AP298A - Herpes simplex vaccine comprising HSV Glycoprotein gD and 3 deacylated mono-phosphoryl lipid A. - Google Patents

Herpes simplex vaccine comprising HSV Glycoprotein gD and 3 deacylated mono-phosphoryl lipid A. Download PDF

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Publication number
AP298A
AP298A APAP/P/1992/000368A AP9200368A AP298A AP 298 A AP298 A AP 298A AP 9200368 A AP9200368 A AP 9200368A AP 298 A AP298 A AP 298A
Authority
AP
ARIPO
Prior art keywords
rgd2t
alum
hsv
mpl
glycoprotein
Prior art date
Application number
APAP/P/1992/000368A
Other languages
English (en)
Other versions
AP9200368A0 (en
Inventor
Myriam Francotte
Jean Paul Prieels
Moncef Slaqui
Nathalie Marie-Josephe Claude Garcon-Johnson
Original Assignee
Smithkline Biologicals S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10691946&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP298(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Smithkline Biologicals S A filed Critical Smithkline Biologicals S A
Publication of AP9200368A0 publication Critical patent/AP9200368A0/xx
Application granted granted Critical
Publication of AP298A publication Critical patent/AP298A/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/245Herpetoviridae, e.g. herpes simplex virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541Mucosal route
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505Inorganic adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55566Emulsions, e.g. Freund's adjuvant, MF59
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55572Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16611Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16634Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
APAP/P/1992/000368A 1991-03-21 1992-03-20 Herpes simplex vaccine comprising HSV Glycoprotein gD and 3 deacylated mono-phosphoryl lipid A. AP298A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9105992A GB9105992D0 (en) 1991-03-21 1991-03-21 Vaccine

Publications (2)

Publication Number Publication Date
AP9200368A0 AP9200368A0 (en) 1992-04-30
AP298A true AP298A (en) 1994-01-14

Family

ID=10691946

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1992/000368A AP298A (en) 1991-03-21 1992-03-20 Herpes simplex vaccine comprising HSV Glycoprotein gD and 3 deacylated mono-phosphoryl lipid A.

Country Status (33)

Country Link
US (1) US6027730A (fr)
EP (1) EP0576478B2 (fr)
JP (1) JP3530526B2 (fr)
KR (1) KR100224329B1 (fr)
CN (2) CN1058191C (fr)
AP (1) AP298A (fr)
AT (1) ATE129160T1 (fr)
AU (1) AU650521B2 (fr)
BR (1) BR9205745A (fr)
CA (1) CA2106492C (fr)
CY (1) CY1936A (fr)
CZ (1) CZ280505B6 (fr)
DE (1) DE69205566T3 (fr)
DK (1) DK0576478T4 (fr)
ES (1) ES2081102T5 (fr)
FI (1) FI107881B (fr)
GB (1) GB9105992D0 (fr)
GR (1) GR3017884T3 (fr)
HU (1) HU218025B (fr)
IE (1) IE69560B1 (fr)
IL (1) IL101290A (fr)
MA (1) MA22471A1 (fr)
MX (1) MX9201245A (fr)
MY (1) MY110086A (fr)
NO (1) NO307499B1 (fr)
NZ (1) NZ242057A (fr)
PL (1) PL170059B1 (fr)
PT (1) PT100262B (fr)
SA (1) SA92120459B1 (fr)
SK (1) SK279190B6 (fr)
WO (1) WO1992016231A1 (fr)
YU (1) YU28392A (fr)
ZA (1) ZA922011B (fr)

