AP2528A - Methods for the preparation of (3R,3aS,6aR) hexahydro- furo [2,3-b] furan-3-ol - Google Patents

Methods for the preparation of (3R,3aS,6aR) hexahydro- furo [2,3-b] furan-3-ol

Info

Publication number
AP2528A
AP2528A AP2006003748A AP2006003748A AP2528A AP 2528 A AP2528 A AP 2528A AP 2006003748 A AP2006003748 A AP 2006003748A AP 2006003748 A AP2006003748 A AP 2006003748A AP 2528 A AP2528 A AP 2528A
Authority
AP
ARIPO
Prior art keywords
furo
hexahydro
furan
preparation
methods
Prior art date
Application number
AP2006003748A
Other languages
English (en)
Other versions
AP2006003748A0 (en
Inventor
Peter Jan Leonard Mario Quaedflieg
Bart Rudolf Romanie Kesteleyn
Robert Jan Vijn
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34928933&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP2528(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of AP2006003748A0 publication Critical patent/AP2006003748A0/xx
Application granted granted Critical
Publication of AP2528A publication Critical patent/AP2528A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyesters Or Polycarbonates (AREA)
AP2006003748A 2004-03-31 2005-03-31 Methods for the preparation of (3R,3aS,6aR) hexahydro- furo [2,3-b] furan-3-ol AP2528A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04101336 2004-03-31
PCT/EP2005/051452 WO2005095410A1 (en) 2004-03-31 2005-03-31 METHODS FOR THE PREPARATION OF (3R,3aS,6aR) HEXAHYDRO-FURO[2,3-b]FURAN-3-OL

Publications (2)

Publication Number Publication Date
AP2006003748A0 AP2006003748A0 (en) 2006-10-31
AP2528A true AP2528A (en) 2012-12-10

Family

ID=34928933

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2006003748A AP2528A (en) 2004-03-31 2005-03-31 Methods for the preparation of (3R,3aS,6aR) hexahydro- furo [2,3-b] furan-3-ol

Country Status (28)

Country Link
US (1) US7595408B2 (es)
EP (1) EP1732931B1 (es)
JP (1) JP4778955B2 (es)
KR (1) KR101135156B1 (es)
CN (1) CN1938316B (es)
AP (1) AP2528A (es)
AU (1) AU2005229435B2 (es)
BR (1) BRPI0509514B1 (es)
CA (1) CA2559959C (es)
CY (1) CY1119150T1 (es)
DK (1) DK1732931T3 (es)
ES (1) ES2587571T3 (es)
HR (1) HRP20161031T1 (es)
HU (1) HUE029886T2 (es)
IL (1) IL178019A (es)
LT (1) LT1732931T (es)
ME (1) ME02525B (es)
NO (1) NO338175B1 (es)
NZ (1) NZ549971A (es)
PL (1) PL1732931T3 (es)
PT (1) PT1732931T (es)
RS (1) RS55011B1 (es)
RU (1) RU2421458C2 (es)
SI (1) SI1732931T1 (es)
TW (1) TWI383975B (es)
UA (1) UA100835C2 (es)
WO (1) WO2005095410A1 (es)
ZA (1) ZA200609008B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS51675B (sr) 2006-11-09 2011-10-31 Tibotec Pharmaceuticals Metode za dobivanje heksahidrofuro[2,3-b]furan-3-ola
CN101024646B (zh) * 2007-02-06 2010-07-14 启东东岳药业有限公司 4-甲氧基呋喃并呋喃-2-酮的纯化方法
WO2008132154A1 (en) 2007-04-27 2008-11-06 Tibotec Pharmaceuticals Ltd. Methods for the preparation of n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide derivatives
WO2009030733A1 (en) * 2007-09-04 2009-03-12 Dsm Ip Assets B.V. Method for the synthesis of 4-alkoxy-, 4-hydroxy- and 4-aryloxy-substituted tetrahydro-furo[3,4-b]furan-2(3h)-one compounds
WO2010120273A2 (en) 2008-12-03 2010-10-21 Massachusetts Institute Of Technology Multifunctional composites based on coated nanostructures
US8921415B2 (en) 2009-01-29 2014-12-30 Mapi Pharma Ltd. Polymorphs of darunavir
BR112012009956A2 (pt) 2009-10-30 2015-09-29 Lupin Ltd um novo processo para a preparação de darunavir e etanolato darunavir de tamanho de partícula.
PL2528923T3 (pl) 2010-01-28 2015-01-30 Mapi Pharma Ltd Sposób wytwarzania darunawiru i pochodnych darunawiru
EP3795572B1 (en) 2012-07-24 2023-11-15 Laurus Labs Limited Darunavir propionate solvate
CN103864813B (zh) * 2012-12-18 2017-02-22 上海迪赛诺化学制药有限公司 一种合成六氢呋喃并[2,3‑b]呋喃‑3‑醇及其对映体的方法
CN104628552A (zh) * 2015-02-09 2015-05-20 许昌豪丰化学科技有限公司 一种新淬灭体系及其应用
WO2017041228A1 (zh) * 2015-09-08 2017-03-16 浙江九洲药业股份有限公司 六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法
EP3532478B1 (en) 2016-10-27 2021-05-26 Gilead Sciences, Inc. Crystalline form of darunavir free base
CN110272398B (zh) 2018-03-16 2022-11-29 江苏瑞科医药科技有限公司 六氢呋喃并呋喃醇衍生物的制备方法、其中间体及其制备方法
CN120405821A (zh) 2019-02-15 2025-08-01 迪吉伦斯公司 使用集成光栅提供全息波导显示的方法和装置
CN115557964A (zh) * 2022-10-18 2023-01-03 启东东岳药业有限公司 一种药物化合物的制备方法
CN117659033B (zh) * 2023-12-05 2026-01-13 南京杰运医药科技有限公司 一种地瑞那韦中间体的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003022853A1 (en) * 2001-09-10 2003-03-20 Tibotec Pharmaceuticals Ltd. Method for the preparation of hexahydro-furo[2,3-b]furan-3-ol

