CU24316B1 - Nuevos derivados fosfatos de 1,2,3,4-tetraisoquinolina amida fenilo, métodos de preparación de los mismos y composiciones farmacéuticas que los contienen - Google Patents

Nuevos derivados fosfatos de 1,2,3,4-tetraisoquinolina amida fenilo, métodos de preparación de los mismos y composiciones farmacéuticas que los contienen

Info

Publication number
CU24316B1
CU24316B1 CUP2014000095A CU20140095A CU24316B1 CU 24316 B1 CU24316 B1 CU 24316B1 CU P2014000095 A CUP2014000095 A CU P2014000095A CU 20140095 A CU20140095 A CU 20140095A CU 24316 B1 CU24316 B1 CU 24316B1
Authority
CU
Cuba
Prior art keywords
formula
compounds
preparation
tetraisoquinolina
phyphate
Prior art date
Application number
CUP2014000095A
Other languages
English (en)
Spanish (es)
Other versions
CU20140095A7 (es
Inventor
I Jen Chen
James Edward Paul Davidson
Nanteuil Guillaume De
Olivier Geneste
Anne Françoise Guillouzic
Jean Michel Henlin
Diguarher Thierry Le
Tiran Arnaud Le
James Brooke Murray
Jerome Benoît Starck
Original Assignee
Servier Lab
Vernalis R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50288170&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU24316(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Servier Lab, Vernalis R&D Ltd filed Critical Servier Lab
Publication of CU20140095A7 publication Critical patent/CU20140095A7/es
Publication of CU24316B1 publication Critical patent/CU24316B1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N2005/1092—Details
    • A61N2005/1098—Enhancing the effect of the particle by an injected agent or implanted device

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CUP2014000095A 2013-07-23 2014-07-23 Nuevos derivados fosfatos de 1,2,3,4-tetraisoquinolina amida fenilo, métodos de preparación de los mismos y composiciones farmacéuticas que los contienen CU24316B1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1357259A FR3008979B1 (fr) 2013-07-23 2013-07-23 Nouveaux derives phosphates, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
CU20140095A7 CU20140095A7 (es) 2016-02-29
CU24316B1 true CU24316B1 (es) 2018-02-08

Family

ID=50288170

Family Applications (1)

Application Number Title Priority Date Filing Date
CUP2014000095A CU24316B1 (es) 2013-07-23 2014-07-23 Nuevos derivados fosfatos de 1,2,3,4-tetraisoquinolina amida fenilo, métodos de preparación de los mismos y composiciones farmacéuticas que los contienen

Country Status (48)

Country Link
US (3) US9115159B2 (ru)
EP (1) EP2829545B1 (ru)
JP (1) JP5894638B2 (ru)
KR (2) KR101713103B1 (ru)
CN (1) CN104341451B (ru)
AP (1) AP2014007773A0 (ru)
AR (1) AR097008A1 (ru)
AU (1) AU2014203808B2 (ru)
BR (1) BR102014017997B1 (ru)
CA (1) CA2856886C (ru)
CL (1) CL2014001865A1 (ru)
CR (1) CR20140336A (ru)
CU (1) CU24316B1 (ru)
CY (1) CY1117834T1 (ru)
DK (1) DK2829545T3 (ru)
DO (1) DOP2014000163A (ru)
EA (1) EA027444B1 (ru)
EC (1) ECSP14008757A (ru)
ES (1) ES2593417T3 (ru)
FR (1) FR3008979B1 (ru)
GE (1) GEP201706704B (ru)
HK (1) HK1204623A1 (ru)
HR (1) HRP20161202T8 (ru)
HU (1) HUE029616T2 (ru)
IL (1) IL233580B (ru)
JO (1) JO3160B1 (ru)
MA (1) MA37213B1 (ru)
MD (1) MD4551C1 (ru)
ME (1) ME02641B (ru)
MX (1) MX351467B (ru)
MY (1) MY173258A (ru)
NI (1) NI201400080A (ru)
PE (1) PE20150218A1 (ru)
PH (1) PH12014000194A1 (ru)
PL (1) PL2829545T3 (ru)
PT (1) PT2829545T (ru)
RS (1) RS55098B1 (ru)
RU (1) RU2617682C2 (ru)
SA (1) SA114350669B1 (ru)
SG (1) SG10201403939WA (ru)
SI (1) SI2829545T1 (ru)
SV (1) SV2014004771A (ru)
TN (1) TN2014000301A1 (ru)
TW (1) TWI527824B (ru)
UA (1) UA119738C2 (ru)
UY (1) UY35661A (ru)
WO (1) WO2015011399A1 (ru)
ZA (1) ZA201405418B (ru)

