AP2126A - Broadspectrum substituted oxindole sulfonamide HIVprotease inhibitors - Google Patents

Broadspectrum substituted oxindole sulfonamide HIVprotease inhibitors

Info

Publication number
AP2126A
AP2126A AP2005003245A AP2005003245A AP2126A AP 2126 A AP2126 A AP 2126A AP 2005003245 A AP2005003245 A AP 2005003245A AP 2005003245 A AP2005003245 A AP 2005003245A AP 2126 A AP2126 A AP 2126A
Authority
AP
ARIPO
Prior art keywords
hivprotease
sulfonamide
inhibitors
substituted oxindole
broadspectrum
Prior art date
Application number
AP2005003245A
Other languages
English (en)
Other versions
AP2005003245A0 (en
Inventor
Abdellah Tahri
Piet Tom Bert Paul Wigerinck
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of AP2005003245A0 publication Critical patent/AP2005003245A0/xx
Application granted granted Critical
Publication of AP2126A publication Critical patent/AP2126A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AP2005003245A 2002-08-14 2003-08-14 Broadspectrum substituted oxindole sulfonamide HIVprotease inhibitors AP2126A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02078384 2002-08-14
PCT/EP2003/050379 WO2004016619A1 (fr) 2002-08-14 2003-08-14 Oxindole sulfonamides substitues inhibiteurs a large spectre de la protease du vih

Publications (2)

Publication Number Publication Date
AP2005003245A0 AP2005003245A0 (en) 2005-03-31
AP2126A true AP2126A (en) 2010-06-03

Family

ID=31725465

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2005003245A AP2126A (en) 2002-08-14 2003-08-14 Broadspectrum substituted oxindole sulfonamide HIVprotease inhibitors

Country Status (18)

Country Link
US (1) US7199148B2 (fr)
EP (1) EP1546153A1 (fr)
JP (1) JP4681296B2 (fr)
KR (1) KR100994759B1 (fr)
CN (1) CN1688586B (fr)
AP (1) AP2126A (fr)
AU (1) AU2003262574B2 (fr)
BR (1) BR0305771A (fr)
CA (1) CA2493940C (fr)
EA (1) EA010486B1 (fr)
HR (1) HRP20050606B1 (fr)
IL (1) IL166462A (fr)
MX (1) MXPA05001792A (fr)
NO (1) NO331846B1 (fr)
NZ (1) NZ538714A (fr)
PL (1) PL375307A1 (fr)
WO (1) WO2004016619A1 (fr)
ZA (1) ZA200501223B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003202914A1 (en) * 2002-01-07 2003-07-24 Sequoia Pharmaceuticals Broad spectrum inhibitors
JP2007528423A (ja) * 2004-03-11 2007-10-11 セコイア、ファーマシューティカルズ、インコーポレイテッド 耐性防止レトロウイルスプロテアーゼ阻害薬
US7378441B2 (en) * 2004-05-07 2008-05-27 Sequoia Pharmaceuticals, Inc. Resistance-repellent retroviral protease inhibitors
TWI482775B (zh) 2008-09-01 2015-05-01 Tibotec Pharm Ltd 用於製備（３ｒ，３ａｓ，６ａｒ）－六氫呋喃并〔２，３－ｂ〕呋喃－３－基（１ｓ，２ｒ）－３－〔〔（４－胺基苯基）磺醯基〕（異丁基）胺基〕－１－苯甲基－２－羥基丙基胺基甲酸酯之方法
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
EP2528923B1 (fr) 2010-01-28 2014-07-30 Mapi Pharma Limited Procédé pour la préparation de darunavir et d'intermédiaires de darunavir
US8580294B2 (en) 2010-10-19 2013-11-12 International Partnership For Microbicides Platinum-catalyzed intravaginal rings
WO2012092168A1 (fr) * 2010-12-27 2012-07-05 Purdue Research Foundation Ligands p2 à système cyclique 6,5 bicyclique fusionné, et procédés de traitement d'une infection par le vih
WO2012092188A1 (fr) * 2010-12-27 2012-07-05 Ghosh Arun K Ligands p1 formant des liaisons hydrogène et procédés de traitement d'une infection par le vih
US10137031B2 (en) 2013-11-14 2018-11-27 International Partnership For Microbicides, Inc. Combination therapy intravaginal rings
WO2016039403A1 (fr) * 2014-09-11 2016-03-17 塩野義製薬株式会社 Inhibiteur prolongé de la protéase du vih

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996022287A1 (fr) * 1995-01-20 1996-07-25 G.D. Searle & Co. Inhibiteurs hydroxyethylamino contenant des bis-sulfinamides utilises pour inhiber des proteases retrovirales
WO1999065870A2 (fr) * 1998-06-19 1999-12-23 Vertex Pharmaceuticals Incorporated Inhibiteurs sulfonamides d'aspartyle protease
WO2001072708A2 (fr) * 2000-03-24 2001-10-04 Cor Therapeutics, Inc. INHIBITEURS D'OXINIDOLE DU FACTEUR Xa

