CN1068000C - 阿朴脂蛋白－b合成抑制剂 - Google Patents

阿朴脂蛋白－b合成抑制剂 Download PDF

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Publication number
CN1068000C
CN1068000C CN95195885A CN95195885A CN1068000C CN 1068000 C CN1068000 C CN 1068000C CN 95195885 A CN95195885 A CN 95195885A CN 95195885 A CN95195885 A CN 95195885A CN 1068000 C CN1068000 C CN 1068000C
Authority
CN
China
Prior art keywords
alkyl
methyl
amino
formula
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN95195885A
Other languages
English (en)
Chinese (zh)
Other versions
CN1161695A (zh
Inventor
J·希尔斯
L·J·J·贝克斯
R·J·M·亨利斯
L·A·L·范德艾肯
D·R·G·G·德查弗德库塞尔利斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elanco Animal Health Ireland Ltd
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/455,304 external-priority patent/US5521186A/en
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of CN1161695A publication Critical patent/CN1161695A/zh
Application granted granted Critical
Publication of CN1068000C publication Critical patent/CN1068000C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN95195885A 1994-10-27 1995-10-19 阿朴脂蛋白－b合成抑制剂 Expired - Fee Related CN1068000C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP94203120.4 1994-10-27
EP94203120 1994-10-27
US08/455,304 US5521186A (en) 1994-10-27 1995-05-31 Apolipoprotein-β synthesis inhibitors
US08/455,304 1995-05-31

Publications (2)

Publication Number Publication Date
CN1161695A CN1161695A (zh) 1997-10-08
CN1068000C true CN1068000C (zh) 2001-07-04

Family

ID=26136684

Family Applications (1)

Application Number Title Priority Date Filing Date
CN95195885A Expired - Fee Related CN1068000C (zh) 1994-10-27 1995-10-19 阿朴脂蛋白－b合成抑制剂

Country Status (30)

