PL2411396T3 - Pochodne tienopirymidynodionu jako modulatory TRPA1 - Google Patents

Pochodne tienopirymidynodionu jako modulatory TRPA1

Info

Publication number: PL2411396T3
Authority: PL; Poland
Prior art keywords: trpa1 modulators; thienopyrimidinedione; derivatives; thienopyrimidinedione derivatives; trpa1
Prior art date: 2009-03-23

Application number

PL10751712T

Other languages

English (en)

Inventor

Sukeerthi Kumar

Abraham Thomas

Nayan Taterao Waghmare

Sanjay Margal

Neelima Khairatkar-Joshi

Indranil Mukhopadhyay

Original Assignee

Glenmark Pharmaceuticals Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-03-23

Filing date

2010-03-23

Publication date

2013-10-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42780205&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2411396(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2010-03-23 Application filed by Glenmark Pharmaceuticals Sa filed Critical Glenmark Pharmaceuticals Sa

2013-10-31 Publication of PL2411396T3 publication Critical patent/PL2411396T3/pl

Links

QAFVXBQPQCSSLI-UHFFFAOYSA-N 1h-thieno[3,2-d]pyrimidine-2,4-dione Chemical class O=C1NC(=O)NC2=C1SC=C2 QAFVXBQPQCSSLI-UHFFFAOYSA-N 0.000 title 1
101100482465 Caenorhabditis elegans trpa-1 gene Proteins 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Otolaryngology (AREA)
Immunology (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

PL10751712T 2009-03-23 2010-03-23 Pochodne tienopirymidynodionu jako modulatory TRPA1 PL2411396T3 (pl)

Applications Claiming Priority (8)

Application Number	Priority Date	Filing Date	Title
IN665MU2009		2009-03-23
US17135509P	2009-04-21	2009-04-21
IN2213MU2009		2009-09-23
US25199409P	2009-10-15	2009-10-15
IN2906MU2009		2009-12-16
US29447010P	2010-01-12	2010-01-12
EP10751712.0A EP2411396B1 (en)	2009-03-23	2010-03-23	Thienopyrimidinedione derivatives as trpa1 modulators
PCT/IB2010/000930 WO2010109334A2 (en)	2009-03-23	2010-03-23	Thienopyrimidinedione derivatives as trpa1 modulators

Publications (1)

Publication Number	Publication Date
PL2411396T3 true PL2411396T3 (pl)	2013-10-31

Family

ID=42780205

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
PL10716050T PL2411395T3 (pl)	2009-03-23	2010-03-22	Pochodne furopirymidynodionu jako modulatory TRPA1
PL13002731T PL2634191T3 (pl)	2009-03-23	2010-03-23	Sposób wytwarzania pochodnych tienopirymidynodionu
PL10751712T PL2411396T3 (pl)	2009-03-23	2010-03-23	Pochodne tienopirymidynodionu jako modulatory TRPA1

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
PL10716050T PL2411395T3 (pl)	2009-03-23	2010-03-22	Pochodne furopirymidynodionu jako modulatory TRPA1
PL13002731T PL2634191T3 (pl)	2009-03-23	2010-03-23	Sposób wytwarzania pochodnych tienopirymidynodionu

Country Status (22)