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
PH30929A (en) 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
IS2334B (is) * 1992-09-08 2008-02-15 Vertex Pharmaceuticals Inc., (A Massachusetts Corporation) Aspartyl próteasi hemjari af nýjum flokki súlfonamíða
US5723490A (en) * 1992-09-08 1998-03-03 Vertex Pharmaceuticals Incorporated THF-containing sulfonamide inhibitors of aspartyl protease
EP0715618B1 (fr) 1993-08-24 1998-12-16 G.D. Searle & Co. Hydroxyethylamino-sulfonamides aptes a etre utilises comme inhibiteurs de protease retrovirale
PT721331E (pt) 1993-10-01 2002-05-31 Astrazeneca Ab Processo i
US5756533A (en) 1995-03-10 1998-05-26 G.D. Searle & Co. Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US6150556A (en) 1995-03-10 2000-11-21 G. D. Dearle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
US5705500A (en) 1995-03-10 1998-01-06 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
BR9607625A (pt) 1995-03-10 1999-06-15 Searle & Co Inibidores de protease retroviral sulfonamida hidroxietilamino de aminoácido heterociclocarbonila
US5753660A (en) 1995-11-15 1998-05-19 G. D. Searle & Co. Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
WO1997044014A1 (fr) 1996-05-20 1997-11-27 Janssen Pharmaceutica N.V. Compositions antifongiques avec biodisponibilite amelioree
SK284813B6 (sk) 1997-03-26 2005-12-01 Janssen Pharmaceutica N. V. Peleta obsahujúca itrakonazol, spôsob jej prípravy a farmaceutická dávková forma s jej obsahom
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
AU2012199A (en) 1997-12-24 1999-07-19 Vertex Pharmaceuticals Incorporated Prodrugs of aspartyl protease inhibitors
WO1999033792A2 (fr) 1997-12-24 1999-07-08 Vertex Pharmaceuticals Incorporated Promedicaments des inhibiteurs de l'aspartyl-transferase
EA200000702A1 (ru) 1997-12-24 2000-12-25 Вертекс Фармасьютикалз Инкорпорейтед Пролекарства ингибиторов аспартилпротеаз
AU4828199A (en) * 1998-06-23 2000-01-10 Board Of Trustees Of The University Of Illinois, The Multi-drug resistant retroviral protease inhibitors and associated methods
CA2872424C (fr) 1998-06-23 2017-03-07 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Derives de bisfurane utiles dans la prevention de l'emergence de souches de vih multiresistantes aux medicaments et le traitement du vih

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996022287A1 (fr) * 1995-01-20 1996-07-25 G.D. Searle & Co. Inhibiteurs hydroxyethylamino contenant des bis-sulfinamides utilises pour inhiber des proteases retrovirales
WO1999065870A2 (fr) * 1998-06-19 1999-12-23 Vertex Pharmaceuticals Incorporated Inhibiteurs sulfonamides d'aspartyle protease
WO2001072708A2 (fr) * 2000-03-24 2001-10-04 Cor Therapeutics, Inc. INHIBITEURS D'OXINIDOLE DU FACTEUR Xa

Also Published As

Publication number Publication date
NZ538714A (en) 2007-03-30
NO20051291L (no) 2005-05-18
NO331846B1 (no) 2012-04-23
EA010486B1 (ru) 2008-10-30
HRP20050606B1 (hr) 2014-04-25
CA2493940C (fr) 2011-11-22
US20060058368A1 (en) 2006-03-16
AU2003262574B2 (en) 2009-07-09
BR0305771A (pt) 2004-10-05
EP1546153A1 (fr) 2005-06-29
IL166462A0 (en) 2006-01-15
IL166462A (en) 2012-04-30
CN1688586B (zh) 2012-05-09
MXPA05001792A (es) 2005-04-25
CA2493940A1 (fr) 2004-02-26
KR20050042141A (ko) 2005-05-04
JP4681296B2 (ja) 2011-05-11
CN1688586A (zh) 2005-10-26
US7199148B2 (en) 2007-04-03
JP2005537305A (ja) 2005-12-08
KR100994759B1 (ko) 2010-11-16
HRP20050606A2 (en) 2006-02-28
EA200500350A1 (ru) 2005-08-25
ZA200501223B (en) 2006-07-26
WO2004016619A1 (fr) 2004-02-26
PL375307A1 (en) 2005-11-28
AU2003262574A1 (en) 2004-03-03
AP2005003245A0 (en) 2005-03-31

Similar Documents

Publication Publication Date Title
IS7607A (is) Ný útskipt indól
EG25482A (en) Inhibitors
DK1534290T3 (da) Hidtil ukendte kinasehæmmere
NO20034389D0 (no) Fremgangsmåte for utledning av data
ATE517888T1 (de) Indolylmaleimid-derivate
SI1569907T1 (sl) Na nikotinamidu osnovani kinazni inhibitorji
DK1501826T3 (da) Substituerede indoler som alpha-1-agonister
EP1558609A4 (fr) Inhibiteurs de kinase
AU2003277674A1 (en) Novel parp inhibitors
EP1532133A4 (fr) Inhibiteurs de nf-:b
IL160752A0 (en) Indole derivatives as cox ii inhibitors
AP2126A (en) Broadspectrum substituted oxindole sulfonamide HIVprotease inhibitors
AU2003286251A1 (en) New bicyclic angiotensin ii agonists
AP2005003242A0 (en) Broadspectrum 2-aminobenzothiazole sulfonamide HIVprotease inhibitors.
IL164898A0 (en) Heterotricyclyl 6-alkylidene-penems as beta-lactamase inhibitors
IL175889A0 (en) Advanced indolinone based protein kinase inhibitors
HRP20040936A2 (en) Broadspectrum substituted benzimidazole sulfonamide hiv protease inhibitors
GB0318913D0 (en) Apoptosis inhibitors
NO20022243L (no) Fremgangsmåte for rörlegging
ATE405560T1 (de) Indolderivaten
HK1079769A (zh) 取代的羟吲哚磺酰胺类广谱hiv蛋白酶抑制剂
FI20020734L (fi) Laiteriippumaton verkkopalvelu
IL163638A0 (en) 5-Heteroaryl substituted indoles
AU2003298513A8 (en) Sterically-awkward beta-lactamase inhibitors
GB0206031D0 (en) Inhibitors