AP779A - Apolipoprotein-B synthesis inhibitors. - Google Patents

Apolipoprotein-B synthesis inhibitors. Download PDF

Info

Publication number: AP779A
Authority: AP; ARIPO
Prior art keywords: methyl; amino; formula; phenyl; triazol
Prior art date: 1994-10-27

Application number

APAP/P/1997/000968A

Other languages

English (en)

Other versions

AP9700968A0 (en

Inventor

Jan Heeres

Leo Jacobus Josef Backx

Robert Josef Maria Hendrickx

Der Eycken Luc Alfons Leo Van

Courcelles Didier Robert Guy Gabriel Der Chaffoy De

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-27

Filing date

1995-10-19

Publication date

1999-11-03

1995-05-31 Priority claimed from US08/455,304 external-priority patent/US5521186A/en

1995-10-19 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

1997-04-30 Publication of AP9700968A0 publication Critical patent/AP9700968A0/xx

1999-11-03 Application granted granted Critical

1999-11-03 Publication of AP779A publication Critical patent/AP779A/en

Links

101710095342 Apolipoprotein B Proteins 0.000 title description 16
102100040202 Apolipoprotein B-100 Human genes 0.000 title description 16
230000015572 biosynthetic process Effects 0.000 title description 8
238000003786 synthesis reaction Methods 0.000 title description 5
239000003112 inhibitor Substances 0.000 title description 4
150000001875 compounds Chemical class 0.000 claims abstract description 81
-1 Ci-6alkyl Chemical group 0.000 claims abstract description 47
239000001257 hydrogen Substances 0.000 claims abstract description 22
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 22
239000002253 acid Substances 0.000 claims abstract description 21
125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 21
150000003839 salts Chemical class 0.000 claims abstract description 17
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239000003814 drug Substances 0.000 claims abstract description 11
238000000034 method Methods 0.000 claims abstract description 8
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 7
125000000623 heterocyclic group Chemical group 0.000 claims abstract description 6
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims abstract description 5
125000004356 hydroxy functional group Chemical group O* 0.000 claims abstract 10
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 35
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 35
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 30
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125000001424 substituent group Chemical group 0.000 claims description 18
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125000004953 trihalomethyl group Chemical group 0.000 claims description 16
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Diabetes (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Steroid Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

APAP/P/1997/000968A 1994-10-27 1995-10-19 Apolipoprotein-B synthesis inhibitors. AP779A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP94203120		1994-10-27
US08/455,304 US5521186A (en)	1994-10-27	1995-05-31	Apolipoprotein-β synthesis inhibitors
PCT/EP1995/004111 WO1996013499A1 (fr)	1994-10-27	1995-10-19	Inhibiteurs de synthese d'apolipoproteines-b

Publications (2)

Publication Number	Publication Date
AP9700968A0 AP9700968A0 (en)	1997-04-30
AP779A true AP779A (en)	1999-11-03

Family

ID=26136684

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
APAP/P/1997/000968A AP779A (en)	1994-10-27	1995-10-19	Apolipoprotein-B synthesis inhibitors.

Country Status (30)

Country	Link
US (1)	US5929075A (fr)
EP (1)	EP0788496B1 (fr)
JP (1)	JP3025907B2 (fr)
KR (1)	KR100227231B1 (fr)
CN (1)	CN1068000C (fr)
AP (1)	AP779A (fr)
AT (1)	ATE198889T1 (fr)
AU (1)	AU697744C (fr)
BG (1)	BG63694B1 (fr)
BR (1)	BR9509436A (fr)
CA (1)	CA2203274C (fr)
CY (1)	CY2256B1 (fr)
CZ (1)	CZ286476B6 (fr)
DE (3)	DE122007000005I2 (fr)
DK (1)	DK0788496T3 (fr)
ES (1)	ES2155535T3 (fr)
FI (1)	FI119548B (fr)
GR (1)	GR3035519T3 (fr)
HR (1)	HRP950532B1 (fr)
HU (1)	HU219862B (fr)
IL (1)	IL115771A (fr)
LU (1)	LU91306I2 (fr)
NO (1)	NO311937B1 (fr)
NZ (1)	NZ295353A (fr)
OA (1)	OA10479A (fr)
PT (1)	PT788496E (fr)
RO (1)	RO118715B1 (fr)
SK (1)	SK281908B6 (fr)
TR (1)	TR199501295A2 (fr)
WO (1)	WO1996013499A1 (fr)

