BRPI1009381A2 - compostos, composição farmacêutica, método para tratar doença ou condição associada com função de trap1 em sujeito em necessidade do mesmo e uso de compostos e composição farmacêutica - Google Patents

compostos, composição farmacêutica, método para tratar doença ou condição associada com função de trap1 em sujeito em necessidade do mesmo e uso de compostos e composição farmacêutica

Info

Publication number: BRPI1009381A2
Authority: BR; Brazil
Prior art keywords: compounds; pharmaceutical composition; trap1; subject; need
Prior art date: 2009-03-23

Application number

BRPI1009381A

Other languages

English (en)

Inventor

Abraham Thomas

Indranil Mukhopadhyay

Nayan Taterao Waghmare

Neelima Khairatkar-Joshi

Sanjay Margal

Sukeerthi Kumar

Original Assignee

Glenmark Pharmaceuticals Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-03-23

Filing date

2010-03-23

Publication date

2016-06-21

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42780205&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI1009381(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2010-03-23 Application filed by Glenmark Pharmaceuticals Sa filed Critical Glenmark Pharmaceuticals Sa

2016-06-21 Publication of BRPI1009381A2 publication Critical patent/BRPI1009381A2/pt

2020-04-14 Publication of BRPI1009381B1 publication Critical patent/BRPI1009381B1/pt

2021-05-25 Publication of BRPI1009381B8 publication Critical patent/BRPI1009381B8/pt

Links

150000001875 compounds Chemical class 0.000 title 2
239000008194 pharmaceutical composition Substances 0.000 title 2
201000010099 disease Diseases 0.000 title 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
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- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Physical Education & Sports Medicine (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Otolaryngology (AREA)
Vascular Medicine (AREA)
Immunology (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

BRPI1009381A 2009-03-23 2010-03-23 compostos, composição farmacêutica e uso de compostos e de composição farmacêutica BRPI1009381B8 (pt)

Applications Claiming Priority (7)

Application Number	Priority Date	Filing Date	Title
IN665MU2009		2009-03-23
US17135509P	2009-04-21	2009-04-21
IN2213MU2009		2009-09-23
US25194409P	2009-10-15	2009-10-15
IN2906MU2009		2009-12-16
US29447010P	2010-01-12	2010-01-12
PCT/IB2010/000930 WO2010109334A2 (en)	2009-03-23	2010-03-23	Thienopyrimidinedione derivatives as trpa1 modulators

Publications (3)

Publication Number	Publication Date
BRPI1009381A2 true BRPI1009381A2 (pt)	2016-06-21
BRPI1009381B1 BRPI1009381B1 (pt)	2020-04-14
BRPI1009381B8 BRPI1009381B8 (pt)	2021-05-25

Family

ID=42780205

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
BRPI1013705A BRPI1013705A2 (pt)	2009-03-23	2010-03-22	compostos, composição farmacêutica, método de tratamento de doença ou condição associada com função de trap1 e usos de compostos e de composição farmacêutica
BRPI1009381A BRPI1009381B8 (pt)	2009-03-23	2010-03-23	compostos, composição farmacêutica e uso de compostos e de composição farmacêutica

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
BRPI1013705A BRPI1013705A2 (pt)	2009-03-23	2010-03-22	compostos, composição farmacêutica, método de tratamento de doença ou condição associada com função de trap1 e usos de compostos e de composição farmacêutica

Country Status (22)

Country	Link
US (4)	US20120178766A1 (pt)
EP (3)	EP2411395B1 (pt)
JP (2)	JP2012521406A (pt)
KR (2)	KR20110128898A (pt)
CN (3)	CN102361874A (pt)
AP (1)	AP2948A (pt)
AU (2)	AU2010227225A1 (pt)
BR (2)	BRPI1013705A2 (pt)
CA (2)	CA2756535A1 (pt)
DK (3)	DK2411395T3 (pt)
EA (2)	EA201190138A1 (pt)
ES (3)	ES2424341T3 (pt)
HU (1)	HUE024538T2 (pt)
IL (2)	IL215177A (pt)
MX (1)	MX2011009822A (pt)
PE (2)	PE20120834A1 (pt)
PL (3)	PL2411395T3 (pt)
PT (3)	PT2411395E (pt)
SG (4)	SG174398A1 (pt)
SI (3)	SI2411395T1 (pt)
WO (2)	WO2010109329A1 (pt)
ZA (2)	ZA201107650B (pt)

