AP2014007846A0 - Synthethic apelin mimetics for the treatment of heart failure - Google Patents

Synthethic apelin mimetics for the treatment of heart failure

Info

Publication number: AP2014007846A0
Authority: AP; ARIPO
Prior art keywords: synthethic; treatment; heart failure; apelin; mimetics
Prior art date: 2012-01-27

Application number

AP2014007846A

Other languages

English (en)

Inventor

Hidetomo Imase

Hongjuan Zhao

Andrei Golosov

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-01-27

Filing date

2013-01-25

Publication date

2014-08-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47997598&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP2014007846(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2013-01-25 Application filed by Novartis Ag filed Critical Novartis Ag

2014-08-31 Publication of AP2014007846A0 publication Critical patent/AP2014007846A0/xx

Links

102000018746 Apelin Human genes 0.000 title 1
108010052412 Apelin Proteins 0.000 title 1
206010019280 Heart failures Diseases 0.000 title 1
BWVPHIKGXQBZPV-QKFDDRBGSA-N apelin Chemical compound NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1[C@H](C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=2NC=NC=2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=2NC=NC=2)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CCSC)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(O)=O)CCC1 BWVPHIKGXQBZPV-QKFDDRBGSA-N 0.000 title 1

Classifications

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- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/10—Peptides having 12 to 20 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/20—Valves specially adapted to medical respiratory devices
- A61M16/201—Controlled valves
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- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/0027—Accessories therefor, e.g. sensors, vibrators, negative pressure pressure meter
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. ventilators; Tracheal tubes
- A61M16/0003—Accessories therefor, e.g. sensors, vibrators, negative pressure
- A61M2016/003—Accessories therefor, e.g. sensors, vibrators, negative pressure with a flowmeter
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
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- A—HUMAN NECESSITIES
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- A61M2205/00—General characteristics of the apparatus
- A61M2205/50—General characteristics of the apparatus with microprocessors or computers
- A61M2205/502—User interfaces, e.g. screens or keyboards

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Emergency Medicine (AREA)
Diabetes (AREA)
Anesthesiology (AREA)
Immunology (AREA)
Epidemiology (AREA)
Gastroenterology & Hepatology (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Dermatology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Toxicology (AREA)
Neurosurgery (AREA)
Neurology (AREA)

AP2014007846A 2012-01-27 2013-01-25 Synthethic apelin mimetics for the treatment of heart failure AP2014007846A0 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US201261591557P	2012-01-27	2012-01-27
US201261717760P	2012-10-24	2012-10-24
US201261731697P	2012-11-30	2012-11-30
PCT/IB2013/050666 WO2013111110A2 (fr)	2012-01-27	2013-01-25	Utilisation de mimétiques synthétiques de l'apeline pour le traitement de l'insuffisance cardiaque

Publications (1)

Publication Number	Publication Date
AP2014007846A0 true AP2014007846A0 (en)	2014-08-31

Family

ID=47997598

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2014007846A AP2014007846A0 (en)	2012-01-27	2013-01-25	Synthethic apelin mimetics for the treatment of heart failure

Country Status (42)