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0427693A1 (en) * 1989-10-11 1991-05-15 Monsanto Company Method for azide displacement of alpha-triflates of 1,5-lactones
ES2127938T3 (es) 1993-08-24 1999-05-01 Searle & Co Hidroxietilamino sulfonamidas utiles como inhibidores de proteasas retroviricas.
MX9603909A (es) 1994-03-07 1997-03-29 Vertex Pharma Derivados de sulfonamida como inhibidores de proteasa aspartilo.
IN188837B (es) * 1998-05-22 2002-11-09 Torrent Pharmaceuticals Ltd
BR9912169A (pt) 1998-06-19 2001-04-10 Vertex Pharma Inibidores de sulfonamida de protease de aspartil
PT2336134T (pt) 1998-06-23 2016-10-19 The Board Of Trustees Of The Univ Of Illionis Ensaio de aptidão e métodos para reduzir a resistência do hiv à terapia
EP1159278B1 (en) 1999-02-12 2005-11-30 Vertex Pharmaceuticals Incorporated Inhibitors of aspartyl protease
AR031520A1 (es) 1999-06-11 2003-09-24 Vertex Pharma Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
CA2386850C (en) 1999-10-06 2010-03-30 Piet Tom Bert Paul Wigerinck Hexahydrofuro[2,3-b]furan-3-yl-n-{3-[(1,3-benzodioxol-5-ylsulfonyl)(isobutyl)amino]-1-benzyl-2-hydroxypropyl} carbamate as retroviral protease inhibitor

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003022853A1 (en) * 2001-09-10 2003-03-20 Tibotec Pharmaceuticals Ltd. Method for the preparation of hexahydro-furo[2,3-b]furan-3-ol

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GHOSH A K ET AL: "Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere" BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 8, no. 6, 17 March 1998 (1998-03-17), pages 687-690, XP004136945 ISSN: 0960-894X *

