AP2005003343A0 - Substituted pyrrolo-pyrazole derivatives as kinaseinhibitors - Google Patents

Substituted pyrrolo-pyrazole derivatives as kinaseinhibitors

Info

Publication number: AP2005003343A0
Authority: AP; ARIPO
Prior art keywords: kinaseinhibitors; pyrazole derivatives; substituted pyrrolo; pyrrolo; substituted
Prior art date: 2002-12-19

Application number

AP2005003343A

Other languages

English (en)

Inventor

Paolo Orsini

Daniele Fancelli

Marcella Et Al Nesi

Original Assignee

Pharmacia Italia Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-12-19

Filing date

2003-12-04

Publication date

2005-06-30

2003-12-04 Application filed by Pharmacia Italia Spa filed Critical Pharmacia Italia Spa

2005-06-30 Publication of AP2005003343A0 publication Critical patent/AP2005003343A0/xx

Links

229940043355 kinase inhibitor Drugs 0.000 title 1
239000003757 phosphotransferase inhibitor Substances 0.000 title 1
GZTPJDLYPMPRDF-UHFFFAOYSA-N pyrrolo[3,2-c]pyrazole Chemical class N1=NC2=CC=NC2=C1 GZTPJDLYPMPRDF-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Oncology (AREA)
Neurology (AREA)
Dermatology (AREA)
Neurosurgery (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Radiology & Medical Imaging (AREA)
Pathology (AREA)
Physical Education & Sports Medicine (AREA)
Hospice & Palliative Care (AREA)
Transplantation (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Molecular Biology (AREA)
Cardiology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AP2005003343A 2002-12-19 2003-12-04 Substituted pyrrolo-pyrazole derivatives as kinaseinhibitors AP2005003343A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US43495202P	2002-12-19	2002-12-19
PCT/EP2003/050942 WO2004056827A2 (en)	2002-12-19	2003-12-04	Substituted pyrrolo-pyrazole derivatives as kinase inhibitors

Publications (1)

Publication Number	Publication Date
AP2005003343A0 true AP2005003343A0 (en)	2005-06-30

Family

ID=32682128

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2005003343A AP2005003343A0 (en)	2002-12-19	2003-12-04	Substituted pyrrolo-pyrazole derivatives as kinaseinhibitors

Country Status (33)