Country Link
US (1) US5929075A (fr)
EP (1) EP0788496B1 (fr)
JP (1) JP3025907B2 (fr)
KR (1) KR100227231B1 (fr)
CN (1) CN1068000C (fr)
AP (1) AP779A (fr)
AT (1) ATE198889T1 (fr)
AU (1) AU697744C (fr)
BG (1) BG63694B1 (fr)
BR (1) BR9509436A (fr)
CA (1) CA2203274C (fr)
CY (1) CY2256B1 (fr)
CZ (1) CZ286476B6 (fr)
DE (3) DE69519995T2 (fr)
DK (1) DK0788496T3 (fr)
ES (1) ES2155535T3 (fr)
FI (1) FI119548B (fr)
GR (1) GR3035519T3 (fr)
HR (1) HRP950532B1 (fr)
HU (1) HU219862B (fr)
IL (1) IL115771A (fr)
LU (1) LU91306I2 (fr)
NO (1) NO311937B1 (fr)
NZ (1) NZ295353A (fr)
OA (1) OA10479A (fr)
PT (1) PT788496E (fr)
RO (1) RO118715B1 (fr)
SK (1) SK281908B6 (fr)
TR (1) TR199501295A2 (fr)
WO (1) WO1996013499A1 (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1028730B1 (fr) * 1997-11-03 2002-04-17 Janssen Pharmaceutica N.V. Compositions d'hypolipemiants
CN1308523A (zh) * 1998-04-27 2001-08-15 詹森药业有限公司 含有用降脂剂和聚合物包衣的丸芯的微丸
US6451802B1 (en) * 1998-12-22 2002-09-17 Janssen Pharmaceutica N.V. S-oxide lipid lowering compounds
DE19945982A1 (de) 1999-09-24 2001-03-29 Knoll Ag Geschwindigkeitsbestimmte Partikel
US20050132022A1 (en) * 2003-12-12 2005-06-16 International Business Machines Corporation Computer system with LAN-based I/O
WO2005070390A2 (fr) * 2004-01-21 2005-08-04 Janssen Pharmaceutica N.V. Solution orale de mitratapide
US7649002B2 (en) 2004-02-04 2010-01-19 Pfizer Inc (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
US7262318B2 (en) * 2004-03-10 2007-08-28 Pfizer, Inc. Substituted heteroaryl- and phenylsulfamoyl compounds
AU2005230397B2 (en) * 2004-04-09 2010-04-08 Elanco Animal Health Ireland Limited Intermittent dosing regimen for the treatment of overweight with MTP-inhibitors
US20050288340A1 (en) * 2004-06-29 2005-12-29 Pfizer Inc Substituted heteroaryl- and phenylsulfamoyl compounds
PA8660701A1 (es) 2005-02-04 2006-09-22 Pfizer Prod Inc Agonistas de pyy y sus usos
JP2008542255A (ja) * 2005-05-27 2008-11-27 ファイザー・プロダクツ・インク 肥満症の治療または体重減量の維持のためのカンナビノイド−１受容体アンタゴニストおよびミクロソームトリグリセリド輸送タンパク質阻害物質の併用
WO2007015162A1 (fr) * 2005-08-04 2007-02-08 Pfizer Limited Composes piperidinoyl-pyrrolidine et piperidinoyl-piperidine
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
ES2402581T3 (es) * 2006-02-23 2013-05-06 Pfizer Limited Piperidinoilpirrolidinas como agonistas del receptor de melanocortina tipo 4
US8383660B2 (en) 2006-03-10 2013-02-26 Pfizer Inc. Dibenzyl amine compounds and derivatives
MX2009004314A (es) 2006-11-13 2009-05-05 Pfizer Prod Inc Diaril, dipiridinil y arilpiridinilderivados y usos de los mismos.
CN101663262B (zh) 2006-12-01 2014-03-26 百时美施贵宝公司 用于治疗动脉粥样硬化和心血管疾病的作为cetp抑制剂的n-(3-苄基)-2,2-(二苯基)-丙-1胺衍生物
MX2009012739A (es) * 2007-05-25 2009-12-10 Janssen Pharmaceutica Nv Sintesis mejorada del metansulfonato(ester) de (2s-cis)-2-(bromometil)-2-(4-clorofenil)-1,3-dioxolan-4-metanol.
JP5530438B2 (ja) * 2008-08-06 2014-06-25 ファイザー・リミテッド Ｍｃ４作動薬としてのジアゼピンおよびジアゾカン化合物
CN102906087B (zh) * 2010-05-19 2016-03-23 桑多斯股份公司 制备手性三唑酮的方法
BR112020018094A2 (pt) 2018-03-08 2020-12-22 Incyte Corporation Compostos de aminopirazina diol como inibidores de pi3k-¿
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0006711A1 (fr) * 1978-06-23 1980-01-09 Janssen Pharmaceutica N.V. Dérivés hétérocycliques de (4-phényl-pipérazin-1-yl-aryloxy méthyl-1,3-dioxolan-2-yl)-méthyl-1H-imidazoles et 1H-1,2,4-triazoles, procédés pour leur préparation et compositions les contenant

