AP2948A - Thienopyrmidinedione derivatives as TRPA1 modulators - Google Patents

Thienopyrmidinedione derivatives as TRPA1 modulators

Info

Publication number: AP2948A
Authority: AP; ARIPO
Prior art keywords: thienopyrmidinedione; derivatives; trpa1 modulators; trpa1; modulators
Prior art date: 2009-03-23

Application number

AP2011005889A

Other languages

English (en)

Other versions

AP2011005889A0 (en

Inventor

Neelima Khairatkar-Joshi

Sukeerthi Kumar

Sanjay Margal

Original Assignee

Glenmark Pharamceuticals Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-03-23

Filing date

2010-03-23

Publication date

2014-07-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42780205&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP2948(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2010-03-23 Application filed by Glenmark Pharamceuticals Sa filed Critical Glenmark Pharamceuticals Sa

2011-10-31 Publication of AP2011005889A0 publication Critical patent/AP2011005889A0/xx

2014-07-31 Application granted granted Critical

2014-07-31 Publication of AP2948A publication Critical patent/AP2948A/xx

Links

101000764872 Homo sapiens Transient receptor potential cation channel subfamily A member 1 Proteins 0.000 title 1
102100026186 Transient receptor potential cation channel subfamily A member 1 Human genes 0.000 title 1

Classifications

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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Otolaryngology (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AP2011005889A 2009-03-23 2010-03-23 Thienopyrmidinedione derivatives as TRPA1 modulators AP2948A (en)

Applications Claiming Priority (7)

Application Number	Priority Date	Filing Date	Title
IN665MU2009		2009-03-23
US17135509P	2009-04-21	2009-04-21
IN2213MU2009		2009-09-23
US25199409P	2009-10-15	2009-10-15
IN2906MU2009		2009-12-16
US29447010P	2010-01-12	2010-01-12
PCT/IB2010/000930 WO2010109334A2 (en)	2009-03-23	2010-03-23	Thienopyrimidinedione derivatives as trpa1 modulators

Publications (2)

Publication Number	Publication Date
AP2011005889A0 AP2011005889A0 (en)	2011-10-31
AP2948A true AP2948A (en)	2014-07-31

Family

ID=42780205

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AP2011005889A AP2948A (en)	2009-03-23	2010-03-23	Thienopyrmidinedione derivatives as TRPA1 modulators

Country Status (22)