Also Published As

Publication number Publication date
TWI383975B (zh) 2013-02-01
BRPI0509514B1 (pt) 2022-09-27
PL1732931T3 (pl) 2016-11-30
RU2421458C2 (ru) 2011-06-20
US7595408B2 (en) 2009-09-29
CA2559959C (en) 2013-11-19
IL178019A (en) 2014-02-27
IL178019A0 (en) 2006-12-31
BRPI0509514A8 (pt) 2016-02-10
RU2006138228A (ru) 2008-05-10
DK1732931T3 (en) 2016-08-29
CN1938316B (zh) 2012-12-12
KR101135156B1 (ko) 2012-04-23
JP4778955B2 (ja) 2011-09-21
CA2559959A1 (en) 2005-10-13
NZ549971A (en) 2010-12-24
BRPI0509514A (pt) 2007-09-11
WO2005095410A1 (en) 2005-10-13
TW200602346A (en) 2006-01-16
JP2007530638A (ja) 2007-11-01
NO338175B1 (no) 2016-08-01
ES2587571T3 (es) 2016-10-25
CN1938316A (zh) 2007-03-28
SI1732931T1 (sl) 2016-10-28
AU2005229435A1 (en) 2005-10-13
US20070208184A1 (en) 2007-09-06
ME02525B (me) 2017-02-20
NO20064977L (no) 2006-10-31
CY1119150T1 (el) 2018-01-10
AP2006003748A0 (en) 2006-10-31
LT1732931T (lt) 2016-09-12
PT1732931T (pt) 2016-07-14
EP1732931A1 (en) 2006-12-20
KR20070026479A (ko) 2007-03-08
ZA200609008B (en) 2008-07-30
HRP20161031T1 (hr) 2016-10-21
AU2005229435B2 (en) 2011-07-07
EP1732931B1 (en) 2016-05-18
RS55011B1 (sr) 2016-11-30
UA100835C2 (ru) 2013-02-11
HUE029886T2 (en) 2017-04-28

Similar Documents

Publication Publication Date Title
IL194122A (en) Process for making (6ar, 3as, 3r) hexahydroporo [3,2– b] furan – 3 – val
WO2008055970A3 (en) Methods for the preparation of hexahydrofuro[2,3-b]furan-3-ol
LT1732931T (lt) (3r,3as,6ar) heksahidro-furo[2,3-b]furan-3-olio gamybos būdai
HUP0402140A3 (en) Method for the preparation of hexahydro-furo[2,3-b]furan-3-ol
IL211191A (en) Oxalate salt of (3as, 4r, 6s, 6ar) –6– (2– hydroxyethoxy) –2,2 – dimethyl tetrahydro –3 ah– cyclopenta [d] [1,3] dioxol – 4 – amine
ZA201202025B (en) INTERMEDIATES USEFUL IN THE PREPARATION OF PYRROLO[2,3-b] PYRIDINE DERIVATIVES
TWI365189B (en) Novel pyrrolo[3,2-d]pyrimidin-4-one derivatives
ZA200708490B (en) Intermediate compounds for the preparation of trans-5-chloro-2-methyl-2,3,3a, 12b-tetrahydro-1H-dibenz[2,3:6,7] oxepino[4,5-c]pyrrole
IL182177A0 (en) Process for preparing 4,5-dihydro-pyrazolo [3,4-c] pyrid-2-ones
ZA200702541B (en) Process for preparing 4,5-dihydro-pyrazolo [3,4-c]pyrid-2-ones
AU2003287038A8 (en) Method of preparing (3r, 3as, 6ar) -3- hydroxyhexahydrofuro (2, 3-b) furan and related compounds
ZA200803173B (en) Pyrazolo [4,3-d] Pyrimidin-5-yl) Derivative used as PDE5 Inhibitors
PL1678182T3 (pl) Sposób wytwarzania podstawionych 5-aminopirazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pirymidyn
SMT201500309B (it) Procedimento per la preparazione di benzil [(3as,4r,6s,6ar)-6-idrossi-2,2-dimetiltetraidro-3ahciclopenta[d][1,3]diossol]-4-il]carbammato ed intermedi nel procedimento
PT2643326T (pt) Processo para a preparação de (3r,3as,6ar)-hexa-hidrofuro[2,3-b]furan-3-ol
IL189395A (en) Processes for making imidazo [2,1– b] pyridazine-3 – il sulfonyl chloride and sulfonamide history
HK1118045A (en) 2-heteroaryl-pyrazolo-[4, 3-e]-1, 2, 4-triazolo-[1,5-c]-pyrimidine as adenosine a2a receptor antagonists
HK1102925A (en) Process for preparing 4,5-dihydro-pyrazolo [3,4-c]pyrid-2-ones