AP9400638A0 - Water soluble derivatives of camptothecin. - Google Patents

Water soluble derivatives of camptothecin.

Info

Publication number: AP9400638A0
Authority: AP; ARIPO
Prior art keywords: lower alkyl; amino; water soluble; methylpyrrolyl; furyl
Prior art date: 1993-04-29

Application number

APAP/P/1994/000638A

Other languages

English (en)

Inventor

Michael Joseph Luzzio

Jeffrey M Besterman

Michael Glenn Evans

Peter Leslie Myers

Original Assignee

Glaxo Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-04-29

Filing date

1994-04-28

Publication date

1995-10-28

1994-04-28 Application filed by Glaxo Inc filed Critical Glaxo Inc

1995-10-28 Publication of AP9400638A0 publication Critical patent/AP9400638A0/en

Links

VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical class C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 title abstract 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 6
-1 n-methylpyrrolyl Chemical group 0.000 abstract 4
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 2
125000002541 furyl group Chemical group 0.000 abstract 2
125000002883 imidazolyl group Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
125000004076 pyridyl group Chemical group 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
239000003534 dna topoisomerase inhibitor Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
229910052757 nitrogen Inorganic materials 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
229940044693 topoisomerase inhibitor Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

APAP/P/1994/000638A 1993-04-29 1994-04-28 Water soluble derivatives of camptothecin. AP9400638A0 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US5458593A	1993-04-29	1993-04-29
US8104293A	1993-06-22	1993-06-22

Publications (1)

Publication Number	Publication Date
AP9400638A0 true AP9400638A0 (en)	1995-10-28

Family

ID=26733234

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
APAP/P/1994/000638A AP9400638A0 (en)	1993-04-29	1994-04-28	Water soluble derivatives of camptothecin.

Country Status (10)

Country	Link
EP (1)	EP0696285A1 (fr)
JP (1)	JPH08509740A (fr)
AP (1)	AP9400638A0 (fr)
AU (1)	AU6777194A (fr)
CA (1)	CA2161681A1 (fr)
IL (1)	IL109470A0 (fr)
IS (1)	IS4152A (fr)
MY (1)	MY141374A (fr)
PE (1)	PE52894A1 (fr)
WO (1)	WO1994025466A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6504029B1 (en) *	1995-04-10	2003-01-07	Daiichi Pharmaceutical Co., Ltd.	Condensed-hexacyclic compounds and a process therefor
US5663177A (en) *	1995-05-31	1997-09-02	Smithkline Beecham Corporation	Water soluble camptothecin analogs
SG103322A1 (en) *	1996-10-30	2004-04-29	Tanabe Seiyaku Co	S type 2-substituted hydroxy-2-indolidinylbutyric ester compounds and process for preparation thereof
US6559309B2 (en)	1996-11-01	2003-05-06	Osi Pharmaceuticals, Inc.	Preparation of a camptothecin derivative by intramolecular cyclisation
US6046209A (en) *	1997-05-27	2000-04-04	Smithkline Beecham Corporation	Water soluble camptothecin analogs
IN189180B (fr) *	1997-07-09	2003-01-04	Chong Kun Dang Corp
US6833373B1 (en)	1998-12-23	2004-12-21	G.D. Searle & Co.	Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en)	1998-12-23	2005-02-22	G. D. Searle & Co.	Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6288072B1 (en) *	1999-12-29	2001-09-11	Monroe E. Wall	Camptothecin β-alanine esters with topoisomerase I inhibition

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0418099T3 (da) *	1989-09-15	2002-04-02	Res Triangle Inst	Fremgangsmåde til fremstilling af 10,11-methylendioxy-20(RS)-camptothecin og 10,11-methylendioxy-20(S)-camptothecinanaloger
EP0540099B1 (fr) *	1991-10-29	1996-04-17	Glaxo Wellcome Inc.	Dérivés de camptothécine solubles dans l'eau
CA2087898A1 (fr) *	1992-01-24	1993-07-25	Hiroshi Akimoto	Composes heterocycliques condenses, leur preparation et leur utilisation