Country	Link
US (4)	US20120178766A1 (xx)
EP (3)	EP2411395B1 (xx)
JP (2)	JP2012521406A (xx)
KR (2)	KR20110128898A (xx)
CN (3)	CN102361874A (xx)
AP (1)	AP2948A (xx)
AU (2)	AU2010227225A1 (xx)
BR (2)	BRPI1013705A2 (xx)
CA (2)	CA2756535A1 (xx)
DK (3)	DK2411395T3 (xx)
EA (2)	EA201190138A1 (xx)
ES (3)	ES2424341T3 (xx)
HU (1)	HUE024538T2 (xx)
IL (2)	IL215177A (xx)
MX (1)	MX2011009822A (xx)
PE (2)	PE20120834A1 (xx)
PL (3)	PL2411395T3 (xx)
PT (3)	PT2411395E (xx)
SG (4)	SG184767A1 (xx)
SI (3)	SI2411395T1 (xx)
WO (2)	WO2010109329A1 (xx)
ZA (2)	ZA201107650B (xx)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BRPI1013559A2 (pt)	2009-03-23	2016-04-12	Glenmark Pharmaceuticals Sa	compostos, composição farmacêutica, método de tratamento de doença ou condição associada à função trpa1 e respectivos usos
EP2411395B1 (en)	2009-03-23	2013-05-29	Glenmark Pharmaceuticals S.A.	Furopyrimidinedione derivatives as trpa1 modulators
AR084294A1 (es) *	2010-12-20	2013-05-08	Glenmark Pharmaceuticals Sa	Compuestos de 2-amino-4-ariltiazol, metodos para su sintesis y uso como antagonista de trpa1
EP2520566A1 (en)	2011-05-06	2012-11-07	Orion Corporation	New Pharmaceutical Compounds
CA2836856A1 (en) *	2011-06-13	2012-12-20	Glenmark Pharmaceuticals, S.A.	Treatment of respiratory disorders using trpa1 antagonists
WO2012176105A1 (en)	2011-06-22	2012-12-27	Glenmark Pharmaceuticals Sa	Pharmaceutical composition comprising a trpa1 antagonist and a leukotriene receptor antagonist
BR112013031820A2 (pt) *	2011-06-22	2016-12-13	Glenmark Pharmaceutical S A	composições farmacêuticas, incluindo para administração oral e por inalação, usos de quantidade sinergicamente eficaz de antagonista trpa1 e métodos para tratar distúrbios respiratórios e para melhorar a função pulmonar
JP2014521634A (ja) *	2011-07-25	2014-08-28	グレンマークファーマシューティカルズ，エセ．アー．	Ｔｒｐａ１アンタゴニスト及びステロイドを含む医薬組成物
EP2787991A1 (en)	2011-12-05	2014-10-15	Glenmark Pharmaceuticals S.A.	Pharmaceutical composition comprising a trpa1 antagonist and an anticholinergic agent
IN2014MN02467A (xx) *	2012-06-08	2015-07-10	Glenmark Pharmaceuticals Sa
CA2884922C (en)	2012-10-01	2020-11-10	Orion Corporation	N-prop-2-ynyl carboxamide derivatives and their use as trpa1 antagonists
CA2912578A1 (en)	2013-06-20	2014-12-24	Glenmark Pharmaceuticals S.A.	Nanoparticulate formulation comprising a trpa1 antagonist