Country	Link
US (4)	US20120178766A1 (pl)
EP (3)	EP2411395B1 (pl)
JP (2)	JP2012521406A (pl)
KR (2)	KR20110128898A (pl)
CN (3)	CN102361874A (pl)
AP (1)	AP2948A (pl)
AU (2)	AU2010227225A1 (pl)
BR (2)	BRPI1013705A2 (pl)
CA (2)	CA2756535A1 (pl)
DK (3)	DK2411395T3 (pl)
EA (2)	EA201190138A1 (pl)
ES (3)	ES2424341T3 (pl)
HU (1)	HUE024538T2 (pl)
IL (2)	IL215175A (pl)
MX (1)	MX2011009822A (pl)
PE (2)	PE20120834A1 (pl)
PL (3)	PL2411395T3 (pl)
PT (3)	PT2411395E (pl)
SG (4)	SG174398A1 (pl)
SI (3)	SI2411395T1 (pl)
WO (2)	WO2010109329A1 (pl)
ZA (2)	ZA201107650B (pl)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AP3280A (en)	2009-03-23	2015-05-31	Glenmark Pharmaceuticals Sa	Fused pyrimidine-dione derivatives as TRPA1 modulators
PT2411395E (pt)	2009-03-23	2013-06-06	Glenmark Pharmaceuticals Sa	Derivados de furopirimidinadiona como moduladores de trpa1
JP5694560B2 (ja)	2010-12-20	2015-04-01	グレンマークファーマシューティカルズ，エセ．アー．	Ｔｒｐａ１アンタゴニストとしての２−アミノ−４−アリールチアゾール化合物
EP2520566A1 (en)	2011-05-06	2012-11-07	Orion Corporation	New Pharmaceutical Compounds
JP2014517031A (ja)	2011-06-13	2014-07-17	グレンマークファーマシューティカルズ，エセ．アー．	Ｔｒｐａ１アンタゴニストを使用した呼吸器疾患の治療
JP2014517062A (ja) *	2011-06-22	2014-07-17	グレンマークファーマシューティカルズ，エセ．アー．	ＴＲＰＡ１アンタゴニスト及びβ２アゴニストを含む医薬組成物
WO2012176105A1 (en)	2011-06-22	2012-12-27	Glenmark Pharmaceuticals Sa	Pharmaceutical composition comprising a trpa1 antagonist and a leukotriene receptor antagonist
US20140148423A1 (en) *	2011-07-25	2014-05-29	Glenmark Pharmaceuticals S.A.	Pharmaceutical composition comprising a trpa1 antagonist and a steroid
EP2787991A1 (en)	2011-12-05	2014-10-15	Glenmark Pharmaceuticals S.A.	Pharmaceutical composition comprising a trpa1 antagonist and an anticholinergic agent
MY165622A (en) *	2012-06-08	2018-04-18	Glenmark Pharmaceuticals Sa	Amides of 2-amino-4aryl thiazole compounds and their salts
PL2903965T3 (pl)	2012-10-01	2017-08-31	Orion Corporation	Pochodne n-prop-2-ynylokarboksamidu i ich zastosowanie jako antagonistów trpa1
EP3010489A1 (en) *	2013-06-20	2016-04-27	Glenmark Pharmaceuticals S.A.	Nanoparticulate formulation comprising a trpa1 antagonist
AU2014335868A1 (en)	2013-10-15	2016-05-05	Glenmark Pharmaceuticals S.A.	Pharmaceutical composition comprising a trpa1 antagonist and an analgesic agent