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DE19945982A1 (de) *	1999-09-24	2001-03-29	Knoll Ag	Geschwindigkeitsbestimmte Partikel
US20050132022A1 (en) *	2003-12-12	2005-06-16	International Business Machines Corporation	Computer system with LAN-based I/O
JP4994043B2 (ja) *	2004-01-21	2012-08-08	エランコ・アニマル・ヘルス・アイルランド・リミテッド	ミトラタピデ経口用溶液
US7649002B2 (en)	2004-02-04	2010-01-19	Pfizer Inc	(3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
US7262318B2 (en) *	2004-03-10	2007-08-28	Pfizer, Inc.	Substituted heteroaryl- and phenylsulfamoyl compounds
AU2005230397B2 (en) *	2004-04-09	2010-04-08	Elanco Animal Health Ireland Limited	Intermittent dosing regimen for the treatment of overweight with MTP-inhibitors
US20050288340A1 (en) *	2004-06-29	2005-12-29	Pfizer Inc	Substituted heteroaryl- and phenylsulfamoyl compounds
PA8660701A1 (es)	2005-02-04	2006-09-22	Pfizer Prod Inc	Agonistas de pyy y sus usos
EP1890767A2 (fr) *	2005-05-27	2008-02-27	Pfizer Products Inc.	Combinaison d'un antagoniste des recepteurs cannabinoides-1 et d'un inhibiteur des proteines microsomales de transfert de triglycerides pour traiter l'obesite ou maintenir une perte de poids
CA2617654A1 (fr) *	2005-08-04	2007-02-08	Pfizer Limited	Composes piperidinoyl-pyrrolidine et piperidinoyl-piperidine
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
WO2007096763A2 (fr) *	2006-02-23	2007-08-30	Pfizer Limited	Pipéridinoylpyrrolidines en tant qu'agonistes du récepteur de la mélanocortine de type 4
US8383660B2 (en)	2006-03-10	2013-02-26	Pfizer Inc.	Dibenzyl amine compounds and derivatives
CN101583593A (zh)	2006-11-13	2009-11-18	辉瑞产品公司	二芳基、二吡啶基和芳基-吡啶基衍生物及其用途
CN101663262B (zh)	2006-12-01	2014-03-26	百时美施贵宝公司	用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
ES2348530T3 (es)	2007-05-25	2010-12-09	Janssen Pharmaceutica, N.V.	Síntesis mejorada de metanosulfonato de (2s-cis)-2-(bromometil)-2-(4-clorofenil)-1,3 dioxolan-4-metanol (éster).
KR101280786B1 (ko) *	2008-08-06	2013-07-05	화이자 리미티드	멜라노코르틴 4 작용제로서 다이아제핀 및 다이아조칸 화합물
US9040539B2 (en) *	2010-05-19	2015-05-26	Sandoz Ag	Process for the preparation of chiral triazolones
BR112020018094A2 (pt)	2018-03-08	2020-12-22	Incyte Corporation	Compostos de aminopirazina diol como inibidores de pi3k-¿
US11046658B2 (en)	2018-07-02	2021-06-29	Incyte Corporation	Aminopyrazine derivatives as PI3K-γ inhibitors

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CA1292472C (fr) *	1985-12-03	1991-11-26	Alfonsus Guilielmus Knaeps	Derives des ({4-¬4-(4-phenyl-1-piperazinyl)-phenoxymethyl\|- 1,3-dioxolan-2-yl}methyl)-1h-imidazoles et 1h-1,2,4-triazoles
NZ223799A (en) *	1987-03-25	1989-12-21	Janssen Pharmaceutica Nv	Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
CA1331757C (fr) *	1988-02-29	1994-08-30	Janssen Pharmaceutica Naamloze Vennootschap	5-lipoxygenase inhibant les 4-(4-phenyl-1-piperazinyl)phenols
AU6359594A (en) *	1993-03-04	1994-09-26	Cytoven International N.V.	Pharmaceutical tryptophan containing dipeptide compositions and methods of use thereof
US5521186A (en) *	1994-10-27	1996-05-28	Janssen Pharmaceutica N.V.	Apolipoprotein-β synthesis inhibitors

1995
- 1995-10-19 DE DE122007000005C patent/DE122007000005I2/de active Active
- 1995-10-19 RO RO97-00812A patent/RO118715B1/ro unknown
- 1995-10-19 BR BR9509436A patent/BR9509436A/pt not_active IP Right Cessation
- 1995-10-19 NZ NZ295353A patent/NZ295353A/en not_active IP Right Cessation
- 1995-10-19 WO PCT/EP1995/004111 patent/WO1996013499A1/fr not_active Ceased
- 1995-10-19 AP APAP/P/1997/000968A patent/AP779A/en active
- 1995-10-19 KR KR1019970702662A patent/KR100227231B1/ko not_active Expired - Fee Related
- 1995-10-19 ES ES95937804T patent/ES2155535T3/es not_active Expired - Lifetime
- 1995-10-19 EP EP95937804A patent/EP0788496B1/fr not_active Expired - Lifetime
- 1995-10-19 CA CA002203274A patent/CA2203274C/fr not_active Expired - Fee Related
- 1995-10-19 DK DK95937804T patent/DK0788496T3/da active
- 1995-10-19 US US08/817,247 patent/US5929075A/en not_active Expired - Lifetime
- 1995-10-19 CN CN95195885A patent/CN1068000C/zh not_active Expired - Fee Related
- 1995-10-19 DE DE1995619995 patent/DE122007000005I1/de active Pending
- 1995-10-19 AU AU38680/95A patent/AU697744C/en not_active Ceased
- 1995-10-19 DE DE69519995T patent/DE69519995T2/de not_active Expired - Lifetime
- 1995-10-19 PT PT95937804T patent/PT788496E/pt unknown
- 1995-10-19 AT AT95937804T patent/ATE198889T1/de active
- 1995-10-19 SK SK507-97A patent/SK281908B6/sk not_active IP Right Cessation
- 1995-10-19 JP JP8514288A patent/JP3025907B2/ja not_active Expired - Fee Related
- 1995-10-19 HU HU9701956A patent/HU219862B/hu not_active IP Right Cessation
- 1995-10-19 CZ CZ19971198A patent/CZ286476B6/cs not_active IP Right Cessation
- 1995-10-20 TR TR95/01295A patent/TR199501295A2/xx unknown
- 1995-10-26 IL IL11577195A patent/IL115771A/xx not_active IP Right Cessation
- 1995-10-27 HR HR950532A patent/HRP950532B1/xx not_active IP Right Cessation
1997
- 1997-04-10 BG BG101402A patent/BG63694B1/bg unknown
- 1997-04-24 NO NO19971895A patent/NO311937B1/no not_active IP Right Cessation
- 1997-04-25 FI FI971784A patent/FI119548B/fi not_active IP Right Cessation
- 1997-04-25 OA OA60997A patent/OA10479A/en unknown
2001
- 2001-03-05 GR GR20010400359T patent/GR3035519T3/el unknown
2002
- 2002-01-04 CY CY0200004A patent/CY2256B1/xx unknown
2007
- 2007-01-17 LU LU91306C patent/LU91306I2/fr unknown

