AP2014007773A0 - New phosphate compounds, a process for their preparation and pharmaceutical compositions containing them - Google Patents

New phosphate compounds, a process for their preparation and pharmaceutical compositions containing them

Info

Publication number
AP2014007773A0
AP2014007773A0 AP2014007773A AP2014007773A AP2014007773A0 AP 2014007773 A0 AP2014007773 A0 AP 2014007773A0 AP 2014007773 A AP2014007773 A AP 2014007773A AP 2014007773 A AP2014007773 A AP 2014007773A AP 2014007773 A0 AP2014007773 A0 AP 2014007773A0
Authority
AP
ARIPO
Prior art keywords
preparation
pharmaceutical compositions
compositions containing
phosphate compounds
new phosphate
Prior art date
Application number
AP2014007773A
Other languages
English (en)
Inventor
Jean-Michel Henlin
Guillaume De Nanteuil
Olivier Geneste
Original Assignee
Vernalis R&D Ltd
Servier Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50288170&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP2014007773(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vernalis R&D Ltd, Servier Lab filed Critical Vernalis R&D Ltd
Publication of AP2014007773A0 publication Critical patent/AP2014007773A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1092—Details
    • A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AP2014007773A 2013-07-23 2014-07-09 New phosphate compounds, a process for their preparation and pharmaceutical compositions containing them AP2014007773A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1357259A FR3008979B1 (fr) 2013-07-23 2013-07-23 Nouveaux derives phosphates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
AP2014007773A0 true AP2014007773A0 (en) 2014-07-31

Family

ID=50288170

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2014007773A AP2014007773A0 (en) 2013-07-23 2014-07-09 New phosphate compounds, a process for their preparation and pharmaceutical compositions containing them

Country Status (48)

Country Link
US (3) US9115159B2 (ru)
EP (1) EP2829545B1 (ru)
JP (1) JP5894638B2 (ru)
KR (2) KR101713103B1 (ru)
CN (1) CN104341451B (ru)
AP (1) AP2014007773A0 (ru)
AR (1) AR097008A1 (ru)
AU (1) AU2014203808B2 (ru)
BR (1) BR102014017997B1 (ru)
CA (1) CA2856886C (ru)
CL (1) CL2014001865A1 (ru)
CR (1) CR20140336A (ru)
CU (1) CU24316B1 (ru)
CY (1) CY1117834T1 (ru)
DK (1) DK2829545T3 (ru)
DO (1) DOP2014000163A (ru)
EA (1) EA027444B1 (ru)
EC (1) ECSP14008757A (ru)
ES (1) ES2593417T3 (ru)
FR (1) FR3008979B1 (ru)
GE (1) GEP201706704B (ru)
HK (1) HK1204623A1 (ru)
HR (1) HRP20161202T8 (ru)
HU (1) HUE029616T2 (ru)
IL (1) IL233580B (ru)
JO (1) JO3160B1 (ru)
MA (1) MA37213B1 (ru)
MD (1) MD4551C1 (ru)
ME (1) ME02641B (ru)
MX (1) MX351467B (ru)
MY (1) MY173258A (ru)
NI (1) NI201400080A (ru)
PE (1) PE20150218A1 (ru)
PH (1) PH12014000194A1 (ru)
PL (1) PL2829545T3 (ru)
PT (1) PT2829545T (ru)
RS (1) RS55098B1 (ru)
RU (1) RU2617682C2 (ru)
SA (1) SA114350669B1 (ru)
SG (1) SG10201403939WA (ru)
SI (1) SI2829545T1 (ru)
SV (1) SV2014004771A (ru)
TN (1) TN2014000301A1 (ru)
TW (1) TWI527824B (ru)
UA (1) UA119738C2 (ru)
UY (1) UY35661A (ru)
WO (1) WO2015011399A1 (ru)
ZA (1) ZA201405418B (ru)

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FR3008976A1 (fr) * 2013-07-23 2015-01-30 Servier Lab "nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent"
FR3008977A1 (fr) 2013-07-23 2015-01-30 Servier Lab Nouveaux derives d'isoindoline ou d'isoquinoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
UY37316A (es) * 2016-07-07 2018-01-31 Servier Lab Dispersión sólida farmacéutica de un inhibidor de bcl-2, composiciones farmacéuticas de ésta, y usos para el tratamiento de cáncer
UA125138C2 (uk) * 2016-07-22 2022-01-19 Ле Лаборатуар Сервьє Комбінація інгібітора bcl-2 та інгібітора mcl-1, їхнє застосування і фармацевтичні композиції
WO2018015526A1 (en) 2016-07-22 2018-01-25 Les Laboratoires Servier Combination of a bcl-2 inhibitor and a mcl-1 inhibitor, uses and pharmaceutical compositions thereof
WO2018158225A1 (en) 2017-02-28 2018-09-07 Les Laboratoires Servier Combination of a bcl-2 inhibitor and a mdm2 inhibitor, uses and pharmaceutical compositions thereof
EA039621B1 (ru) * 2017-06-09 2022-02-17 Ле Лаборатуар Сервье Комбинация bcl-2 ингибитора и mcl-1 ингибитора, их применения и фармацевтические композиции
TWI672302B (zh) * 2017-07-06 2019-09-21 法商施維雅藥廠 Bcl-2抑制劑之新結晶型、其製備方法及含其之醫藥組合物
FR3072679B1 (fr) * 2017-10-25 2020-10-30 Servier Lab Nouveaux derives macrocycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CN118903436A (zh) 2018-01-31 2024-11-08 德西费拉制药有限责任公司 治疗肥大细胞增多症的组合疗法
KR102708177B1 (ko) 2018-01-31 2024-09-23 데시페라 파마슈티칼스, 엘엘씨. 위장관 기질 종양의 치료를 위한 병용 요법
IL330104A (en) 2019-03-11 2026-08-01 Deciphera Pharmaceuticals Llc Crystalline forms of rifatinib
HRP20260411T1 (hr) 2019-08-12 2026-05-08 Deciphera Pharmaceuticals, Llc Ripretinib za liječenje gastrointestinalnih stromalnih tumora
CN110606860B (zh) 2019-09-29 2021-12-10 上海勋和医药科技有限公司 一种吡啶磺酰胺磷酸酯类化合物、其制备方法及其用途
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CN116981458A (zh) * 2021-03-12 2023-10-31 伊尔治疗学股份有限公司 具有四氢吲哚-1-甲酰胺作为bcl-2抑制剂的化合物
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IL317101A (en) 2022-05-20 2025-01-01 Novartis Ag Antibody-drug conjugates of anticancer compounds and methods of using them
US11779572B1 (en) 2022-09-02 2023-10-10 Deciphera Pharmaceuticals, Llc Methods of treating gastrointestinal stromal tumors
AR134424A1 (es) 2023-11-22 2026-01-14 Novartis Ag Conjugados de anticuerpo anti-cd7-fármaco y métodos de uso de los mismos
UY40985A (es) 2023-11-22 2025-06-30 Servier Lab Conjugados de anticuerpo anti-cd74-fármaco y métodos de uso de los mismos