EP3180345B1 (en) *	2014-08-11	2018-10-10	Hydra Biosciences, Inc.	Thieno- and furo[2,3-d]pyrimidine-2,4[1h,3h]-dione derivatives as trpc5 modulators for the treatment of neuropsychiatric disorders
EP3180337B1 (en) *	2014-08-11	2018-10-10	Hydra Biosciences, Inc.	Pyrido[3,4-d]pyrimidine-2,4(1h,3h)-dione derivatives
WO2016023831A1 (en) *	2014-08-11	2016-02-18	Hydra Biosciences, Inc.	Pyrrolo[3,2-d]pyrimidine-2,4(3h,5h)-dione derivatives
JP6667093B2 (ja) *	2014-08-11	2020-03-18	ハイドラ・バイオサイエンシーズ・リミテッド・ライアビリティ・カンパニーＨｙｄｒａＢｉｏｓｃｉｅｎｃｅｓ，ＬＬＣ	ピリド［２，３−ｄ］ピリミジン−２，４（１Ｈ，３Ｈ）−ジオン誘導体
US10329265B2 (en)	2014-08-22	2019-06-25	Duke University	TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch
WO2016042501A1 (en)	2014-09-16	2016-03-24	Glenmark Pharmaceuticals S.A.	Trpa1 antagonist for the treatment of pain associated to diabetic neuropathic pain
US11229628B2 (en)	2015-01-09	2022-01-25	Duke University	TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch
WO2017060488A1 (en)	2015-10-09	2017-04-13	Almirall, S.A.	New trpa1 antagonists
WO2017064068A1 (en)	2015-10-14	2017-04-20	Almirall, S.A.	New trpa1 antagonists
CN109310683A (zh)	2016-04-07	2019-02-05	杜克大学	用于消毒和麻醉的trpv4和trpa1的小分子双重抑制剂
WO2018162607A1 (en) *	2017-03-07	2018-09-13	F. Hoffmann-La Roche Ag	Oxadiazole transient receptor potential channel inhibitors
CN109422749B (zh) *	2017-08-21	2023-01-24	重庆医药工业研究院有限责任公司	一种抑制单羧酸转运蛋白的嘧啶二酮衍生物
JP7612682B2 (ja)	2019-10-15	2025-01-14	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	新規なテトラゾール
JP7565439B2 (ja) *	2020-10-14	2024-10-10	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	Ｔｒｐａ１阻害剤としてのテトラゾール誘導体
WO2022079091A1 (en) *	2020-10-14	2022-04-21	Boehringer Ingelheim International Gmbh	Tetrazole derivatives as trpa1 inhibitors
CN116940575A (zh) *	2021-02-23	2023-10-24	深圳市康哲药业有限公司	噻吩并嘧啶二酮类化合物及其应用
CA3210965A1 (en)	2021-04-14	2022-10-20	Boehringer Ingelheim International Gmbh	3h,4h-thieno[2,3-d]pyrimidin-4-one derivatives as trpa1 inhibitors
CN114656480B (zh) *	2022-04-27	2024-01-26	成都施贝康生物医药科技有限公司	噻吩并嘧啶类化合物、异构体或盐及其制备方法和用途
CN114671875A (zh) *	2022-04-27	2022-06-28	成都施贝康生物医药科技有限公司	新型二氢嘧啶类化合物、异构体或盐及其制备方法和用途
WO2025264860A2 (en)	2024-06-18	2025-12-26	Yale University	Methods of treating post-covid airway disease