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US6620414B2 (en) 1992-03-27 2003-09-16 Smithkline Beecham Biologicals (S.A.) Hepatitis vaccines containing 3-0-deacylated monophoshoryl lipid A
WO1994019013A1 (fr) * 1993-02-19 1994-09-01 Smithkline Beecham Corporation Compositions de vaccin contre la grippe, contenant un lipide a de monophosphoryle desacyle en position 3-o
EP0689454B2 (fr) * 1993-03-23 2005-02-23 SMITHKLINE BEECHAM BIOLOGICALS s.a. Compositions vaccinales renfermant le lipide a monophosphorylique 3-o desacetyle
DE69426077T3 (de) * 1993-05-25 2004-09-02 Wyeth Holdings Corp. Adjuvantien für impfstoffe gegen das respiratorische synzitialvirus
GB9326253D0 (en) * 1993-12-23 1994-02-23 Smithkline Beecham Biolog Vaccines
ES2197217T3 (es) * 1994-12-28 2004-01-01 University Of Kentucky Research Foundation Anticuerpo 3h1 monoclonal anti-id-murino.
US6949244B1 (en) 1995-12-20 2005-09-27 The Board Of Trustees Of The University Of Kentucky Murine monoclonal anti-idiotype antibody 11D10 and methods of use thereof
US20020041872A1 (en) 1996-04-12 2002-04-11 Malaya Chatterjee Methods of delaying development of CEA-associated tumors using anti-idiotype antibody 3H1
US6235280B1 (en) 1996-04-12 2001-05-22 Malaya Chatterjee Methods of delaying development of CEA-associated tumors using anti-idiotype antibody 3H1
US6468782B1 (en) 1996-12-05 2002-10-22 Quadrant Healthcare (Uk) Limited Methods of preserving prokaryotic cells and compositions obtained thereby
US6274143B1 (en) 1997-06-13 2001-08-14 Malaya Chatterjee Methods of delaying development of HMFG-associated tumors using anti-idiotype antibody 11D10
US6355244B1 (en) 1997-11-17 2002-03-12 University Of Kentucky Research Foundation Methods and compositions for the treatment of psoriasis
GB9819898D0 (en) * 1998-09-11 1998-11-04 Smithkline Beecham Plc New vaccine and method of use
US6692752B1 (en) * 1999-09-08 2004-02-17 Smithkline Beecham Biologicals S.A. Methods of treating human females susceptible to HSV infection
DE122007000087I1 (de) 1998-10-16 2008-03-27 Glaxosmithkline Biolog Sa Adjuvanzsysteme und impfstoffe
US7026155B2 (en) 1999-02-02 2006-04-11 Regents Of The University Of California Method of reducing bacterial proliferation
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US9273326B2 (en) 2004-04-30 2016-03-01 The Brigham And Women's Hospital, Inc. Tetracycline-regulated gene expression in HSV-1 vectors
JP2008513406A (ja) 2004-09-22 2008-05-01 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 免疫原性組成物
TW200700079A (en) 2005-03-23 2007-01-01 Glaxosmithkline Biolog Sa Composition
GB0607088D0 (en) 2006-04-07 2006-05-17 Glaxosmithkline Biolog Sa Vaccine
CN103251940A (zh) 2005-12-22 2013-08-21 葛兰素史密丝克莱恩生物有限公司 疫苗
EP1998802A2 (fr) 2006-03-30 2008-12-10 GlaxoSmithKline Biologicals S.A. Composition immunogène
MX2009000660A (es) 2006-07-17 2009-04-08 Glaxosmithkline Biolog Sa Vacuna de influenza.
US20090181078A1 (en) * 2006-09-26 2009-07-16 Infectious Disease Research Institute Vaccine composition containing synthetic adjuvant
HUE036180T2 (hu) 2006-09-26 2018-06-28 Infectious Disease Res Inst Szintetikus adjuvánst tartalmazó vakcina készítmény
US9452209B2 (en) 2007-04-20 2016-09-27 Glaxosmithkline Biologicals Sa Influenza vaccine
MX2009013949A (es) 2007-06-26 2010-05-24 Glaxosmithkline Biolog Sa Vacuna que comprende conjugados de polisacárido capsular de streptococcus pneumoniae.
AU2010249330B2 (en) 2009-05-22 2015-11-05 Genocea Biosciences Inc. Vaccines against Herpes Simplex Virus type 2: compositions and methods for eliciting an immune response
HUE031051T2 (en) * 2009-06-05 2017-06-28 Infectious Disease Res Inst Synthetic glycopyranosyl lipid adjuvant and vaccine compositions containing it
GB0913680D0 (en) 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition
GB0913681D0 (en) 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition
US8809047B2 (en) * 2009-12-21 2014-08-19 The Brigham And Women's Hospital, Inc. Herpes simplex virus vaccines
AU2011336894B2 (en) 2010-11-24 2016-11-17 Genocea Biosciences, Inc. Vaccines against Herpes Simplex Virus type 2: compositions and methods for eliciting an immune response
EP2683402B1 (fr) * 2011-03-11 2020-06-24 Turnstone Limited Partnership Méthode de vaccination faisant intervenir un inhibiteur d'histone désacétylase
EP3632463A1 (fr) 2011-04-08 2020-04-08 Immune Design Corp. Compositions immunogènes et leurs procédés d'utilisation pour induire des réponses immunitaires humorales et cellulaires
WO2013028738A1 (fr) 2011-08-22 2013-02-28 Nanobio Corporation Vaccin contre le virus de l'herpès simplex sous forme de nanoémulsion
AU2012340712B2 (en) 2011-11-23 2017-09-14 Genocea Biosciences, Inc. Nucleic acid vaccines against Herpes Simplex Virus type 2: compositions and methods for eliciting an immune response
SI2850431T1 (en) 2012-05-16 2018-08-31 Immune Design Corp. Vaccines for hsv-2
DK2941269T3 (da) 2013-01-07 2021-01-11 Mucosal Vaccine Tech Llc Terapeutiske vacciner til behandling af herpes simplex-virus type 2-infektioner
EP2986303B1 (fr) 2013-04-18 2020-02-26 Immune Design Corp. Monothérapie par gla pour une utilisation dans le traitement du cancer
US9463198B2 (en) 2013-06-04 2016-10-11 Infectious Disease Research Institute Compositions and methods for reducing or preventing metastasis
JP2019537555A (ja) 2016-09-28 2019-12-26 ジェノセア バイオサイエンシーズ, インコーポレイテッド ヘルペスを処置するための方法および組成物
WO2019152821A1 (fr) 2018-02-05 2019-08-08 The Brigham And Women's Hospital, Inc. Virus de l'herpès simplex 2 recombinant exprimant des antigènes de glycoprotéine b et d
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GB2220211A (en) * 1988-06-29 1990-01-04 Ribi Immunochem Research Inc Modified lipopolysaccharides

