AP2008004481A0 - Estrogen modulators - Google Patents

Estrogen modulators

Info

Publication number
AP2008004481A0
AP2008004481A0 AP2008004481A AP2008004481A AP2008004481A0 AP 2008004481 A0 AP2008004481 A0 AP 2008004481A0 AP 2008004481 A AP2008004481 A AP 2008004481A AP 2008004481 A AP2008004481 A AP 2008004481A AP 2008004481 A0 AP2008004481 A0 AP 2008004481A0
Authority
AP
ARIPO
Prior art keywords
estrogen modulators
estrogen
modulators
Prior art date
Application number
AP2008004481A
Other languages
English (en)
Inventor
Simon Bailey
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AP2008004481A0 publication Critical patent/AP2008004481A0/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30Oestrogens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32Antioestrogens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/18Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/08Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/08Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AP2008004481A 2005-12-22 2006-12-11 Estrogen modulators AP2008004481A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75278005P 2005-12-22 2005-12-22
US80523306P 2006-06-20 2006-06-20
PCT/IB2006/003671 WO2007072164A2 (en) 2005-12-22 2006-12-11 Estrogen modulators

Publications (1)

Publication Number Publication Date
AP2008004481A0 true AP2008004481A0 (en) 2008-06-30

Family

ID=38066616

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2008004481A AP2008004481A0 (en) 2005-12-22 2006-12-11 Estrogen modulators

Country Status (17)

Country Link
US (2) US7470715B2 (nl)
EP (1) EP1966170A2 (nl)
JP (1) JP2009520808A (nl)
KR (1) KR20080073346A (nl)
AP (1) AP2008004481A0 (nl)
AR (1) AR058611A1 (nl)
AU (1) AU2006327877A1 (nl)
BR (1) BRPI0620215A2 (nl)
CA (1) CA2628596A1 (nl)
EA (1) EA200801407A1 (nl)
EC (1) ECSP088533A (nl)
NL (1) NL2000351C2 (nl)
NO (1) NO20082992L (nl)
PE (1) PE20070815A1 (nl)
RS (1) RS20080267A (nl)
UY (1) UY30047A1 (nl)
WO (1) WO2007072164A2 (nl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH12013500275A1 (en) * 2010-08-10 2017-08-23 Abbvie Inc Novel trpv3 modulators
CN111938907B (zh) * 2020-08-12 2022-07-01 中国人民解放军陆军军医大学第一附属医院 一种鼻部手术后外敷面罩
GB2608397B (en) * 2021-06-29 2025-04-09 Chaitowitz Ilan Gynecomastia treatment