1994
- 1994-04-25 IS IS4152A patent/IS4152A/is unknown
- 1994-04-27 MY MYPI94001039A patent/MY141374A/en unknown
- 1994-04-27 PE PE1994241061A patent/PE52894A1/es not_active Application Discontinuation
- 1994-04-28 WO PCT/US1994/004681 patent/WO1994025466A1/fr not_active Ceased
- 1994-04-28 AU AU67771/94A patent/AU6777194A/en not_active Abandoned
- 1994-04-28 EP EP94915931A patent/EP0696285A1/fr not_active Withdrawn
- 1994-04-28 IL IL10947094A patent/IL109470A0/xx unknown
- 1994-04-28 AP APAP/P/1994/000638A patent/AP9400638A0/en unknown
- 1994-04-28 CA CA002161681A patent/CA2161681A1/fr not_active Abandoned
- 1994-04-28 JP JP6524540A patent/JPH08509740A/ja active Pending

Also Published As

Publication number	Publication date
IS4152A (is)	1994-10-30
PE52894A1 (es)	1995-01-06
EP0696285A1 (fr)	1996-02-14
CA2161681A1 (fr)	1994-11-10
AU6777194A (en)	1994-11-21
WO1994025466A1 (fr)	1994-11-10
IL109470A0 (en)	1994-07-31
MY141374A (en)	2010-04-16
JPH08509740A (ja)	1996-10-15

Publication	Publication Date	Title
MY108261A (en)	1996-09-30	Water soluble camptothecin derivatives
CA2100258A1 (fr)	1992-07-12	Derives de l'acridine
MY109296A (en)	1996-12-31	Water soluble camptothecin derivatives
DK584886D0 (da)	1986-12-05	Vanduoplaeselige, mono- og disubstituerede derivater af rapamycin og farmaceutisk acceptable salte deraf
MY113208A (en)	2001-12-31	Pharmaceutical and compositions inhibiting kinases
ATE219765T1 (de)	2002-07-15	Indolderivate als cgmp-pde inhibitoren
TR199900481T2 (xx)	1999-06-21	�ndazol t�revleri; fosfodiesteraz tip IV inhibit�rleri olarak kullan�mlar�.
DE60015927D1 (en)	2004-12-23	Phenylharnstoff und phenylthioharnstoffderivate
IL98392A0 (en)	1992-07-15	Indole derivatives,their preparation and pharmaceutical compositions containing them
NZ330816A (en)	2000-05-26	Quinazoline derivatives as antitumor agents
MY105438A (en)	1994-10-31	3-aminopiperidine derivatives and related nitrogen containing heterocycles.
EP0409406A3 (en)	1991-04-03	Aryl-substituted amine derivatives useful in cancer therapy
MY116952A (en)	2004-04-30	4 substituted 2-carboxy-tetrahydroquinoline derivatives, pharmaceutical compositions comprising them and process for their preparation
AP9400638A0 (en)	1995-10-28	Water soluble derivatives of camptothecin.
NZ292782A (en)	1999-02-25	Ant-inflammatory benzofuran and benzothiophene derivatives and medicaments thereof
NZ335252A (en)	2000-11-24	Substituted 3-thia-1,2,3,4-tetrahydrocarbazole, 6,7,8,9-tetrahydropyrido[1,2-a]indole, 4,5-dihydro-thiopyrano[3,4-b]indole, pyrano[3,4-b]indole or beta-carbolinyl derivatives
MD502G2 (ro)	1996-11-30	Derivaţi noi ai adenozinei, procedee de preparare a lor, compoziţii farmaceutice ce le conţin
EP0315434A3 (fr)	1990-01-10	Dérivés de pyridoxalhydrazones, leur préparation et leur utilisation et compositions pharmaceutiques qui les contiennent
MY110683A (en)	1999-01-30	Ellipticine derivative and process for preparing the same
MY103515A (en)	1993-07-31	Ergolinyl heterocycles
SE0000537D0 (sv)	2000-02-18	Use of a compound for preparing a drug
DE60010665D1 (de)	2004-06-17	Mittel zur verwendung in der transplantation