AP2006003486A0 - Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors. - Google Patents

Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors.

Info

Publication number: AP2006003486A0
Authority: AP; ARIPO
Prior art keywords: inhibitors; glycogen synthase; synthase kinase; triazolopyrimidine derivatives; triazolopyrimidine
Prior art date: 2003-07-16

Application number

AP2006003486A

Other languages

English (en)

Inventor

Peter Jacobs Johann Buijnsters

Marc Willems

Werner Constant Joha Embrechts

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-16

Filing date

2004-07-12

Publication date

2006-02-28

2004-07-12 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2006-02-28 Publication of AP2006003486A0 publication Critical patent/AP2006003486A0/xx

Links

239000003572 glycogen synthase kinase 3 inhibitor Substances 0.000 title 1
YWBFPKPWMSWWEA-UHFFFAOYSA-O triazolopyrimidine Chemical class BrC1=CC=CC(C=2N=C3N=CN[N+]3=C(NCC=3C=CN=CC=3)C=2)=C1 YWBFPKPWMSWWEA-UHFFFAOYSA-O 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/16—Masculine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Diabetes (AREA)
Hematology (AREA)
Endocrinology (AREA)
Dermatology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Oncology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Psychology (AREA)
Hospice & Palliative Care (AREA)
Rheumatology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AP2006003486A 2003-07-16 2004-07-12 Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors. AP2006003486A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP0350310		2003-07-16
PCT/EP2004/051455 WO2005012307A1 (en)	2003-07-16	2004-07-12	Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors

Publications (1)

Publication Number	Publication Date
AP2006003486A0 true AP2006003486A0 (en)	2006-02-28

Family

ID=34112425

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2006003486A AP2006003486A0 (en)	2003-07-16	2004-07-12	Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors.

Country Status (26)

Country	Link
US (2)	US7560458B2 (pt)
EP (1)	EP1658292B1 (pt)
JP (1)	JP2009514782A (pt)
KR (1)	KR20060120393A (pt)
CN (1)	CN100404536C (pt)
AP (1)	AP2006003486A0 (pt)
AR (1)	AR045698A1 (pt)
AT (1)	ATE370142T1 (pt)
AU (1)	AU2004260738B2 (pt)
BR (1)	BRPI0412596A (pt)
CA (1)	CA2531333A1 (pt)
DE (1)	DE602004008303T2 (pt)
DK (1)	DK1658292T3 (pt)
EA (1)	EA010109B1 (pt)
ES (1)	ES2290754T3 (pt)
IL (1)	IL173139A (pt)
JO (1)	JO2460B1 (pt)
MX (1)	MXPA06000540A (pt)
NO (1)	NO20060678L (pt)
NZ (1)	NZ545058A (pt)
PA (1)	PA8607001A1 (pt)
PL (1)	PL1658292T3 (pt)
PT (1)	PT1658292E (pt)
TW (1)	TW200524935A (pt)
WO (1)	WO2005012307A1 (pt)
ZA (1)	ZA200600385B (pt)