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4313953A (en) * 1978-06-23 1982-02-02 Janssen Pharmaceutica, N.V. Heterocyclic derivatives of (4-aryloxymethyl-1,3-dioxolan-2-yl)methyl-1H-imidazoles and 1H-1,2,4-triazoles
US4766125A (en) * 1981-06-23 1988-08-23 Janssen Pharmaceutica N.V. N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia
US4619931A (en) * 1983-02-28 1986-10-28 Janssen Pharmaceutica, N.V. [[4-[4-(4-phenyl-1-piperazinyl)phenoxymethyl]-1,3-dioxolan-2-yl]methyl]-1H-imidazoles and 1H-1,2,4-triazoles
CA1292472C (fr) * 1985-12-03 1991-11-26 Alfonsus Guilielmus Knaeps Derives des ({4-¬4-(4-phenyl-1-piperazinyl)-phenoxymethyl|- 1,3-dioxolan-2-yl}methyl)-1h-imidazoles et 1h-1,2,4-triazoles
NZ223799A (en) * 1987-03-25 1989-12-21 Janssen Pharmaceutica Nv Azolylmethyl-dioxolanylmethoxyphenyl-piperazinyl-phenyl-triazolones and antimicrobial compositions
CA1331757C (fr) * 1988-02-29 1994-08-30 Janssen Pharmaceutica Naamloze Vennootschap 5-lipoxygenase inhibant les 4-(4-phenyl-1-piperazinyl)phenols
AU6359594A (en) * 1993-03-04 1994-09-26 Cytoven International N.V. Pharmaceutical tryptophan containing dipeptide compositions and methods of use thereof
US5521186A (en) * 1994-10-27 1996-05-28 Janssen Pharmaceutica N.V. Apolipoprotein-β synthesis inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0006711A1 (fr) * 1978-06-23 1980-01-09 Janssen Pharmaceutica N.V. Dérivés hétérocycliques de (4-phényl-pipérazin-1-yl-aryloxy méthyl-1,3-dioxolan-2-yl)-méthyl-1H-imidazoles et 1H-1,2,4-triazoles, procédés pour leur préparation et compositions les contenant

Also Published As

Publication number Publication date
CA2203274C (fr) 2002-02-19
CZ119897A3 (cs) 1998-03-18
DE122007000005I2 (de) 2008-04-24
FI119548B (fi) 2008-12-31
KR100227231B1 (ko) 1999-11-01
CN1161695A (zh) 1997-10-08
NO311937B1 (no) 2002-02-18
MX9703074A (es) 1997-07-31
PT788496E (pt) 2001-07-31
JP3025907B2 (ja) 2000-03-27
EP0788496A1 (fr) 1997-08-13
SK281908B6 (sk) 2001-09-11
DE69519995T2 (de) 2001-08-23
BG63694B1 (bg) 2002-09-30
CA2203274A1 (fr) 1996-05-09
NZ295353A (en) 1998-08-26
OA10479A (en) 2002-04-09
LU91306I2 (fr) 2007-03-19
ES2155535T3 (es) 2001-05-16
CY2256B1 (en) 2003-07-04
AP9700968A0 (en) 1997-04-30
RO118715B1 (ro) 2003-09-30
JPH09511759A (ja) 1997-11-25
AP779A (en) 1999-11-03
DE69519995D1 (en) 2001-03-01
HUT77360A (hu) 1998-03-30
HU219862B (hu) 2001-08-28
TR199501295A2 (tr) 1996-06-21
HRP950532B1 (en) 2001-06-30
AU697744B2 (en) 1998-10-15
SK50797A3 (en) 1998-04-08
ATE198889T1 (de) 2001-02-15
NO971895L (no) 1997-04-24
BG101402A (en) 1997-10-31
AU3868095A (en) 1996-05-23
FI971784A0 (fi) 1997-04-25
US5929075A (en) 1999-07-27
DE122007000005I1 (de) 2007-04-26
EP0788496B1 (fr) 2001-01-24
IL115771A0 (en) 1996-01-19
BR9509436A (pt) 1998-01-06
FI971784L (fi) 1997-04-25
NO971895D0 (no) 1997-04-24
IL115771A (en) 2000-02-29
AU697744C (en) 2002-08-22
CZ286476B6 (en) 2000-04-12
WO1996013499A1 (fr) 1996-05-09
HRP950532A2 (en) 1997-08-31
DK0788496T3 (da) 2001-06-18
GR3035519T3 (en) 2001-06-29

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
ASS Succession or assignment of patent right

Owner name: ELANCO ANIMAL HEALTH IRELAND LTD.

Free format text: FORMER OWNER: JANSSEN PHARMACEUTICA N.V.

Effective date: 20120409

C41 Transfer of patent application or patent right or utility model
TR01 Transfer of patent right

Effective date of registration: 20120409

Address after: Dublin, Ireland

Patentee after: Elanco Animal Health Ireland Limited

Address before: Beals Belgium

Patentee before: Janssen Pharmaceutica N. V.

C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20010704

Termination date: 20121019