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WO2012176105A1 (en)	2011-06-22	2012-12-27	Glenmark Pharmaceuticals Sa	Pharmaceutical composition comprising a trpa1 antagonist and a leukotriene receptor antagonist
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WO2014203210A1 (en) *	2013-06-20	2014-12-24	Glenmark Pharmaceuticals S.A.	Nanoparticulate formulation comprising a trpa1 antagonist
MX2016004741A (es)	2013-10-15	2016-07-26	Glenmark Pharmaceuticals Sa	Composicion farmaceutica que comprende un antagonista de trpa1 y un agente analgesico.
EP3180345B1 (en) *	2014-08-11	2018-10-10	Hydra Biosciences, Inc.	Thieno- and furo[2,3-d]pyrimidine-2,4[1h,3h]-dione derivatives as trpc5 modulators for the treatment of neuropsychiatric disorders
JP6667092B2 (ja) *	2014-08-11	2020-03-18	ハイドラ・バイオサイエンシーズ・リミテッド・ライアビリティ・カンパニーＨｙｄｒａＢｉｏｓｃｉｅｎｃｅｓ，ＬＬＣ	ピロロ［３，２−ｄ］ピリミジン−２，４（３Ｈ，５Ｈ）−ジオン誘導体
EP3180337B1 (en) *	2014-08-11	2018-10-10	Hydra Biosciences, Inc.	Pyrido[3,4-d]pyrimidine-2,4(1h,3h)-dione derivatives
EP3180340B1 (en) *	2014-08-11	2018-10-10	Hydra Biosciences, Inc.	Pyrido[2,3-d]pyrimidine-2,4(1h,3h)-dione derivatives
WO2016028325A1 (en)	2014-08-22	2016-02-25	Duke University	Trpa1 and trpv4 inhibitors and methods of using the same for organ-specific inflammation and itch
WO2016042501A1 (en)	2014-09-16	2016-03-24	Glenmark Pharmaceuticals S.A.	Trpa1 antagonist for the treatment of pain associated to diabetic neuropathic pain
US11229628B2 (en)	2015-01-09	2022-01-25	Duke University	TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch
WO2017060488A1 (en)	2015-10-09	2017-04-13	Almirall, S.A.	New trpa1 antagonists
WO2017064068A1 (en)	2015-10-14	2017-04-20	Almirall, S.A.	New trpa1 antagonists
CN109310683A (zh)	2016-04-07	2019-02-05	杜克大学	用于消毒和麻醉的trpv4和trpa1的小分子双重抑制剂
JP7178357B2 (ja) *	2017-03-07	2022-11-25	エフ．ホフマン－ラロシュアーゲー	オキサジアゾール一過性受容器電位チャネル阻害剤
CN109422749B (zh) *	2017-08-21	2023-01-24	重庆医药工业研究院有限责任公司	一种抑制单羧酸转运蛋白的嘧啶二酮衍生物
JP7612682B2 (ja)	2019-10-15	2025-01-14	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	新規なテトラゾール
IL301717B2 (en) *	2020-10-14	2026-05-01	Boehringer Ingelheim Int	History of tetrazoles as TRPA1 inhibitors
KR20230087531A (ko) *	2020-10-14	2023-06-16	베링거 인겔하임 인터내셔날 게엠베하	Trpa1 억제제로서 테트라졸 유도체
WO2022179469A1 (zh) *	2021-02-23	2022-09-01	南京明德新药研发有限公司	噻吩并嘧啶二酮类化合物及其应用
JP7565457B2 (ja)	2021-04-14	2024-10-10	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	ＴＲＰＡ１阻害剤としての３Ｈ，４Ｈ－チエノ－［２，３－ｄ］ピリミジン－４－オン誘導体
CN114656480B (zh) *	2022-04-27	2024-01-26	成都施贝康生物医药科技有限公司	噻吩并嘧啶类化合物、异构体或盐及其制备方法和用途
