A1 (es) * 1998-12-23 2000-12-18 Pfizer Moduladores de ccr5
TWI244481B (en) * 1998-12-23 2005-12-01 Pfizer 3-azabicyclo[3.1.0]hexane derivatives useful in therapy

Also Published As

Publication number Publication date
NZ523141A (en) 2005-06-24
BG107329A (en) 2003-07-31
EP1292574A1 (fr) 2003-03-19
MA26915A1 (fr) 2004-12-20
CA2412188A1 (fr) 2001-12-27
UY26787A1 (es) 2002-01-31
EA005117B1 (ru) 2004-10-28
PA8519401A1 (es) 2002-12-30
PE20020253A1 (es) 2002-04-08
SK17172002A3 (sk) 2004-09-08
BR0111867A (pt) 2003-07-01
IL153427A0 (en) 2003-07-06
NO20026168L (no) 2003-02-18
AU781837B2 (en) 2005-06-16
HRP20020998A2 (en) 2004-02-29
ZA200210278B (en) 2003-12-19
CN1639121A (zh) 2005-07-13
DOP2001000187A (es) 2002-03-30
HUP0301228A3 (en) 2005-08-29
MXPA02012878A (es) 2003-05-14
NO20026168D0 (no) 2002-12-20
YU91802A (sh) 2006-05-25
KR20040002386A (ko) 2004-01-07
WO2001098267A8 (fr) 2003-02-27
PL365956A1 (en) 2005-01-24
CZ20023967A3 (cs) 2004-02-18
WO2001098267A1 (fr) 2001-12-27
GB0015562D0 (en) 2000-08-16
OA12293A (en) 2004-03-18
AP2002002698A0 (en) 2002-12-31
JP2004512263A (ja) 2004-04-22
EA200201269A1 (ru) 2003-06-26
AR028969A1 (es) 2003-05-28
HUP0301228A2 (hu) 2003-08-28
AU6259101A (en) 2002-01-02
UA73176C2 (en) 2005-06-15
TNSN01094A1 (fr) 2005-11-10
IS6637A (is) 2002-11-28

Similar Documents

Publication Publication Date Title
DZ3368A1 (fr) Derives 3-azabicyclo[3.1.0] hexane ayant une affinite pour le recepteur opioide
ATE335725T1 (de) 3-azabicyclo(3.1.0)hexanderivate als opiat rezeptoren liganden
MA27032A1 (fr) Nouveaux derives de l'indole a affinite pour le recepteur 5-ht6
IS7187A (is) 3-asabísýkló (3.1.0) hexanafleiður sem ópíóíðviðtaka mótlyf
ATE354570T1 (de) 5,6-diaryl-pyrazineamidderivate als cb1 antagonisten
ZA991413B (en) Substituted quinoxaline derivatives as interleukin-8 receptor antagonists.
EE200100145A (et) Opioidiretseptoriga koos toimivad 4,4-biarüülpiperidiini derivaadid
CY2010003I2 (el) Αγωνιστες των βητα-2 αδρενεργικων υποδοχεων
PL365377A1 (en) Amide derivatives as nmda receptor antagonists
MA26932A1 (fr) Derives d'imidazole.
EP1337601A4 (fr) Suspension epaisse pour le polissage chimio-mecanique de structures damascenes en cuivre
MXPA03006991A (es) Derivados de piperidina como antagonistas de neurocinina 1.
IL144299A0 (en) N-triazolymethyl-piperazine derivatives as neurokinin receptor antagonists
MXPA03003892A (es) Antagonistas del receptor bombesin.
NO995081D0 (no) Anordning for H.323 proxy
EP1248617A4 (fr) Nouveaux antagonistes nmda/nr2b de 2-aza-bicyclo 2.2.2]octane
NL1022106A1 (nl) Onderstel voor caravans.
FR2787305B3 (fr) Pietement autostabilise pour meubles
SE9800815D0 (sv) Bio-chelating agents, high affinity bio-target antagonists
FIU20000198U0 (fi) Istuin
ES1047406Y (es) Percha perfeccionada.
ITCT990025A0 (it) La cattedra multimediale attrezzata.
IT1310362B1 (it) Sedile per macchine ginniche.
NO990815D0 (no) Seteoppheng for tohjuling
ES1049696Y (es) Percha con dispositivo de enganche.