AP2014007399A0 - Phenyl-3-AZA-bicycloÄ3.1.0Ühex-3-YL-methanones andthe use thereof as medicament - Google Patents

Phenyl-3-AZA-bicycloÄ3.1.0Ühex-3-YL-methanones andthe use thereof as medicament

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Publication number
AP2014007399A0
AP2014007399A0 AP2014007399A AP2014007399A AP2014007399A0 AP 2014007399 A0 AP2014007399 A0 AP 2014007399A0 AP 2014007399 A AP2014007399 A AP 2014007399A AP 2014007399 A AP2014007399 A AP 2014007399A AP 2014007399 A0 AP2014007399 A0 AP 2014007399A0
Authority
AP
ARIPO
Prior art keywords
methanones
aza
medicament
phenyl
andthe use
Prior art date
Application number
AP2014007399A
Other languages
English (en)
Inventor
Barbara Bertani
Marco Ferrara
Riccardo Giovannini
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AP2014007399A0 publication Critical patent/AP2014007399A0/xx

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
AP2014007399A 2011-08-03 2012-08-02 Phenyl-3-AZA-bicycloÄ3.1.0Ühex-3-YL-methanones andthe use thereof as medicament AP2014007399A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11176468 2011-08-03
PCT/EP2012/065140 WO2013017657A1 (en) 2011-08-03 2012-08-02 Phenyl-3-aza-bicyclo[3.1.0]hex-3-yl-methanones and the use thereof as medicament

Publications (1)

Publication Number Publication Date
AP2014007399A0 true AP2014007399A0 (en) 2014-01-31

Family

ID=46598566

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2014007399A AP2014007399A0 (en) 2011-08-03 2012-08-02 Phenyl-3-AZA-bicycloÄ3.1.0Ühex-3-YL-methanones andthe use thereof as medicament

Country Status (37)

Country Link
US (1) US9012489B2 (de)
EP (1) EP2739615B1 (de)
JP (1) JP5850589B2 (de)
KR (1) KR101944686B1 (de)
CN (2) CN105837562B (de)
AP (1) AP2014007399A0 (de)
AR (1) AR087436A1 (de)
AU (1) AU2012292036C1 (de)
BR (1) BR112014001642B1 (de)
CA (1) CA2843805C (de)
CL (1) CL2014000246A1 (de)
CO (1) CO6870037A2 (de)
CY (1) CY1119326T1 (de)
DK (1) DK2739615T3 (de)
EA (1) EA024933B1 (de)
EC (1) ECSP14013221A (de)
ES (1) ES2623006T3 (de)
GE (1) GEP20166483B (de)
HR (1) HRP20170695T1 (de)
HU (1) HUE033134T2 (de)
IL (1) IL229962A (de)
LT (1) LT2739615T (de)
MA (1) MA35286B1 (de)
ME (1) ME02672B (de)
MX (1) MX347828B (de)
MY (1) MY167396A (de)
PE (1) PE20141352A1 (de)
PH (1) PH12014500276A1 (de)
PL (1) PL2739615T3 (de)
PT (1) PT2739615T (de)
RS (1) RS55927B1 (de)
SI (1) SI2739615T1 (de)
TN (1) TN2014000044A1 (de)
TW (1) TWI543974B (de)
UA (1) UA114405C2 (de)
UY (1) UY34239A (de)
WO (1) WO2013017657A1 (de)

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BR122021017881B1 (pt) 2014-06-06 2021-11-23 Basf Se Uso dos compostos, composição agroquímica e método para o combate dos fungos fitopatogênicos
AR106679A1 (es) 2015-11-13 2018-02-07 Basf Se Oxadiazoles sustituidos para combatir hongos fitopatógenos
WO2017081309A1 (en) 2015-11-13 2017-05-18 Basf Se Substituted oxadiazoles for combating phytopathogenic fungi
CN108289449A (zh) 2015-11-19 2018-07-17 巴斯夫欧洲公司 用于防除植物病原性真菌的取代噁二唑
US10986839B2 (en) 2016-04-11 2021-04-27 Basf Se Substituted oxadiazoles for combating phytopathogenic fungi
WO2018224455A1 (en) 2017-06-07 2018-12-13 Basf Se Substituted cyclopropyl derivatives
UA129159C2 (uk) * 2019-05-01 2025-01-29 Бьорінгер Інгельхайм Інтернаціональ Гмбх ТВЕРДІ ФОРМИ ІНГІБІТОРА GlyT1
KR20220125326A (ko) 2020-01-09 2022-09-14 디스크 메디슨, 인크. 적혈구형성 프로토포르피린증, x-연계된 프로토포르피린증, 또는 선천성 적혈구 조혈포르피린증을 글리신 운반 억제제로 치료하는 방법
BR112022026698A2 (pt) * 2020-08-13 2023-02-23 Boehringer Ingelheim Int Tratamento da deficiência cognitiva associada à esquizofrenia
CA3195702A1 (en) * 2020-10-13 2022-04-21 Boehringer Ingelheim International Gmbh Process of reworking
IL313067A (en) * 2021-11-24 2024-07-01 Maplight Therapeutics Inc Methods of treating neurological disorders
CN114957087A (zh) * 2022-04-13 2022-08-30 湖南复瑞生物医药技术有限责任公司 一种帕罗韦德中间体制备方法
CN117597342A (zh) * 2022-06-10 2024-02-23 成都百裕制药股份有限公司 吡咯烷衍生物、药物组合物及其在医药上的应用
EP4577540A1 (de) 2022-08-24 2025-07-02 Boehringer Ingelheim International GmbH Skalierbares verfahren zur herstellung eines glyt-1-inhibitors
IL324862A (en) * 2023-05-25 2026-01-01 Maplight Therapeutics Inc Compounds for the treatment of neurological disorders
WO2025140479A1 (zh) * 2023-12-29 2025-07-03 苏州科睿思制药有限公司 Iclepertin的晶型及其制备方法和用途