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TWI329105B (en)	2002-02-01	2010-08-21	Rigel Pharmaceuticals Inc	2,4-pyrimidinediamine compounds and their uses
BR0313059B8 (pt)	2002-07-29	2021-07-27	Rigel Pharmaceuticals	composto, e, composição farmacêutica
ATE370142T1 (de) *	2003-07-16	2007-09-15	Janssen Pharmaceutica Nv	Triazolopyrimidinderivate als inhibitoren von glycogensynthasekinase-3
CN102358738A (zh)	2003-07-30	2012-02-22	里格尔药品股份有限公司	2,4-嘧啶二胺化合物及其预防和治疗自体免疫疾病的用途
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MX2007003327A (es)	2004-09-20	2007-06-05	Xenon Pharmaceuticals Inc	Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa.
MX2007003319A (es)	2004-09-20	2007-06-05	Xenon Pharmaceuticals Inc	Derivados heterociclicos y su uso como agentes terapeuticos.
EP2269610A3 (en)	2004-09-20	2011-03-09	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors
EP1799667B1 (en)	2004-09-20	2013-03-20	Xenon Pharmaceuticals Inc.	Heterocyclic derivatives and their use as therapeutic agents
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JP4958786B2 (ja)	2004-09-20	2012-06-20	ゼノン・ファーマシューティカルズ・インコーポレイテッド	複素環誘導体および治療薬としてのそれらの使用
MX2007003332A (es)	2004-09-20	2007-06-05	Xenon Pharmaceuticals Inc	Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa.
DE602005023333D1 (de)	2004-10-15	2010-10-14	Takeda Pharmaceutical	Kinaseinhibitoren
US8153640B2 (en)	2004-10-29	2012-04-10	Tibotec Pharmaceuticals Ltd.	HIV inhibiting bicyclic pyrimdine derivatives
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JP2009506069A (ja)	2005-08-26	2009-02-12	ブレインセルス，インコーポレイティド	ムスカリン性受容体調節による神経発生
EP2258359A3 (en)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenesis by muscarinic receptor modulation with sabcomelin
US8119655B2 (en) *	2005-10-07	2012-02-21	Takeda Pharmaceutical Company Limited	Kinase inhibitors
US7985756B2 (en)	2005-10-21	2011-07-26	Braincells Inc.	Modulation of neurogenesis by PDE inhibition
WO2007053596A1 (en)	2005-10-31	2007-05-10	Braincells, Inc.	Gaba receptor mediated modulation of neurogenesis
JP2009528295A (ja)	2006-02-24	2009-08-06	ライジェルファーマシューティカルズ，インコーポレイテッド	Ｊａｋ経路の阻害のための組成物および方法
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
WO2007134136A2 (en)	2006-05-09	2007-11-22	Braincells, Inc.	Neurogenesis by modulating angiotensin
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
SG158147A1 (en)	2006-10-09	2010-01-29	Takeda Pharmaceutical	Kinase inhibitors
NZ582349A (en) *	2007-06-29	2012-06-29	Sunesis Pharmaceuticals Inc	Heterocyclic compounds useful as raf kinase inhibitors
CL2008001933A1 (es)	2007-06-29	2009-09-25	Millennium Pharm Inc	Compuestos derivados de pirimidina, inhibidores de la raf quinasa; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar trastornos proliferativos, cardiacos, neurodegenerativos, inflamatorios, oseos, inmunologicos enfermedad viral, entre otros.
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BR112012029647A2 (pt)	2010-05-21	2016-08-02	Chemilia Ab	novos derivados de pirimidinas
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WO2013110309A1 (en) *	2012-01-28	2013-08-01	Merck Patent Gmbh	Triazolo[4,5-d]pyrimidine derivatives
JP6049768B2 (ja)	2012-03-07	2016-12-21	メルクパテントゲゼルシャフトミットベシュレンクテルハフツングＭｅｒｃｋＰａｔｅｎｔＧｅｓｅｌｌｓｃｈａｆｔｍｉｔｂｅｓｃｈｒａｅｎｋｔｅｒＨａｆｔｕｎｇ	トリアゾロピラジン誘導体
ES2636936T3 (es) *	2013-03-05	2017-10-10	Merck Patent Gmbh	Derivados de triazolo[4,5-d]pirimidina para el tratamiento de enfermedades tales como cáncer
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CA2911259A1 (en)	2013-05-06	2014-11-13	Merck Patent Gmbh	Macrocycles as kinase inhibitors
EP3226861A2 (en) *	2014-12-05	2017-10-11	Centre National de la Recherche Scientifique (CNRS)	Compounds for treating cystic fibrosis
US11370793B2 (en)	2015-08-27	2022-06-28	Nantneuro, Llc	Triazolopyridines and triazolopyrimidines that lower stress-induced p-tau
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EP3920885A1 (en)	2019-02-08	2021-12-15	Frequency Therapeutics, Inc.	Valproic acid compounds and wnt agonists for treating ear disorders
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EP1347972A1 (en) *	2000-12-19	2003-10-01	Smithkline Beecham Plc	Pyrazolo 3,4-c]pyridines as gsk-3 inhibitors
ATE370142T1 (de) *	2003-07-16	2007-09-15	Janssen Pharmaceutica Nv	Triazolopyrimidinderivate als inhibitoren von glycogensynthasekinase-3

2004
- 2004-07-12 AT AT04766189T patent/ATE370142T1/de active
- 2004-07-12 MX MXPA06000540A patent/MXPA06000540A/es active IP Right Grant
- 2004-07-12 EP EP04766189A patent/EP1658292B1/en not_active Expired - Lifetime
- 2004-07-12 KR KR1020057024541A patent/KR20060120393A/ko not_active Ceased
- 2004-07-12 NZ NZ545058A patent/NZ545058A/en not_active IP Right Cessation
- 2004-07-12 WO PCT/EP2004/051455 patent/WO2005012307A1/en not_active Ceased
- 2004-07-12 ES ES04766189T patent/ES2290754T3/es not_active Expired - Lifetime
- 2004-07-12 JP JP2006519926A patent/JP2009514782A/ja not_active Withdrawn
- 2004-07-12 DK DK04766189T patent/DK1658292T3/da active
- 2004-07-12 PL PL04766189T patent/PL1658292T3/pl unknown
- 2004-07-12 US US10/564,844 patent/US7560458B2/en not_active Expired - Fee Related
- 2004-07-12 EA EA200600258A patent/EA010109B1/ru not_active IP Right Cessation
- 2004-07-12 AP AP2006003486A patent/AP2006003486A0/xx unknown
- 2004-07-12 AU AU2004260738A patent/AU2004260738B2/en not_active Ceased
- 2004-07-12 DE DE602004008303T patent/DE602004008303T2/de not_active Expired - Lifetime
- 2004-07-12 BR BRPI0412596-7A patent/BRPI0412596A/pt not_active IP Right Cessation
- 2004-07-12 JO JO200496A patent/JO2460B1/en active
- 2004-07-12 CA CA002531333A patent/CA2531333A1/en not_active Abandoned
- 2004-07-12 PT PT04766189T patent/PT1658292E/pt unknown
- 2004-07-12 CN CNB2004800201486A patent/CN100404536C/zh not_active Expired - Fee Related
- 2004-07-15 TW TW093121066A patent/TW200524935A/zh unknown
- 2004-07-15 AR ARP040102496A patent/AR045698A1/es not_active Application Discontinuation
- 2004-07-15 PA PA20048607001A patent/PA8607001A1/es unknown
2006
- 2006-01-12 IL IL173139A patent/IL173139A/en not_active IP Right Cessation
- 2006-01-13 ZA ZA200600385A patent/ZA200600385B/en unknown
- 2006-02-10 NO NO20060678A patent/NO20060678L/no not_active Application Discontinuation
2008
- 2008-09-16 US US12/211,361 patent/US20090036471A1/en not_active Abandoned