Country	Link
US (5)	US7407971B2 (pt)
EP (2)	EP1575954B1 (pt)
JP (2)	JP4739761B2 (pt)
KR (2)	KR20120038465A (pt)
CN (1)	CN1726217B (pt)
AP (1)	AP2005003343A0 (pt)
AR (1)	AR042525A1 (pt)
AU (1)	AU2003300255B9 (pt)
BR (1)	BR0317455A (pt)
CA (1)	CA2508069C (pt)
CR (2)	CR7880A (pt)
CU (1)	CU23550B7 (pt)
EA (1)	EA010596B1 (pt)
EC (1)	ECSP055864A (pt)
ES (2)	ES2605848T3 (pt)
GE (1)	GEP20084435B (pt)
HR (1)	HRP20050562A2 (pt)
IL (2)	IL169019A (pt)
IS (1)	IS7857A (pt)
MA (1)	MA27569A1 (pt)
ME (1)	MEP52408A (pt)
MX (1)	MXPA05006791A (pt)
MY (1)	MY141196A (pt)
NO (1)	NO333178B1 (pt)
NZ (1)	NZ540644A (pt)
OA (1)	OA13015A (pt)
PL (1)	PL377285A1 (pt)
RS (1)	RS20050462A (pt)
TN (1)	TNSN05163A1 (pt)
TW (1)	TWI327470B (pt)
UA (1)	UA81790C2 (pt)
WO (1)	WO2004056827A2 (pt)
ZA (1)	ZA200504298B (pt)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP4555547B2 (ja) *	2000-08-10	2010-10-06	ファイザーイタリアソシエタアレスポンサビリタリミタータ	キナーゼ阻害剤としての二環式ピラゾール、それらを製造するための方法およびそれらを含む医薬組成物
UA81790C2 (uk) *	2002-12-19	2008-02-11	Фармация Италия С.П.А.	Заміщені піролопіразольні похідні як інгібітори кінази
NZ541836A (en)	2003-02-27	2008-12-24	Palau Pharma Sa	Pyrazolopyridine derivatives
JP2006519816A (ja) *	2003-03-11	2006-08-31	ファルマシア・イタリア・ソシエタ・ペル・アツィオーニ	キナーゼ阻害剤として活性なビシクロピラゾール誘導体、それらの製造方法、及びそれらを含んでなる医薬組成物
AU2004276341B2 (en)	2003-09-23	2011-04-14	Vertex Pharmaceuticals Incorporated	Pyrazolopyrrole derivatives as protein kinase inhibitors
WO2005061519A1 (en)	2003-12-19	2005-07-07	Takeda San Diego, Inc.	Kinase inhibitors
JP2007529555A (ja) *	2004-03-18	2007-10-25	ザブライハムアンドウイメンズホスピタル，インコーポレイテッド	シヌクレイノパチーを治療する方法
US20060106060A1 (en) *	2004-03-18	2006-05-18	The Brigham And Women's Hospital, Inc.	Methods for the treatment of synucleinopathies (Lansbury)
US20070293539A1 (en) *	2004-03-18	2007-12-20	Lansbury Peter T	Methods for the treatment of synucleinopathies
EP1744751A4 (en) *	2004-03-18	2010-03-10	Brigham & Womens Hospital	METHOD FOR THE TREATMENT OF SYNUCLEINOPATHIES
WO2005089515A2 (en) *	2004-03-18	2005-09-29	The Brigham And Women's Hospital, Inc.	Methods for the treatment of synucleinopathies
US7550598B2 (en)	2004-08-18	2009-06-23	Takeda Pharmaceutical Company Limited	Kinase inhibitors
DE602005023333D1 (de)	2004-10-15	2010-10-14	Takeda Pharmaceutical	Kinaseinhibitoren
CA2589271A1 (en)	2004-12-07	2006-06-15	Locus Pharmaceuticals, Inc.	Urea inhibitors of map kinases
JP2008523072A (ja)	2004-12-07	2008-07-03	ルーカスファーマシューティカルズ，インコーポレイテッド	タンパク質キナーゼの阻害剤
KR100919343B1 (ko)	2005-01-10	2009-09-25	화이자 인코포레이티드	키네이스 억제제로서 피롤로피라졸
US8119655B2 (en)	2005-10-07	2012-02-21	Takeda Pharmaceutical Company Limited	Kinase inhibitors
JP4635089B2 (ja) *	2005-12-21	2011-02-16	ファイザー・プロダクツ・インク	有効なキナーゼ阻害剤であるカルボニルアミノピロロピラゾール
SI1979356T1 (sl) *	2005-12-21	2013-11-29	Pfizer Products Inc.	Karbonilamino pirolopirazoli, močni inhibitorji kinaze