CN105813638A (zh) *	2013-10-15	2016-07-27	格兰马克药品股份有限公司	包含trpa1拮抗剂和镇痛剂的药物组合物
EP3180340B1 (en) *	2014-08-11	2018-10-10	Hydra Biosciences, Inc.	Pyrido[2,3-d]pyrimidine-2,4(1h,3h)-dione derivatives
WO2016023831A1 (en) *	2014-08-11	2016-02-18	Hydra Biosciences, Inc.	Pyrrolo[3,2-d]pyrimidine-2,4(3h,5h)-dione derivatives
WO2016023825A1 (en) *	2014-08-11	2016-02-18	Hydra Biosciences, Inc.	Pyrido[3,4-d]pyrimidine-2,4(1h,3h)-dione derivatives
EP3180345B1 (en) *	2014-08-11	2018-10-10	Hydra Biosciences, Inc.	Thieno- and furo[2,3-d]pyrimidine-2,4[1h,3h]-dione derivatives as trpc5 modulators for the treatment of neuropsychiatric disorders
WO2016028325A1 (en)	2014-08-22	2016-02-25	Duke University	Trpa1 and trpv4 inhibitors and methods of using the same for organ-specific inflammation and itch
WO2016042501A1 (en)	2014-09-16	2016-03-24	Glenmark Pharmaceuticals S.A.	Trpa1 antagonist for the treatment of pain associated to diabetic neuropathic pain
US11229628B2 (en)	2015-01-09	2022-01-25	Duke University	TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch
WO2017060488A1 (en)	2015-10-09	2017-04-13	Almirall, S.A.	New trpa1 antagonists
WO2017064068A1 (en)	2015-10-14	2017-04-20	Almirall, S.A.	New trpa1 antagonists
EP3439656A4 (en) *	2016-04-07	2020-03-11	Duke University	DOUBLE SMALL MOLECULE INHIBITORS OF TRPV4 AND TRPA1 FOR DISINFECTION AND ANESTHESIA
WO2018162607A1 (en) *	2017-03-07	2018-09-13	F. Hoffmann-La Roche Ag	Oxadiazole transient receptor potential channel inhibitors
CN109422749B (zh) *	2017-08-21	2023-01-24	重庆医药工业研究院有限责任公司	一种抑制单羧酸转运蛋白的嘧啶二酮衍生物
CN114555601B (zh)	2019-10-15	2024-04-02	勃林格殷格翰国际有限公司	新颖的四唑类
CA3193607A1 (en) *	2020-10-14	2022-04-21	Boehringer Ingelheim International Gmbh	Tetrazole derivatives as trpa1 inhibitors
US11661427B2 (en) *	2020-10-14	2023-05-30	Boehringer Ingelheim International Gmbh	Tetrazole derivatives as TRPA1 inhibitors
WO2022179469A1 (zh) *	2021-02-23	2022-09-01	南京明德新药研发有限公司	噻吩并嘧啶二酮类化合物及其应用
JP7565457B2 (ja)	2021-04-14	2024-10-10	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	ＴＲＰＡ１阻害剤としての３Ｈ，４Ｈ－チエノ－［２，３－ｄ］ピリミジン－４－オン誘導体
CN114656480B (zh) *	2022-04-27	2024-01-26	成都施贝康生物医药科技有限公司	噻吩并嘧啶类化合物、异构体或盐及其制备方法和用途
CN114671875A (zh) *	2022-04-27	2022-06-28	成都施贝康生物医药科技有限公司	新型二氢嘧啶类化合物、异构体或盐及其制备方法和用途
WO2025264860A2 (en)	2024-06-18	2025-12-26	Yale University	Methods of treating post-covid airway disease