Country	Link
US (3)	US8673848B2 (fr)
EP (1)	EP2807183B1 (fr)
JP (2)	JP6313222B2 (fr)
KR (2)	KR20200003229A (fr)
CN (1)	CN104220452B (fr)
AP (1)	AP2014007846A0 (fr)
AR (1)	AR089808A1 (fr)
AU (1)	AU2013213265C1 (fr)
BR (1)	BR112014018306A8 (fr)
CA (1)	CA2862240A1 (fr)
CL (1)	CL2014001994A1 (fr)
CO (1)	CO7020879A2 (fr)
CR (1)	CR20140364A (fr)
CU (1)	CU24266B1 (fr)
CY (1)	CY1120239T1 (fr)
DK (1)	DK2807183T3 (fr)
EA (1)	EA027853B1 (fr)
EC (1)	ECSP14016014A (fr)
ES (1)	ES2670832T3 (fr)
GT (1)	GT201400166A (fr)
HR (1)	HRP20180806T1 (fr)
HU (1)	HUE039137T2 (fr)
IL (1)	IL233792B (fr)
JO (1)	JO3380B1 (fr)
LT (1)	LT2807183T (fr)
MX (1)	MX351569B (fr)
MY (1)	MY172268A (fr)
NZ (1)	NZ627772A (fr)
PE (1)	PE20142194A1 (fr)
PH (1)	PH12014501701A1 (fr)
PL (1)	PL2807183T3 (fr)
PT (1)	PT2807183T (fr)
RS (1)	RS57200B1 (fr)
SG (1)	SG11201404369PA (fr)
SI (1)	SI2807183T1 (fr)
TN (1)	TN2014000318A1 (fr)
TR (1)	TR201807309T4 (fr)
TW (1)	TWI576356B (fr)
UA (1)	UA116196C2 (fr)
UY (1)	UY34593A (fr)
WO (1)	WO2013111110A2 (fr)
ZA (1)	ZA201405400B (fr)

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Publication number	Publication date
MX2014009085A (es)	2014-08-27
PH12014501701A1 (en)	2014-10-13
JO3380B1 (ar)	2019-03-13
DK2807183T3 (en)	2018-06-06
RS57200B1 (sr)	2018-07-31
US9067971B2 (en)	2015-06-30
EP2807183B1 (fr)	2018-02-28
CA2862240A1 (fr)	2013-08-01
HK1200470A1 (en)	2015-08-07
LT2807183T (lt)	2018-05-10
UA116196C2 (uk)	2018-02-26
KR20200003229A (ko)	2020-01-08
TN2014000318A1 (en)	2015-12-21
KR20140117603A (ko)	2014-10-07
TR201807309T4 (tr)	2018-06-21
US20140142022A1 (en)	2014-05-22
ECSP14016014A (es)	2015-11-30
US20150252076A1 (en)	2015-09-10
CY1120239T1 (el)	2019-07-10
US8673848B2 (en)	2014-03-18
CN104220452B (zh)	2018-01-26
IL233792A0 (en)	2014-09-30
PE20142194A1 (es)	2014-12-21
AU2013213265C1 (en)	2016-09-29
CU20140097A7 (es)	2015-03-30
HRP20180806T1 (hr)	2018-06-29
PT2807183T (pt)	2018-05-29
JP6595553B2 (ja)	2019-10-23
SG11201404369PA (en)	2014-08-28
AU2013213265A1 (en)	2014-09-18
WO2013111110A2 (fr)	2013-08-01
GT201400166A (es)	2015-10-15
AR089808A1 (es)	2014-09-17
IL233792B (en)	2018-04-30
HUE039137T2 (hu)	2018-12-28
US9982017B2 (en)	2018-05-29
CO7020879A2 (es)	2014-08-11
NZ627772A (en)	2015-11-27
WO2013111110A3 (fr)	2013-10-31
JP2015506370A (ja)	2015-03-02
EA201491433A1 (ru)	2014-12-30
KR102068370B1 (ko)	2020-01-21
SI2807183T1 (en)	2018-05-31
CN104220452A (zh)	2014-12-17
CL2014001994A1 (es)	2014-11-03
EP2807183A2 (fr)	2014-12-03
ZA201405400B (en)	2016-08-31
JP2018048157A (ja)	2018-03-29
TW201335190A (zh)	2013-09-01
ES2670832T3 (es)	2018-06-01
UY34593A (es)	2013-09-02
MX351569B (es)	2017-10-19
TWI576356B (zh)	2017-04-01
EA027853B1 (ru)	2017-09-29
BR112014018306A2 (fr)	2017-06-20
AU2013213265B2 (en)	2016-05-26
JP6313222B2 (ja)	2018-04-18
CU24266B1 (es)	2017-07-04
MY172268A (en)	2019-11-20
US20130196899A1 (en)	2013-08-01
PL2807183T3 (pl)	2018-08-31
CR20140364A (es)	2014-11-17
BR112014018306A8 (pt)	2017-07-11

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