US9012487B2 (en)	2006-03-03	2015-04-21	Nerviano Medical Sciences S.R.L.	Bicyclo-pyrazoles active as kinase inhibitors
SG158147A1 (en)	2006-10-09	2010-01-29	Takeda Pharmaceutical	Kinase inhibitors
JP5415271B2 (ja)	2006-10-11	2014-02-12	ネルビアーノ・メデイカル・サイエンシーズ・エツセ・エルレ・エルレ	キナーゼ阻害剤としての置換ピロロ−ピラゾール誘導体
EP2118112B1 (en)	2007-02-07	2015-07-08	Pfizer Inc.	3-amino-pyrrolo[3,4-c] pyrazole- 5 (1h, 4h, 6h) carbaldehyde derivatives as pkc inhibitors
CN101646673B (zh) *	2007-02-07	2014-06-25	辉瑞大药厂	作为pkc抑制剂的3-氨基-吡咯并[3,4-c]吡唑-5(1h,4h,6h)甲醛衍生物
CA2683695C (en) *	2007-04-12	2013-06-18	Pfizer Inc.	3-amido-pyrrolo[3,4-c]pyrazole-5(1h,4h,6h) carbaldehyde derivatives
US8232402B2 (en) *	2008-03-12	2012-07-31	Link Medicine Corporation	Quinolinone farnesyl transferase inhibitors for the treatment of synucleinopathies and other indications
US20110060005A1 (en) *	2008-11-13	2011-03-10	Link Medicine Corporation	Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
US20100331363A1 (en) *	2008-11-13	2010-12-30	Link Medicine Corporation	Treatment of mitochondrial disorders using a farnesyl transferase inhibitor
MX2011005096A (es) *	2008-11-13	2011-11-18	Link Medicine Corp	Derivados de azaquinolinona y usos de los mismos.
EP2937345B1 (en)	2009-12-29	2018-03-21	Dana-Farber Cancer Institute, Inc.	Type ii raf kinase inhibitors
WO2013074986A1 (en)	2011-11-17	2013-05-23	Dana-Farber Cancer Institute, Inc.	Inhibitors of c-jun-n-terminal kinase (jnk)
US10112927B2 (en)	2012-10-18	2018-10-30	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinase 7 (CDK7)
US9758522B2 (en)	2012-10-19	2017-09-12	Dana-Farber Cancer Institute, Inc.	Hydrophobically tagged small molecules as inducers of protein degradation
US10000483B2 (en)	2012-10-19	2018-06-19	Dana-Farber Cancer Institute, Inc.	Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof
WO2015058140A1 (en)	2013-10-18	2015-04-23	Dana-Farber Cancer Institute, Inc.	Polycyclic inhibitors of cyclin-dependent kinase 7 (cdk7)
WO2015058126A1 (en)	2013-10-18	2015-04-23	Syros Pharmaceuticals, Inc.	Heteroaromatic compounds useful for the treatment of prolferative diseases
US10017477B2 (en)	2014-04-23	2018-07-10	Dana-Farber Cancer Institute, Inc.	Janus kinase inhibitors and uses thereof
WO2015164604A1 (en)	2014-04-23	2015-10-29	Dana-Farber Cancer Institute, Inc.	Hydrophobically tagged janus kinase inhibitors and uses thereof
WO2015179847A1 (en)	2014-05-23	2015-11-26	Mingsight Pharmaceuticals, Inc.	Treatment of autoimmune disease
JP6690543B2 (ja) *	2014-10-31	2020-04-28	宇部興産株式会社	置換ジヒドロピロロピラゾール化合物
AU2015371251B2 (en) *	2014-12-23	2020-06-11	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinase 7 (CDK7)
CN107427521B (zh)	2015-03-27	2021-08-03	达纳-法伯癌症研究所股份有限公司	细胞周期蛋白依赖性激酶的抑制剂
EP3307728A4 (en)	2015-06-12	2019-07-17	Dana Farber Cancer Institute, Inc.	COMBINATION THERAPY OF TRANSCRIPTION INHIBITORS AND CHINESE INHIBITORS