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2248231A1 (de)	1972-10-02	1974-04-11	Basf Ag	3-aminoisothiazolo eckige klammer auf 3,4-d eckige klammer zu pyrimidine
SE9701398D0 (sv)	1997-04-15	1997-04-15	Astra Pharma Prod	Novel compounds
SE9702001D0 (sv) *	1997-05-28	1997-05-28	Astra Pharma Prod	Novel compounds
ATE253580T1 (de) *	1998-08-28	2003-11-15	Astrazeneca Ab	Neue thieno(2,3-d)pyrimidindione, verfahren für ihre herstellung und ihre verwendung in der therapie
ES2193839B1 (es) *	2001-06-22	2005-02-16	Almirall Prodesfarma, S.A.	Nuevos derivados de 6-fenildihidropirrolpirimidindiona.
GB0118479D0 (en) *	2001-07-28	2001-09-19	Astrazeneca Ab	Novel compounds
WO2004014916A1 (en) *	2002-08-13	2004-02-19	Warner-Lambert Company Llc	Pyrimidine fused bicyclic metalloproteinase inhibitors
EP1558607B1 (en) *	2002-10-30	2010-05-05	Vertex Pharmaceuticals Incorporated	Compositions useful as inhibitors of rock and other protein kinases
US6890923B2 (en) *	2002-12-16	2005-05-10	Astrazeneca Ab	Compounds
AU2003290066A1 (en)	2002-12-18	2004-07-09	Novartis Ag	Anktm1, a cold-activated trp-like channel expressed in nociceptive neurons
SE0300119D0 (sv) *	2003-01-17	2003-01-17	Astrazeneca Ab	Novel compounds
EP1657238A4 (en)	2003-08-22	2008-12-03	Takeda Pharmaceutical	CONDENSATE PYRIMIDINE DERIVATIVE AND ITS USE
WO2005077959A1 (en) *	2004-02-11	2005-08-25	Smithkline Beecham Corporation	Pth agonists
US20070196866A1 (en)	2004-03-13	2007-08-23	Irm Llc	Modulators of ion channel trpa1
WO2006083005A1 (ja) *	2005-02-03	2006-08-10	Takeda Pharmaceutical Company Limited	縮合ピリミジン誘導体およびその用途
JP2009503107A (ja) *	2005-08-04	2009-01-29	アポジー・バイオテクノロジー・コーポレイション	スフィンゴシンキナーゼ阻害剤およびそれらの使用方法
CN101351463A (zh) *	2005-11-08	2009-01-21	欧加农股份有限公司	用于治疗trpv1相关病症的2-(苯并咪唑-1-基)-n-(4-苯基噻唑-2-基)乙酰胺衍生物
WO2007054480A1 (en) *	2005-11-08	2007-05-18	N.V. Organon	2-(benzimidazol-1-yl)-acetamide biaryl derivatives and their use as inhibitors of the trpv1 receptor
US20070105920A1 (en) *	2005-11-08	2007-05-10	Akzo Nobel N.V.	2-(Benzimidazol-1-Yl)-N-(4-phenylthiazol-2-yl) acetamide derivatives
JP5858557B2 (ja) *	2005-12-22	2016-02-10	ハイドラバイオサイエンシズインコーポレイテッドＨｙｄｒａＢｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ．	疼痛を処置するためのｔｒｐａ１阻害剤
TW200800997A (en)	2006-03-22	2008-01-01	Astrazeneca Ab	Chemical compounds
AR065081A1 (es) *	2007-01-29	2009-05-13	Xenon Pharmaceuticals Inc	Compuestos de quinazolinona y pirimidona fusionados y composicion farmaceutica
JP2010530901A (ja) *	2007-06-22	2010-09-16	ハイドラバイオサイエンシズインコーポレイテッド	障害を治療するための方法および組成物
CN101711413B (zh) *	2007-06-25	2013-09-04	桑迪士克科技股份有限公司	具有位于存储元件之间的可单独控制的屏蔽板的非易失性存储装置
WO2010004390A1 (en)	2008-06-17	2010-01-14	Glenmark Pharmaceuticals, S.A.	Quinazoline dione derivatives as trpa1 modulators
WO2009158719A2 (en)	2008-06-27	2009-12-30	Hydra Biosciences, Inc.	Methods and compositions for treating disorders
UA103918C2 (en)	2009-03-02	2013-12-10	Айерем Элелси	N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators
US8623880B2 (en)	2009-03-23	2014-01-07	Glenmark Pharmaceuticals S.A.	Fused pyrimidine-dione derivatives as TRPA1 modulators
PT2411395E (pt)	2009-03-23	2013-06-06	Glenmark Pharmaceuticals Sa	Derivados de furopirimidinadiona como moduladores de trpa1
DK2411397T3 (da)	2009-03-23	2013-08-05	Glenmark Pharmaceuticals Sa	Isothiazol-pyrimidindionderivater som modulatorer af TRPA1
AR076332A1 (es)	2009-04-21	2011-06-01	Boehringer Ingelheim Int	Derivados heterociclicos de 5-alquinil-piridinas, composiciones farmaceuticas que los comprenden y uso de los mismos para el tratamiento y/o prevencion del cancer, procesos inflamatorios, autoinmunes, y/o infecciones.
AR078522A1 (es)	2009-10-15	2011-11-16	Lilly Co Eli	Compuesto de espiropiperidina, composicion farmaceutica que lo comprende, su uso para preparar un medicamento util para tratar diabetes y compuesto intermediario para su sintesis
US8440710B2 (en)	2009-10-15	2013-05-14	Hoffmann-La Roche Inc.	HSL inhibitors useful in the treatment of diabetes
CA2776028C (en)	2009-10-15	2015-12-01	Pfizer Inc.	Pyrrolo[2,3-d]pyrimidine compounds
US8377980B2 (en)	2009-12-16	2013-02-19	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
MX2012008083A (es)	2010-01-12	2012-08-15	Ab Science	Inhibidores de triazol y oxazol quinaza.
PH12012500361A1 (en)	2010-07-13	2012-01-19	Novartis Ag	Oxazine derivatives and their use in the treatment of neurological disorders