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2007073505A2 (en) *	2005-12-22	2007-06-28	Hydra Biosciences, Inc.	Trpa1 inhibitors for treating pain
WO2007108750A1 (en) *	2006-03-22	2007-09-27	Astrazeneca Ab	Pyridopyrimidine derivatives and their use as pde4 inhibitors
WO2009002933A1 (en) *	2007-06-22	2008-12-31	Hydra Biosciences, Inc.	Methods and compositions for treating disorders

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2248231A1 (de)	1972-10-02	1974-04-11	Basf Ag	3-aminoisothiazolo eckige klammer auf 3,4-d eckige klammer zu pyrimidine
SE9701398D0 (sv)	1997-04-15	1997-04-15	Astra Pharma Prod	Novel compounds
SE9702001D0 (sv) *	1997-05-28	1997-05-28	Astra Pharma Prod	Novel compounds
PT1107973E (pt) *	1998-08-28	2004-03-31	Astrazeneca Ab	Novas tieno¬2,3-d\| pirimidinodionas processo para a sua preparacao e sua utilizacao em terapia
ES2193839B1 (es) *	2001-06-22	2005-02-16	Almirall Prodesfarma, S.A.	Nuevos derivados de 6-fenildihidropirrolpirimidindiona.
GB0118479D0 (en) *	2001-07-28	2001-09-19	Astrazeneca Ab	Novel compounds
AU2003253165A1 (en) *	2002-08-13	2004-02-25	Warner-Lambert Company Llc	Pyrimidine fused bicyclic metalloproteinase inhibitors
JP2006514684A (ja) *	2002-10-30	2006-05-11	バーテックス　ファーマシューティカルズ　インコーポレイテッド	Ｒｏｃｋおよび他のプロテインキナーゼとして有用な組成物
US6890923B2 (en) *	2002-12-16	2005-05-10	Astrazeneca Ab	Compounds
US7465581B2 (en)	2002-12-18	2008-12-16	The Scripps Research Institute	ANKTM1, a cold-activated TRP-like channel expressed in nociceptive neurons
SE0300119D0 (sv) *	2003-01-17	2003-01-17	Astrazeneca Ab	Novel compounds
EP1657238A4 (en)	2003-08-22	2008-12-03	Takeda Pharmaceutical	CONDENSATE PYRIMIDINE DERIVATIVE AND ITS USE
EP1713815A4 (en) *	2004-02-11	2009-03-11	Smithkline Beecham Corp	PTH AGONISTS
US20070196866A1 (en)	2004-03-13	2007-08-23	Irm Llc	Modulators of ion channel trpa1
EP1847541A4 (en) *	2005-02-03	2009-12-30	Takeda Pharmaceutical	CONDENSED PYRIMIDINE DERIVATIVE AND USE THEREOF
AU2006278592A1 (en) *	2005-08-04	2007-02-15	Apogee Biotechnology Corporation	Sphingosine kinase inhibitors and methods of their use
ES2344751T3 (es) *	2005-11-08	2010-09-06	N.V. Organon	Derivados de 2-(benzoimidazol-1-il)-n-(4-feniltiazol-2-il)acetamida utiles en el tratamiento de trastornos relacionados con trpv1.
WO2007054480A1 (en) *	2005-11-08	2007-05-18	N.V. Organon	2-(benzimidazol-1-yl)-acetamide biaryl derivatives and their use as inhibitors of the trpv1 receptor
US20070105920A1 (en) *	2005-11-08	2007-05-10	Akzo Nobel N.V.	2-(Benzimidazol-1-Yl)-N-(4-phenylthiazol-2-yl) acetamide derivatives
CL2008000252A1 (es) *	2007-01-29	2008-03-14	Xenon Pharmaceuticals Inc	Compuestos derivados de quinazolinona o pirimidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar enfermedades mediadas por los canales de calcio, tales como dolor, depresion, enfermedades cardiovasculares, respir
CN101711413B (zh) *	2007-06-25	2013-09-04	桑迪士克科技股份有限公司	具有位于存储元件之间的可单独控制的屏蔽板的非易失性存储装置
WO2010004390A1 (en)	2008-06-17	2010-01-14	Glenmark Pharmaceuticals, S.A.	Quinazoline dione derivatives as trpa1 modulators
WO2009158719A2 (en)	2008-06-27	2009-12-30	Hydra Biosciences, Inc.	Methods and compositions for treating disorders
UA103918C2 (xx)	2009-03-02	2013-12-10	Айерем Элелси	N-(гетеро)арил, 2-(гетеро)арилзаміщені ацетаміди для застосування як модуляторів wnt передачі сигналу$n-(гетеро)арил, 2-(гетеро)арилзамещенные ацетамиды для применения как модуляторов wnt передачи сигнала
US8623880B2 (en)	2009-03-23	2014-01-07	Glenmark Pharmaceuticals S.A.	Fused pyrimidine-dione derivatives as TRPA1 modulators
EP2411395B1 (en)	2009-03-23	2013-05-29	Glenmark Pharmaceuticals S.A.	Furopyrimidinedione derivatives as trpa1 modulators
DK2411397T3 (da)	2009-03-23	2013-08-05	Glenmark Pharmaceuticals Sa	Isothiazol-pyrimidindionderivater som modulatorer af TRPA1
AR076332A1 (es)	2009-04-21	2011-06-01	Boehringer Ingelheim Int	Derivados heterociclicos de 5-alquinil-piridinas, composiciones farmaceuticas que los comprenden y uso de los mismos para el tratamiento y/o prevencion del cancer, procesos inflamatorios, autoinmunes, y/o infecciones.
US8440710B2 (en)	2009-10-15	2013-05-14	Hoffmann-La Roche Inc.	HSL inhibitors useful in the treatment of diabetes
EA201290147A1 (ru)	2009-10-15	2012-11-30	Пфайзер Инк.	Пирроло[2,3-d]пиримидиновые соединения
AR078522A1 (es)	2009-10-15	2011-11-16	Lilly Co Eli	Compuesto de espiropiperidina, composicion farmaceutica que lo comprende, su uso para preparar un medicamento util para tratar diabetes y compuesto intermediario para su sintesis
US8377980B2 (en)	2009-12-16	2013-02-19	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
CN102812022B (zh)	2010-01-12	2016-02-03	Ab科学有限公司	噻唑和噁唑激酶抑制剂
BR112012004154A2 (pt)	2010-07-13	2017-05-30	Novartis Ag	"derivados de oxazina e seu uso no tratamento de distúrbios neurológicos"

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Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2007073505A2 (en) *	2005-12-22	2007-06-28	Hydra Biosciences, Inc.	Trpa1 inhibitors for treating pain
WO2007108750A1 (en) *	2006-03-22	2007-09-27	Astrazeneca Ab	Pyridopyrimidine derivatives and their use as pde4 inhibitors
WO2009002933A1 (en) *	2007-06-22	2008-12-31	Hydra Biosciences, Inc.	Methods and compositions for treating disorders