CN114671875A (zh) *	2022-04-27	2022-06-28	成都施贝康生物医药科技有限公司	新型二氢嘧啶类化合物、异构体或盐及其制备方法和用途
WO2025264860A2 (en)	2024-06-18	2025-12-26	Yale University	Methods of treating post-covid airway disease
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Publication number	Publication date
MX2011009822A (es)	2012-01-25
SI2411396T1 (sl)	2013-07-31
KR101524337B1 (ko)	2015-05-29
US20120295924A1 (en)	2012-11-22
SG184769A1 (en)	2012-10-30
CA2756535A1 (en)	2010-09-30
KR20110128898A (ko)	2011-11-30
IL215175A (en)	2014-01-30
HK1166073A1 (en)	2012-10-19
IL215177A0 (en)	2011-12-29
PT2411395E (pt)	2013-06-06
US8507503B2 (en)	2013-08-13
US20150150876A1 (en)	2015-06-04
PL2411396T3 (pl)	2013-10-31
CN102361877A (zh)	2012-02-22
EP2411396B1 (en)	2013-05-29
ES2424341T3 (es)	2013-10-01
BRPI1009381B1 (pt)	2020-04-14
DK2634191T3 (en)	2015-03-23
WO2010109334A3 (en)	2010-11-25
IL215175A0 (en)	2011-12-29
IL215177A (en)	2014-01-30
DK2411396T3 (da)	2013-08-05
AU2010227230A1 (en)	2011-09-22
EP2411395A1 (en)	2012-02-01
SG174398A1 (en)	2011-10-28
EP2634191A1 (en)	2013-09-04
CN103755720A (zh)	2014-04-30
PE20120834A1 (es)	2012-07-25
US20130289054A1 (en)	2013-10-31
CN102361877B (zh)	2014-05-07
PL2634191T3 (pl)	2015-06-30
EP2411395B1 (en)	2013-05-29
HUE024538T2 (hu)	2016-01-28
JP2012521406A (ja)	2012-09-13
SG184767A1 (en)	2012-10-30
KR20120004422A (ko)	2012-01-12
SG174404A1 (en)	2011-10-28
ES2424342T3 (es)	2013-10-01
AU2010227225A2 (en)	2011-10-06
SI2411395T1 (sl)	2013-07-31
BRPI1013705A2 (pt)	2016-04-05
PL2411395T3 (pl)	2013-10-31
US20120178766A1 (en)	2012-07-12
EA022029B1 (ru)	2015-10-30
US9474758B2 (en)	2016-10-25
JP5612070B2 (ja)	2014-10-22
EP2634191B1 (en)	2014-12-24
DK2411395T3 (da)	2013-08-05
CA2756536C (en)	2015-10-06
PT2634191E (pt)	2015-03-04
PE20120775A1 (es)	2012-06-27
ES2532386T3 (es)	2015-03-26
HK1166074A1 (en)	2012-10-19
WO2010109329A1 (en)	2010-09-30
JP2012521407A (ja)	2012-09-13
CN103755720B (zh)	2016-07-06
AU2010227230A2 (en)	2011-10-27
BRPI1009381B8 (pt)	2021-05-25
PT2411396E (pt)	2013-06-06
SI2634191T1 (sl)	2015-04-30
EA201190138A1 (ru)	2013-05-30
AU2010227230B2 (en)	2015-11-26
AP2011005889A0 (en)	2011-10-31
WO2010109334A2 (en)	2010-09-30
AP2948A (en)	2014-07-31
ZA201107649B (en)	2012-07-25
US8987278B2 (en)	2015-03-24
EP2411396A2 (en)	2012-02-01
CA2756536A1 (en)	2010-09-30
EA201190139A1 (ru)	2012-03-30
CN102361874A (zh)	2012-02-22
ZA201107650B (en)	2012-07-25
AU2010227225A1 (en)	2011-09-15

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