Patent Citations (1)

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EP0006711A1 (fr) *	1978-06-23	1980-01-09	Janssen Pharmaceutica N.V.	Dérivés hétérocycliques de (4-phényl-pipérazin-1-yl-aryloxy méthyl-1,3-dioxolan-2-yl)-méthyl-1H-imidazoles et 1H-1,2,4-triazoles, procédés pour leur préparation et compositions les contenant

Also Published As

Publication number	Publication date
DK0788496T3 (da)	2001-06-18
HUT77360A (hu)	1998-03-30
FI119548B (fi)	2008-12-31
FI971784A0 (fi)	1997-04-25
MX9703074A (es)	1997-07-31
AU697744C (en)	2002-08-22
HU219862B (hu)	2001-08-28
CA2203274C (fr)	2002-02-19
CA2203274A1 (fr)	1996-05-09
NO311937B1 (no)	2002-02-18
JP3025907B2 (ja)	2000-03-27
BR9509436A (pt)	1998-01-06
JPH09511759A (ja)	1997-11-25
DE69519995D1 (en)	2001-03-01
KR100227231B1 (ko)	1999-11-01
AU3868095A (en)	1996-05-23
CZ119897A3 (cs)	1998-03-18
EP0788496A1 (fr)	1997-08-13
CN1068000C (zh)	2001-07-04
BG63694B1 (bg)	2002-09-30
EP0788496B1 (fr)	2001-01-24
LU91306I2 (fr)	2007-03-19
PT788496E (pt)	2001-07-31
ATE198889T1 (de)	2001-02-15
NZ295353A (en)	1998-08-26
TR199501295A2 (tr)	1996-06-21
DE122007000005I1 (de)	2007-04-26
NO971895L (no)	1997-04-24
FI971784L (fi)	1997-04-25
HRP950532B1 (en)	2001-06-30
IL115771A (en)	2000-02-29
DE122007000005I2 (de)	2008-04-24
HRP950532A2 (en)	1997-08-31
OA10479A (en)	2002-04-09
CZ286476B6 (en)	2000-04-12
DE69519995T2 (de)	2001-08-23
AP9700968A0 (en)	1997-04-30
NO971895D0 (no)	1997-04-24
GR3035519T3 (en)	2001-06-29
RO118715B1 (ro)	2003-09-30
ES2155535T3 (es)	2001-05-16
WO1996013499A1 (fr)	1996-05-09
US5929075A (en)	1999-07-27
CN1161695A (zh)	1997-10-08
AU697744B2 (en)	1998-10-15
CY2256B1 (en)	2003-07-04
BG101402A (en)	1997-10-31
SK50797A3 (en)	1998-04-08
IL115771A0 (en)	1996-01-19
SK281908B6 (sk)	2001-09-11

Publication	Publication Date	Title
AP779A (en)	1999-11-03	Apolipoprotein-B synthesis inhibitors.
US5521186A (en)	1996-05-28	Apolipoprotein-β synthesis inhibitors
KR101472370B1 (ko)	2014-12-15	Ｈｄｌ－ｃ의 증가, ｌｄｌ－ｃ의 감소 및 콜레스테롤의 감소에 사용되는 ｐｐａｒ－델타 효능제로서의 벤조아제핀－옥시－아세트산 유도체
EP2194046A1 (fr)	2010-06-09	Dérivé de triazolone
EP0871626B1 (fr)	2001-11-07	Triazolones utilises en tant qu'inhibiteurs de la synthese de l'apolipoproteine b
US6451802B1 (en)	2002-09-17	S-oxide lipid lowering compounds
MXPA97003074A (en)	1997-12-01	Synthesis of apoliprotein synthesis
HK1012186B (en)	2002-02-22	Triazolones as apolipoprotein-b synthesis inhibitors