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Publication number	Publication date
DK2634191T3 (en)	2015-03-23
EP2634191B1 (en)	2014-12-24
HK1166073A1 (en)	2012-10-19
IL215177A0 (en)	2011-12-29
ES2424341T3 (es)	2013-10-01
ZA201107650B (en)	2012-07-25
WO2010109329A1 (en)	2010-09-30
PE20120775A1 (es)	2012-06-27
DK2411396T3 (da)	2013-08-05
PL2411396T3 (pl)	2013-10-31
IL215177A (en)	2014-01-30
IL215175A (en)	2014-01-30
AU2010227230A2 (en)	2011-10-27
AP2011005889A0 (en)	2011-10-31
US20130289054A1 (en)	2013-10-31
IL215175A0 (en)	2011-12-29
SG174398A1 (en)	2011-10-28
AU2010227225A1 (en)	2011-09-15
CN102361874A (zh)	2012-02-22
SI2411396T1 (sl)	2013-07-31
CA2756536A1 (en)	2010-09-30
CN103755720A (zh)	2014-04-30
US20120178766A1 (en)	2012-07-12
SG184767A1 (en)	2012-10-30
US20120295924A1 (en)	2012-11-22
PL2634191T3 (pl)	2015-06-30
DK2411395T3 (da)	2013-08-05
SG184769A1 (en)	2012-10-30
SI2634191T1 (sl)	2015-04-30
AU2010227225A2 (en)	2011-10-06
BRPI1013705A2 (pt)	2016-04-05
JP2012521406A (ja)	2012-09-13
KR20120004422A (ko)	2012-01-12
HK1166074A1 (en)	2012-10-19
PT2411396E (pt)	2013-06-06
EA201190138A1 (ru)	2013-05-30
BRPI1009381B1 (pt)	2020-04-14
CA2756535A1 (en)	2010-09-30
US20150150876A1 (en)	2015-06-04
PT2411395E (pt)	2013-06-06
WO2010109334A2 (en)	2010-09-30
SI2411395T1 (sl)	2013-07-31
PT2634191E (pt)	2015-03-04
ES2532386T3 (es)	2015-03-26
KR20110128898A (ko)	2011-11-30
CN103755720B (zh)	2016-07-06
US9474758B2 (en)	2016-10-25
WO2010109334A3 (en)	2010-11-25
BRPI1009381B8 (pt)	2021-05-25
CA2756536C (en)	2015-10-06
EP2411395B1 (en)	2013-05-29
EP2634191A1 (en)	2013-09-04
MX2011009822A (es)	2012-01-25
EA022029B1 (ru)	2015-10-30
PE20120834A1 (es)	2012-07-25
JP5612070B2 (ja)	2014-10-22
HUE024538T2 (hu)	2016-01-28
US8987278B2 (en)	2015-03-24
ZA201107649B (en)	2012-07-25
BRPI1009381A2 (pt)	2016-06-21
AU2010227230A1 (en)	2011-09-22
EP2411395A1 (en)	2012-02-01
EP2411396B1 (en)	2013-05-29
JP2012521407A (ja)	2012-09-13
SG174404A1 (en)	2011-10-28
EA201190139A1 (ru)	2012-03-30
CN102361877A (zh)	2012-02-22
KR101524337B1 (ko)	2015-05-29
PL2411395T3 (pl)	2013-10-31
CN102361877B (zh)	2014-05-07
US8507503B2 (en)	2013-08-13
ES2424342T3 (es)	2013-10-01
EP2411396A2 (en)	2012-02-01
AU2010227230B2 (en)	2015-11-26

Publication	Publication Date	Title
AP2948A (en)	2014-07-31	Thienopyrmidinedione derivatives as TRPA1 modulators
ZA201107646B (en)	2012-06-25	Isothiazolo-prrimidinedione derivatives as trpa1 modulators
AP3280A (en)	2015-05-31	Fused pyrimidine-dione derivatives as TRPA1 modulators
IL219087A0 (en)	2012-06-28	Benzimidazole-imidazole derivatives
IL217956A0 (en)	2012-03-29	N1-sulfonyl-5-fluoropyrimidinone derivatives
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IL215109A0 (en)	2011-12-29	Isoxazole-pyridazine derivatives
IL214941A0 (en)	2011-11-30	Isoxazole-pyrazole derivatives
IL217952A0 (en)	2012-03-29	N1-acyl-5-fluoropyrimidinone derivatives
IL213927A0 (en)	2011-07-31	Deoxyactagardine derivatives
IL216761A0 (en)	2012-02-29	Pyrazinooxazepine derivatives
GB0921967D0 (en)	2010-02-03	Novel Aryloxyanilide Derivatives
IL213262A0 (en)	2011-07-31	Tetrahydronaphthalen-2-ol derivatives
GB0912499D0 (en)	2009-08-26	Indopyl-pyridone derivatives
AP2011005883A0 (en)	2011-10-31	Furopyrimidinedione derivatives as TRPA1 modulators.