AP484A - Novel imidazole compounds, processes for the preparation thereof and their use in therapy. - Google Patents

Novel imidazole compounds, processes for the preparation thereof and their use in therapy. Download PDF

Info

Publication number: AP484A
Authority: AP; ARIPO
Prior art keywords: imidazole; fluorophenyl; alkyl; pyridyl; compound
Prior art date: 1993-07-16

Application number

APAP/P/1994/000654A

Other languages

English (en)

Other versions

AP9400654A0 (en

Inventor

Jerry Leroy Adams

Peter William Sheldrake

Timothy Francis Gallagher

Ravi Shanker Garigipati

Paul Elliot Bender

Jeffrey Charles Boehm

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-16

Filing date

1994-07-13

Publication date

1996-04-23

1994-07-13 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

1994-07-31 Publication of AP9400654A0 publication Critical patent/AP9400654A0/xx

1996-04-23 Application granted granted Critical

1996-04-23 Publication of AP484A publication Critical patent/AP484A/en

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Diabetes (AREA)
Pulmonology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Virology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Neurology (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Obesity (AREA)
Immunology (AREA)
Emergency Medicine (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
AIDS & HIV (AREA)
Hospice & Palliative Care (AREA)
Toxicology (AREA)
Endocrinology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)

APAP/P/1994/000654A 1993-07-16 1994-07-13 Novel imidazole compounds, processes for the preparation thereof and their use in therapy. AP484A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US9273393A	1993-07-16	1993-07-16

Publications (2)

Publication Number	Publication Date
AP9400654A0 AP9400654A0 (en)	1994-07-31
AP484A true AP484A (en)	1996-04-23

Family

ID=22234840

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
APAP/P/1994/000654A AP484A (en)	1993-07-16	1994-07-13	Novel imidazole compounds, processes for the preparation thereof and their use in therapy.

Country Status (31)

Country	Link
EP (5)	EP1227091A3 (de)
JP (4)	JPH09500137A (de)
CN (2)	CN1050126C (de)
AP (1)	AP484A (de)
AT (2)	ATE236896T1 (de)
AU (1)	AU694130C (de)
BR (2)	BR9407079A (de)
CA (1)	CA2167311A1 (de)
CZ (1)	CZ11996A3 (de)
DE (2)	DE69432463T2 (de)
DK (1)	DK0708768T3 (de)
DZ (1)	DZ1798A1 (de)
ES (2)	ES2197167T3 (de)
FI (1)	FI960177A7 (de)
HK (3)	HK1049657A1 (de)
HU (1)	HUT75313A (de)
IL (2)	IL110296A (de)
MA (1)	MA23270A1 (de)
MY (1)	MY116478A (de)
NO (4)	NO316881B1 (de)
NZ (2)	NZ329994A (de)
PL (4)	PL181694B1 (de)
PT (1)	PT708768E (de)
RU (1)	RU2140918C1 (de)
SG (1)	SG52368A1 (de)
SI (1)	SI0708768T1 (de)
SK (1)	SK282342B6 (de)
TW (1)	TW330934B (de)
UA (1)	UA63875C2 (de)
WO (1)	WO1995002591A1 (de)
ZA (1)	ZA945193B (de)

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1994
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- 1994-07-13 DZ DZ940081A patent/DZ1798A1/fr active
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- 1994-07-15 ES ES94923503T patent/ES2197167T3/es not_active Expired - Lifetime
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- 1994-07-15 EP EP94923503A patent/EP0708768B1/de not_active Expired - Lifetime
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- 1994-07-15 EP EP02076581A patent/EP1229035A1/de not_active Withdrawn
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1996
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1997
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1998
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2001
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2003
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Also Published As