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JP2006514978A (ja) 2003-04-10 2006-05-18 ランバクシー ラボラトリーズ リミテッド ムスカリン受容体アンタゴニストである置換アザビシクロヘキサン誘導体
CN101838271A (zh) * 2003-10-14 2010-09-22 辉瑞产品公司 作为甘氨酸转运蛋白抑制剂的二环[3.1.0]衍生物
DE102004035280A1 (de) 2004-07-21 2006-03-16 Robert Bosch Gmbh Kraftstoffinjektor mit direkter mehrstufiger Einspritzventilgliedansteuerung
KR20070094955A (ko) * 2005-01-06 2007-09-27 에프. 호프만-라 로슈 아게 신경 질환 및 신경정신 질환을 치료하기 위한 글라이신수송자 1(glyt-1) 저해제로서의 설파닐 치환 페닐메타논
RU2396270C2 (ru) * 2005-01-07 2010-08-10 Ф.Хоффманн-Ля Рош Аг Производные [4-(гетероарил)пиперазин-1-ил]-(2,5-замещенный фенил)метанона в качестве ингибиторов переносчика глицина-1 (glyt-1) для лечения неврологических и психоневрологических заболеваний
CN101119968B (zh) * 2005-02-07 2011-08-31 弗·哈夫曼-拉罗切有限公司 作为甘氨酸转运蛋白1抑制剂的杂环取代的苯基甲酮衍生物
ES2406085T3 (es) * 2006-06-22 2013-06-05 F. Hoffmann-La Roche Ag Derivados de fenil-metanona sustituida y su empleo como inhibidores de receptores de GlyT1 y GlyT2
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TW200833328A (en) * 2006-12-28 2008-08-16 Actelion Pharmaceuticals Ltd 2-aza-bicyclo[3.1.0]hexane derivatives
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Also Published As

Publication number Publication date
GEP20166483B (en) 2016-05-25
JP5850589B2 (ja) 2016-02-03
AR087436A1 (es) 2014-03-26
WO2013017657A1 (en) 2013-02-07
SI2739615T1 (sl) 2017-07-31
JP2014524414A (ja) 2014-09-22
US20130197011A1 (en) 2013-08-01
UA114405C2 (uk) 2017-06-12
CN105837562A (zh) 2016-08-10
UY34239A (es) 2013-02-28
RS55927B1 (sr) 2017-09-29
TWI543974B (zh) 2016-08-01
CN105837562B (zh) 2020-01-17
AU2012292036A1 (en) 2014-01-16
BR112014001642B1 (pt) 2022-03-22
NZ619258A (en) 2015-12-24
ECSP14013221A (es) 2014-03-31
PE20141352A1 (es) 2014-10-12
CN103797005B (zh) 2016-05-11
IL229962A (en) 2016-09-29
ES2623006T3 (es) 2017-07-10
EP2739615B1 (de) 2017-03-15
AU2012292036B2 (en) 2016-10-06
CA2843805C (en) 2021-03-23
TN2014000044A1 (en) 2015-07-01
PL2739615T3 (pl) 2017-08-31
CL2014000246A1 (es) 2014-08-08
US9012489B2 (en) 2015-04-21
CA2843805A1 (en) 2013-02-07
ME02672B (de) 2017-06-20
DK2739615T3 (en) 2017-05-08
PH12014500276A1 (en) 2017-02-01
LT2739615T (lt) 2017-04-10
MY167396A (en) 2018-08-16
AU2012292036C1 (en) 2017-03-23
MA35286B1 (fr) 2014-07-03
HUE033134T2 (en) 2017-11-28
CO6870037A2 (es) 2014-02-20
KR20140051922A (ko) 2014-05-02
BR112014001642A2 (pt) 2017-02-14
CY1119326T1 (el) 2018-02-14
TW201321364A (zh) 2013-06-01
HK1193100A1 (zh) 2014-09-12
CN103797005A (zh) 2014-05-14
PT2739615T (pt) 2017-06-09
MX347828B (es) 2017-05-15
HRP20170695T1 (hr) 2017-07-28
EP2739615A1 (de) 2014-06-11
EA024933B1 (ru) 2016-11-30
EA201400183A1 (ru) 2014-06-30
MX2014001252A (es) 2014-05-13
KR101944686B1 (ko) 2019-02-01

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