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Also Published As

Publication number	Publication date
WO2010109334A2 (en)	2010-09-30
WO2010109334A3 (en)	2010-11-25
EP2411395B1 (en)	2013-05-29
ES2532386T3 (es)	2015-03-26
JP5612070B2 (ja)	2014-10-22
BRPI1013705A2 (pt)	2016-04-05
EP2634191A1 (en)	2013-09-04
ZA201107649B (en)	2012-07-25
EA022029B1 (ru)	2015-10-30
PT2411396E (pt)	2013-06-06
HUE024538T2 (hu)	2016-01-28
KR20120004422A (ko)	2012-01-12
AU2010227230A1 (en)	2011-09-22
DK2411396T3 (da)	2013-08-05
CA2756536C (en)	2015-10-06
MX2011009822A (es)	2012-01-25
CN102361877B (zh)	2014-05-07
US20120178766A1 (en)	2012-07-12
EP2411395A1 (en)	2012-02-01
SG174404A1 (en)	2011-10-28
AU2010227225A1 (en)	2011-09-15
HK1166074A1 (en)	2012-10-19
DK2411395T3 (da)	2013-08-05
US20150150876A1 (en)	2015-06-04
AU2010227225A2 (en)	2011-10-06
BRPI1009381B1 (pt)	2020-04-14
ES2424341T3 (es)	2013-10-01
EP2634191B1 (en)	2014-12-24
CN102361874A (zh)	2012-02-22
CN102361877A (zh)	2012-02-22
KR20110128898A (ko)	2011-11-30
ES2424342T3 (es)	2013-10-01
PE20120834A1 (es)	2012-07-25
US20130289054A1 (en)	2013-10-31
PE20120775A1 (es)	2012-06-27
BRPI1009381B8 (pt)	2021-05-25
US8507503B2 (en)	2013-08-13
EA201190139A1 (ru)	2012-03-30
SG184769A1 (en)	2012-10-30
AP2011005889A0 (en)	2011-10-31
JP2012521407A (ja)	2012-09-13
ZA201107650B (en)	2012-07-25
AU2010227230B2 (en)	2015-11-26
HK1166073A1 (en)	2012-10-19
IL215177A0 (en)	2011-12-29
PT2634191E (pt)	2015-03-04
EP2411396A2 (en)	2012-02-01
SG184767A1 (en)	2012-10-30
CN103755720B (zh)	2016-07-06
EP2411396B1 (en)	2013-05-29
CN103755720A (zh)	2014-04-30
SI2411396T1 (sl)	2013-07-31
AP2948A (en)	2014-07-31
PT2411395E (pt)	2013-06-06
PL2634191T3 (pl)	2015-06-30
IL215175A (en)	2014-01-30
CA2756536A1 (en)	2010-09-30
CA2756535A1 (en)	2010-09-30
SI2634191T1 (sl)	2015-04-30
SI2411395T1 (sl)	2013-07-31
WO2010109329A1 (en)	2010-09-30
IL215177A (en)	2014-01-30
US20120295924A1 (en)	2012-11-22
EA201190138A1 (ru)	2013-05-30
US9474758B2 (en)	2016-10-25
DK2634191T3 (en)	2015-03-23
US8987278B2 (en)	2015-03-24
SG174398A1 (en)	2011-10-28
BRPI1009381A2 (pt)	2016-06-21
JP2012521406A (ja)	2012-09-13
AU2010227230A2 (en)	2011-10-27
PL2411395T3 (pl)	2013-10-31
KR101524337B1 (ko)	2015-05-29
IL215175A0 (en)	2011-12-29

Publication	Publication Date	Title
AP2948A (en)	2014-07-31	Thienopyrmidinedione derivatives as TRPA1 modulators
ZA201107646B (en)	2012-06-25	Isothiazolo-prrimidinedione derivatives as trpa1 modulators
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IL217952A0 (en)	2012-03-29	N1-acyl-5-fluoropyrimidinone derivatives
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IL213262A0 (en)	2011-07-31	Tetrahydronaphthalen-2-ol derivatives
GB0912499D0 (en)	2009-08-26	Indopyl-pyridone derivatives
AP2011005883A0 (en)	2011-10-31	Furopyrimidinedione derivatives as TRPA1 modulators.