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US207927A (en) * 1878-09-10 Improvement in horse hay-rakes
US171412A (en) * 1875-12-21 Improvement in buck-boards
US256210A (en) * 1882-04-11 Bodolphe t
US9799A (en) * 1853-06-21 Simon ikgeksoll
US525666A (en) * 1894-09-04 Axel sarnmark
GB1012182A (en) 1963-04-23 1965-12-08 Ass Portland Cement Improvement in the manufacture of hydraulic cement
JPS63108339A (ja) 1986-10-27 1988-05-13 Fuji Photo Film Co Ltd ハロゲン化銀カラ−感光材料の処理方法
GB2201672A (en) 1986-12-18 1988-09-07 Shell Int Research Diphenyl ether compounds
US4952700A (en) 1988-04-25 1990-08-28 W.R. Grace & Co.-Conn. Preparation of isoxazolines and isoxazoles
US4933464A (en) * 1988-04-25 1990-06-12 W. R. Grace & Co.-Conn. Process for forming 3-phenylisoxazolines and 3-phenylisoxazoles
JPH089599B2 (ja) 1988-08-02 1996-01-31 三井東圧化学株式会社 ピラゾールカルボン酸類の製造方法
JPH089600B2 (ja) 1988-08-02 1996-01-31 三井東圧化学株式会社 ピラゾールカルボン酸類の製造方法
IT1228288B (it) 1989-01-09 1991-06-07 Zambon Spa Composti ad attivita' antiserotoninica
DE4016049A1 (de) * 1990-05-18 1991-11-21 Basf Ag 3-isoxazolylbenzylester, ihre herstellung und ihre verwendung
US5256632A (en) * 1990-05-30 1993-10-26 Bayer Aktiengesellschaft Herbicidal sulphonylated carboxamides
DK178590D0 (da) 1990-07-26 1990-07-26 Novo Nordisk As 1,4-disubstituerede piperaziner
US5260322A (en) 1990-10-08 1993-11-09 Merck & Co., Inc. Angiotension II antagonists in the treatment of hyperuricemia
JP3010387B2 (ja) 1991-05-13 2000-02-21 コニカ株式会社 ピラゾール誘導体
JP3454531B2 (ja) * 1991-11-07 2003-10-06 三共株式会社 ニトロキシアルキルアミド誘導体
DE4137940A1 (de) 1991-11-18 1993-05-19 Basf Ag 3-isoxazolylphenylverbindungen, ihre herstellung und ihre verwendung
AU5891494A (en) 1993-01-29 1994-08-15 Nippon Soda Co., Ltd. Heterocyclic derivative
IT1263751B (it) 1993-02-05 1996-08-27 Mini Ricerca Scient Tecnolog Derivati di esteri arilacetici ad attivita' fungicida
JPH06236057A (ja) 1993-02-10 1994-08-23 Fuji Xerox Co Ltd 電子写真感光体
JPH07304748A (ja) 1993-06-29 1995-11-21 Nissan Chem Ind Ltd アルドキシム誘導体および農園芸用殺菌剤
WO1995011896A1 (en) 1993-10-26 1995-05-04 Nissan Chemical Industries, Ltd. Substituted pyrazole derivative and agrohorticultural fungicide
JP3791015B2 (ja) 1994-03-31 2006-06-28 日産化学工業株式会社 スルホンアミド誘導体の製造方法
JP3329061B2 (ja) 1994-04-19 2002-09-30 三菱化学株式会社 電子写真用感光体
JPH0873436A (ja) 1994-07-06 1996-03-19 Nissan Chem Ind Ltd セミカルバゾン誘導体
US5486534A (en) 1994-07-21 1996-01-23 G. D. Searle & Co. 3,4-substituted pyrazoles for the treatment of inflammation
FR2725988B1 (fr) 1994-10-24 1997-01-24 Roussel Uclaf Nouveaux derives de pyrazolones et pyrazoles acides, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
CN1117080A (zh) 1995-01-11 1996-02-21 刘波 苏云金芽胞杆菌培养基
ES2183935T3 (es) * 1995-02-13 2003-04-01 Searle & Co Isoxazoles sustituidos para el tratamiento de la inflamacion.
WO1996033994A1 (en) 1995-04-28 1996-10-31 Nippon Soda Co., Ltd. Amino-substituted derivatives, process for the preparation thereof, and herbicide
DE69635048T2 (de) * 1995-06-12 2006-02-16 G.D. Searle & Co. Mittel, enthaltend einen cyclooxygenase-2 inhibitor und einen 5-lipoxygenase inhibitor
KR19990064310A (ko) 1995-10-17 1999-07-26 윌리암스 로저 에이 시클로옥시게나제-2의 검출방법
AU1952597A (en) 1996-02-13 1997-09-02 G.D. Searle & Co. Combinations, having immunosuppressive effects, containing cyclooxygenase-2 inhibitor and a leukotriene a4 hydrolase inhibitor
SK285353B6 (sk) 1996-04-12 2006-11-03 G. D. Searle & Co. Substituované benzénsulfónamidy ako proliečivá COX-2 inhibítorov, farmaceutická kompozícia a spôsobich prípravy a použitia
JP3399756B2 (ja) * 1996-10-22 2003-04-21 三菱製紙株式会社 平版印刷版の処理方法
ES2195388T3 (es) * 1997-09-05 2003-12-01 Basf Ag Procedimiento para la obtencion de hidroxilaminas (hetero)aromaticas.
CA2372912C (en) 1997-10-14 2008-12-02 G.D. Searle & Co. Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia
US5972986A (en) * 1997-10-14 1999-10-26 G.D. Searle & Co. Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of neoplasia
JPH11124306A (ja) 1997-10-22 1999-05-11 Nissan Chem Ind Ltd 殺虫・殺ダニ・殺菌剤組成物
EP1102755B1 (en) * 1998-08-07 2006-01-04 Chiron Corporation Substituted isoxazole derivatives as estrogen receptor modulators
WO2000019994A1 (en) 1998-10-02 2000-04-13 Board Of Trustees Of The University Of Illinois Estrogen receptor ligands
AU766648B2 (en) * 1999-03-17 2003-10-23 Axys Pharmaceuticals, Inc. Compounds and methods for modulation of estrogen receptors
AU3253800A (en) 1999-05-14 2000-11-16 Pfizer Products Inc. Combination therapy for the treatment of migraine
US6413965B1 (en) 1999-06-30 2002-07-02 Pfizer Inc. Compositions and treatment for diabetic complications
CO5190678A1 (es) 1999-06-30 2002-08-29 Pfizer Prod Inc Terapia combinada para el tratamiento de la migrana
JP4645871B2 (ja) 1999-09-24 2011-03-09 日本農薬株式会社 イソキサゾリン誘導体及び除草剤並びにその使用方法
US6673820B2 (en) 1999-12-02 2004-01-06 Novartis Animal Health Us, Inc. Aminoheterocyclylamides as pesticides and antiparasitic agents
AU2001255600A1 (en) 2000-04-25 2001-11-07 Pharmacia Corporation Regioselective synthesis of 3,4-di(carbocyclyl or heterocyclyl)thiophenes
JP2001302662A (ja) 2000-04-27 2001-10-31 Nissan Chem Ind Ltd アクリロニトリル化合物
EP1339683B1 (en) 2000-11-27 2006-06-14 Merck & Co., Inc. Estrogen receptor modulators
US6693295B2 (en) * 2000-12-25 2004-02-17 Fuji Photo Film Co., Ltd. Indole derivative, material for light-emitting device and light-emitting device using the same
WO2002079163A1 (en) 2001-03-30 2002-10-10 Smithkline Beecham Corporation Aminopyridine derivatives as estrogen receptor modulators
US6673818B2 (en) 2001-04-20 2004-01-06 Pharmacia Corporation Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation
EP1270535A3 (de) * 2001-06-20 2004-02-18 Clariant GmbH Verfahren zur Herstellung von substituierten aromatischen Verbindungen
US6960607B2 (en) 2001-12-13 2005-11-01 Wyeth Naphthyl benzoxazoles and benzisoxazoles as estrogenic agents
US6884814B2 (en) 2001-12-13 2005-04-26 Wyeth Phenyl benzisoxazoles as estrogenic agents
GB0130339D0 (en) 2001-12-19 2002-02-06 Lilly Co Eli Isochroman compounds
EP1456180B1 (en) 2001-12-21 2007-10-03 Vernalis (Cambridge) Limited 3-(2,4)dihydroxyphenyl-4-phenylpyrazoles and their medical use
AU2002367426A1 (en) 2001-12-28 2003-07-24 Takeda Chemical Industries, Ltd. Neurotrophic factor production/secretion accelerator
US6803379B2 (en) * 2002-06-04 2004-10-12 Jose A. Fernandez-Pol Pharmacological agents and methods of treatment that inactivate pathogenic prokaryotic and eukaryotic cells and viruses by attacking highly conserved domains in structural metalloprotein and metalloenzyme targets
PT1606307E (pt) 2002-07-03 2007-11-21 Ortho Mcneil Pharm Inc Derivados de estrieno[3,2-b]/[3,4-c]pirrole úteis como moduladores dos receptores de estrogénio
JP2006508927A (ja) 2002-09-19 2006-03-16 メルク エンド カムパニー インコーポレーテッド エストロゲン受容体修飾因子
CA2512000C (en) 2002-12-26 2011-08-09 Eisai Co., Ltd. Selective estrogen receptor modulator
WO2004073610A2 (en) 2003-02-13 2004-09-02 Merck & Co., Inc. Estrogen receptor modulators
WO2004073612A2 (en) 2003-02-13 2004-09-02 Merck & Co. Inc. Estrogen receptor modulators
CA2527659A1 (en) 2003-05-31 2005-01-06 Janssen Pharmaceutica N.V. Cyclohexyl derivatives as selective estrogen receptor modulators
DE602004014806D1 (de) 2003-10-08 2008-08-14 Smithkline Beecham Corp Triphenylethyleneverbindungen als selektive modulatoren des östrogenrezeptors
CN1997618A (zh) 2004-05-04 2007-07-11 阿卡迪亚医药公司 对雌激素受体具有活性的化合物