US10273252B2 (en)	2015-06-15	2019-04-30	Ube Industries, Ltd.	Substituted dihydropyrrolopyrazole derivative
KR101845931B1 (ko) *	2015-06-18	2018-04-05	한국화학연구원	헤테로아릴 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 pi3 키나아제 관련 질환의 예방 또는 치료용 약학적 조성물
JP7028766B2 (ja)	2015-09-09	2022-03-02	ダナ－ファーバーキャンサーインスティテュート，インコーポレイテッド	サイクリン依存性キナーゼの阻害剤
SG11201804210XA (en) *	2015-11-20	2018-06-28	Mingsight Pharmaceuticals Inc	Treatment of autoimmune disease
JP2019112306A (ja) *	2016-04-28	2019-07-11	宇部興産株式会社	慢性閉塞性肺疾患の治療または予防のための医薬組成物
JP2019112305A (ja) *	2016-04-28	2019-07-11	宇部興産株式会社	アトピー性皮膚炎の治療または予防のための医薬組成物
JP2019112307A (ja) *	2016-04-28	2019-07-11	宇部興産株式会社	置換ジヒドロピロロピラゾール化合物および他の乾癬治療薬が組み合わせて投与される医薬組成物
CN107337674B (zh) *	2016-04-29	2019-09-20	江苏吉贝尔药业股份有限公司	用于dpp-iv抑制剂的四氢吡喃胺衍生物、其药物组合物和制剂以及用途
JP7590185B2 (ja)	2018-06-25	2024-11-26	ダナ－ファーバーキャンサーインスティテュート，インコーポレイテッド	Ｔａｉｒｅファミリーキナーゼインヒビターおよびそれらの使用
WO2020100944A1 (ja)	2018-11-14	2020-05-22	宇部興産株式会社	ジヒドロピロロピラゾール誘導体
WO2020140098A1 (en)	2018-12-28	2020-07-02	Dana-Farber Cancer Institute, Inc.	Inhibitors of cyclin-dependent kinase 7 and uses thereof
CN114401719A (zh) *	2019-07-23	2022-04-26	达纳-法伯癌症研究所股份有限公司	细胞周期蛋白依赖性激酶7的抑制剂及其用途
US12600718B2 (en)	2020-06-30	2026-04-14	Boryung Corporation	Method for preparing compound as PI3K inhibitor and intermediate compound for preparing same
CN115073471B (zh) *	2021-03-11	2023-03-21	沈阳药科大学	吡唑并四氢吡咯类衍生物、其制备方法和在医药上的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3526633A (en) *	1968-03-06	1970-09-01	American Cyanamid Co	Substituted 2,4,5,6-tetrahydropyrrolo(3,4-c)pyrazoles
GB9911053D0 (en)	1999-05-12	1999-07-14	Pharmacia & Upjohn Spa	4,5,6,7-tetrahydroindazole derivatives process for their preparation and their use as antitumour agents
WO2001012189A1 (en)	1999-08-12	2001-02-22	Pharmacia Italia S.P.A.	3(5)-amino-pyrazole derivatives, process for their preparation and their use as antitumor agents
US6387900B1 (en)	1999-08-12	2002-05-14	Pharmacia & Upjohn S.P.A.	3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents
JP4555547B2 (ja) *	2000-08-10	2010-10-06	ファイザーイタリアソシエタアレスポンサビリタリミタータ	キナーゼ阻害剤としての二環式ピラゾール、それらを製造するための方法およびそれらを含む医薬組成物
AU2002215053A1 (en) *	2000-11-27	2002-06-24	Pharmacia Italia S.P.A.	Phenylacetamido- pyrazole derivatives and their use as antitumor agents
CA2434066A1 (en) *	2001-01-26	2002-09-12	Pharmacia Italia S.P.A.	Chromane derivatives, process for their preparation and their use as antitumor agents
CZ2004359A3 (cs)	2001-09-26	2004-09-15	Pharmacia Italia S.P.A.	Aminoindazolové deriváty aktivní jako inhibitory kinázy, způsob jejich přípravy a farmaceutické prostředky obsahující tyto deriváty
UA81790C2 (uk) *	2002-12-19	2008-02-11	Фармация Италия С.П.А.	Заміщені піролопіразольні похідні як інгібітори кінази