Also Published As

Publication number	Publication date
EP1658292B1 (en)	2007-08-15
ES2290754T3 (es)	2008-02-16
TW200524935A (en)	2005-08-01
DE602004008303T2 (de)	2008-05-08
AR045698A1 (es)	2005-11-09
US20060205721A1 (en)	2006-09-14
ZA200600385B (en)	2007-05-30
AU2004260738A1 (en)	2005-02-10
JP2009514782A (ja)	2009-04-09
CA2531333A1 (en)	2005-02-10
DE602004008303D1 (de)	2007-09-27
PL1658292T3 (pl)	2008-01-31
EA010109B1 (ru)	2008-06-30
BRPI0412596A (pt)	2006-09-19
DK1658292T3 (da)	2007-11-12
CN1823068A (zh)	2006-08-23
PT1658292E (pt)	2007-10-25
WO2005012307A1 (en)	2005-02-10
IL173139A (en)	2010-04-29
IL173139A0 (en)	2006-06-11
NZ545058A (en)	2008-05-30
CN100404536C (zh)	2008-07-23
KR20060120393A (ko)	2006-11-27
US20090036471A1 (en)	2009-02-05
US7560458B2 (en)	2009-07-14
EA200600258A1 (ru)	2006-06-30
EP1658292A1 (en)	2006-05-24
PA8607001A1 (es)	2005-05-10
ATE370142T1 (de)	2007-09-15
JO2460B1 (en)	2009-01-20
AU2004260738B2 (en)	2009-07-16
NO20060678L (no)	2006-02-10
MXPA06000540A (es)	2006-03-30

Publication	Publication Date	Title
IL173139A0 (en)	2006-06-11	Triazolopyrimidine derivatives as glycogen synthase kinase 3 inhibitors
AP2005003353A0 (en)	2005-09-30	Diazepinoindole derivatives as kinase inhibitors.
HRP20180578T1 (hr)	2018-06-29	Pirolo[2,3-b]piridin-4-il-amini i pirolo[2m3-b]pirimidin-4-il-amini kao inhibitori janus kinaze
AP2005003452A0 (en)	2005-12-31	Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors.
SI2395004T1 (sl)	2016-05-31	Derivati piro (2,3-b) piridina kot inhibitorji proteinske kinaze
IL173381A0 (en)	2006-06-11	2-aminophenyl-4-phenylpyrimidines as kinase inhibitors
IL172132A0 (en)	2006-04-10	Thienopyridone derivatives as kinase inhibitors
IL173380A0 (en)	2006-06-11	Pyridinylamino-pyrimidine derivatives as protein kinase inhibitors
EG24774A (en)	2010-08-19	Quinoline derivatives as phosphodiesterase inhibitors.
IL165515A0 (en)	2006-01-15	Bisindolyl-maleimid derivatives as kinase inhibitors
EP1590333A4 (en)	2008-04-30	GLYCOGENE SYNTHASE KINASE 3BETA INHIBITOR, COMPOSITION AND PROCESS FOR PREPARING THE SAME
SI3184526T1 (sl)	2019-03-29	Derivati pirolo(2,3-D)pirimidina kot inhibitorji Janus kinaze
AP2214A (en)	2011-03-04	Pyrrolo [3,4-c] pyrazole derivatives active as kinase inhibitors.
IL173200A0 (en)	2006-06-11	Piperidyl-quinazoline derivatives as tyrosine kinase inhibitors
AP2006003620A0 (en)	2006-06-30	Imidazopyrazine tyroshine kinase inhibitors
AU2003271566A8 (en)	2004-03-03	Pyrrolopyrazines as kinase inhibitors
AP2326A (en)	2011-11-24	Triazolopyridinylsulfanyl derivatives as p38 map kinase inhibitors.
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