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FR3008976A1 (fr) * 2013-07-23 2015-01-30 Servier Lab "nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent"
FR3008977A1 (fr) 2013-07-23 2015-01-30 Servier Lab Nouveaux derives d'isoindoline ou d'isoquinoline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
UY37316A (es) * 2016-07-07 2018-01-31 Servier Lab Dispersión sólida farmacéutica de un inhibidor de bcl-2, composiciones farmacéuticas de ésta, y usos para el tratamiento de cáncer
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WO2018015526A1 (en) 2016-07-22 2018-01-25 Les Laboratoires Servier Combination of a bcl-2 inhibitor and a mcl-1 inhibitor, uses and pharmaceutical compositions thereof
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IL330104A (en) 2019-03-11 2026-08-01 Deciphera Pharmaceuticals Llc Crystalline forms of rifatinib
HRP20260411T1 (hr) 2019-08-12 2026-05-08 Deciphera Pharmaceuticals, Llc Ripretinib za liječenje gastrointestinalnih stromalnih tumora
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FR2986002B1 (fr) * 2012-01-24 2014-02-21 Servier Lab Nouveaux derives d'indolizine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

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MX351467B (es) 2017-10-17
US20170143746A1 (en) 2017-05-25
NI201400080A (es) 2014-10-24
EA027444B1 (ru) 2017-07-31
JP2015028017A (ja) 2015-02-12
DOP2014000163A (es) 2015-01-15
MA37213B1 (fr) 2017-03-31
EA201400754A3 (ru) 2015-03-31
ECSP14008757A (es) 2016-01-29
PE20150218A1 (es) 2015-02-14
BR102014017997B1 (pt) 2020-05-19
CY1117834T1 (el) 2017-05-17
AU2014203808A1 (en) 2015-02-12
US9115159B2 (en) 2015-08-25
PH12014000194B1 (en) 2015-06-29
TWI527824B (zh) 2016-04-01
FR3008979B1 (fr) 2015-07-24
HUE029616T2 (en) 2017-03-28
HK1201536A1 (zh) 2015-09-04
RU2014130129A (ru) 2016-02-10
IL233580A0 (en) 2014-11-02
ZA201405418B (en) 2020-02-26
PH12014000194A1 (en) 2015-06-29
BR102014017997A2 (pt) 2015-11-17
UY35661A (es) 2015-02-27
JO3160B1 (ar) 2017-09-20
US20150031648A1 (en) 2015-01-29
GEP201706704B (en) 2017-07-25
DK2829545T3 (en) 2016-09-19
RS55098B1 (sr) 2016-12-30
SV2014004771A (es) 2015-01-28
NZ627178A (en) 2016-01-29
ME02641B (me) 2017-06-20
US9597341B2 (en) 2017-03-21
MX2014008866A (es) 2015-07-21
SA114350669B1 (ar) 2016-04-11
MA37213A1 (fr) 2016-06-30
WO2015011399A1 (fr) 2015-01-29
CL2014001865A1 (es) 2015-06-26
ES2593417T3 (es) 2016-12-09
MD4551B1 (ru) 2018-02-28
RU2617682C2 (ru) 2017-04-26
FR3008979A1 (fr) 2015-01-30
TN2014000301A1 (fr) 2015-12-21
UA119738C2 (uk) 2019-08-12
MD4551C1 (ru) 2018-09-30
CU20140095A7 (es) 2016-02-29
CA2856886C (fr) 2016-08-02
CN104341451B (zh) 2018-04-03
KR101713103B1 (ko) 2017-03-07
US20150313923A1 (en) 2015-11-05
MD20140073A2 (ru) 2015-01-31
AU2014203808B2 (en) 2018-09-20
IL233580B (en) 2020-03-31
HRP20161202T8 (hr) 2016-12-30
SI2829545T1 (sl) 2016-10-28
EA201400754A2 (ru) 2014-12-30
EP2829545B1 (fr) 2016-06-22
AR097008A1 (es) 2016-02-10
MY173258A (en) 2020-01-09
AP2014007773A0 (en) 2014-07-31
KR20150011785A (ko) 2015-02-02
EP2829545A1 (fr) 2015-01-28
CR20140336A (es) 2015-10-07
PL2829545T3 (pl) 2016-12-30
PT2829545T (pt) 2016-07-13
CA2856886A1 (fr) 2015-01-23
HK1204623A1 (en) 2015-11-27
TW201504254A (zh) 2015-02-01
KR20170001694A (ko) 2017-01-04
CN104341451A (zh) 2015-02-11
HRP20161202T1 (hr) 2016-11-04
SG10201403939WA (en) 2015-02-27
JP5894638B2 (ja) 2016-03-30

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