2003
- 2003-04-12 UA UAA200507098A patent/UA81790C2/uk unknown
- 2003-12-04 ES ES03799536.2T patent/ES2605848T3/es not_active Expired - Lifetime
- 2003-12-04 AP AP2005003343A patent/AP2005003343A0/xx unknown
- 2003-12-04 EP EP03799536.2A patent/EP1575954B1/en not_active Expired - Lifetime
- 2003-12-04 PL PL377285A patent/PL377285A1/pl unknown
- 2003-12-04 GE GEAP20038905A patent/GEP20084435B/en unknown
- 2003-12-04 BR BR0317455-7A patent/BR0317455A/pt not_active IP Right Cessation
- 2003-12-04 JP JP2004561484A patent/JP4739761B2/ja not_active Expired - Fee Related
- 2003-12-04 ES ES10179134.1T patent/ES2635191T3/es not_active Expired - Lifetime
- 2003-12-04 KR KR1020127002938A patent/KR20120038465A/ko not_active Ceased
- 2003-12-04 CA CA2508069A patent/CA2508069C/en not_active Expired - Fee Related
- 2003-12-04 NZ NZ540644A patent/NZ540644A/en not_active IP Right Cessation
- 2003-12-04 CN CN2003801064477A patent/CN1726217B/zh not_active Expired - Lifetime
- 2003-12-04 EP EP10179134.1A patent/EP2266987B1/en not_active Expired - Lifetime
- 2003-12-04 AU AU2003300255A patent/AU2003300255B9/en not_active Ceased
- 2003-12-04 EA EA200501009A patent/EA010596B1/ru not_active IP Right Cessation
- 2003-12-04 OA OA1200500186A patent/OA13015A/fr unknown
- 2003-12-04 RS YUP-2005/0462A patent/RS20050462A/sr unknown
- 2003-12-04 MX MXPA05006791A patent/MXPA05006791A/es active IP Right Grant
- 2003-12-04 WO PCT/EP2003/050942 patent/WO2004056827A2/en not_active Ceased
- 2003-12-04 ME MEP-524/08A patent/MEP52408A/xx unknown
- 2003-12-04 US US10/539,145 patent/US7407971B2/en not_active Expired - Lifetime
- 2003-12-04 KR KR1020057011433A patent/KR101223826B1/ko not_active Expired - Fee Related
- 2003-12-04 HR HR20050562A patent/HRP20050562A2/hr not_active Application Discontinuation
- 2003-12-05 MY MYPI20034670A patent/MY141196A/en unknown
- 2003-12-16 TW TW092135527A patent/TWI327470B/zh not_active IP Right Cessation
- 2003-12-18 AR ARP030104702A patent/AR042525A1/es unknown
2005
- 2005-05-23 IS IS7857A patent/IS7857A/is unknown
- 2005-05-26 ZA ZA200504298A patent/ZA200504298B/en unknown
- 2005-06-06 IL IL169019A patent/IL169019A/en not_active IP Right Cessation
- 2005-06-09 NO NO20052805A patent/NO333178B1/no not_active IP Right Cessation
- 2005-06-14 CU CU20050117A patent/CU23550B7/es not_active IP Right Cessation
- 2005-06-17 EC EC2005005864A patent/ECSP055864A/es unknown
- 2005-06-17 TN TNP2005000163A patent/TNSN05163A1/fr unknown
- 2005-06-17 CR CR7880A patent/CR7880A/es unknown
- 2005-06-17 MA MA28347A patent/MA27569A1/fr unknown
2008
- 2008-07-29 US US12/181,772 patent/US8557857B2/en not_active Expired - Fee Related
- 2008-10-16 CR CR10370A patent/CR10370A/es not_active Application Discontinuation
2011
- 2011-02-14 JP JP2011028813A patent/JP2011144180A/ja not_active Withdrawn
- 2011-10-06 IL IL215617A patent/IL215617A0/en unknown
2012
- 2012-09-13 US US13/614,545 patent/US8557845B2/en not_active Expired - Fee Related
- 2012-09-13 US US13/614,499 patent/US8481585B2/en not_active Expired - Fee Related
2013
- 2013-08-27 US US14/010,819 patent/US8785448B2/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CA2508069A1 (en)	2004-07-08
KR20050085796A (ko)	2005-08-29
IL215617A0 (en)	2011-11-30
US20090082346A1 (en)	2009-03-26
GEP20084435B (en)	2008-07-25
EP1575954A2 (en)	2005-09-21
EA200501009A1 (ru)	2005-12-29
KR20120038465A (ko)	2012-04-23
EP1575954B1 (en)	2016-08-03
ES2635191T3 (es)	2017-10-02
AU2003300255B9 (en)	2010-03-04
ZA200504298B (en)	2006-02-22
US20130344031A1 (en)	2013-12-26
NZ540644A (en)	2008-09-26
WO2004056827A2 (en)	2004-07-08
TW200418461A (en)	2004-10-01
EP2266987A1 (en)	2010-12-29
IL169019A (en)	2011-11-30
TWI327470B (en)	2010-07-21
BR0317455A (pt)	2005-11-16
MXPA05006791A (es)	2005-09-08
US8557845B2 (en)	2013-10-15
JP2006514026A (ja)	2006-04-27
CR10370A (es)	2008-10-31
OA13015A (en)	2006-11-10
AR042525A1 (es)	2005-06-22
MA27569A1 (fr)	2005-10-03
ES2605848T3 (es)	2017-03-16
CN1726217A (zh)	2006-01-25
HK1086256A1 (en)	2006-09-15
CR7880A (es)	2005-07-08
ECSP055864A (es)	2005-09-20
HRP20050562A2 (en)	2005-12-31
CA2508069C (en)	2012-05-22
EA010596B1 (ru)	2008-10-30
US7407971B2 (en)	2008-08-05
EP2266987B1 (en)	2017-05-17
TNSN05163A1 (fr)	2007-05-14
WO2004056827A3 (en)	2004-10-28
US20130012507A1 (en)	2013-01-10
RS20050462A (sr)	2007-08-03
AU2003300255B2 (en)	2009-10-29
CU23550B7 (es)	2010-07-20
NO20052805L (no)	2005-07-14
PL377285A1 (pl)	2006-01-23
AU2003300255A1 (en)	2004-07-14
UA81790C2 (uk)	2008-02-11
US20130017170A1 (en)	2013-01-17
CN1726217B (zh)	2010-05-26
MEP52408A (en)	2011-02-10
US8481585B2 (en)	2013-07-09
JP4739761B2 (ja)	2011-08-03
US8785448B2 (en)	2014-07-22
US8557857B2 (en)	2013-10-15
IS7857A (is)	2005-08-18
US20070004705A1 (en)	2007-01-04
NO333178B1 (no)	2013-03-25
MY141196A (en)	2010-03-31
KR101223826B1 (ko)	2013-01-17
JP2011144180A (ja)	2011-07-28