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AU2012355623A1 (en) 2011-12-23 2014-07-17 Novartis Ag Compounds for inhibiting the interaction of BCL2 with binding partners
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CN103177906A (zh) 2011-12-26 2013-06-26 西门子公司 用于中压开关设备的断路器
ITPR20110103A1 (it) 2011-12-27 2013-06-28 G E A F S R L Metodo e apparato per la sterilizzazione di una soluzione liquida mediante radio frequenza
US9114953B2 (en) 2011-12-29 2015-08-25 Inventio Ag Emergency operation of elevators based on an indicated emergency condition
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FR2986002B1 (fr) * 2012-01-24 2014-02-21 Servier Lab Nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
MX351467B (es) 2017-10-17
US20170143746A1 (en) 2017-05-25
NI201400080A (es) 2014-10-24
EA027444B1 (ru) 2017-07-31
JP2015028017A (ja) 2015-02-12
DOP2014000163A (es) 2015-01-15
MA37213B1 (fr) 2017-03-31
EA201400754A3 (ru) 2015-03-31
ECSP14008757A (es) 2016-01-29
PE20150218A1 (es) 2015-02-14
BR102014017997B1 (pt) 2020-05-19
CY1117834T1 (el) 2017-05-17
AU2014203808A1 (en) 2015-02-12
US9115159B2 (en) 2015-08-25
PH12014000194B1 (en) 2015-06-29
TWI527824B (zh) 2016-04-01
FR3008979B1 (fr) 2015-07-24
HUE029616T2 (en) 2017-03-28
HK1201536A1 (zh) 2015-09-04
RU2014130129A (ru) 2016-02-10
IL233580A0 (en) 2014-11-02
ZA201405418B (en) 2020-02-26
PH12014000194A1 (en) 2015-06-29
BR102014017997A2 (pt) 2015-11-17
UY35661A (es) 2015-02-27
JO3160B1 (ar) 2017-09-20
US20150031648A1 (en) 2015-01-29
GEP201706704B (en) 2017-07-25
DK2829545T3 (en) 2016-09-19
RS55098B1 (sr) 2016-12-30
SV2014004771A (es) 2015-01-28
NZ627178A (en) 2016-01-29
ME02641B (me) 2017-06-20
US9597341B2 (en) 2017-03-21
CU24316B1 (es) 2018-02-08
MX2014008866A (es) 2015-07-21
SA114350669B1 (ar) 2016-04-11
MA37213A1 (fr) 2016-06-30
WO2015011399A1 (fr) 2015-01-29
CL2014001865A1 (es) 2015-06-26
ES2593417T3 (es) 2016-12-09
MD4551B1 (ru) 2018-02-28
RU2617682C2 (ru) 2017-04-26
FR3008979A1 (fr) 2015-01-30
TN2014000301A1 (fr) 2015-12-21
UA119738C2 (uk) 2019-08-12
MD4551C1 (ru) 2018-09-30
CU20140095A7 (es) 2016-02-29
CA2856886C (fr) 2016-08-02
CN104341451B (zh) 2018-04-03
KR101713103B1 (ko) 2017-03-07
US20150313923A1 (en) 2015-11-05
MD20140073A2 (ru) 2015-01-31
AU2014203808B2 (en) 2018-09-20
IL233580B (en) 2020-03-31
HRP20161202T8 (hr) 2016-12-30
SI2829545T1 (sl) 2016-10-28
EA201400754A2 (ru) 2014-12-30
EP2829545B1 (fr) 2016-06-22
AR097008A1 (es) 2016-02-10
MY173258A (en) 2020-01-09
KR20150011785A (ko) 2015-02-02
EP2829545A1 (fr) 2015-01-28
CR20140336A (es) 2015-10-07
PL2829545T3 (pl) 2016-12-30
PT2829545T (pt) 2016-07-13
CA2856886A1 (fr) 2015-01-23
HK1204623A1 (en) 2015-11-27
TW201504254A (zh) 2015-02-01
KR20170001694A (ko) 2017-01-04
CN104341451A (zh) 2015-02-11
HRP20161202T1 (hr) 2016-11-04
SG10201403939WA (en) 2015-02-27
JP5894638B2 (ja) 2016-03-30

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