Publication number	Publication date
NO10839A (no)	1996-01-15
EP1291346B1 (de)	2005-03-23
TW330934B (en)	1998-05-01
EP1227091A2 (de)	2002-07-31
AU694130C (en)	2002-12-05
AU7335494A (en)	1995-02-13
CZ11996A3 (en)	1996-10-16
PL181721B1 (en)	2001-09-28
SK4796A3 (en)	1997-01-08
SI0708768T1 (en)	2003-10-31
ZA945193B (en)	1995-04-20
CN1218801A (zh)	1999-06-09
EP1229035A1 (de)	2002-08-07
HUT75313A (en)	1997-05-28
NO960173D0 (no)	1996-01-15
HK1049659A1 (en)	2003-05-23
DE69432463T2 (de)	2004-02-12
BR9407079A (pt)	1996-08-27
AU694130B2 (en)	1998-07-16
DE69434316D1 (de)	2005-04-28
HK1049658A1 (en)	2003-05-23
ATE236896T1 (de)	2003-04-15
FI960177A0 (fi)	1996-01-15
ES2197167T3 (es)	2004-01-01
EP1227091A3 (de)	2002-08-07
SG52368A1 (en)	1998-09-28
IL110296A0 (en)	1994-10-21
NO20010839D0 (no)	2001-02-19
FI960177L (fi)	1996-01-15
IL110296A (en)	1999-12-31
DE69432463D1 (de)	2003-05-15
SK282342B6 (sk)	2002-01-07
EP1227092A3 (de)	2002-08-07
EP0708768A1 (de)	1996-05-01
FI960177A7 (fi)	1996-01-15
NO20010838D0 (no)	2001-02-19
AU705568B2 (en)	1999-05-27
JP2004149541A (ja)	2004-05-27
EP1291346A1 (de)	2003-03-12
PT708768E (pt)	2003-08-29
NO10837A (no)	1996-01-15
IL124318A0 (en)	1998-12-06
JP2004083600A (ja)	2004-03-18
NO20010837D0 (no)	2001-02-19
ATE291576T1 (de)	2005-04-15
MY116478A (en)	2004-02-28
CA2167311A1 (en)	1995-01-26
PL181723B1 (pl)	2001-09-28
PL181694B1 (pl)	2001-09-28
UA63875C2 (en)	2004-02-16
EP1227092A2 (de)	2002-07-31
PL181705B1 (pl)	2001-09-28
EP0708768B1 (de)	2003-04-09
PL312614A1 (en)	1996-04-29
JP2004099622A (ja)	2004-04-02
DK0708768T3 (da)	2003-08-04
NO316881B1 (no)	2004-06-14
NZ269457A (en)	1998-08-26
NZ329994A (en)	1999-07-29
CN1129447A (zh)	1996-08-21
HK1012392A1 (en)	1999-07-30
AP9400654A0 (en)	1994-07-31
CN1050126C (zh)	2000-03-08
AU7185098A (en)	1998-08-27
HK1049657A1 (en)	2003-05-23
RU2140918C1 (ru)	1999-11-10
EP0708768A4 (de)	1996-08-21
MA23270A1 (fr)	1995-04-01
NO10838A (no)	1996-01-15
ES2237650T3 (es)	2005-08-01
JPH09500137A (ja)	1997-01-07
BR1100546A (pt)	2004-08-31
NO960173L (no)	1996-01-15
WO1995002591A1 (en)	1995-01-26
DZ1798A1 (fr)	2002-02-17
HU9503855D0 (en)	1996-02-28
DE69434316T2 (de)	2006-03-09

Publication	Publication Date	Title
AP484A (en)	1996-04-23	Novel imidazole compounds, processes for the preparation thereof and their use in therapy.
US5969184A (en)	1999-10-19	Amide compounds
US6222036B1 (en)	2001-04-24	Process of preparing 2-thiopyrimidine aldehyde
US5593991A (en)	1997-01-14	Imidazole compounds, use and process of making
EP0831830B1 (de)	2003-03-05	Imidazolverbindungen
WO1997025046A1 (en)	1997-07-17	Novel substituted imidazole compounds
HK1055113A (en)	2003-12-24	Process for the preparation of trisubstituted imidazole compounds with multiple therapeutic properties
HK1012392B (en)	2003-12-05	Tri-substituted imidazoles having multiple therapeutic properties
AU1869402A (en)	2002-04-18	Intermediates used in the manufacture of tri-substituted imidazoles having multiple therapeutic properties
AU1869302A (en)	2002-04-18	Intermediates used in the manufacture of tri-substituted imidazoles having multiple therapeutic properties
HK1052690A (en)	2003-09-26	Process for the preparation of tosylbenzylformamides
HK1057540A (en)	2004-04-08	Pyridyl and pyrimidinyl imines as intermediates for imidazole derivatives
AU4478299A (en)	1999-11-11	Tri-substituted imidazoles having multiple therapeutic properties