Publication	Publication Date	Title
AP1850A (en)	2008-05-26	Spiroindolineplperidine derivatives
EG24050A (en)	2008-04-13	Heterocylocarboxamide derivatives
PL374718A1 (en)	2005-10-31	Azolidinone-vinyl fused-benzene derivatives
IL166121A0 (en)	2006-01-15	Indole-3-sulphur derivatives
EP1522540A4 (en)	2011-08-10	AZAARENE DERIVATIVES
PL376475A1 (en)	2005-12-27	N-substituted-2-oxodihydropyridine derivatives
IL169905A0 (en)	2007-07-04	Novel 2-pyridinecarboxamide derivatives
HUS1400037I1 (hu)	2017-08-28	Új 2-piridiletilbenzamid származékok
SI1594840T1 (sl)	2006-12-31	Derivati piperidin-benzensulfonamida
GB0317665D0 (en)	2003-09-03	Qinazoline derivatives
PL1682493T3 (pl)	2009-06-30	Pochodne amidoacetonitrylu
SI1606277T1 (sl)	2008-08-31	Derivati imidazol-4-il-etinil-piridina
IL166426A0 (en)	2006-01-15	N-biarylmethyl aminocycloalkanecarboxamide derivatives
IL175189A0 (en)	2006-09-05	N-thiazol-2-yl-benzamide derivatives
PT1706373E (pt)	2009-12-21	Derivados de amidoacetonitrilo
AU2003222659A8 (en)	2003-11-03	23-o-substituted 5-o-mycaminosyltylonide derivatives
GB0312368D0 (en)	2003-07-02	Novel ureido- and amido-pyrazolone derivatives
EP1531854A4 (en)	2006-06-28	O-DERIVATED NOCATHIACIN DERIVATIVES
GB0319793D0 (en)	2003-09-24	Pyridinylmorpholine derivatives
GB0213488D0 (en)	2002-07-24	2-Naphthamide derivatives
AU2003243397A8 (en)	2003-12-19	Homo-camptothecin derivatives
SI1654253T1 (sl)	2007-04-30	Substituirani 3-pirolidin-indolni derivati
GB0210512D0 (en)	2002-06-19	Tetrahydro-napthalene derivatives
GB0221143D0 (en)	2002-10-23	Dihydropyridinone derivatives
AU2003285777A8 (en)	2004-07-09	3-substituted-4-pyrimidone derivatives