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WO1994019013A1 (fr) * 1993-02-19 1994-09-01 Smithkline Beecham Corporation Compositions de vaccin contre la grippe, contenant un lipide a de monophosphoryle desacyle en position 3-o
EP0689454B2 (fr) * 1993-03-23 2005-02-23 SMITHKLINE BEECHAM BIOLOGICALS s.a. Compositions vaccinales renfermant le lipide a monophosphorylique 3-o desacetyle
DE69426077T3 (de) * 1993-05-25 2004-09-02 Wyeth Holdings Corp. Adjuvantien für impfstoffe gegen das respiratorische synzitialvirus

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WO1988002634A1 (fr) * 1986-10-20 1988-04-21 Chiron Corporation Vaccin utilise pour le traitement therapeutique de hsv
GB2220211A (en) * 1988-06-29 1990-01-04 Ribi Immunochem Research Inc Modified lipopolysaccharides

Also Published As

Publication number Publication date
PT100262A (pt) 1993-06-30
CY1936A (en) 1992-03-17
EP0576478B2 (fr) 2001-04-18
HU9302645D0 (en) 1994-01-28
JP3530526B2 (ja) 2004-05-24
AU650521B2 (en) 1994-06-23
CN1101226C (zh) 2003-02-12
PL170059B1 (pl) 1996-10-31
JPH06505727A (ja) 1994-06-30
EP0576478B1 (fr) 1995-10-18
IL101290A (en) 1996-07-23
NO933343L (no) 1993-09-20
ES2081102T3 (es) 1996-02-16
BR9205745A (pt) 1994-10-18
SK94693A3 (en) 1994-05-11
HUT67052A (en) 1995-01-30
MY110086A (en) 1997-12-31
ATE129160T1 (de) 1995-11-15
NO307499B1 (no) 2000-04-17
KR100224329B1 (ko) 1999-10-15
SK279190B6 (sk) 1998-07-08
YU28392A (sh) 1994-11-15
IL101290A0 (en) 1992-11-15
DE69205566T3 (de) 2002-09-05
GB9105992D0 (en) 1991-05-08
ZA922011B (en) 1993-01-27
NO933343D0 (no) 1993-09-20
DE69205566D1 (en) 1995-11-23
FI107881B (fi) 2001-10-31
CA2106492A1 (fr) 1992-09-22
DE69205566T2 (de) 1996-04-18
CZ195893A3 (en) 1994-07-13
CN1065997A (zh) 1992-11-11
EP0576478A1 (fr) 1994-01-05
IE69560B1 (en) 1996-10-02
FI934134A0 (fi) 1993-09-21
HK1004525A1 (en) 1998-11-27
SA92120459B1 (ar) 2005-06-14
CZ280505B6 (cs) 1996-02-14
NZ242057A (en) 1993-12-23
WO1992016231A1 (fr) 1992-10-01
DK0576478T4 (da) 2001-07-23
CN1058191C (zh) 2000-11-08
GR3017884T3 (en) 1996-01-31
MX9201245A (es) 1992-10-01
IE920881A1 (en) 1992-09-23
HU218025B (hu) 2000-05-28
AU1365792A (en) 1992-10-21
CA2106492C (fr) 2003-12-09
FI934134L (fi) 1993-09-21
CN1201692A (zh) 1998-12-16
AP9200368A0 (en) 1992-04-30
PT100262B (pt) 2001-05-31
US6027730A (en) 2000-02-22
MA22471A1 (fr) 1992-10-01
DK0576478T3 (da) 1995-12-04
ES2081102T5 (es) 2001-09-01

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