Also Published As

Publication number Publication date
NL2000351A1 (nl) 2007-06-25
AR058611A1 (es) 2008-02-13
NO20082992L (no) 2008-09-22
US20070149564A1 (en) 2007-06-28
BRPI0620215A2 (pt) 2011-11-01
RS20080267A (sr) 2009-05-06
JP2009520808A (ja) 2009-05-28
EA200801407A1 (ru) 2008-10-30
WO2007072164A3 (en) 2007-10-04
NL2000351C2 (nl) 2007-09-11
EP1966170A2 (en) 2008-09-10
UY30047A1 (es) 2007-07-31
KR20080073346A (ko) 2008-08-08
WO2007072164A2 (en) 2007-06-28
ECSP088533A (es) 2008-07-30
AU2006327877A1 (en) 2007-06-28
PE20070815A1 (es) 2007-08-27
US20090131397A1 (en) 2009-05-21
CA2628596A1 (en) 2007-06-28
US7470715B2 (en) 2008-12-30

Similar Documents

Publication Publication Date Title
IL184657A0 (en) Adam-9 modulators
GB0522477D0 (en) Modulator
GB0505941D0 (en) Human-to-mobile interfaces
IL183543A0 (en) Estrogen receptor modulators
IL182829A0 (en) Estrogen receptor modulators
IL189846A0 (en) Theramutein modulators
IL190349A0 (en) Tetrahydro-indazolyl cannabinoid modulators
GB2445525B (en) Airbrush
GB0506677D0 (en) Iron modulators
AP2672A (en) Glucuronidate nebivoloi metabolites
ZA200805405B (en) Substituted 5-heteroaryl-1-phenyl-pyrazole cannabinoid modulators
ZA200804871B (en) Estrogen modulators
ZA200709385B (en) Androgen modulators
GB0624980D0 (en) Modification
ZA200801986B (en) Standard
AP2008004481A0 (en) Estrogen modulators
EP1877320A4 (en) Coating Aid
AU304349S (en) Stamp
GB0427954D0 (en) Modulator
ZA200802433B (en) Theramutein modulators
GB0510121D0 (en) Modulator
IL179559A0 (en) Theramutein modulators
GB0401131D0 (en) Modulators
GB0401130D0 (en) Modulators
AU302353S (en) Sign